Published in Mol Microbiol on August 01, 2008
Molecular regulation of antibiotic biosynthesis in streptomyces. Microbiol Mol Biol Rev (2013) 2.24
Complete genome sequence of Streptomyces cattleya NRRL 8057, a producer of antibiotics and fluorometabolites. J Bacteriol (2011) 0.95
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus. J Bacteriol (2011) 0.89
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Positive feedback regulation of stgR expression for secondary metabolism in Streptomyces coelicolor. J Bacteriol (2013) 0.87
Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya. Antimicrob Agents Chemother (2011) 0.84
The Sound of Silence: Activating Silent Biosynthetic Gene Clusters in Marine Microorganisms. Mar Drugs (2015) 0.84
Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009. Chembiochem (2014) 0.80
Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis. J Bacteriol (2008) 0.79
New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis. Microb Cell Fact (2016) 0.78
FkbN and Tcs7 are pathway-specific regulators of the FK506 biosynthetic gene cluster in Streptomyces tsukubaensis L19. J Ind Microbiol Biotechnol (2016) 0.76
The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation. Appl Environ Microbiol (2015) 0.76
Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation. Microb Biotechnol (2014) 0.76
Regulatory genes and their roles for improvement of antibiotic biosynthesis in Streptomyces. 3 Biotech (2017) 0.75
Retracted Reactome array: forging a link between metabolome and genome. Science (2009) 2.27
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol (2004) 2.01
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol (2004) 1.81
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol (2002) 1.75
Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci U S A (2004) 1.72
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity. Nat Prod Rep (2006) 1.59
Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng (2008) 1.48
Antitumor compounds from marine actinomycetes. Mar Drugs (2009) 1.44
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem Biol (2005) 1.42
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Appl Microbiol Biotechnol (2006) 1.39
Engineering the glycosylation of natural products in actinomycetes. Trends Microbiol (2007) 1.39
The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins. Mol Microbiol (2004) 1.28
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol (2006) 1.24
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol (2004) 1.20
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. Chem Biol (2002) 1.17
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol (2003) 1.17
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep (2010) 1.16
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Chembiochem (2006) 1.16
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep (2009) 1.13
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Chembiochem (2006) 1.12
Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun (Camb) (2005) 1.09
Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment. Fertil Steril (2009) 1.05
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol (2002) 1.04
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb Biotechnol (2014) 1.03
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol (2006) 1.03
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem (2005) 1.03
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol (2009) 1.02
Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT. J Nat Prod (2002) 1.01
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem (2008) 1.01
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res (2007) 1.01
Indolocarbazole antitumour compounds by combinatorial biosynthesis. Curr Opin Chem Biol (2009) 1.00
DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis. Biochemistry (2010) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod (2008) 0.99
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem (2004) 0.97
Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives. J Mol Microbiol Biotechnol (2005) 0.96
A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis. J Med Chem (2012) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96