Published in Nat Prod Rep on April 01, 2010
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Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose. Chembiochem (2011) 0.90
Engineered polyketide biosynthesis and biocatalysis in Escherichia coli. Appl Microbiol Biotechnol (2010) 0.88
The crystal structure and mechanism of an unusual oxidoreductase, GilR, involved in gilvocarcin V biosynthesis. J Biol Chem (2011) 0.87
Harnessing the potential of halogenated natural product biosynthesis by mangrove-derived actinomycetes. Mar Drugs (2013) 0.87
Chemoenzymatic synthesis of spinosyn A. Angew Chem Int Ed Engl (2014) 0.86
Structural and biochemical characterization of the salicylyl-acyltranferase SsfX3 from a tetracycline biosynthetic pathway. J Biol Chem (2011) 0.83
Molecular insights on the biosynthesis of antitumour compounds by actinomycetes. Microb Biotechnol (2010) 0.82
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Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs. Chem Biol (2004) 1.81
Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase. Mol Microbiol (2005) 1.76
The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives. Chem Biol (2002) 1.75
Combinatorial biosynthesis of antitumor indolocarbazole compounds. Proc Natl Acad Sci U S A (2004) 1.72
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Improving production of bioactive secondary metabolites in actinomycetes by metabolic engineering. Metab Eng (2008) 1.48
Antitumor compounds from marine actinomycetes. Mar Drugs (2009) 1.44
A regioselective tryptophan 5-halogenase is involved in pyrroindomycin biosynthesis in Streptomyces rugosporus LL-42D005. Chem Biol (2005) 1.42
The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives. Appl Microbiol Biotechnol (2006) 1.39
Engineering the glycosylation of natural products in actinomycetes. Trends Microbiol (2007) 1.39
The formation of the rodlet layer of streptomycetes is the result of the interplay between rodlins and chaplins. Mol Microbiol (2004) 1.28
Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol (2006) 1.24
Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin. Chem Biol (2004) 1.20
Engineering deoxysugar biosynthetic pathways from antibiotic-producing microorganisms. A tool to produce novel glycosylated bioactive compounds. Chem Biol (2002) 1.17
Generation of new landomycins by combinatorial biosynthetic manipulation of the LndGT4 gene of the landomycin E cluster in S. globisporus. Chem Biol (2004) 1.17
The biosynthetic gene cluster for the beta-lactam carbapenem thienamycin in Streptomyces cattleya. Chem Biol (2003) 1.17
Reevaluation of the violacein biosynthetic pathway and its relationship to indolocarbazole biosynthesis. Chembiochem (2006) 1.16
Antitumor compounds from actinomycetes: from gene clusters to new derivatives by combinatorial biosynthesis. Nat Prod Rep (2009) 1.13
Deciphering the biosynthesis pathway of the antitumor thiocoraline from a marine actinomycete and its expression in two streptomyces species. Chembiochem (2006) 1.12
Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins. Chem Commun (Camb) (2005) 1.09
Cytogenetic analysis of early nonviable pregnancies after assisted reproduction treatment. Fertil Steril (2009) 1.05
Engineering specificity of starter unit selection by the erythromycin-producing polyketide synthase. Mol Microbiol (2002) 1.04
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074. Microb Biotechnol (2014) 1.03
Deoxysugar transfer during chromomycin A3 biosynthesis in Streptomyces griseus subsp. griseus: new derivatives with antitumor activity. Appl Environ Microbiol (2006) 1.03
Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII. Chembiochem (2005) 1.03
Deciphering biosynthesis of the RNA polymerase inhibitor streptolydigin and generation of glycosylated derivatives. Chem Biol (2009) 1.02
Identification of transcriptional activators for thienamycin and cephamycin C biosynthetic genes within the thienamycin gene cluster from Streptomyces cattleya. Mol Microbiol (2008) 1.01
Digitoxosyltetracenomycin C and glucosyltetracenomycin C, two novel elloramycin analogues obtained by exploring the sugar donor substrate specificity of glycosyltransferase ElmGT. J Nat Prod (2002) 1.01
Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis. Chembiochem (2008) 1.01
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences. Nucleic Acids Res (2007) 1.01
Indolocarbazole antitumour compounds by combinatorial biosynthesis. Curr Opin Chem Biol (2009) 1.00
DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis. Biochemistry (2010) 1.00
Glycosyltransferases, important tools for drug design. Curr Top Med Chem (2008) 0.99
Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity. J Nat Prod (2008) 0.99
Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses. Appl Environ Microbiol (2006) 0.98
Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem (2004) 0.97
Biosynthesis pathways for deoxysugars in antibiotic-producing actinomycetes: isolation, characterization and generation of novel glycosylated derivatives. J Mol Microbiol Biotechnol (2005) 0.96
Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways. J Am Chem Soc (2002) 0.96
A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis. J Med Chem (2012) 0.96
Deoxysugars in bioactive natural products: development of novel derivatives by altering the sugar pattern. Curr Top Med Chem (2008) 0.96
Biosynthesis of the angiogenesis inhibitor borrelidin by Streptomyces parvulus Tü4055: insights into nitrile formation. Mol Microbiol (2004) 0.94
Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster. Microbiology (2008) 0.93
Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus. Mol Microbiol (2004) 0.92
Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem (2009) 0.91
Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate. J Bacteriol (2011) 0.91
Evidence from engineered gene fusions for the repeated use of a module in a modular polyketide synthase. Chem Commun (Camb) (2003) 0.89
Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus. J Bacteriol (2011) 0.89
Purification and characterization of a monooxygenase involved in the biosynthetic pathway of the antitumor drug mithramycin. J Bacteriol (2003) 0.89
Generation of potent and selective kinase inhibitors by combinatorial biosynthesis of glycosylated indolocarbazoles. Chem Commun (Camb) (2009) 0.89
Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis. Microbiology (2007) 0.88
Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring. Chem Biol (2012) 0.87
Glycosylated derivatives of steffimycin: insights into the role of the sugar moieties for the biological activity. Chembiochem (2008) 0.87
Biosynthesis of the angiogenesis inhibitor borrelidin: directed biosynthesis of novel analogues. Chem Commun (Camb) (2006) 0.85