Published in Proc Natl Acad Sci U S A on May 24, 1994
Oncogenic CSF3R mutations in chronic neutrophilic leukemia and atypical CML. N Engl J Med (2013) 3.57
Granulocyte colony-stimulating factor: molecular mechanisms of action during steady state and 'emergency' hematopoiesis. Cytokine (2008) 1.95
The new genetics of chronic neutrophilic leukemia and atypical CML: implications for diagnosis and treatment. Blood (2013) 1.79
Profiling of tyrosine phosphorylation pathways in human cells using mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.68
G-CSF induced reactive oxygen species involves Lyn-PI3-kinase-Akt and contributes to myeloid cell growth. Blood (2005) 1.45
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J Exp Med (1996) 1.39
Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev (2009) 1.25
Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils. J Exp Med (1996) 1.24
Neutrophil cell surface receptors and their intracellular signal transduction pathways. Int Immunopharmacol (2013) 1.23
Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis. Blood (2006) 1.07
The intracellular signal transduction mechanism of interleukin 5 in eosinophils: the involvement of lyn tyrosine kinase and the Ras-Raf-1-MEK-microtubule-associated protein kinase pathway. J Exp Med (1995) 1.05
Tyrosine 763 of the murine granulocyte colony-stimulating factor receptor mediates Ras-dependent activation of the JNK/SAPK mitogen-activated protein kinase pathway. Mol Cell Biol (1997) 1.05
Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor. J Exp Med (2009) 1.04
Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells. EMBO J (1997) 1.02
The tandem Src homology 2 domain of the Syk kinase: a molecular device that adapts to interphosphotyrosine distances. Proc Natl Acad Sci U S A (2003) 0.95
Ligand independence of the T618I mutation in the colony-stimulating factor 3 receptor (CSF3R) protein results from loss of O-linked glycosylation and increased receptor dimerization. J Biol Chem (2014) 0.94
CSF3R, SETBP1 and CALR mutations in chronic neutrophilic leukemia. J Hematol Oncol (2014) 0.91
Interactions among HCLS1, HAX1 and LEF-1 proteins are essential for G-CSF-triggered granulopoiesis. Nat Med (2012) 0.91
Src family kinases and the MEK/ERK pathway in the regulation of myeloid differentiation and myeloid leukemogenesis. Adv Enzyme Regul (2007) 0.89
G-CSF stimulates Jak2-dependent Gab2 phosphorylation leading to Erk1/2 activation and cell proliferation. Cell Signal (2008) 0.89
Signaling through a novel domain of gp130 mediates cell proliferation and activation of Hck and Erk kinases. Mol Cell Biol (2001) 0.88
Distinct signal transduction through the tyrosine-containing domains of the granulocyte colony-stimulating factor receptor. EMBO J (1995) 0.85
Hematopoietic colony-stimulating factors: new players in tumor-nerve interactions. J Mol Med (Berl) (2010) 0.84
Stimulation of c-Src by prolactin is independent of Jak2. Biochem J (2000) 0.82
Granulocyte colony-stimulating factor receptor mutations in myeloid malignancy. Front Oncol (2014) 0.82
CSF3R mutations have a high degree of overlap with CEBPA mutations in pediatric AML. Blood (2016) 0.79
Highly metastatic 13762NF rat mammary adenocarcinoma cell clones stimulate bone marrow by secretion of granulocyte-macrophage colony-stimulating factor/interleukin-3 activity. Am J Pathol (1995) 0.76
Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. J Exp Med (2001) 0.75
Granulocyte colony-stimulating factor receptor signaling in severe congenital neutropenia, chronic neutrophilic leukemia, and related malignancies. Exp Hematol (2016) 0.75
Enhanced MAPK signaling is essential for CSF3R induced leukemia. Leukemia (2016) 0.75
SH2 domains recognize specific phosphopeptide sequences. Cell (1993) 17.28
Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol (1991) 15.04
JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin. Cell (1993) 6.04
Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell (1993) 5.37
Critical cytoplasmic region of the interleukin 6 signal transducer gp130 is conserved in the cytokine receptor family. Proc Natl Acad Sci U S A (1991) 3.31
Cytokine receptors and signal transduction. Annu Rev Immunol (1992) 3.27
T cell antigen receptor signal transduction: a tale of tails and cytoplasmic protein-tyrosine kinases. Cell (1993) 3.25
Granulocyte colony-stimulating factor and its receptor. Blood (1991) 3.24
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature (1992) 2.95
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem (1991) 2.89
The cytoplasmic region of the erythropoietin receptor contains nonoverlapping positive and negative growth-regulatory domains. Mol Cell Biol (1991) 2.77
Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol (1987) 2.54
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci U S A (1990) 1.97
Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor (1). N Engl J Med (1992) 1.95
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol (1991) 1.84
Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J (1991) 1.82
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem (1991) 1.68
Expression cloning of a human granulocyte colony-stimulating factor receptor: a structural mosaic of hematopoietin receptor, immunoglobulin, and fibronectin domains. J Exp Med (1990) 1.63
The Src family of tyrosine protein kinases in hemopoietic signal transduction. FASEB J (1992) 1.61
Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor. Cell (1993) 1.51
Triggering signaling cascades by receptor tyrosine kinases. Trends Biochem Sci (1992) 1.50
Nonreceptor tyrosine protein kinases. Oncogene (1993) 1.47
Multiple hematopoietic growth factors signal through tyrosine phosphorylation. Growth Factors (1990) 1.43
B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr Biol (1993) 1.38
Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation. Mol Cell Biol (1993) 1.38
Effects of recombinant human granulocyte and macrophage colony-stimulating factors on signal transduction pathways in human granulocytes. J Immunol (1987) 1.23
Association with B-cell-antigen receptor with protein-tyrosine kinase p72syk and activation by engagement of membrane IgM. Eur J Biochem (1993) 1.22
Involvement of p72syk, a protein-tyrosine kinase, in Fc gamma receptor signaling. J Biol Chem (1993) 1.22
Distinct regions of the human granulocyte-colony-stimulating factor receptor cytoplasmic domain are required for proliferation and gene induction. Mol Cell Biol (1993) 1.20
Signal transduction by T- and B-cell antigen receptors: converging structures and concepts. Curr Opin Immunol (1992) 1.13
Protein-tyrosine kinase p72syk is activated by thrombin and is negatively regulated through Ca2+ mobilization in platelets. J Biol Chem (1993) 1.12
Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells. Biochem Biophys Res Commun (1992) 1.12
Stimulation of the Na+/H+ exchanger in human endothelial cells activated by granulocyte- and granulocyte-macrophage-colony-stimulating factor. Evidence for a role in proliferation and migration. J Biol Chem (1989) 0.99
Characterization of a 97-kDa phosphotyrosylprotein regulated by multiple cytokines. J Biol Chem (1992) 0.95
Granulocyte colony-stimulating factor receptor and its related receptors. Growth Factors (1993) 0.88
Role of tyrosyl phosphorylation in neutrophil priming by tumor necrosis factor-alpha and granulocyte colony stimulating factor. Arch Biochem Biophys (1992) 0.83
Molecular cloning of cDNAs for the human granulocyte colony-stimulating factor receptor from HL-60 and mapping of the gene to chromosome region 1p32-34. Blood (1992) 0.80
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell (1988) 10.47
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (1989) 5.20
Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell (1984) 5.05
Levels of TGF-alpha and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst (1998) 5.05
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (1995) 4.84
Syk tyrosine kinase required for mouse viability and B-cell development. Nature (1995) 3.87
Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen. Proc Natl Acad Sci U S A (1984) 3.80
Elevated levels of transforming growth factor alpha and epidermal growth factor receptor messenger RNA are early markers of carcinogenesis in head and neck cancer. Cancer Res (1993) 3.62
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A (1991) 3.57
Human papillomavirus type 16 DNA-induced malignant transformation of NIH 3T3 cells. J Virol (1986) 3.03
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitro. J Clin Invest (1998) 3.01
Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature (1992) 2.95
Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A (1991) 2.93
Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity (1995) 2.74
Cytokine-dependent granulocytic differentiation. Regulation of proliferative and differentiative responses in a murine progenitor cell line. J Immunol (1987) 2.54
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acids. Mol Cell Biol (1988) 2.50
Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor. J Biol Chem (1992) 2.12
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10
Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07
Interleukin-6 induces prostate cancer cell growth accompanied by activation of stat3 signaling pathway . Prostate (2000) 2.03
T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proc Natl Acad Sci U S A (1991) 2.03
Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock. J Exp Med (1998) 1.96
Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. Proc Natl Acad Sci U S A (1985) 1.96
Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J Biol Chem (1993) 1.95
src-related tyrosine protein kinases as signaling components in hematopoietic cells. Cancer Cells (1990) 1.92
Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc Natl Acad Sci U S A (1987) 1.92
Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation. Mol Cell Biol (1988) 1.90
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem (1994) 1.90
Mechanisms of p34cdc2 regulation. Mol Cell Biol (1993) 1.89
Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol (1991) 1.84
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83
Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res (1998) 1.83
Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock. Am J Physiol Cell Physiol (2001) 1.81
Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C. Oncogene Res (1988) 1.80
Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem (1995) 1.78
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. J Virol (1992) 1.74
Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta. J Exp Med (1993) 1.73
Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. Oncogene (1999) 1.72
Middle tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with pp60c-src. J Virol (1985) 1.71
Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol (2001) 1.69
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem (1991) 1.68
Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. J Biol Chem (1986) 1.67
Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature (1989) 1.66
The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem (1995) 1.65
Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1. J Virol (1989) 1.65
Differences in the subpopulations of the structural proteins of polyoma virions and capsids: biological functions of the multiple VP1 species. J Virol (1981) 1.64
Identification of a novel neuronal C-SRC exon expressed in human brain. Mol Cell Biol (1990) 1.63
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell (2001) 1.61
CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A (1993) 1.60
Differential adsorption of polyoma virions and capsids to mouse kidney cells and guinea pig erythrocytes. J Virol (1979) 1.59
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J Exp Med (1989) 1.58
Susceptibility of penicillin-resistant pneumococci to eighteen antimicrobials: implications for treatment of meningitis. J Antimicrob Chemother (1983) 1.56
Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes. Mol Cell Biol (1989) 1.55
Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem (1993) 1.53
Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res (1988) 1.53
Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product. Proc Natl Acad Sci U S A (1985) 1.52
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. J Virol (1989) 1.47
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis. J Biol Chem (1991) 1.46
Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol (1994) 1.45
Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. J Biol Chem (1995) 1.44
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol (1995) 1.44
Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells. J Biol Chem (1994) 1.38
CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J (1993) 1.37
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
Tyrosine phosphorylation of band 3 inhibits peripheral protein binding. J Biol Chem (1987) 1.35
Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking. J Biol Chem (1992) 1.32
Separation of neutralizing and hemagglutination-inhibiting antibody activities and specificity of antisera to sodium dodecyl sulfate-derived polypeptides of polyoma virions. J Virol (1980) 1.32
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta (1997) 1.31
Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement. J Biol Chem (1994) 1.31
Granulocyte colony-stimulating factor activation of Stat3 alpha and Stat3 beta in immature normal and leukemic human myeloid cells. Blood (1996) 1.29
A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity (2001) 1.27
Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI. Mol Cell Biol (1995) 1.26
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod (1992) 1.24
The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J (1996) 1.24
Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1986) 1.24
Purification and characterization of a protein-tyrosine kinase from bovine thymus. J Biol Chem (1986) 1.23
Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J Biol Chem (1979) 1.23
Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene (1999) 1.22
Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. J Biol Chem (1982) 1.21
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals. J Biol Chem (1993) 1.19
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity (1996) 1.19
Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury. Am J Physiol (1998) 1.17
Association of altered dynamics of monocyte surface expression of human leukocyte antigen DR with immunosuppression in tuberculosis. J Infect Dis (1984) 1.16
Expression of p60fyn in human platelets. Oncogene (1990) 1.15
Regulation of pp60c-src synthesis by inducible RNA complementary to c-src mRNA in polyomavirus-transformed rat cells. Mol Cell Biol (1986) 1.15
FK 506, rapamycin, and cyclosporine: effects on IL-4 and IL-10 mRNA levels in a T-helper 2 cell line. Transplant Proc (1991) 1.15
Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J Biol Chem (1994) 1.15