Published in J Med Chem on February 01, 1991
Bioflavonoids as poisons of human topoisomerase II alpha and II beta. Biochemistry (2007) 1.10
Maize Lc transcription factor enhances biosynthesis of anthocyanins, distinct proanthocyanidins and phenylpropanoids in apple (Malus domestica Borkh.). Planta (2007) 1.01
QSAR study of p56(lck) protein tyrosine kinase inhibitory activity of flavonoid derivatives using MLR and GA-PLS. Int J Mol Sci (2008) 0.91
Phytochemicals as Anticancer and Chemopreventive Topoisomerase II Poisons. Phytochem Rev (2014) 0.91
Flavonol Glycosides from Euphorbia microsciadia Bioss. with their Immunomodulatory Activities. Iran J Pharm Res (2012) 0.78
Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J (1991) 0.78
Regulation of the serine-base exchange enzyme system by CD4: effects of monoclonal antibodies, jacalin, interleukin 16 and the HIV membrane protein gp120. Biochem J (1998) 0.77
Covalent attachment of the plant natural product naringenin to small glass and ceramic beads. BMC Chem Biol (2005) 0.75
GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature (1998) 5.03
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (1995) 4.84
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J Biol Chem (1992) 2.12
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10
Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem (1994) 1.90
Mechanisms of p34cdc2 regulation. Mol Cell Biol (1993) 1.89
Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. J Med Chem (1991) 1.84
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol (2001) 1.69
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem (1991) 1.68
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell (2001) 1.61
CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A (1993) 1.60
Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem (1993) 1.53
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis. J Biol Chem (1991) 1.46
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.42
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
Tyrosine phosphorylation of band 3 inhibits peripheral protein binding. J Biol Chem (1987) 1.35
Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. J Med Chem (1992) 1.32
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta (1997) 1.31
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity (2001) 1.27
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod (1992) 1.24
Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1986) 1.24
Purification and characterization of a protein-tyrosine kinase from bovine thymus. J Biol Chem (1986) 1.23
Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J Biol Chem (1979) 1.23
Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. J Biol Chem (1982) 1.21
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals. J Biol Chem (1993) 1.19
Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J Biol Chem (1994) 1.15
Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Anal Biochem (1990) 1.14
T and B lymphocytes express distinct tyrosine protein kinases. J Biol Chem (1984) 1.14
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry (1990) 1.13
Kinase inhibitors from Polygonum cuspidatum. J Nat Prod (1993) 1.10
Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis. J Biol Chem (1988) 1.09
Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol (1999) 1.08
Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol (1999) 1.08
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene (2009) 1.07
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem (1997) 1.06
Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ (1997) 1.06
Cosalane analogues with enhanced potencies as inhibitors of HIV-1 protease and integrase. J Med Chem (1995) 1.04
Interactions of Lyn with the antigen receptor during B cell activation. J Biol Chem (1994) 1.01
Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective alpha1a-adrenergic receptor antagonists. Bioorg Med Chem Lett (2000) 1.00
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol (2000) 0.99
Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. Biochemistry (1993) 0.98
Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. J Cell Sci (2000) 0.96
Interactions of a photoaffinity analog of GTP with the proteins of microtubules. Proc Natl Acad Sci U S A (1977) 0.96
Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. J Biol Chem (1999) 0.93
In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. J Med Chem (2000) 0.92
An alternative method of panning for rat B lymphocytes. Immunol Lett (1987) 0.91
The engagement of beta1 integrins on promonocytic cells promotes phosphorylation of Syk and formation of a protein complex containing Lyn and beta1 integrin. Eur J Immunol (1999) 0.91
Induction of a substrate for casein kinase II during lymphocyte mitogenesis. Biochim Biophys Acta (1984) 0.91
Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight. J Med Chem (1991) 0.90
Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. J Biol Chem (1980) 0.90
Cytotoxicities of some flavonoid analogues. J Nat Prod (1992) 0.89
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J Med Chem (1993) 0.89
Design, synthesis, and biological evaluation of cosalane, a novel anti-HIV agent which inhibits multiple features of virus reproduction. J Med Chem (1994) 0.88
Studies on the phosphorylation of the type I cAMP-dependent protein kinase. J Biol Chem (1980) 0.86
Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Methods Enzymol (1991) 0.85
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J Biol Chem (2000) 0.85
Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochim Biophys Acta (1985) 0.84
Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. J Med Chem (2001) 0.83
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem (1996) 0.83
Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Biochem Biophys Res Commun (1991) 0.82
Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk. J Biol Chem (1994) 0.82
Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem (1994) 0.82
Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck. J Biol Chem (1996) 0.81
S-(2-oxopentadecyl)-CoA, a nonhydrolyzable analogue of myristoyl-CoA, is a potent inhibitor of myristoyl-CoA:protein N-myristoyltransferase. J Med Chem (1989) 0.80
Characterization of specific binding of [125I]L-762,459, a selective alpha1A-adrenoceptor radioligand to rat and human tissues. Eur J Pharmacol (1998) 0.80
Posttranslational acylation of the transferrin receptor in LSTRA cells with myristate, palmitate and stearate: evidence for distinct acyltransferases. Biochim Biophys Acta (1994) 0.79
In vitro studies on L-771,688 (SNAP 6383), a new potent and selective alpha1A-adrenoceptor antagonist. Eur J Pharmacol (2000) 0.79
Selective inhibition of the growth of ras-transformed human bronchial epithelial cells by emodin, a protein-tyrosine kinase inhibitor. Biochem Biophys Res Commun (1993) 0.78
Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J (1991) 0.78
Polyclonal activation of primed rat B cells. Cell Immunol (1986) 0.78
Detection of myristoyl CoA:protein N-myristoyltransferase activity by ion-exchange chromatography. Anal Biochem (1989) 0.78
Extracellular control of erythrocyte metabolism mediated by a cytoplasmic tyrosine kinase. Biomed Biochim Acta (1990) 0.78
Synthesis and use of 8-azidoguanosine 3',5'-cyclic monophosphate as photoaffinity label for cyclic GMP-dependent protein kinase. Proc Natl Acad Sci U S A (1979) 0.78
Effect of phosphorylation on the regulatory subunit of the type I cAMP-dependent protein kinase. J Biol Chem (1981) 0.78
The role of Syk in cell signaling. Adv Exp Med Biol (1994) 0.78
Cell cycle-specific activation of the PTK72 protein-tyrosine kinase in B lymphocytes. J Biol Chem (1993) 0.77
Detection of a novel lymphocyte protein-tyrosine kinase by renaturation in polyacrylamide gels. Biochem Biophys Res Commun (1986) 0.77
Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck. J Nat Prod (1992) 0.77
Identification of a dihydropyridine as a potent alpha1a adrenoceptor-selective antagonist that inhibits phenylephrine-induced contraction of the human prostate. J Med Chem (1998) 0.77
Phosphorylation of glycogen synthase by a bovine thymus protein-tyrosine kinase, p40. Biochem Biophys Res Commun (1988) 0.76
De novo design of a novel oxazolidinone analogue as a potent and selective alpha1A adrenergic receptor antagonist with high oral bioavailability. J Med Chem (2000) 0.76
Phosphorylation of cAMP-dependent protein kinase subunits. Adv Enzyme Regul (1982) 0.76
The effect of mild oxidants on glycolysis in human erythrocytes. Biochem J (1992) 0.75
Protein-tyrosine kinase inhibition: mechanism-based discovery of antitumor agents. J Nat Prod (1992) 0.75
Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett (1999) 0.75
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. J Med Chem (1999) 0.75
Synthesis of myristoyl CoA analogues and myristoyl peptides as inhibitors of myristoyl CoA:protein N-myristoyltransferase. J Pharm Sci (1994) 0.75
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 4. Structure-activity relationship in the dihydropyrimidine series. J Med Chem (1999) 0.75
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 3. Approaches to eliminate opioid agonist metabolites by using substituted phenylpiperazine side chains. J Med Chem (1999) 0.75
Flavonoids from Koelreuteria henryi and other sources as protein-tyrosine kinase inhibitors. J Nat Prod (1993) 0.75