Published in Cancer Res on April 01, 2005
Senescence in tumours: evidence from mice and humans. Nat Rev Cancer (2010) 6.34
Mapping intact protein isoforms in discovery mode using top-down proteomics. Nature (2011) 4.84
What has senescence got to do with cancer? Cancer Cell (2005) 2.55
Therapy-induced senescence in cancer. J Natl Cancer Inst (2010) 2.45
Cellular senescence and organismal aging. Mech Ageing Dev (2008) 1.92
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit Rev Oncol Hematol (2010) 1.82
Suppressed expression of T-box transcription factors is involved in senescence in chronic obstructive pulmonary disease. PLoS Comput Biol (2012) 1.41
Interconnections between apoptotic, autophagic and necrotic pathways: implications for cancer therapy development. J Cell Mol Med (2013) 1.36
IL1- and TGFβ-Nox4 signaling, oxidative stress and DNA damage response are shared features of replicative, oncogene-induced, and drug-induced paracrine 'bystander senescence'. Aging (Albany NY) (2012) 1.32
EGF receptor inhibition radiosensitizes NSCLC cells by inducing senescence in cells sustaining DNA double-strand breaks. Cancer Res (2011) 1.24
Evaluation of the compact high-field orbitrap for top-down proteomics of human cells. J Proteome Res (2012) 1.22
Primary and compensatory roles for RB family members at cell cycle gene promoters that are deacetylated and downregulated in doxorubicin-induced senescence of breast cancer cells. Mol Cell Biol (2006) 1.16
Stem cells, senescence, neosis and self-renewal in cancer. Cancer Cell Int (2006) 1.11
Cellular senescence predicts treatment outcome in metastasised colorectal cancer. Br J Cancer (2010) 1.09
The ATM and ATR inhibitors CGK733 and caffeine suppress cyclin D1 levels and inhibit cell proliferation. Radiat Oncol (2009) 1.05
Persistent DNA damage caused by low levels of mitomycin C induces irreversible cell senescence. Cell Cycle (2012) 1.01
Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal. Cancer Cell Int (2013) 1.01
Cancer cell survival following DNA damage-mediated premature senescence is regulated by mammalian target of rapamycin (mTOR)-dependent Inhibition of sirtuin 1. J Biol Chem (2011) 1.00
Size Does Matter: Why Polyploid Tumor Cells are Critical Drug Targets in the War on Cancer. Front Oncol (2014) 1.00
Cellular senescence and cancer chemotherapy resistance. Drug Resist Updat (2012) 0.99
Profiling influences of senescent and aged fibroblasts on prostate carcinogenesis. Br J Cancer (2008) 0.97
p35 is required for CDK5 activation in cellular senescence. J Biol Chem (2010) 0.96
Oxidative Stress Increases the Number of Stress Granules in Senescent Cells and Triggers a Rapid Decrease in p21waf1/cip1 Translation. J Biol Chem (2009) 0.95
Role of stress-activated OCT4A in the cell fate decisions of embryonal carcinoma cells treated with etoposide. Cell Cycle (2015) 0.95
Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget (2011) 0.91
Survivin and escaping in therapy-induced cellular senescence. Int J Cancer (2010) 0.90
A high-throughput method to identify novel senescence-inducing compounds. J Biomol Screen (2009) 0.90
Features of senescence and cell death induced by doxorubicin in A549 cells: organization and level of selected cytoskeletal proteins. J Cancer Res Clin Oncol (2009) 0.90
Gene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines. Mol Cancer (2008) 0.90
Bmal1 suppresses cancer cell invasion by blocking the phosphoinositide 3-kinase-Akt-MMP-2 signaling pathway. Oncol Rep (2013) 0.90
Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer? Cancer Cell (2014) 0.89
Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo. Br J Cancer (2008) 0.89
Decreased skp2 expression is necessary but not sufficient for therapy-induced senescence in prostate cancer. Transl Oncol (2012) 0.88
BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells. J Biol Chem (2009) 0.86
Expression of p14(ARF), p15(INK4b), p16(INK4a) and skp2 increases during esophageal squamous cell cancer progression. Exp Ther Med (2012) 0.85
ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev (2016) 0.85
EGFR-mediated chromatin condensation protects KRAS-mutant cancer cells against ionizing radiation. Cancer Res (2014) 0.84
Therapeutic targeting of replicative immortality. Semin Cancer Biol (2015) 0.83
Repopulation of ovarian cancer cells after chemotherapy. Cancer Growth Metastasis (2013) 0.82
Treatment-induced cell cycle kinetics dictate tumor response to chemotherapy. Oncotarget (2015) 0.81
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours. Nat Commun (2015) 0.81
The impact of cellular senescence in cancer therapy: is it true or not? Acta Pharmacol Sin (2011) 0.81
Activation of p53 contributes to pseudolaric acid B-induced senescence in human lung cancer cells in vitro. Acta Pharmacol Sin (2016) 0.81
Expression of coxsackie and adenovirus receptor distinguishes transitional cancer states in therapy-induced cellular senescence. Cell Death Dis (2010) 0.80
Radiosensitization by PARP Inhibition in DNA Repair Proficient and Deficient Tumor Cells: Proliferative Recovery in Senescent Cells. Radiat Res (2016) 0.79
Involvement of autophagy induction in penta-1,2,3,4,6-O-galloyl-β-D-glucose-induced senescence-like growth arrest in human cancer cells. Autophagy (2013) 0.79
Low-dose etoposide-treatment induces endoreplication and cell death accompanied by cytoskeletal alterations in A549 cells: Does the response involve senescence? The possible role of vimentin. Cancer Cell Int (2013) 0.79
Immortalised breast epithelia survive prolonged DNA replication stress and return to cycle from a senescent-like state. Cell Death Dis (2014) 0.77
Cancer-associated S100P protein binds and inactivates p53, permits therapy-induced senescence and supports chemoresistance. Oncotarget (2016) 0.77
Nucleolar repression facilitates initiation and maintenance of senescence. Cell Cycle (2015) 0.77
Characterization of Senescence of Culture-expanded Human Adipose-derived Mesenchymal Stem Cells. Int J Stem Cells (2016) 0.77
Extensive disease small cell lung cancer dose-response relationships: implications for resistance mechanisms. J Thorac Oncol (2010) 0.76
Natural killer cell recognition of in vivo drug-induced senescent multiple myeloma cells. Oncoimmunology (2016) 0.76
The yin-yang of DNA damage response: roles in tumorigenesis and cellular senescence. Int J Mol Sci (2013) 0.76
Proteomics analysis of normal and senescent NG108-15 cells: GRP78 plays a negative role in cisplatin-induced senescence in the NG108-15 cell line. PLoS One (2014) 0.75
Carnitine-induced senescence in glioblastoma cells. Exp Ther Med (2012) 0.75
Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice. Oncotarget (2016) 0.75
PKCι depletion initiates mitotic slippage-induced senescence in glioblastoma. Cell Cycle (2015) 0.75
Wnt7a is a novel inducer of β-catenin-independent tumor-suppressive cellular senescence in lung cancer. Oncogene (2015) 0.75
Induction of accelerated senescence by the microtubule-stabilizing agent peloruside A. Invest New Drugs (2017) 0.75
Vinorelbine plus cisplatin vs. observation in resected non-small-cell lung cancer. N Engl J Med (2005) 10.58
Molecular cloning of ESET, a novel histone H3-specific methyltransferase that interacts with ERG transcription factor. Oncogene (2002) 2.97
High concordance between immunohistochemistry and fluorescence in situ hybridization testing for HER2 status in breast cancer requires a normalized IHC scoring system. Mod Pathol (2008) 1.81
Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease. Eur J Cancer (2004) 1.73
Time from treatment to subsequent diagnosis of brain metastases in stage III non-small-cell lung cancer: a retrospective review by the Southwest Oncology Group. J Clin Oncol (2005) 1.41
Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity. Mod Pathol (2006) 1.20
Prospective randomized study evaluating a biodegradable polymeric sealant for sealing intraoperative air leaks that occur during pulmonary resection. Ann Thorac Surg (2004) 1.13
2006 Bethesda International Consensus recommendations on the immunophenotypic analysis of hematolymphoid neoplasia by flow cytometry: optimal reagents and reporting for the flow cytometric diagnosis of hematopoietic neoplasia. Cytometry B Clin Cytom (2007) 1.12
Novel FLT3 point mutations within exon 14 found in patients with acute myeloid leukaemia. Br J Haematol (2004) 1.05
Determining true HER2 gene status in breast cancers with polysomy by using alternative chromosome 17 reference genes: implications for anti-HER2 targeted therapy. J Clin Oncol (2011) 1.05
Polyploidy road to therapy-induced cellular senescence and escape. Int J Cancer (2012) 0.99
Identification and purification of classical Hodgkin cells from lymph nodes by flow cytometry and flow cytometric cell sorting. Am J Clin Pathol (2006) 0.96
CTL are inactivated by herpes simplex virus-infected cells expressing a viral protein kinase. J Immunol (2003) 0.95
EWS/FLI1 suppresses retinoblastoma protein function and senescence in Ewing's sarcoma cells. J Orthop Res (2008) 0.93
Survivin and escaping in therapy-induced cellular senescence. Int J Cancer (2010) 0.90
Comparison of demographic characteristics, surgical resection patterns, and survival outcomes for veterans and nonveterans with non-small cell lung cancer in the Pacific Northwest. J Thorac Oncol (2011) 0.90
Lineage-specific identification of nonhematopoietic neoplasms by flow cytometry. Am J Clin Pathol (2003) 0.89
Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer. Mol Ther (2006) 0.88
Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. Mol Cell Biol (2003) 0.83
Chronic traumatic and congenital diaphragmatic hernias: presentation and surgical management. Can Respir J (2002) 0.82
TLS-ERG leukemia fusion protein deregulates cyclin-dependent kinase 1 and blocks terminal differentiation of myeloid progenitor cells. Mol Cancer Res (2008) 0.79
Primary Rosai-Dorfman disease of the bone in a patient with history of breast cancer: appearance on 99mTc-MDP scintigraphy, CT, and X-ray. Clin Nucl Med (2015) 0.77
Marked Variability in Reported Minimal Residual Disease Lower Level of Detection of 4 Hematolymphoid Neoplasms: A Survey of Participants in the College of American Pathologists Flow Cytometry Proficiency Testing Program. Arch Pathol Lab Med (2015) 0.77
Non-small cell lung cancer with chest wall involvement. Chest (2003) 0.75
Endoscopic and manometric position-related characteristics of the normal gastroesophageal junction. Surg Endosc (2010) 0.75
Intravascular large B-cell lymphoma involving hemangiomas: an unusual presentation of a rare neoplasm. Mod Pathol (2005) 0.75