Published in J Nat Prod on November 01, 2002
Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew Chem Int Ed Engl (2008) 2.69
Recombinant E. coli prototype strains for in vivo glycorandomization. ACS Chem Biol (2010) 1.82
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76
A comprehensive review of glycosylated bacterial natural products. Chem Soc Rev (2015) 1.13
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod (2008) 0.99
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98
Development of a Streptomyces venezuelae-based combinatorial biosynthetic system for the production of glycosylated derivatives of doxorubicin and its biosynthetic intermediates. Appl Environ Microbiol (2011) 0.89
Engineering biosynthetic pathways to generate antitumor indolocarbazole derivatives. J Ind Microbiol Biotechnol (2006) 0.82
Molecular insights on the biosynthesis of antitumour compounds by actinomycetes. Microb Biotechnol (2010) 0.82
Modulation of deoxysugar transfer by the elloramycin glycosyltransferase ElmGT through site-directed mutagenesis. J Bacteriol (2009) 0.82
Enzymatic basis of "hybridity" in thiomarinol biosynthesis. Angew Chem Int Ed Engl (2015) 0.76
Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT. Bioorg Med Chem Lett (2012) 0.75
Modification of post-PKS tailoring steps through combinatorial biosynthesis. Nat Prod Rep (2002) 2.06
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol (2004) 2.01
An audience response system strategy to improve student motivation, attention, and feedback. Am J Pharm Educ (2009) 1.92
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol (2004) 1.81
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol (2002) 1.75
Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci U S A (2004) 1.72
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity. Nat Prod Rep (2006) 1.59
Retracted Psoralidin, an herbal molecule, inhibits phosphatidylinositol 3-kinase-mediated Akt signaling in androgen-independent prostate cancer cells. Cancer Prev Res (Phila) (2009) 1.57
Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng (2008) 1.48
Antitumor compounds from marine actinomycetes. Mar Drugs (2009) 1.44
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem Biol (2005) 1.42
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Appl Microbiol Biotechnol (2006) 1.39
Engineering the glycosylation of natural products in actinomycetes. Trends Microbiol (2007) 1.39
Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. J Neurosci (2011) 1.36
Flavin-dependent halogenases involved in secondary metabolism in bacteria. Appl Microbiol Biotechnol (2006) 1.29
Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target. Biochemistry (2003) 1.27
Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus. J Am Chem Soc (2005) 1.26
The complete gene cluster of the antitumor agent gilvocarcin V and its implication for the biosynthesis of the gilvocarcins. J Am Chem Soc (2003) 1.26
Angucyclines: Biosynthesis, mode-of-action, new natural products, and synthesis. Nat Prod Rep (2011) 1.26
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol (2006) 1.24
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol (2004) 1.20
Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy. Nucleic Acids Res (2006) 1.19
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. Chem Biol (2002) 1.17
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol (2003) 1.17
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Chembiochem (2006) 1.16
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep (2010) 1.16
The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis. J Am Chem Soc (2004) 1.13
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep (2009) 1.13
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Chembiochem (2006) 1.12
Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun (Camb) (2005) 1.09
Oxidative rearrangement processes in the biosynthesis of gilvocarcin V. J Am Chem Soc (2004) 1.08
The oxidative ring cleavage in jadomycin biosynthesis: a multistep oxygenation cascade in a biosynthetic black box. Chembiochem (2005) 1.08
Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway . Biochemistry (2009) 1.07
Functional analyses of oxygenases in jadomycin biosynthesis and identification of JadH as a bifunctional oxygenase/dehydrase. J Biol Chem (2005) 1.06
Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment. Fertil Steril (2009) 1.05
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb Biotechnol (2014) 1.03
Multi-oxygenase complexes of the gilvocarcin and jadomycin biosyntheses. J Am Chem Soc (2007) 1.03
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem (2005) 1.03
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol (2006) 1.03
Cloning and characterization of the ravidomycin and chrysomycin biosynthetic gene clusters. Chembiochem (2010) 1.03
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol (2009) 1.02
Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya. Mol Microbiol (2008) 1.01
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem (2008) 1.01
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res (2007) 1.01
Indolocarbazole antitumour compounds by combinatorial biosynthesis. Curr Opin Chem Biol (2009) 1.00
DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis. Biochemistry (2010) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
Characterization of LipL as a non-heme, Fe(II)-dependent α-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis. J Biol Chem (2011) 0.99
Investigation on Semecarpus Lehyam--a Siddha medicine for breast cancer. Planta (2004) 0.99
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod (2008) 0.99
Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002. J Nat Prod (2008) 0.99
Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated. Chembiochem (2006) 0.99
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98