Published in Curr Top Med Chem on January 01, 2008
Natural-product sugar biosynthesis and enzymatic glycodiversification. Angew Chem Int Ed Engl (2008) 2.69
A biosynthetic pathway for BE-7585A, a 2-thiosugar-containing angucycline-type natural product. J Am Chem Soc (2010) 1.04
Construction of the octose 8-phosphate intermediate in lincomycin A biosynthesis: characterization of the reactions catalyzed by LmbR and LmbN. J Am Chem Soc (2012) 0.94
A de novo approach to the synthesis of glycosylated methymycin analogues with structural and stereochemical diversity. Org Lett (2010) 0.93
Combined chemical and biosynthetic route to access a new apoptolidin congener. Org Lett (2009) 0.91
Mechanistic studies of the biosynthesis of 2-thiosugar: evidence for the formation of an enzyme-bound 2-ketohexose intermediate in BexX-catalyzed reaction. J Am Chem Soc (2010) 0.86
In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-α-D-gluco-octose as a key intermediate in lincomycin A biosynthesis. J Am Chem Soc (2014) 0.86
Enzymatic synthesis of TDP-deoxysugars. Methods Enzymol (2009) 0.84
Molecular insights on the biosynthesis of antitumour compounds by actinomycetes. Microb Biotechnol (2010) 0.82
Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives. Microb Cell Fact (2016) 0.75
Tracking down biotransformation to the genetic level: identification of a highly flexible glycosyltransferase from Saccharothrix espanaensis. Appl Environ Microbiol (2013) 0.75
Retracted Reactome array: forging a link between metabolome and genome. Science (2009) 2.27
Type II polyketide synthases: gaining a deeper insight into enzymatic teamwork. Nat Prod Rep (2006) 2.25
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: cluster analysis and assignment of functions. Chem Biol (2004) 2.01
Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol (2004) 1.81
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol (2002) 1.75
Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci U S A (2004) 1.72
A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol (2013) 1.59
Indolocarbazole natural products: occurrence, biosynthesis, and biological activity. Nat Prod Rep (2006) 1.59
Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng (2008) 1.48
Antitumor compounds from marine actinomycetes. Mar Drugs (2009) 1.44
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem Biol (2005) 1.42
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Appl Microbiol Biotechnol (2006) 1.39
Structure and action of the C-C bond-forming glycosyltransferase UrdGT2 involved in the biosynthesis of the antibiotic urdamycin. J Mol Biol (2007) 1.28
The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins. Mol Microbiol (2004) 1.28
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol (2006) 1.24
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol (2004) 1.20
Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete Saccharothrix espanaensis. J Bacteriol (2006) 1.19
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. Chem Biol (2002) 1.17
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol (2003) 1.17
Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis. Nat Prod Rep (2010) 1.16
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Chembiochem (2006) 1.16
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep (2009) 1.13
A genomic screening approach to the structure-guided identification of drug candidates from natural sources. Chembiochem (2007) 1.13
The glycosyltransferase UrdGT2 catalyzes both C- and O-glycosidic sugar transfers. Angew Chem Int Ed Engl (2004) 1.13
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Chembiochem (2006) 1.12
Structure and function of the antibiotic resistance-mediating methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol (2005) 1.10
Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun (Camb) (2005) 1.09
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives. Chem Biol (2006) 1.06
Engineered urdamycin glycosyltransferases are broadened and altered in substrate specificity. Chem Biol (2002) 1.05
Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136. FEMS Microbiol Lett (2008) 1.05
Organisation of the biosynthetic gene cluster and tailoring enzymes in the biosynthesis of the tetracyclic quinone glycoside antibiotic polyketomycin. Chembiochem (2009) 1.04
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol (2002) 1.04
Beta-glucuronidase as a sensitive and versatile reporter in actinomycetes. Appl Environ Microbiol (2011) 1.03
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb Biotechnol (2014) 1.03
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol (2006) 1.03
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem (2005) 1.03
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol (2009) 1.02
Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya. Mol Microbiol (2008) 1.01
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem (2008) 1.01
Glycosyltransferases involved in the biosynthesis of biologically active natural products that contain oligosaccharides. Mol Biosyst (2005) 1.01
Iteratively acting glycosyltransferases involved in the hexasaccharide biosynthesis of landomycin A. Chem Biol (2005) 1.01
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res (2007) 1.01
DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis. Biochemistry (2010) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Generation of novel landomycins M and O through targeted gene disruption. Chembiochem (2005) 0.99
The avilamycin resistance determinants AviRa and AviRb methylate 23S rRNA at the guanosine 2535 base and the uridine 2479 ribose. Mol Microbiol (2003) 0.98
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem (2004) 0.97
Urdamycin L: a novel metabolic shunt product that provides evidence for the role of the urdM gene in the urdamycin A biosynthetic pathway of Streptomyces fradiae TU 2717. Chembiochem (2003) 0.96
Genes and enzymes involved in bacterial isoprenoid biosynthesis. Curr Opin Chem Biol (2009) 0.96
A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis. J Med Chem (2012) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
Actinomycetes biosynthetic potential: how to bridge in silico and in vivo? J Ind Microbiol Biotechnol (2013) 0.95
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Mol Microbiol (2004) 0.94
Heterologous expression and genetic engineering of the phenalinolactone biosynthetic gene cluster by using red/ET recombineering. Chembiochem (2008) 0.94
Design, construction and characterisation of a synthetic promoter library for fine-tuned gene expression in actinomycetes. Metab Eng (2013) 0.93
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology (2008) 0.93
Functional expression of the Cre recombinase in actinomycetes. Appl Microbiol Biotechnol (2008) 0.93
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus. Mol Microbiol (2004) 0.92
A bacterial glycosyltransferase gene toolbox: generation and applications. Phytochemistry (2009) 0.92
Generation of new landomycins with altered saccharide patterns through over-expression of the glycosyltransferase gene lanGT3 in the biosynthetic gene cluster of landomycin A in Streptomyces cyanogenus S-136. Chembiochem (2007) 0.92
Site-specific recombination strategies for engineering actinomycete genomes. Appl Environ Microbiol (2012) 0.92
Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem (2009) 0.91
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate. J Bacteriol (2011) 0.91
Marker removal from actinomycetes genome using Flp recombinase. Gene (2008) 0.91
Function of lanGT3, a glycosyltransferase gene involved in landomycin A biosynthesis. Chembiochem (2004) 0.90
Features and applications of bacterial glycosyltransferases: current state and prospects. Appl Microbiol Biotechnol (2008) 0.90
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun (Camb) (2003) 0.89
On the acceptor substrate of C-glycosyltransferase UrdGT2: three prejadomycin C-Glycosides from an engineered mutant of Streptomyces globisporus 1912 DeltalndE(urdGT2). Angew Chem Int Ed Engl (2006) 0.89
Cloning and heterologous expression of the aranciamycin biosynthetic gene cluster revealed a new flexible glycosyltransferase. Chembiochem (2007) 0.89
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus. J Bacteriol (2011) 0.89
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles. Chem Commun (Camb) (2009) 0.89
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin. J Bacteriol (2003) 0.89
LanV, a bifunctional enzyme: aromatase and ketoreductase during landomycin A biosynthesis. Chembiochem (2005) 0.89
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis. Microbiology (2007) 0.88
LanGT2 Catalyzes the First Glycosylation Step during landomycin A biosynthesis. Chembiochem (2005) 0.88
The future of natural products as a source of new antibiotics. Curr Opin Investig Drugs (2007) 0.87
Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring. Chem Biol (2012) 0.87
Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin. Open Biol (2013) 0.87
Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity. Chembiochem (2008) 0.87
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. BMC Genomics (2014) 0.86
Rational design of an aryl-C-glycoside catalyst from a natural product O-glycosyltransferase. Chem Biol (2011) 0.86
The C-Glycosyltransferase UrdGT2 is unselective toward d- and l-configured nucleotide-bound rhodinoses. J Am Chem Soc (2003) 0.86