Published in Proc Natl Acad Sci U S A on January 21, 2009
Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci U S A (2009) 3.06
The amyloid precursor protein has a flexible transmembrane domain and binds cholesterol. Science (2012) 2.06
Neuroprotective secreted amyloid precursor protein acts by disrupting amyloid precursor protein dimers. J Biol Chem (2009) 1.25
Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid-Alzheimer's disease relationships? Biochim Biophys Acta (2010) 1.11
Competition between homodimerization and cholesterol binding to the C99 domain of the amyloid precursor protein. Biochemistry (2013) 1.07
Transmembrane structures of amyloid precursor protein dimer predicted by replica-exchange molecular dynamics simulations. J Am Chem Soc (2009) 1.04
Evidence from solid-state NMR for nonhelical conformations in the transmembrane domain of the amyloid precursor protein. Biophys J (2011) 1.02
Single-spanning transmembrane domains in cell growth and cell-cell interactions: More than meets the eye? Cell Adh Migr (2010) 1.01
The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ-secretase. J Am Chem Soc (2013) 0.93
Conformational changes induced by the A21G Flemish mutation in the amyloid precursor protein lead to increased Aβ production. Structure (2014) 0.93
Molecular determinants and thermodynamics of the amyloid precursor protein transmembrane domain implicated in Alzheimer's disease. J Mol Biol (2011) 0.93
γ-Secretase associated with lipid rafts: multiple interactive pathways in the stepwise processing of β-carboxyl-terminal fragment. J Biol Chem (2013) 0.92
Familial Alzheimer's mutations within APPTM increase Aβ42 production by enhancing accessibility of ε-cleavage site. Nat Commun (2014) 0.92
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity. EMBO Mol Med (2013) 0.91
The effects of transmembrane sequence and dimerization on cleavage of the p75 neurotrophin receptor by γ-secretase. J Biol Chem (2012) 0.91
What is the role of amyloid precursor protein dimerization? Cell Adh Migr (2010) 0.90
Chemical Biology, Molecular Mechanism and Clinical Perspective of γ-Secretase Modulators in Alzheimer's Disease. Curr Neuropharmacol (2011) 0.89
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase. Front Physiol (2014) 0.87
Structure elucidation of dimeric transmembrane domains of bitopic proteins. Cell Adh Migr (2010) 0.85
Solution NMR approaches for establishing specificity of weak heterodimerization of membrane proteins. J Am Chem Soc (2011) 0.85
Impact of bilayer lipid composition on the structure and topology of the transmembrane amyloid precursor C99 protein. J Am Chem Soc (2014) 0.85
Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology. Front Aging Neurosci (2014) 0.85
Structural biology of presenilins and signal peptide peptidases. J Biol Chem (2013) 0.85
Structural heterogeneity in transmembrane amyloid precursor protein homodimer is a consequence of environmental selection. J Am Chem Soc (2014) 0.84
Gly25-Ser26 amyloid β-protein structural isomorphs produce distinct Aβ42 conformational dynamics and assembly characteristics. J Mol Biol (2014) 0.83
Side-chain to main-chain hydrogen bonding controls the intrinsic backbone dynamics of the amyloid precursor protein transmembrane helix. Biophys J (2014) 0.79
Analysis by a highly sensitive split luciferase assay of the regions involved in APP dimerization and its impact on processing. FEBS Open Bio (2015) 0.78
Comparable dimerization found in wildtype and familial Alzheimer's disease amyloid precursor protein mutants. Am J Neurodegener Dis (2013) 0.78
Modulation of γ-secretase activity by multiple enzyme-substrate interactions: implications in pathogenesis of Alzheimer's disease. PLoS One (2012) 0.78
Impact of membrane lipid composition on the structure and stability of the transmembrane domain of amyloid precursor protein. Proc Natl Acad Sci U S A (2016) 0.78
Transmembrane Substrate Determinants for γ-Secretase Processing of APP CTFβ. Biochemistry (2016) 0.77
Presenilin transmembrane domain 8 conserved AXXXAXXXG motifs are required for the activity of the γ-secretase complex. J Biol Chem (2015) 0.77
Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Sci Adv (2017) 0.75
Extension of a protein docking algorithm to membranes and applications to amyloid precursor protein dimerization. Proteins (2015) 0.75
Backbone hydrogen bond strengths can vary widely in transmembrane helices. J Am Chem Soc (2017) 0.75
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the gamma-secretase cleavage sites. J Biol Chem (2017) 0.75
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
The GxxxG motif: a framework for transmembrane helix-helix association. J Mol Biol (2000) 5.09
Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem (1992) 4.66
Functional gamma-secretase inhibitors reduce beta-amyloid peptide levels in brain. J Neurochem (2001) 4.45
Crystal structure of a rhomboid family intramembrane protease. Nature (2006) 3.37
The Calpha ---H...O hydrogen bond: a determinant of stability and specificity in transmembrane helix interactions. Proc Natl Acad Sci U S A (2001) 2.97
Loss-of-function presenilin mutations in Alzheimer disease. Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep (2007) 2.85
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Structure of a site-2 protease family intramembrane metalloprotease. Science (2007) 2.08
Alzheimer disease: mechanistic understanding predicts novel therapies. Ann Intern Med (2004) 2.06
Homodimerization of amyloid precursor protein and its implication in the amyloidogenic pathway of Alzheimer's disease. J Biol Chem (2001) 1.96
Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junction as determined by cysteine panning. J Biol Chem (1998) 1.96
A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing. Biochemistry (2002) 1.93
Equimolar production of amyloid beta-protein and amyloid precursor protein intracellular domain from beta-carboxyl-terminal fragment by gamma-secretase. J Biol Chem (2006) 1.66
Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease. Proc Natl Acad Sci U S A (2000) 1.62
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem (2008) 1.54
Ectodomain shedding and intramembrane cleavage of mammalian Notch proteins is not regulated through oligomerization. J Biol Chem (2004) 1.45
Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. J Mol Biol (2001) 1.44
Implications of threonine hydrogen bonding in the glycophorin A transmembrane helix dimer. Biophys J (2002) 1.34
Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiol Dis (2004) 1.29
Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. J Neurochem (2005) 1.28
Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants. BMC Neurosci (2008) 1.17
Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors. Biochemistry (2000) 1.13
Glycine and beta-branched residues support and modulate peptide helicity in membrane environments. FEBS Lett (1992) 1.13
Val-->Ala mutations selectively alter helix-helix packing in the transmembrane segment of phage M13 coat protein. Proc Natl Acad Sci U S A (1993) 1.10
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. J Neurochem (2005) 1.02
Progressive decrease of amyloid precursor protein carboxy terminal fragments (APP-CTFs), associated with tau pathology stages, in Alzheimer's disease. J Neurochem (2002) 0.92
Fe65 does not stabilize AICD during activation of transcription in a luciferase assay. Biochem Biophys Res Commun (2007) 0.83
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature (2005) 18.43
Development of human protein reference database as an initial platform for approaching systems biology in humans. Genome Res (2003) 14.79
Structural conversion of neurotoxic amyloid-beta(1-42) oligomers to fibrils. Nat Struct Mol Biol (2010) 3.75
Somatically acquired JAK1 mutations in adult acute lymphoblastic leukemia. J Exp Med (2008) 3.24
Electrostatic sequestration of PIP2 on phospholipid membranes by basic/aromatic regions of proteins. Biophys J (2004) 2.66
NetPath: a public resource of curated signal transduction pathways. Genome Biol (2010) 2.62
New mutations and pathogenesis of myeloproliferative neoplasms. Blood (2011) 2.53
JAKs in pathology: role of Janus kinases in hematopoietic malignancies and immunodeficiencies. Semin Cell Dev Biol (2008) 2.37
Helix movement is coupled to displacement of the second extracellular loop in rhodopsin activation. Nat Struct Mol Biol (2009) 2.32
Inhibitors of amyloid toxicity based on beta-sheet packing of Abeta40 and Abeta42. Biochemistry (2006) 1.88
Comparison of helix interactions in membrane and soluble alpha-bundle proteins. Biophys J (2002) 1.88
Active and inactive orientations of the transmembrane and cytosolic domains of the erythropoietin receptor dimer. Mol Cell (2003) 1.84
Multiple switches in G protein-coupled receptor activation. Trends Pharmacol Sci (2009) 1.83
Definition of an inhibitory juxtamembrane WW-like domain in the platelet-derived growth factor beta receptor. J Biol Chem (2002) 1.75
JAK1 and Tyk2 activation by the homologous polycythemia vera JAK2 V617F mutation: cross-talk with IGF1 receptor. J Biol Chem (2005) 1.74
Location of Trp265 in metarhodopsin II: implications for the activation mechanism of the visual receptor rhodopsin. J Mol Biol (2006) 1.69
An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family. J Gen Physiol (2005) 1.64
Interaction of small molecule inhibitors of HIV-1 entry with CCR5. Virology (2006) 1.59
Thrombopoietin receptor down-modulation by JAK2 V617F: restoration of receptor levels by inhibitors of pathologic JAK2 signaling and of proteasomes. Blood (2012) 1.59
An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J Exp Med (2009) 1.58
Coupling of retinal isomerization to the activation of rhodopsin. Proc Natl Acad Sci U S A (2004) 1.57
Activating mutations in human acute megakaryoblastic leukemia. Blood (2008) 1.56
High-resolution atomic force microscopy of soluble Abeta42 oligomers. J Mol Biol (2006) 1.55
Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs. J Biol Chem (2008) 1.54
Helix packing moments reveal diversity and conservation in membrane protein structure. J Mol Biol (2004) 1.53
Changes in interhelical hydrogen bonding upon rhodopsin activation. J Mol Biol (2005) 1.51
Binding of peptides with basic and aromatic residues to bilayer membranes: phenylalanine in the myristoylated alanine-rich C kinase substrate effector domain penetrates into the hydrophobic core of the bilayer. J Biol Chem (2003) 1.51
An amphipathic motif at the transmembrane-cytoplasmic junction prevents autonomous activation of the thrombopoietin receptor. Blood (2005) 1.50
Location of the retinal chromophore in the activated state of rhodopsin*. J Biol Chem (2009) 1.48
Janus kinases affect thrombopoietin receptor cell surface localization and stability. J Biol Chem (2005) 1.41
miR-28 is a thrombopoietin receptor targeting microRNA detected in a fraction of myeloproliferative neoplasm patient platelets. Blood (2010) 1.41
Implications of threonine hydrogen bonding in the glycophorin A transmembrane helix dimer. Biophys J (2002) 1.34
The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood (2007) 1.27
Conformational differences between two amyloid β oligomers of similar size and dissimilar toxicity. J Biol Chem (2012) 1.26
Substitution of pseudokinase domain residue Val-617 by large non-polar amino acids causes activation of JAK2. J Biol Chem (2008) 1.20
A senescence-like cell-cycle arrest occurs during megakaryocytic maturation: implications for physiological and pathological megakaryocytic proliferation. PLoS Biol (2010) 1.14
Highly conserved tyrosine stabilizes the active state of rhodopsin. Proc Natl Acad Sci U S A (2010) 1.13
Oncogenic JAK1 and JAK2-activating mutations resistant to ATP-competitive inhibitors. Haematologica (2011) 1.12
Characterization of the ligand-binding specificities of integrin alpha3beta1 and alpha6beta1 using a panel of purified laminin isoforms containing distinct alpha chains. J Biochem (2003) 1.12
A unique activating mutation in JAK2 (V617F) is at the origin of polycythemia vera and allows a new classification of myeloproliferative diseases. Hematology Am Soc Hematol Educ Program (2005) 1.11
Structure of the membrane reconstituted transmembrane-juxtamembrane peptide EGFR(622-660) and its interaction with Ca2+/calmodulin. Biochemistry (2006) 1.10
Dipolar assisted rotational resonance NMR of tryptophan and tyrosine in rhodopsin. J Biomol NMR (2004) 1.09
Induction of myeloproliferative disorder and myelofibrosis by thrombopoietin receptor W515 mutants is mediated by cytosolic tyrosine 112 of the receptor. Blood (2009) 1.08
A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects. Trends Mol Med (2005) 1.08
Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. J Biol Chem (2009) 1.07
Microarray analysis of LIF/Stat3 transcriptional targets in embryonic stem cells. Stem Cells (2005) 1.05
Comparison of class A and D G protein-coupled receptors: common features in structure and activation. Biochemistry (2005) 1.05
JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors. PLoS One (2010) 1.04
Role of group-conserved residues in the helical core of beta2-adrenergic receptor. Proc Natl Acad Sci U S A (2007) 1.02
Transmembrane interactions in the activation of the Neu receptor tyrosine kinase. Biochemistry (2002) 1.02
Mechanisms and kinetics of Bowman's epithelial-myofibroblast transdifferentiation in the formation of glomerular crescents. Nephron (2002) 1.02
Light activation of rhodopsin: insights from molecular dynamics simulations guided by solid-state NMR distance restraints. J Mol Biol (2009) 1.01
Structural role of glycine in amyloid fibrils formed from transmembrane alpha-helices. Biochemistry (2005) 1.00
Role of side-chain conformational entropy in transmembrane helix dimerization of glycophorin A. Biophys J (2003) 1.00
Degradation of amyloid beta protein by purified myelin basic protein. J Biol Chem (2009) 1.00
Structure and function of G protein-coupled receptors using NMR spectroscopy. Prog Nucl Magn Reson Spectrosc (2010) 1.00
FLT3-ITDs instruct a myeloid differentiation and transformation bias in lymphomyeloid multipotent progenitors. Cell Rep (2013) 0.99
Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif. J Biol Chem (2008) 0.99
Role of tyrosine kinases and phosphatases in polycythemia vera. Semin Hematol (2005) 0.99
Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation. Proc Natl Acad Sci U S A (2013) 0.99
EGFR juxtamembrane domain, membranes, and calmodulin: kinetics of their interaction. Biophys J (2009) 0.99
Germ-line JAK2 mutations in the kinase domain are responsible for hereditary thrombocytosis and are resistant to JAK2 and HSP90 inhibitors. Blood (2014) 0.98
Mechanism of penetration of Antp(43-58) into membrane bilayers. Biochemistry (2005) 0.96
Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors. J Biol Chem (2005) 0.96
Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J (2009) 0.96
Orientation-specific signalling by thrombopoietin receptor dimers. EMBO J (2011) 0.95
Therapy targets in glioblastoma and cancer stem cells: lessons from haematopoietic neoplasms. J Cell Mol Med (2013) 0.95
Aromatic residues at the extracellular ends of transmembrane domains 5 and 6 promote ligand activation of the G protein-coupled alpha-factor receptor. Biochemistry (2003) 0.95
Proline cis/trans-isomerase Pin1 regulates peroxisome proliferator-activated receptor gamma activity through the direct binding to the activation function-1 domain. J Biol Chem (2009) 0.94
A highly redundant gene network controls assembly of the outer spore wall in S. cerevisiae. PLoS Genet (2013) 0.94
Structural requirements of the extracellular to transmembrane domain junction for erythropoietin receptor function. J Biol Chem (2005) 0.93
Transmembrane helix orientation influences membrane binding of the intracellular juxtamembrane domain in Neu receptor peptides. Proc Natl Acad Sci U S A (2013) 0.92
Magic angle spinning nuclear magnetic resonance of isotopically labeled rhodopsin. Methods Enzymol (2002) 0.92
High-resolution 1H MAS RFDR NMR of biological membranes. J Magn Reson (2008) 0.92
Active domains of salivary statherin on apatitic surfaces for binding to Fusobacterium nucleatum cells. Microbiology (2004) 0.91
Myelin basic protein binds to and inhibits the fibrillar assembly of Abeta42 in vitro. Biochemistry (2009) 0.91
Amyloid precursor protein controls cholesterol turnover needed for neuronal activity. EMBO Mol Med (2013) 0.91
Lithium chloride increases the production of amyloid-beta peptide independently from its inhibition of glycogen synthase kinase 3. J Biol Chem (2005) 0.91
Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain. J Biol Chem (2008) 0.90
Differential effects of the peptides Stomagen, EPF1 and EPF2 on activation of MAP kinase MPK6 and the SPCH protein level. Plant Cell Physiol (2013) 0.90
NMR spectroscopy of phosphorylated wild-type rhodopsin: mobility of the phosphorylated C-terminus of rhodopsin in the dark and upon light activation. Biochemistry (2004) 0.90
Association of HCV core antigen seropositivity with long-term mortality in patients on regular hemodialysis. Nephron Extra (2012) 0.90
What is the role of amyloid precursor protein dimerization? Cell Adh Migr (2010) 0.90