Published in J Biol Chem on January 28, 2009
Eukaryotic stress granules: the ins and outs of translation. Mol Cell (2009) 6.09
mRNP granules. Assembly, function, and connections with disease. RNA Biol (2014) 1.50
The Arabidopsis tandem zinc finger protein AtTZF1 traffics between the nucleus and cytoplasmic foci and binds both DNA and RNA. Plant Physiol (2009) 1.27
p21(WAF1/CIP1) upregulation through the stress granule-associated protein CUGBP1 confers resistance to bortezomib-mediated apoptosis. PLoS One (2011) 1.09
The translation inhibitor pateamine A prevents cachexia-induced muscle wasting in mice. Nat Commun (2012) 1.05
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA. Nat Commun (2013) 0.88
Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res (2013) 0.87
Destabilization of nucleophosmin mRNA by the HuR/KSRP complex is required for muscle fibre formation. Nat Commun (2014) 0.86
Characterization of cellular senescence mechanisms in human corneal endothelial cells. Aging Cell (2011) 0.86
Transportin 2 regulates apoptosis through the RNA-binding protein HuR. J Biol Chem (2011) 0.84
Could stress granules be involved in age-related diseases? Aging (Albany NY) (2009) 0.84
Kinase Inhibitor Screening Identifies Cyclin-Dependent Kinases and Glycogen Synthase Kinase 3 as Potential Modulators of TDP-43 Cytosolic Accumulation during Cell Stress. PLoS One (2013) 0.82
Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem (2016) 0.75
Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases. Oxid Med Cell Longev (2017) 0.75
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A (1995) 32.89
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007) 16.95
Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
Restoration of p53 function leads to tumour regression in vivo. Nature (2007) 12.62
Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. J Cell Biol (2005) 9.25
Cellular senescence in cancer and aging. Cell (2007) 9.04
WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis. Cancer Res (1994) 9.00
RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules. J Cell Biol (1999) 8.07
Senescent fibroblasts promote epithelial cell growth and tumorigenesis: a link between cancer and aging. Proc Natl Acad Sci U S A (2001) 7.93
RNA granules. J Cell Biol (2006) 7.79
Stress granules: the Tao of RNA triage. Trends Biochem Sci (2008) 6.27
Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans (2002) 6.08
Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules. J Cell Biol (2000) 5.99
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
The RasGAP-associated endoribonuclease G3BP assembles stress granules. J Cell Biol (2003) 4.97
HuR regulates p21 mRNA stabilization by UV light. Mol Cell Biol (2000) 4.96
Mammalian stress granules and processing bodies. Methods Enzymol (2007) 4.76
Stressful initiations. J Cell Sci (2002) 4.31
HuR binding to cytoplasmic mRNA is perturbed by heat shock. Proc Natl Acad Sci U S A (2000) 4.14
MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J (2004) 4.08
Ribonomics: identifying mRNA subsets in mRNP complexes using antibodies to RNA-binding proteins and genomic arrays. Methods (2002) 3.92
Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts. Mol Cell Biol (1989) 3.89
Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci U S A (1996) 3.55
Putting the stress on senescence. Curr Opin Cell Biol (2001) 3.41
Cancer and ageing: rival demons? Nat Rev Cancer (2003) 3.25
Trapping of messenger RNA by Fragile X Mental Retardation protein into cytoplasmic granules induces translation repression. Hum Mol Genet (2002) 3.17
Inhibition of ribosome recruitment induces stress granule formation independently of eukaryotic initiation factor 2alpha phosphorylation. Mol Biol Cell (2006) 2.84
Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation. Cell Stress Chaperones (2002) 2.70
Eukaryotic initiation factor 2alpha-independent pathway of stress granule induction by the natural product pateamine A. J Biol Chem (2006) 2.67
Differential roles for cyclin-dependent kinase inhibitors p21 and p16 in the mechanisms of senescence and differentiation in human fibroblasts. Mol Cell Biol (1999) 2.64
Eukaryotic translation initiation factors and regulators. Curr Opin Struct Biol (2003) 2.63
What has senescence got to do with cancer? Cancer Cell (2005) 2.55
HuR as a negative posttranscriptional modulator in inflammation. Mol Cell (2005) 2.27
Loss of HuR is linked to reduced expression of proliferative genes during replicative senescence. Mol Cell Biol (2001) 2.15
Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08
Protein oxidation and proteolysis during aging and oxidative stress. Arch Biochem Biophys (1989) 2.00
Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res (2005) 1.84
Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell (2007) 1.75
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol (2008) 1.63
Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol (2008) 1.60
Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate. EMBO J (2004) 1.54
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol (2007) 1.54
NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol (2005) 1.43
Aging reduces adaptive capacity and stress protein expression in the liver after heat stress. J Appl Physiol (1985) (2000) 1.27
How and why we age. Exp Gerontol (1999) 1.10
A dual role of p21 in stem cell aging. Ann N Y Acad Sci (2007) 1.05
The cell biology of aging. Clin Geriatr Med (1985) 0.99
Special feature for the Olympics: effects of exercise on the immune system: effects of exercise on the immune system in the elderly population. Immunol Cell Biol (2000) 0.97
Integrating epithelial cancer, aging stroma and cellular senescence. Adv Gerontol (2003) 0.97
Capacity for recovery and possible mechanisms in immobilization atrophy of young and old animals. Ann N Y Acad Sci (2001) 0.91
Cancer and aging: yin, yang, and p53. Sci Aging Knowledge Environ (2002) 0.90
Attenuation of NF-kappaB signaling response to UVB light during cellular senescence. Exp Cell Res (1999) 0.89
Aging and cancer cell biology, 2007. Aging Cell (2007) 0.89
Stress response of senescent T lymphocytes: reduced hsp70 is independent of the proliferative block. J Gerontol (1994) 0.88
Age-related sensitivity to lung oxidative stress during ozone exposure. Free Radic Res (2005) 0.86
HSP70 accumulation in tissues of heat-stressed rats is blunted with advancing age. J Appl Physiol (1985) (1995) 0.86
Reduction in heat shock gene expression correlates with increased thermosensitivity in senescent human fibroblasts. Exp Cell Res (1992) 0.85
Hydrogen peroxide-mediated protein oxidation in young and old human MRC-5 fibroblasts. Arch Biochem Biophys (2000) 0.84
p53, p21(WAF1/CIP1), and MDM2 involvement in the proliferation and apoptosis in an in vitro model of conditionally immortalized human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2000) 0.83
Response of the senescent heart to stress: clinical therapeutic strategies and quest for mitochondrial predictors of biological age. Ann N Y Acad Sci (2004) 0.77
Lack of recovery from oxygen-induced damage to colony formation and DNA synthesis in senescent human diploid fibroblasts. Mech Ageing Dev (1987) 0.76
Inhibition of the ubiquitin-proteasome system induces stress granule formation. Mol Biol Cell (2007) 1.75
Caspase-mediated cleavage of HuR in the cytoplasm contributes to pp32/PHAP-I regulation of apoptosis. J Cell Biol (2008) 1.63
Decoding ARE-mediated decay: is microRNA part of the equation? J Cell Biol (2008) 1.60
The RNA-binding protein HuR promotes cell migration and cell invasion by stabilizing the beta-actin mRNA in a U-rich-element-dependent manner. Mol Cell Biol (2007) 1.54
NF-kappa B-mediated MyoD decay during muscle wasting requires nitric oxide synthase mRNA stabilization, HuR protein, and nitric oxide release. Mol Cell Biol (2005) 1.43
Turnover of AU-rich-containing mRNAs during stress: a matter of survival. Wiley Interdiscip Rev RNA (2010) 1.27
The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites. Virology (2009) 1.05
Protein kinase RNA/FADD/caspase-8 pathway mediates the proapoptotic activity of the RNA-binding protein human antigen R (HuR). J Biol Chem (2010) 1.04
Inducible nitric oxide synthase (iNOS) in muscle wasting syndrome, sarcopenia, and cachexia. Aging (Albany NY) (2011) 0.99
2',3'-Cyclic nucleotide 3'-phosphodiesterase: a novel RNA-binding protein that inhibits protein synthesis. J Neurosci Res (2009) 0.99
Involvement of transportin 2-mediated HuR import in muscle cell differentiation. Mol Biol Cell (2007) 0.98
Nuclear localization of the adenovirus E4orf4 protein is mediated through an arginine-rich motif and correlates with cell death. Oncogene (2004) 0.93
Down-regulation of cytokine-induced interleukin-8 requires inhibition of p38 mitogen-activated protein kinase (MAPK) via MAPK phosphatase 1-dependent and -independent mechanisms. J Biol Chem (2011) 0.91
Quantitative proteomics and dynamic imaging reveal that G3BP-mediated stress granule assembly is poly(ADP-ribose)-dependent following exposure to MNNG-induced DNA alkylation. J Cell Sci (2012) 0.89
HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA. Nat Commun (2013) 0.88
The impact of mRNA turnover and translation on age-related muscle loss. Ageing Res Rev (2012) 0.86
HuR and myogenesis: being in the right place at the right time. Biochim Biophys Acta (2011) 0.85
Transportin 2 regulates apoptosis through the RNA-binding protein HuR. J Biol Chem (2011) 0.84
Aryl hydrocarbon receptor-dependent retention of nuclear HuR suppresses cigarette smoke-induced cyclooxygenase-2 expression independent of DNA-binding. PLoS One (2013) 0.82
FasL expression in activated T lymphocytes involves HuR-mediated stabilization. J Biol Chem (2010) 0.81
PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed. Mol Cell (2012) 0.77
Post-transcriptional regulation of connexin43 in H-Ras-transformed cells. PLoS One (2013) 0.76