Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.

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Published in J Biol Chem on January 16, 2008

Authors

Pascal Kienlen-Campard1, Bernadette Tasiaux, Joanne Van Hees, Mingli Li, Sandra Huysseune, Takeshi Sato, Jeffrey Z Fei, Saburo Aimoto, Pierre J Courtoy, Steven O Smith, Stefan N Constantinescu, Jean-Noël Octave

Author Affiliations

1: Center for Neurosciences, Experimental Pharmacology Unit, Université Catholique de Louvain, B-1200 Brussels, Belgium.

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