Published in J Biol Chem on April 25, 1992
Tyrosine kinases Lyn and Syk regulate B cell receptor-coupled Ca2+ mobilization through distinct pathways. EMBO J (1994) 4.23
Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med (1994) 2.26
Functional characterization of a signal transducing motif present in the T cell antigen receptor zeta chain. J Exp Med (1993) 2.17
Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. J Exp Med (1995) 1.73
Requirement of phospholipase C-gamma 2 activation in surface immunoglobulin M-induced B cell apoptosis. J Exp Med (1995) 1.71
Visualizing lipid raft dynamics and early signaling events during antigen receptor-mediated B-lymphocyte activation. Mol Biol Cell (2003) 1.66
Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J Exp Med (1995) 1.62
CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A (1993) 1.60
B cells from patients with systemic lupus erythematosus display abnormal antigen receptor-mediated early signal transduction events. J Clin Invest (1996) 1.56
Syk and pTyr'd: Signaling through the B cell antigen receptor. Biochim Biophys Acta (2009) 1.55
Tyrosine 112 of latent membrane protein 2A is essential for protein tyrosine kinase loading and regulation of Epstein-Barr virus latency. J Virol (1998) 1.52
A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proc Natl Acad Sci U S A (1995) 1.49
Identification of HS1 protein as a major substrate of protein-tyrosine kinase(s) upon B-cell antigen receptor-mediated signaling. Proc Natl Acad Sci U S A (1993) 1.49
Bruton tyrosine kinase is tyrosine phosphorylated and activated in pre-B lymphocytes and receptor-ligated B cells. Proc Natl Acad Sci U S A (1994) 1.45
Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol (1995) 1.44
Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk. Mol Cell Biol (1996) 1.40
Dominant-negative zeta-associated protein 70 inhibits T cell antigen receptor signaling. J Exp Med (1996) 1.39
Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor. EMBO J (1994) 1.32
Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med (1996) 1.29
Analysis of the interaction of ZAP-70 and syk protein-tyrosine kinases with the T-cell antigen receptor by plasmon resonance. Proc Natl Acad Sci U S A (1995) 1.26
Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI. Mol Cell Biol (1995) 1.26
Conformational changes induced in the protein tyrosine kinase p72syk by tyrosine phosphorylation or by binding of phosphorylated immunoreceptor tyrosine-based activation motif peptides. Mol Cell Biol (1996) 1.22
p56lck-independent activation and tyrosine phosphorylation of p72syk by T-cell antigen receptor/CD3 stimulation. Proc Natl Acad Sci U S A (1994) 1.19
The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM. J Exp Med (1995) 1.11
Clustering of Syk is sufficient to induce tyrosine phosphorylation and release of allergic mediators from rat basophilic leukemia cells. Mol Cell Biol (1995) 1.03
Involvement of p59fynT in interleukin-5 receptor signaling. J Exp Med (1995) 1.03
Human spleen tyrosine kinase p72Syk associates with the Src-family kinase p53/56Lyn and a 120-kDa phosphoprotein. Proc Natl Acad Sci U S A (1995) 1.02
Inhibition of spleen tyrosine kinase prevents mast cell activation and airway hyperresponsiveness. Am J Respir Crit Care Med (2005) 1.01
Constitutive tyrosine phosphorylation of the T-cell receptor (TCR) zeta subunit: regulation of TCR-associated protein tyrosine kinase activity by TCR zeta. Mol Cell Biol (1993) 1.00
The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85. EMBO J (2011) 1.00
Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate. Proc Natl Acad Sci U S A (1995) 1.00
Syk tyrosine kinase and B cell antigen receptor (BCR) immunoglobulin-alpha subunit determine BCR-mediated major histocompatibility complex class II-restricted antigen presentation. J Exp Med (1998) 0.99
Nck-mediated recruitment of BCAP to the BCR regulates the PI(3)K-Akt pathway in B cells. Nat Immunol (2013) 0.99
Tyrosine phosphorylation of CD19 in pre-B and mature B cells. EMBO J (1993) 0.97
In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation. Mol Cell Biol (1996) 0.94
Tyrosine phosphorylation of Blk and Fyn Src homology 2 domain-binding proteins occurs in response to antigen-receptor ligation in B cells and constitutively in pre-B cells. Proc Natl Acad Sci U S A (1994) 0.91
Activation of the high-affinity immunoglobulin E receptor Fc epsilon RI in RBL-2H3 cells is inhibited by Syk SH2 domains. Mol Cell Biol (1995) 0.90
Tyrosine phosphorylation and association of Syk with Fc gamma RII in monocytic THP-1 cells. Biochem J (1995) 0.89
Abrogation of the Fc gamma receptor IIA-mediated phagocytic signal by stem-loop Syk antisense oligonucleotides. Mol Biol Cell (1996) 0.89
Ig alpha and Ig beta are functionally homologous to the signaling proteins of the T-cell receptor. Mol Cell Biol (1994) 0.88
Models of signal transduction through the B-cell antigen receptor. Immunology (2003) 0.87
Characterization of the roles of SH2 domain-containing proteins in T-lymphocyte activation by using dominant negative SH2 domains. Mol Cell Biol (1996) 0.87
Phosphorylation/dephosphorylation of high-affinity IgE receptors: a mechanism for coupling/uncoupling a large signaling complex. Proc Natl Acad Sci U S A (1992) 0.86
Activation of mTORC1 signaling pathway in AIDS-related lymphomas. Am J Pathol (2009) 0.85
The membrane immunoglobulin receptor utilizes a Shc/Grb2/hSOS complex for activation of the mitogen-activated protein kinase cascade in a B-cell line. Biochem J (1995) 0.83
A novel nonreceptor tyrosine kinase, Srm: cloning and targeted disruption. Mol Cell Biol (1994) 0.83
Hematopoietic cell phosphatase, SHP-1, is constitutively associated with the SH2 domain-containing leukocyte protein, SLP-76, in B cells. J Exp Med (1996) 0.82
Critical Role for an acidic amino acid region in platelet signaling by the HemITAM (hemi-immunoreceptor tyrosine-based activation motif) containing receptor CLEC-2 (C-type lectin receptor-2). J Biol Chem (2012) 0.81
Cis and trans regulatory mechanisms control AP2-mediated B cell receptor endocytosis via select tyrosine-based motifs. PLoS One (2013) 0.79
Oxidative stress triggers tyrosine phosphorylation in B cells through a redox- and inflammatory cytokine-sensitive mechanism. Immunology (1996) 0.76
Activation of integrin-beta3-associated syk in platelets. Biochem J (1999) 0.75
Assignment of the porcine spleen tyrosine kinase gene, SYK, to chromosome 14q14 by fluorescence in situ hybridization. Mamm Genome (1997) 0.75
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature (1995) 4.84
Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. Proc Natl Acad Sci U S A (1982) 2.25
DAP12-mediated signal transduction in natural killer cells. A dominant role for the Syk protein-tyrosine kinase. J Biol Chem (1998) 2.10
Cloning and expression of a protein-tyrosine-phosphatase. Proc Natl Acad Sci U S A (1990) 2.07
Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. J Biol Chem (1994) 1.90
Mechanisms of p34cdc2 regulation. Mol Cell Biol (1993) 1.89
Fc epsilon RI-mediated tyrosine phosphorylation and activation of the 72-kDa protein-tyrosine kinase, PTK72, in RBL-2H3 rat tumor mast cells. Proc Natl Acad Sci U S A (1992) 1.77
A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nat Genet (1995) 1.75
Visualization of Syk-antigen receptor interactions using green fluorescent protein: differential roles for Syk and Lyn in the regulation of receptor capping and internalization. J Immunol (2001) 1.69
B lymphocyte activation is accompanied by phosphorylation of a 72-kDa protein-tyrosine kinase. J Biol Chem (1991) 1.68
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases. Mol Cell (2001) 1.61
CD22 associates with the human surface IgM-B-cell antigen receptor complex. Proc Natl Acad Sci U S A (1993) 1.60
Reversible palmitoylation of the protein-tyrosine kinase p56lck. J Biol Chem (1993) 1.53
Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J Immunol (1998) 1.50
Role of band 3 tyrosine phosphorylation in the regulation of erythrocyte glycolysis. J Biol Chem (1991) 1.46
A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. J Biol Chem (1983) 1.45
Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.42
Syk, activated by cross-linking the B-cell antigen receptor, localizes to the cytosol where it interacts with and phosphorylates alpha-tubulin on tyrosine. J Biol Chem (1996) 1.37
Tyrosine phosphorylation of band 3 inhibits peripheral protein binding. J Biol Chem (1987) 1.35
Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk. Biochim Biophys Acta (1997) 1.31
Regulation of glycolysis via reversible enzyme binding to the membrane protein, band 3. J Biol Chem (1993) 1.28
Inhibition of beta 2 integrin receptor and Syk kinase signaling in monocytes by the Src family kinase Fgr. Immunity (2001) 1.27
Emodin, a protein tyrosine kinase inhibitor from Polygonum cuspidatum. J Nat Prod (1992) 1.24
Detection of protein kinase activity in sodium dodecyl sulfate-polyacrylamide gels. Anal Biochem (1986) 1.24
Purification and characterization of a protein-tyrosine kinase from bovine thymus. J Biol Chem (1986) 1.23
Use of a GTP photoaffinity probe to resolve aspects of the mechanism of tubulin polymerization. J Biol Chem (1979) 1.23
Type II regulatory subunit of cAMP-dependent protein kinase. Phosphorylation by casein kinase II at a site that is also phosphorylated in vivo. J Biol Chem (1982) 1.21
Localization of the ankyrin-binding site on erythrocyte membrane protein, band 3. J Biol Chem (1989) 1.21
p72syk tyrosine kinase is activated by oxidizing conditions that induce lymphocyte tyrosine phosphorylation and Ca2+ signals. J Biol Chem (1993) 1.19
A lymphoma protein with an in vitro site of tyrosine phosphorylation homologous to that in pp60src. J Biol Chem (1982) 1.15
Phosphorylation of human erythrocyte band 3 by endogenous p72syk. J Biol Chem (1994) 1.15
T and B lymphocytes express distinct tyrosine protein kinases. J Biol Chem (1984) 1.14
Immunochemical detection of adenine nucleotide-binding proteins with antibodies to 5'-p-fluorosulfonylbenzoyladenosine. Anal Biochem (1990) 1.14
Metabolic activation of 2-substituted derivatives of myristic acid to form potent inhibitors of myristoyl CoA:protein N-myristoyltransferase. Biochemistry (1990) 1.13
Kinase inhibitors from Polygonum cuspidatum. J Nat Prod (1993) 1.10
Generation of an active protein-tyrosine kinase from lymphocytes by proteolysis. J Biol Chem (1988) 1.09
Inhibition of signaling through the B cell antigen receptor by the protooncogene product, c-Cbl, requires Syk tyrosine 317 and the c-Cbl phosphotyrosine-binding domain. J Immunol (1999) 1.08
Matrix valency regulates integrin-mediated lymphoid adhesion via Syk kinase. J Cell Biol (1999) 1.08
The protein-tyrosine kinase Syk interacts with TRAF-interacting protein TRIP in breast epithelial cells. Oncogene (2009) 1.07
Syk activation and dissociation from the B-cell antigen receptor is mediated by phosphorylation of tyrosine 130. J Biol Chem (1997) 1.06
Cross-linking of integrins induces tyrosine phosphorylation of the proto-oncogene product Vav and the protein tyrosine kinase Syk in human factor-dependent myeloid cells. Cell Growth Differ (1997) 1.06
Interactions of Lyn with the antigen receptor during B cell activation. J Biol Chem (1994) 1.01
Purification and characterization of adenosine deaminase from a genetically enriched mouse cell line. J Biol Chem (1985) 1.00
Hierarchy of protein tyrosine kinases in interleukin-2 (IL-2) signaling: activation of syk depends on Jak3; however, neither Syk nor Lck is required for IL-2-mediated STAT activation. Mol Cell Biol (2000) 0.99
Treatment of T cells with 2-hydroxymyristic acid inhibits the myristoylation and alters the stability of p56lck. Biochemistry (1993) 0.98
Syk-dependent phosphorylation of microtubules in activated B-lymphocytes. J Cell Sci (2000) 0.96
Interactions of a photoaffinity analog of GTP with the proteins of microtubules. Proc Natl Acad Sci U S A (1977) 0.96
A review of screening mammography participation and utilization in Canada. Chronic Dis Inj Can (2011) 0.94
Phosphorylation- and activation-independent association of the tyrosine kinase Syk and the tyrosine kinase substrates Cbl and Vav with tubulin in B-cells. J Biol Chem (1999) 0.93
The Annonaceous acetogenin bullatacin is cytotoxic against multidrug-resistant human mammary adenocarcinoma cells. Cancer Lett (1997) 0.91
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Induction of a substrate for casein kinase II during lymphocyte mitogenesis. Biochim Biophys Acta (1984) 0.91
Synthesis and protein-tyrosine kinase inhibitory activities of flavonoid analogues. J Med Chem (1991) 0.90
Regulatory subunit of the type I cAMP-dependent protein kinase as an inhibitor and substrate of the cGMP-dependent protein kinase. J Biol Chem (1980) 0.90
Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol. J Med Chem (1993) 0.89
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Studies on the phosphorylation of the type I cAMP-dependent protein kinase. J Biol Chem (1980) 0.86
Renaturation and assay of protein kinases after electrophoresis in sodium dodecyl sulfate-polyacrylamide gels. Methods Enzymol (1991) 0.85
Substrate recognition by the Lyn protein-tyrosine kinase. NMR structure of the immunoreceptor tyrosine-based activation motif signaling region of the B cell antigen receptor. J Biol Chem (2000) 0.85
Preliminary X-ray analysis of crystals of murine adenosine deaminase. J Mol Biol (1988) 0.85
Properties of a tyrosine protein kinase from calf thymus. Response to ionic strength and divalent cations. Biochim Biophys Acta (1985) 0.84
Prevention of alcohol withdrawal seizures with oral diazepam loading. Can Med Assoc J (1985) 0.84
Angiographically cryptic AVM presenting as a pontine tumor. Case report. J Neurosurg (1980) 0.83
The protein-tyrosine kinase Lck associates with and is phosphorylated by Cdc2. J Biol Chem (1996) 0.83
Oxidative stress and thiol depletion in plasma and peripheral blood lymphocytes from HIV-infected patients: toxicological and pathological implications. AIDS (1997) 0.83
Design, synthesis, and biological evaluation of a series of lavendustin A analogues that inhibit EGFR and Syk tyrosine kinases, as well as tubulin polymerization. J Med Chem (2001) 0.83
Identification of tyrosine 67 in bovine brain myelin basic protein as a specific phosphorylation site for thymus p56lck. Biochem Biophys Res Commun (1991) 0.82
Signaling-induced association of a tyrosine-phosphorylated 36-kDa protein with p50csk. J Biol Chem (1994) 0.82
Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src. J Med Chem (1994) 0.82
Prolonged survival in a patient with an occult primary small-cell lung cancer and a solitary brain metastasis at diagnosis. Intern Med J (2002) 0.82
Carcinoma in diverticulum of female urethra. Urology (1985) 0.81
Acute and late toxicity associated with sequential bleomycin-containing chemotherapy regimens and radiation therapy in the treatment of carcinoma of the nasopharynx. Int J Radiat Oncol Biol Phys (1988) 0.81
Activation of T cell Raf-1 at mitosis requires the protein-tyrosine kinase Lck. J Biol Chem (1996) 0.81