Published in Circ Res on January 15, 2009
Central nervous system pericytes in health and disease. Nat Neurosci (2011) 2.90
Pericyte recruitment during vasculogenic tube assembly stimulates endothelial basement membrane matrix formation. Blood (2009) 2.73
Canonical Notch signaling in the developing lung is required for determination of arterial smooth muscle cells and selection of Clara versus ciliated cell fate. J Cell Sci (2010) 2.07
Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization. Blood (2010) 1.81
Notch signaling in the vasculature. Curr Top Dev Biol (2010) 1.62
The adventitia: a dynamic interface containing resident progenitor cells. Arterioscler Thromb Vasc Biol (2011) 1.58
ChIP-seq reveals cell type-specific binding patterns of BMP-specific Smads and a novel binding motif. Nucleic Acids Res (2011) 1.55
Mural cell associated VEGF is required for organotypic vessel formation. PLoS One (2009) 1.48
Molecular basis for endothelial lumen formation and tubulogenesis during vasculogenesis and angiogenic sprouting. Int Rev Cell Mol Biol (2011) 1.36
Signaling mechanisms that regulate smooth muscle cell differentiation. Arterioscler Thromb Vasc Biol (2011) 1.34
EGFL7: a unique angiogenic signaling factor in vascular development and disease. Blood (2011) 1.33
Notch3 is critical for proper angiogenesis and mural cell investment. Circ Res (2010) 1.27
Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis. Nat Med (2016) 1.26
Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. Development (2012) 1.21
Novel insights into the differential functions of Notch ligands in vascular formation. J Angiogenes Res (2009) 1.16
CADASIL: experimental insights from animal models. Stroke (2010) 1.15
Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis. BMC Cancer (2010) 1.14
Notch activation of Jagged1 contributes to the assembly of the arterial wall. Circulation (2011) 1.14
A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis. PLoS One (2012) 1.12
The notch ligand JAGGED1 as a target for anti-tumor therapy. Front Oncol (2014) 1.11
The miR-143/145 cluster is a novel transcriptional target of Jagged-1/Notch signaling in vascular smooth muscle cells. J Biol Chem (2011) 1.10
Patent ductus arteriosus in mice with smooth muscle-specific Jag1 deletion. Development (2010) 1.10
KSHV-induced notch components render endothelial and mural cell characteristics and cell survival. Blood (2009) 1.09
Molecular pathways of notch signaling in vascular smooth muscle cells. Front Physiol (2012) 1.07
Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane. Blood (2011) 1.01
ETOILE regulates developmental patterning in the filamentous brown alga Ectocarpus siliculosus. Plant Cell (2011) 0.98
Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma. Clin Cancer Res (2010) 0.97
The induction of yes-associated protein expression after arterial injury is crucial for smooth muscle phenotypic modulation and neointima formation. Arterioscler Thromb Vasc Biol (2012) 0.97
Colon cancer progression is driven by APEX1-mediated upregulation of Jagged. J Clin Invest (2013) 0.96
Feed-forward signaling by membrane-bound ligand receptor circuit: the case of NOTCH DELTA-like 4 ligand in endothelial cells. J Biol Chem (2010) 0.94
CD248 facilitates tumor growth via its cytoplasmic domain. BMC Cancer (2011) 0.93
Notch signaling in developmental and tumor angiogenesis. Genes Cancer (2011) 0.93
A switch in Notch gene expression parallels stem cell to endothelial transition in infantile hemangioma. Angiogenesis (2010) 0.92
Notch2 and Notch3 function together to regulate vascular smooth muscle development. PLoS One (2012) 0.92
Brain pericytes: emerging concepts and functional roles in brain homeostasis. Cell Mol Neurobiol (2011) 0.91
Vascular smooth muscle Notch signals regulate endothelial cell sensitivity to angiogenic stimulation. J Biol Chem (2011) 0.91
Signaling required for blood vessel maintenance: molecular basis and pathological manifestations. Int J Vasc Med (2011) 0.91
Biochemical characterization and cellular effects of CADASIL mutants of NOTCH3. PLoS One (2012) 0.90
Activation dynamics and signaling properties of Notch3 receptor in the developing pulmonary artery. J Biol Chem (2011) 0.88
The antiangiogenic 16K prolactin impairs functional tumor neovascularization by inhibiting vessel maturation. PLoS One (2011) 0.87
Dll4-Notch signaling in regulation of tumor angiogenesis. J Cancer Res Clin Oncol (2013) 0.86
Notch signaling contributes to lung cancer clonogenic capacity in vitro but may be circumvented in tumorigenesis in vivo. Mol Cancer Res (2011) 0.86
Building a vessel wall with notch signaling. Circ Res (2009) 0.85
Notch signalling in ischaemia-induced angiogenesis. Biochem Soc Trans (2009) 0.85
The role of pericytes in neurovascular unit remodeling in brain disorders. Int J Mol Sci (2014) 0.84
Mesenchymal stem cells: roles and relationships in vascularization. Tissue Eng Part B Rev (2014) 0.84
BRD4 Regulates Breast Cancer Dissemination through Jagged1/Notch1 Signaling. Cancer Res (2016) 0.84
A receptor-specific function for Notch2 in mediating vascular smooth muscle cell growth arrest through cyclin-dependent kinase inhibitor 1B. Circ Res (2013) 0.83
Impaired endothelium-mesenchymal stem cells cross-talk in systemic sclerosis: a link between vascular and fibrotic features. Arthritis Res Ther (2014) 0.83
Combined deficiency of Notch1 and Notch3 causes pericyte dysfunction, models CADASIL, and results in arteriovenous malformations. Sci Rep (2015) 0.82
Notch signaling in ocular vasculature development and diseases. Mol Med (2012) 0.82
Clarification of mural cell coverage of vascular endothelial cells by live imaging of zebrafish. Development (2016) 0.82
Anti-DLL4, a cancer therapeutic with multiple mechanisms of action. Vasc Cell (2011) 0.82
CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. Am J Respir Cell Mol Biol (2013) 0.82
Endothelial cells direct mesenchymal stem cells toward a smooth muscle cell fate. Stem Cells Dev (2014) 0.82
Transcriptome analysis for Notch3 target genes identifies Grip2 as a novel regulator of myogenic response in the cerebrovasculature. Arterioscler Thromb Vasc Biol (2012) 0.82
MicroRNA miR145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells. Circ Res (2014) 0.82
γ-Secretase inhibitor DAPT attenuates intimal hyperplasia of vein grafts by inhibition of Notch1 signaling. Lab Invest (2014) 0.81
Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells. J Biol Chem (2012) 0.81
Coexpression analysis of large cancer datasets provides insight into the cellular phenotypes of the tumour microenvironment. BMC Genomics (2013) 0.81
Notch signaling functions in retinal pericyte survival. Invest Ophthalmol Vis Sci (2014) 0.80
Notch signal integration in the vasculature during remodeling. Vascul Pharmacol (2014) 0.80
The Notch pathway attenuates interleukin 1β (IL1β)-mediated induction of adenylyl cyclase 8 (AC8) expression during vascular smooth muscle cell (VSMC) trans-differentiation. J Biol Chem (2012) 0.79
Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions. Oncotarget (2015) 0.78
Inhibition of tumor angiogenesis and tumor growth by the DSL domain of human Delta-like 1 targeted to vascular endothelial cells. Neoplasia (2013) 0.78
Lunatic Fringe is a potent tumor suppressor in Kras-initiated pancreatic cancer. Oncogene (2015) 0.78
The evolving roles of pericyte in early brain injury after subarachnoid hemorrhage. Brain Res (2015) 0.78
Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells. J Biol Chem (2015) 0.77
NOTCH3 Is Induced in Cancer-Associated Fibroblasts and Promotes Angiogenesis in Oral Squamous Cell Carcinoma. PLoS One (2016) 0.77
Notch regulation of hematopoiesis, endothelial precursor cells, and blood vessel formation: orchestrating the vasculature. Stem Cells Int (2012) 0.77
Regulation of vascular smooth muscle cell phenotype in three-dimensional coculture system by Jagged1-selective Notch3 signaling. Tissue Eng Part A (2014) 0.76
Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling. Am J Physiol Heart Circ Physiol (2011) 0.75
Vascular Notch proteins and Notch signaling in the peri-implantation mouse uterus. Vasc Cell (2015) 0.75
Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Stem Cells Dev (2015) 0.75
Stability and function of adult vasculature is sustained by Akt/Jagged1 signalling axis in endothelium. Nat Commun (2016) 0.75
Regulation of retinal angiogenesis by endothelial nitric oxide synthase signaling pathway. Korean J Physiol Pharmacol (2016) 0.75
Tumor Vascular Morphology Undergoes Dramatic Changes during Outgrowth of B16 Melanoma While Proangiogenic Gene Expression Remains Unchanged. ISRN Oncol (2011) 0.75
Constitutively active Notch1 converts cranial neural crest-derived frontonasal mesenchyme to perivascular cells in vivo. Biol Open (2017) 0.75
Jagged-1 Signaling in the Bone Marrow Microenvironment Promotes Endothelial Progenitor Cell Expansion and Commitment of CD133+ Human Cord Blood Cells for Postnatal Vasculogenesis. PLoS One (2016) 0.75
Mutual interaction between endothelial cells and mural cells enhances BMP9 signaling in endothelial cells. Biol Open (2017) 0.75
Distinct gene expression profiles associated with Notch ligands Delta-like 4 and Jagged1 in plaque material from peripheral artery disease patients: a pilot study. J Transl Med (2017) 0.75
PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death Dis (2016) 0.75
Src- and Fyn-dependent apical membrane trafficking events control endothelial lumen formation during vascular tube morphogenesis. PLoS One (2017) 0.75
Role of Delta-Notch signaling in cerebral cavernous malformations. Neurosurg Rev (2016) 0.75
Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1. Nat Commun (2017) 0.75
Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev (2004) 16.52
Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol (2006) 13.12
Molecular regulation of vessel maturation. Nat Med (2003) 11.74
Endothelial/pericyte interactions. Circ Res (2005) 8.24
Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia. Nature (1996) 8.02
Notch signaling is essential for vascular morphogenesis in mice. Genes Dev (2000) 6.88
Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilization. Circ Res (2005) 5.08
IL-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J Clin Invest (2007) 4.71
Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol (2003) 4.43
Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev (2004) 3.95
Presenilin 1 is required for Notch1 and DII1 expression in the paraxial mesoderm. Nature (1997) 3.14
Notch signaling in vascular development and physiology. Development (2007) 3.03
Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev (2004) 3.00
Regulation of blood flow in the microcirculation. Microcirculation (2005) 2.68
Notch function in the vasculature: insights from zebrafish, mouse and man. Bioessays (2004) 2.59
Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. Dev Biol (2003) 2.57
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Coregulation of vascular tube stabilization by endothelial cell TIMP-2 and pericyte TIMP-3. J Cell Biol (2006) 2.50
Essential role of endothelial Notch1 in angiogenesis. Circulation (2005) 2.28
Notch activation results in phenotypic and functional changes consistent with endothelial-to-mesenchymal transformation. Circ Res (2004) 2.10
An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. J Clin Invest (2007) 2.09
Smooth Muscle alpha-actin is a direct target of Notch/CSL. Circ Res (2006) 1.90
Early contribution of pericytes to angiogenic sprouting and tube formation. Angiogenesis (2003) 1.89
Jagged1-selective notch signaling induces smooth muscle differentiation via a RBP-Jkappa-dependent pathway. J Biol Chem (2006) 1.78
Notch signaling represses myocardin-induced smooth muscle cell differentiation. J Biol Chem (2005) 1.71
Members of the Jagged/Notch gene families are expressed in injured arteries and regulate cell phenotype via alterations in cell matrix and cell-cell interaction. Am J Pathol (2001) 1.61
Determinants of Notch-3 receptor expression and signaling in vascular smooth muscle cells: implications in cell-cycle regulation. Circ Res (2002) 1.55
Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression. J Biol Chem (2007) 1.52
Endothelial dysfunction: from physiology to therapy. J Mol Cell Cardiol (1999) 1.47
Reciprocal regulatory interactions between the Notch and Ras signaling pathways in the Drosophila embryonic mesoderm. Dev Biol (2002) 1.45
Paracrine induction of angiogenesis in vitro by Swiss 3T3 fibroblasts. J Cell Sci (1993) 1.44
Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol (2005) 1.44
Endothelial-stromal interactions in angiogenesis. Curr Opin Hematol (2008) 1.43
Murine notch homologs (N1-4) undergo presenilin-dependent proteolysis. J Biol Chem (2001) 1.39
Gap junction communication mediates transforming growth factor-beta activation and endothelial-induced mural cell differentiation. Circ Res (2003) 1.33
Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am J Physiol Cell Physiol (2006) 1.31
Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1. Angiogenesis (2008) 1.24
Consequences of Notch-mediated induction of Jagged1. Exp Cell Res (2004) 1.23
Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK. J Biol Chem (2002) 1.19
Regulation of angiogenesis by homotypic and heterotypic notch signalling in endothelial cells and pericytes: from basic research to potential therapies. Angiogenesis (2008) 1.18
Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis. Gene Expr Patterns (2006) 1.15
An overview of Notch3 function in vascular smooth muscle cells. Prog Biophys Mol Biol (2007) 1.14
Paracrine interactions between fibroblasts and endothelial cells in a serum-free coculture model. Modulation of angiogenesis and collagen gel contraction. Lab Invest (1994) 1.13
Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling. Physiol Genomics (2008) 1.05
Acid-induced activation of the urease promoters is mediated directly by the ArsRS two-component system of Helicobacter pylori. Infect Immun (2005) 1.56
Transforming growth factor-beta (TGF- 1) down-regulates Notch3 in fibroblasts to promote smooth muscle gene expression. J Biol Chem (2007) 1.52
Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer. Dev Biol (2007) 1.35
Notch3 is critical for proper angiogenesis and mural cell investment. Circ Res (2010) 1.27
Fibroblasts potentiate blood vessel formation partially through secreted factor TIMP-1. Angiogenesis (2008) 1.24
Acid-responsive gene regulation in the human pathogen Helicobacter pylori. J Biotechnol (2006) 1.10
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease. J Mol Cell Cardiol (2013) 1.09
Differential gene expression in a coculture model of angiogenesis reveals modulation of select pathways and a role for Notch signaling. Physiol Genomics (2008) 1.05
Regulation of expression of atypical orphan response regulators of Helicobacter pylori. Microbiol Res (2006) 0.97
Hypoxia-inducible factor 1alpha modulates adhesion, migration, and FAK phosphorylation in vascular smooth muscle cells. J Cell Biochem (2005) 0.96
NAD(P)H oxidase-dependent regulation of CCL2 production during retinal inflammation. Invest Ophthalmol Vis Sci (2009) 0.92
Notch2 and Notch3 function together to regulate vascular smooth muscle development. PLoS One (2012) 0.92
Protein kinase C and downstream signaling pathways in a three-dimensional model of phorbol ester-induced angiogenesis. Angiogenesis (2006) 0.91
Generation and characterization of Csrp1 enhancer-driven tissue-restricted Cre-recombinase mice. Genesis (2008) 0.85
Ca2+/calmodulin-dependent protein kinase IV activates cysteine-rich protein 1 through adjacent CRE and CArG elements. Am J Physiol Cell Physiol (2005) 0.84
Small molecule inhibitors of arginyltransferase regulate arginylation-dependent protein degradation, cell motility, and angiogenesis. Biochem Pharmacol (2012) 0.84
Endothelial cells direct mesenchymal stem cells toward a smooth muscle cell fate. Stem Cells Dev (2014) 0.82
Notch signaling governs phenotypic modulation of smooth muscle cells. Vascul Pharmacol (2014) 0.81
Reciprocal regulation of syndecan-2 and Notch signaling in vascular smooth muscle cells. J Biol Chem (2012) 0.81
Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation. Vascul Pharmacol (2013) 0.80
Temporal and embryonic lineage-dependent regulation of human vascular SMC development by NOTCH3. Stem Cells Dev (2015) 0.75
Endothelial cells downregulate apolipoprotein D expression in mural cells through paracrine secretion and Notch signaling. Am J Physiol Heart Circ Physiol (2011) 0.75