Published in Diabetes on February 10, 2009
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A functional role for interleukin-21 in promoting the synthesis of the T-cell chemoattractant, MIP-3alpha, by gut epithelial cells. Gastroenterology (2006) 1.38
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Increased expression of CCL2 in insulin-producing cells of transgenic mice promotes mobilization of myeloid cells from the bone marrow, marked insulitis, and diabetes. Diabetes (2008) 1.31
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The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science (2013) 8.53
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The IL-21 receptor augments Th2 effector function and alternative macrophage activation. J Clin Invest (2006) 3.33
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Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. J Exp Med (2003) 2.71
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Enhanced interleukin (IL)-13 responses in mice lacking IL-13 receptor alpha 2. J Exp Med (2003) 2.54
PDLIM2-mediated termination of transcription factor NF-kappaB activation by intranuclear sequestration and degradation of the p65 subunit. Nat Immunol (2007) 2.45
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Interleukin 21 is a T helper (Th) cell 2 cytokine that specifically inhibits the differentiation of naive Th cells into interferon gamma-producing Th1 cells. J Exp Med (2002) 2.28
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice. J Allergy Clin Immunol (2006) 2.16
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Mast cells produce interleukin-25 upon Fc epsilon RI-mediated activation. Blood (2003) 1.95
Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell (2009) 1.95
IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression. J Immunol (2006) 1.86
IL-13 receptor alpha 2 down-modulates granulomatous inflammation and prolongs host survival in schistosomiasis. Proc Natl Acad Sci U S A (2003) 1.80
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Constraints in antigen presentation severely restrict T cell recognition of the allogeneic fetus. J Clin Invest (2007) 1.75
IL-21 induces the apoptosis of resting and activated primary B cells. J Immunol (2003) 1.67
Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption. J Biol Chem (2004) 1.66
SLIM is a nuclear ubiquitin E3 ligase that negatively regulates STAT signaling. Immunity (2005) 1.64
IL-4 and IL-12 regulate proteoglycan-induced arthritis through Stat-dependent mechanisms. J Immunol (2002) 1.61
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IL-21 activates both innate and adaptive immunity to generate potent antitumor responses that require perforin but are independent of IFN-gamma. J Immunol (2003) 1.55
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Antigen-specific immunotherapy for type 1 diabetes: maximizing the potential. Diabetes (2010) 1.40
Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A (2008) 1.38
c-Maf activates the promoter and enhancer of the IL-21 gene, and TGF-beta inhibits c-Maf-induced IL-21 production in CD4+ T cells. J Leukoc Biol (2009) 1.38
PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood (2009) 1.36
Interleukin-4-mediated protection of primary B cells from apoptosis through Stat6-dependent up-regulation of Bcl-xL. J Biol Chem (2002) 1.34
NKT cell-plasmacytoid dendritic cell cooperation via OX40 controls viral infection in a tissue-specific manner. Immunity (2009) 1.32
Unraveling the autoimmune translational research process layer by layer. Nat Med (2012) 1.27
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Stat6 and IRS-2 cooperate in interleukin 4 (IL-4)-induced proliferation and differentiation but are dispensable for IL-4-dependent rescue from apoptosis. Mol Cell Biol (2002) 1.21
Development of autoimmune hepatitis-like disease and production of autoantibodies to nuclear antigens in mice lacking B and T lymphocyte attenuator. Arthritis Rheum (2008) 1.18
IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome. J Immunol (2007) 1.18
Negative regulation of interleukin-12 signaling by suppressor of cytokine signaling-1. J Biol Chem (2002) 1.18
IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest (2008) 1.17
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements. Mol Cell Biol (2011) 1.17
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Regulation of signal transducer and activator of transcription signaling by the tyrosine phosphatase PTP-BL. Immunity (2007) 1.09
Intravital imaging of CTLs killing islet cells in diabetic mice. J Clin Invest (2011) 1.08
PDLIM2 restricts Th1 and Th17 differentiation and prevents autoimmune disease. Cell Biosci (2012) 1.08
Zinc finger protein Zbtb20 is essential for postnatal survival and glucose homeostasis. Mol Cell Biol (2009) 1.07
IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung. J Immunol (2008) 1.07
Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc Natl Acad Sci U S A (2006) 1.05
IL-21 promotes CD8+ CTL activity via the transcription factor T-bet. J Immunol (2013) 1.05
Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation. Blood (2007) 1.05
A novel technique for the in vivo imaging of autoimmune diabetes development in the pancreas by two-photon microscopy. PLoS One (2010) 1.03
IL-4-Stat6 signaling induces tristetraprolin expression and inhibits TNF-alpha production in mast cells. J Exp Med (2003) 1.03
PDLIM2 inhibits T helper 17 cell development and granulomatous inflammation through degradation of STAT3. Sci Signal (2011) 1.02
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Proteolytic processing of Stat6 signaling in mast cells as a negative regulatory mechanism. J Exp Med (2002) 0.98
How viral infections affect the autoimmune process leading to type 1 diabetes. Cell Immunol (2005) 0.98
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Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med (2011) 0.97
Overlapping and distinct roles of STAT4 and T-bet in the regulation of T cell differentiation and allergic airway inflammation. J Immunol (2008) 0.97
Islet antigen specific IL-10+ immune responses but not CD4+CD25+FoxP3+ cells at diagnosis predict glycemic control in type 1 diabetes. Clin Immunol (2008) 0.96
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Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. J Immunol (2007) 0.95
B and T lymphocyte attenuator suppresses IL-21 production from follicular Th cells and subsequent humoral immune responses. J Immunol (2010) 0.95
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Indispensable role of Stat5a in Stat6-independent Th2 cell differentiation and allergic airway inflammation. J Immunol (2005) 0.95
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IL-4 synergistically enhances both IL-2- and IL-12-induced IFN-gamma expression in murine NK cells. Blood (2003) 0.92
The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice. Gastroenterology (2012) 0.92
Functional role for I kappa BNS in T cell cytokine regulation as revealed by targeted gene disruption. J Immunol (2007) 0.92
Molecular and cellular control of T1/T2 immunity at the interface between antimicrobial defense and immune pathology. DNA Cell Biol (2004) 0.92
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc Natl Acad Sci U S A (2013) 0.91
Increased memory conversion of naïve CD8 T cells activated during late phases of acute virus infection due to decreased cumulative antigen exposure. PLoS One (2011) 0.91
Immunotherapy for the prevention and treatment of type 1 diabetes: optimizing the path from bench to bedside. Diabetes Care (2009) 0.90
Protein geranylgeranylation regulates the balance between Th17 cells and Foxp3+ regulatory T cells. Int Immunol (2009) 0.90
Identification of the small protein rich in arginine and glycine (SRAG): a newly identified nucleolar protein that can regulate cell proliferation. J Biol Chem (2009) 0.88
Antigen-specific induction of regulatory T cells for type 1 diabetes therapy. Int Rev Immunol (2005) 0.88
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Protective roles of B and T lymphocyte attenuator in NKT cell-mediated experimental hepatitis. J Immunol (2009) 0.87