Published in Oncogene on January 19, 2009
In-depth analyses of kinase-dependent tyrosine phosphoproteomes based on metal ion-functionalized soluble nanopolymers. Mol Cell Proteomics (2010) 1.62
TRAF-interacting protein (TRIP) negatively regulates IFN-β production and antiviral response by promoting proteasomal degradation of TANK-binding kinase 1. J Exp Med (2012) 1.16
Role of the protein tyrosine kinase Syk in regulating cell-cell adhesion and motility in breast cancer cells. Mol Cancer Res (2009) 1.13
A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk. Br J Cancer (2010) 1.09
NOPO modulates Egr-induced JNK-independent cell death in Drosophila. Cell Res (2011) 1.02
Syk tyrosine kinase acts as a pancreatic adenocarcinoma tumor suppressor by regulating cellular growth and invasion. Am J Pathol (2009) 0.98
Syk interacts with and phosphorylates nucleolin to stabilize Bcl-x(L) mRNA and promote cell survival. Mol Cell Biol (2014) 0.84
Identification of direct tyrosine kinase substrates based on protein kinase assay-linked phosphoproteomics. Mol Cell Proteomics (2013) 0.82
TRIP/NOPO E3 ubiquitin ligase promotes ubiquitylation of DNA polymerase η. Development (2014) 0.82
The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Biochim Biophys Acta (2011) 0.81
Tumor necrosis factor (TNF) receptor-associated factor (TRAF)-interacting protein (TRIP) negatively regulates the TRAF2 ubiquitin-dependent pathway by suppressing the TRAF2-sphingosine 1-phosphate (S1P) interaction. J Biol Chem (2015) 0.81
Syk inhibits the activity of protein kinase A by phosphorylating tyrosine 330 of the catalytic subunit. J Biol Chem (2013) 0.79
Modulation by Syk of Bcl-2, calcium and the calpain-calpastatin proteolytic system in human breast cancer cells. Biochim Biophys Acta (2013) 0.78
The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation. J Biol Chem (2014) 0.77
TRAIP is involved in chromosome alignment and SAC regulation in mouse oocyte meiosis. Sci Rep (2016) 0.77
The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis. Oncotarget (2015) 0.77
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy. J Biol Chem (2015) 0.76
Two-layer modular analysis of gene and protein networks in breast cancer. BMC Syst Biol (2014) 0.76
Anti-Inflammatory Effects of TRAF-Interacting Protein in Rheumatoid Arthritis Fibroblast-Like Synoviocytes. Mediators Inflamm (2016) 0.75
Disruption of Tumor Necrosis Factor Receptor-Associated Factor 5 Exacerbates Murine Experimental Colitis via Regulating T Helper Cell-Mediated Inflammation. Mediators Inflamm (2016) 0.75
TRAIP regulates replication fork recovery and progression via PCNA. Cell Discov (2016) 0.75
The Syk tyrosine kinase suppresses malignant growth of human breast cancer cells. Nature (2000) 2.17
Daxx: death or survival protein? Trends Cell Biol (2006) 1.93
Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol (2001) 1.69
Proximal protein tyrosine kinases in immunoreceptor signaling. Curr Opin Immunol (2001) 1.67
TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation. J Exp Med (1997) 1.56
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. J Exp Med (2003) 1.44
Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells. J Biol Chem (2006) 1.37
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
MMTV Env encodes an ITAM responsible for transformation of mammary epithelial cells in three-dimensional culture. J Exp Med (2005) 1.34
Nucleocytoplasmic trafficking of the Syk protein tyrosine kinase. Mol Cell Biol (2006) 1.26
Syk tyrosine kinase participates in beta1-integrin signaling and inflammatory responses in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 1.21
Progressive loss of Syk and abnormal proliferation in breast cancer cells. Cancer Res (2004) 1.21
Molecular basis for a direct interaction between the Syk protein-tyrosine kinase and phosphoinositide 3-kinase. J Biol Chem (2004) 1.13
The role of cytokines in the epithelial cancer microenvironment. Semin Cancer Biol (2002) 1.13
Transcription repressor activity of spleen tyrosine kinase mediates breast tumor suppression. Cancer Res (2005) 1.12
Reduced expression of the Syk gene is correlated with poor prognosis in human breast cancer. Cancer Lett (2003) 1.05
The Syk tyrosine kinase localizes to the centrosomes and negatively affects mitotic progression. Cancer Res (2005) 1.05
TRAF-interacting protein (TRIP) is a RING-dependent ubiquitin ligase. Biochem Biophys Res Commun (2007) 1.03
Functional dissection of BCR signaling pathways. Curr Opin Immunol (2000) 1.01
TNF activates Syk protein tyrosine kinase leading to TNF-induced MAPK activation, NF-kappaB activation, and apoptosis. J Immunol (2004) 0.98
The tyrosine kinase Syk regulates TPL2 activation signals. J Biol Chem (2005) 0.85
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (1995) 4.84
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J Biol Chem (1992) 2.12
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10
Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem (1994) 1.90
Mechanisms of p34cdc2 regulation. Mol Cell Biol (1993) 1.89
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol (2001) 1.69
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem (1991) 1.68
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell (2001) 1.61
CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A (1993) 1.60
Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem (1993) 1.53
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis. J Biol Chem (1991) 1.46
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.42
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
Tyrosine phosphorylation of band 3 inhibits peripheral protein binding. J Biol Chem (1987) 1.35
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta (1997) 1.31
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity (2001) 1.27
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod (1992) 1.24
Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1986) 1.24
Purification and characterization of a protein-tyrosine kinase from bovine thymus. J Biol Chem (1986) 1.23
Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J Biol Chem (1979) 1.23
Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. J Biol Chem (1982) 1.21
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals. J Biol Chem (1993) 1.19
Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J Biol Chem (1994) 1.15
T and B lymphocytes express distinct tyrosine protein kinases. J Biol Chem (1984) 1.14
Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Anal Biochem (1990) 1.14
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry (1990) 1.13
Kinase inhibitors from Polygonum cuspidatum. J Nat Prod (1993) 1.10
Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis. J Biol Chem (1988) 1.09
Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol (1999) 1.08
Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol (1999) 1.08
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem (1997) 1.06
Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ (1997) 1.06
Interactions of Lyn with the antigen receptor during B cell activation. J Biol Chem (1994) 1.01
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol (2000) 0.99
Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. Biochemistry (1993) 0.98
Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. J Cell Sci (2000) 0.96
Interactions of a photoaffinity analog of GTP with the proteins of microtubules. Proc Natl Acad Sci U S A (1977) 0.96
Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. J Biol Chem (1999) 0.93
The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. Eur J Immunol (1999) 0.91
Induction of a substrate for casein kinase II during lymphocyte mitogenesis. Biochim Biophys Acta (1984) 0.91
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J Med Chem (1991) 0.90
Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. J Biol Chem (1980) 0.90
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J Med Chem (1993) 0.89
Studies on the phosphorylation of the type I cAMP-dependent protein kinase. J Biol Chem (1980) 0.86
Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Methods Enzymol (1991) 0.85
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J Biol Chem (2000) 0.85
Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochim Biophys Acta (1985) 0.84
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem (1996) 0.83
Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. J Med Chem (2001) 0.83
Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Biochem Biophys Res Commun (1991) 0.82
Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk. J Biol Chem (1994) 0.82
Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem (1994) 0.82
Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck. J Biol Chem (1996) 0.81
S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase. J Med Chem (1989) 0.80
Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases. Biochim Biophys Acta (1994) 0.79
Effect of phosphorylation on the regulatory subunit of the type I cAMP-dependent protein kinase. J Biol Chem (1981) 0.78
Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A (1979) 0.78
Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J (1991) 0.78
Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography. Anal Biochem (1989) 0.78
Extracellular control of erythrocyte metabolism mediated by a cytoplasmic tyrosine kinase. Biomed Biochim Acta (1990) 0.78
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochem Biophys Res Commun (1993) 0.78
Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels. Biochem Biophys Res Commun (1986) 0.77
Cell cycle-specific activation of the PTK72 protein-tyrosine kinase in B lymphocytes. J Biol Chem (1993) 0.77
Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck. J Nat Prod (1992) 0.77
Phosphorylation of cAMP-dependent protein kinase subunits. Adv Enzyme Regul (1982) 0.76
Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40. Biochem Biophys Res Commun (1988) 0.76
The effect of mild oxidants on glycolysis in human erythrocytes. Biochem J (1992) 0.75
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod (1992) 0.75
Oncogene signal transduction inhibitors from medicinal plants. In Vivo (1997) 0.75
Synthesis of [beta-(4-pyridyl-1-oxide)-L-alanine4]-angiotensin I as a potential suicide substrate for protein-tyrosine kinases. Int J Pept Protein Res (1990) 0.75
Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase. J Pharm Sci (1994) 0.75
Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. J Nat Prod (1993) 0.75