Published in PLoS One on January 19, 2009
Reversal of type 1 diabetes via islet β cell regeneration following immune modulation by cord blood-derived multipotent stem cells. BMC Med (2012) 1.44
Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases. Biomater Res (2016) 1.38
Immunological applications of stem cells in type 1 diabetes. Endocr Rev (2011) 1.20
Epigallocatechin gallate delays the onset of type 1 diabetes in spontaneous non-obese diabetic mice. Br J Nutr (2010) 0.94
Targeting regulatory T cells in the treatment of type 1 diabetes mellitus. Curr Mol Med (2012) 0.92
Systemic transplantation of human umbilical cord derived mesenchymal stem cells-educated T regulatory cells improved the impaired cognition in AβPPswe/PS1dE9 transgenic mice. PLoS One (2013) 0.91
HUCBCs increase angiopoietin 1 and induce neurorestorative effects after stroke in T1DM rats. CNS Neurosci Ther (2014) 0.91
Testing agents for prevention or reversal of type 1 diabetes in rodents. PLoS One (2013) 0.84
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Umbilical cord-derived mesenchymal stem cells reversed the suppressive deficiency of T regulatory cells from peripheral blood of patients with multiple sclerosis in a co-culture - a preliminary study. Oncotarget (2016) 0.77
Dietary flavonol epicatechin prevents the onset of type 1 diabetes in nonobese diabetic mice. J Agric Food Chem (2013) 0.77
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HUCMNCs protect vascular endothelium and prevent ISR after endovascular interventional therapy for vascular diseases in T2DM rabbits. Mol Cell Biochem (2017) 0.75
In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature (2008) 16.21
Immunomodulatory properties of mesenchymal stromal cells. Blood (2007) 6.97
Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction. Immunity (2008) 6.08
Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest (2002) 4.73
TGF-beta: a master of all T cell trades. Cell (2008) 4.60
Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans. Nat Rev Immunol (2007) 4.55
Defective suppressor function in CD4(+)CD25(+) T-cells from patients with type 1 diabetes. Diabetes (2005) 4.34
New sources of pancreatic beta-cells. Nat Biotechnol (2005) 3.11
T cells with low avidity for a tissue-restricted antigen routinely evade central and peripheral tolerance and cause autoimmunity. Immunity (2006) 3.02
Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med (2007) 2.86
Anti-CD3 and nasal proinsulin combination therapy enhances remission from recent-onset autoimmune diabetes by inducing Tregs. J Clin Invest (2006) 2.73
Functional defects and the influence of age on the frequency of CD4+ CD25+ T-cells in type 1 diabetes. Diabetes (2005) 2.63
Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia (2006) 2.53
The effector T cells of diabetic subjects are resistant to regulation via CD4+ FOXP3+ regulatory T cells. J Immunol (2008) 2.39
Functional waning of naturally occurring CD4+ regulatory T-cells contributes to the onset of autoimmune diabetes. Diabetes (2007) 2.27
Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes. Diabetes (2008) 2.25
Autoimmune diabetes onset results from qualitative rather than quantitative age-dependent changes in pathogenic T-cells. Diabetes (2005) 2.10
A human peripheral blood monocyte-derived subset acts as pluripotent stem cells. Proc Natl Acad Sci U S A (2003) 2.09
CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells. Nat Med (2008) 2.07
Single cell analysis shows decreasing FoxP3 and TGFbeta1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. J Exp Med (2005) 2.05
No alterations in the frequency of FOXP3+ regulatory T-cells in type 1 diabetes. Diabetes (2007) 1.99
Translational mini-review series on type 1 diabetes: Immune-based therapeutic approaches for type 1 diabetes. Clin Exp Immunol (2007) 1.86
Interferon-alpha initiates type 1 diabetes in nonobese diabetic mice. Proc Natl Acad Sci U S A (2008) 1.66
T regulatory cells in autoimmune diabetes: past challenges, future prospects. J Clin Immunol (2008) 1.52
The roles for cytokines in the generation and maintenance of regulatory T cells. Immunol Rev (2006) 1.46
Systemic overexpression of IL-10 induces CD4+CD25+ cell populations in vivo and ameliorates type 1 diabetes in nonobese diabetic mice in a dose-dependent fashion. J Immunol (2003) 1.32
Unique role of CD4+CD62L+ regulatory T cells in the control of autoimmune diabetes in T cell receptor transgenic mice. Proc Natl Acad Sci U S A (2004) 1.32
Plasmacytoid dendritic cells are proportionally expanded at diagnosis of type 1 diabetes and enhance islet autoantigen presentation to T-cells through immune complex capture. Diabetes (2008) 1.26
Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res (2006) 1.25
Regeneration of the pancreatic beta cell. J Clin Invest (2005) 1.14
Autoimmunity and beta cell regeneration in mouse and human type 1 diabetes: the peace is not enough. Ann N Y Acad Sci (2007) 1.08
Beta-cell transplantation for diabetes therapy. Lancet (2008) 0.99
Immune regulation of T lymphocyte by a newly characterized human umbilical cord blood stem cell. Immunol Lett (2006) 0.96
Early defect of immunoregulatory T cells in autoimmune diabetes. C R Acad Sci III (1996) 0.95
Reduced IFN-alpha secretion by blood dendritic cells in human diabetes. Clin Immunol (2006) 0.93
APC dysfunction is correlated with defective suppression of T cell proliferation in human type 1 diabetes. Clin Immunol (2008) 0.92
Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse. J Immunol (2007) 0.91
Differential contributions of APC subsets to T cell activation in nonobese diabetic mice. J Immunol (2008) 0.90
Regulatory T cells in the control of autoimmune diabetes: the case of the NOD mouse. Int Rev Immunol (2005) 0.90
The role of interleukin 10 in the control of autoimmunity. J Autoimmun (2003) 0.89
Plasmacytoid precursor dendritic cells from NOD mice exhibit impaired function: are they a component of diabetes pathogenesis? Diabetes (2008) 0.85
Efficacy of regulatory T-cell immunotherapy: are inflammatory cytokines key determinants? Nat Rev Immunol (2008) 0.79
Resetting the functional capacity of regulatory T cells: a novel immunotherapeutic strategy to promote immune tolerance. Expert Opin Biol Ther (2005) 0.78
Novel mechanism of endothelial nitric oxide synthase activation mediated by caveolae internalization in endothelial cells. Circ Res (2006) 1.92
Caveolin-1 regulates store-operated Ca2+ influx by binding of its scaffolding domain to transient receptor potential channel-1 in endothelial cells. Mol Pharmacol (2006) 1.92
Evidence of oxidative stress in human corneal diseases. J Histochem Cytochem (2002) 1.76
Novel mechanisms of G protein-dependent regulation of endothelial nitric-oxide synthase. Mol Pharmacol (2005) 1.48
Treatment eligibility of patients with chronic hepatitis B initially ineligible for therapy. Clin Gastroenterol Hepatol (2013) 1.48
A phosphoinositide 3-kinase-AKT-nitric oxide-cGMP signaling pathway in stimulating platelet secretion and aggregation. J Biol Chem (2006) 1.38
Targeted CTLA-4 engagement induces CD4+CD25+CTLA-4high T regulatory cells with target (allo)antigen specificity. J Immunol (2004) 1.33
Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. Virology (2004) 1.27
ICAM-1-activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration. Blood (2012) 1.17
Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition. Mol Biol Cell (2012) 1.16
Augmented inducible nitric oxide synthase expression and increased NO production reduce sepsis-induced lung injury and mortality in myeloperoxidase-null mice. Am J Physiol Lung Cell Mol Physiol (2008) 1.14
Wnt transmembrane signaling and long-term spatial memory. Hippocampus (2011) 1.14
Preferential costimulation by CD80 results in IL-10-dependent TGF-beta1(+) -adaptive regulatory T cell generation. J Immunol (2008) 1.11
Members of adenovirus species B utilize CD80 and CD86 as cellular attachment receptors. Virus Res (2006) 1.09
Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity. J Mol Biol (2004) 1.09
Kinin B1 receptors stimulate nitric oxide production in endothelial cells: signaling pathways activated by angiotensin I-converting enzyme inhibitors and peptide ligands. Mol Pharmacol (2004) 1.09
Dynamic receptor-dependent activation of inducible nitric-oxide synthase by ERK-mediated phosphorylation of Ser745. J Biol Chem (2007) 1.07
Angiotensin I-converting enzyme inhibitors are allosteric enhancers of kinin B1 and B2 receptor function. Hypertension (2010) 1.04
Enhanced engagement of CTLA-4 induces antigen-specific CD4+CD25+Foxp3+ and CD4+CD25- TGF-beta 1+ adaptive regulatory T cells. J Immunol (2007) 1.04
Novel mode of action of angiotensin I converting enzyme inhibitors: direct activation of bradykinin B1 receptor. J Biol Chem (2002) 1.02
Bilateral intrathoracic kidneys and adrenal glands associated with posterior congenital diaphragmatic hernias. Ann Thorac Surg (2008) 0.98
Carboxypeptidase M and kinin B1 receptors interact to facilitate efficient b1 signaling from B2 agonists. J Biol Chem (2008) 0.97
Targeted engagement of CTLA-4 prevents autoimmune thyroiditis. Int Immunol (2003) 0.97
Kininase I-type carboxypeptidases enhance nitric oxide production in endothelial cells by generating bradykinin B1 receptor agonists. Am J Physiol Heart Circ Physiol (2003) 0.95
A novel pathway for receptor-mediated post-translational activation of inducible nitric oxide synthase. J Cell Mol Med (2011) 0.93
Elements of the nitric oxide pathway can degrade TIMP-1 and increase gelatinase activity. Mol Vis (2004) 0.92
Signaling-mediated functional activation of inducible nitric-oxide synthase and its role in stimulating platelet activation. J Biol Chem (2008) 0.92
Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction. Am J Cardiovasc Dis (2013) 0.90
Absence of IL-4, and not suppression of the Th2 response, prevents development of experimental autoimmune Graves' disease. J Immunol (2003) 0.89
Aminopeptidase N reduces basolateral Na+ -K+ -ATPase in proximal tubule cells. Am J Physiol Renal Physiol (2007) 0.89
Activation of bradykinin B1 receptor by ACE inhibitors. Int Immunopharmacol (2002) 0.89
Dendritic cell-directed CTLA-4 engagement during pancreatic beta cell antigen presentation delays type 1 diabetes. J Immunol (2010) 0.88
Endothelial nitric-oxide synthase activation generates an inducible nitric-oxide synthase-like output of nitric oxide in inflamed endothelium. J Biol Chem (2012) 0.87
Low hepatitis B envelope antigen seroconversion rate in chronic hepatitis B patients on long-term entecavir 0.5 mg daily in routine clinical practice. Eur J Gastroenterol Hepatol (2013) 0.87
Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway. FASEB J (2004) 0.87
CD80 and CD86 C domains play an important role in receptor binding and co-stimulatory properties. Int Immunol (2003) 0.86
Subunit structure of benzylsuccinate synthase. Biochemistry (2009) 0.86
Expression of neuregulin 1, a member of the epidermal growth factor family, is expressed as multiple splice variants in the adult human cornea. Invest Ophthalmol Vis Sci (2004) 0.86
Cross-talk between carboxypeptidase M and the kinin B1 receptor mediates a new mode of G protein-coupled receptor signaling. J Biol Chem (2011) 0.85
Cartilaginous extracellular matrix-modified chitosan hydrogels for cartilage tissue engineering. ACS Appl Mater Interfaces (2014) 0.85
New type of human blood stem cell: a double-edged sword for the treatment of type 1 diabetes. Transl Res (2010) 0.84
CD80 (B7-1) and CD86 (B7-2) are functionally equivalent in the initiation and maintenance of CD4+ T-cell proliferation after activation with suboptimal doses of PHA. DNA Cell Biol (2002) 0.84
Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase. FASEB J (2010) 0.84
Angiotensin I-converting enzyme inhibitors block protein kinase C epsilon by activating bradykinin B1 receptors in human endothelial cells. J Pharmacol Exp Ther (2005) 0.84
A prospective trial for laparoscopic adjustable gastric banding in morbidly obese adolescents: an interim report of weight loss, metabolic and quality of life outcomes. J Pediatr Surg (2010) 0.83
Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. J Mol Biol (2006) 0.83
Comparison of refluxing, ultrasonic- and microwave-assisted extraction of dihydromyricetin from Ampelopsis grossedentata. J AOAC Int (2009) 0.83
Experience of mini-percutaneous nephrolithotomy in the treatment of large impacted proximal ureteral stones. Urol Int (2013) 0.83
Carboxypeptidase-mediated enhancement of nitric oxide production in rat lungs and microvascular endothelial cells. Am J Physiol Lung Cell Mol Physiol (2004) 0.83
Immunosuppressive effects of demethylzeylasteral in a rat kidney transplantation model. Int Immunopharmacol (2009) 0.83
The ectodomain shedding of angiotensin-converting enzyme is independent of its localisation in lipid rafts. J Cell Sci (2003) 0.81
Modulation of dendritic cell function and cytokine production to prevent thyroid autoimmunity. Autoimmunity (2003) 0.81
Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring. Biochem J (2003) 0.81
High proportion of hepatitis C virus in community Asian American patients with non-liver-related complaints. J Clin Gastroenterol (2013) 0.80
Less-established risk factors are common in Asian Americans with hepatitis C virus: a case-controlled study. Dig Dis Sci (2013) 0.80
Laparoscopic adjustable gastric banding for the treatment of adolescent morbid obesity in the United States: a safe alternative to gastric bypass. J Pediatr Surg (2005) 0.79
Extraction of aucubin from seeds of Eucommia ulmoides Oliv. using supercritical carbon dioxide. J AOAC Int (2009) 0.79
Carboxypeptidase M is a positive allosteric modulator of the kinin B1 receptor. J Biol Chem (2013) 0.79
Costimulatory molecule immune enhancement in a plasmid vaccine model is regulated in part through the Ig constant-like domain of CD80/86. J Immunol (2003) 0.79
Proliferation of regulatory mechanisms for eNOS: an emerging role for the cytoskeleton. Am J Physiol Lung Cell Mol Physiol (2002) 0.79
In situ transduction of cytosine deaminase gene followed by systemic use of 5-fluorocytosine inhibits tumor growth and metastasis in orthotopic prostate cancer mouse models. Chin Med J (Engl) (2002) 0.78
Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers. J Mol Neurosci (2002) 0.78
Electron beam CT scan is a valuable and safe imaging tool for the pediatric surgical patient. J Pediatr Surg (2004) 0.77
Carboxypeptidase M augments kinin B1 receptor signaling by conformational crosstalk and enhances endothelial nitric oxide output. Biol Chem (2013) 0.77
Increase of fluorescence anisotropy upon self-assembly in headgroup-labeled surfactants. Macromol Biosci (2007) 0.77
Structural characterization of the human carboxypeptidase D gene and its promoter. Int Immunopharmacol (2002) 0.77
Selective destruction of mouse islet beta cells by human T lymphocytes in a newly-established humanized type 1 diabetic model. Biochem Biophys Res Commun (2010) 0.77
Characterization of dual agonists for kinin B1 and B2 receptors and their biased activation of B2 receptors. Cell Signal (2012) 0.76
Plasmin alters the activity and quaternary structure of human plasma carboxypeptidase N. Biochem J (2005) 0.76
Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Mol Pharmacol (2013) 0.75
Ultrasonically assisted acid extraction of manganese from slag. Ultrason Sonochem (2007) 0.75
Laparoscopic-assisted endorectal pull-through for Hirschsprung's disease. A retrospective study. Saudi Med J (2017) 0.75
Persistent hypoglycemia in a child with a gastrocolic fistula--an unexpected presentation of leucine-sensitive hypoglycemia. J Pediatr Surg (2009) 0.75
Simultaneous costal cartilage-sparing modified Ravitch procedure and latissimus dorsi transfer for chest wall deformity repair in Poland's syndrome. J Pediatr Surg (2009) 0.75