Published in Biochim Biophys Acta on July 26, 2014
Identification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation. Oncotarget (2015) 0.85
Mitochondria, calcium, and tumor suppressor Fus1: At the crossroad of cancer, inflammation, and autoimmunity. Oncotarget (2015) 0.84
Inhibiting NFAT1 for breast cancer therapy: New insights into the mechanism of action of MDM2 inhibitor JapA. Oncotarget (2015) 0.80
Autotaxin, a lysophospholipase D with pleomorphic effects in oncogenesis and cancer progression. J Lipid Res (2015) 0.80
Cell cycle and apoptosis regulation by NFAT transcription factors: new roles for an old player. Cell Death Dis (2016) 0.79
SOCE and cancer: Recent progress and new perspectives. Int J Cancer (2015) 0.77
Structural Basis of Targeting the Exportin CRM1 in Cancer. Cells (2015) 0.77
Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines. Oncotarget (2016) 0.76
NFAT2 Isoforms Differentially Regulate Gene Expression, Cell Death, and Transformation through Alternative N-Terminal Domains. Mol Cell Biol (2015) 0.76
NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract. Transl Oncol (2017) 0.75
NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight (2016) 0.75
Inulanolide A as a new dual inhibitor of NFAT1-MDM2 pathway for breast cancer therapy. Oncotarget (2016) 0.75
Identification of lineariifolianoid A as a novel dual NFAT1 and MDM2 inhibitor for human cancer therapy. J Biomed Res (2016) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell (1991) 15.76
Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol (1997) 11.57
Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev (2003) 9.39
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell (2007) 9.20
Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts. Dev Cell (2002) 9.10
MAP kinase signalling pathways in cancer. Oncogene (2007) 8.52
NFAT signaling: choreographing the social lives of cells. Cell (2002) 8.17
Identification of a putative regulator of early T cell activation genes. Science (1988) 6.62
NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol (2005) 6.25
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancer. Nat Immunol (2007) 6.22
The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. Carcinogenesis (2009) 5.01
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3. Science (1997) 4.99
NF-AT components define a family of transcription factors targeted in T-cell activation. Nature (1994) 4.90
Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol Cell Biol (1988) 4.33
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A. Science (1999) 4.20
Role of the NF-ATc transcription factor in morphogenesis of cardiac valves and septum. Nature (1998) 4.18
The transcription factor NF-ATc is essential for cardiac valve formation. Nature (1998) 4.14
Gene regulation mediated by calcium signals in T lymphocytes. Nat Immunol (2001) 4.09
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma. Nat Med (2008) 3.98
The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages. Crit Rev Oncol Hematol (2007) 3.95
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1. Nature (2009) 3.93
NFATc1 balances quiescence and proliferation of skin stem cells. Cell (2008) 3.81
Akt blocks breast cancer cell motility and invasion through the transcription factor NFAT. Mol Cell (2005) 3.78
Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity. Proc Natl Acad Sci U S A (1999) 3.74
Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature (1998) 3.71
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFAT. Nature (2006) 3.61
Concerted dephosphorylation of the transcription factor NFAT1 induces a conformational switch that regulates transcriptional activity. Mol Cell (2000) 3.44
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell (2001) 3.37
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction. Genes Dev (1997) 3.29
Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science (1996) 3.28
Isolation of the cyclosporin-sensitive T cell transcription factor NFATp. Science (1993) 3.24
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity (1995) 3.07
The role of NFAT transcription factors in integrin-mediated carcinoma invasion. Nat Cell Biol (2002) 3.05
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice. Immunity (1996) 3.05
DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet (2000) 2.93
NFAT, immunity and cancer: a transcription factor comes of age. Nat Rev Immunol (2010) 2.77
Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1. Cell (1998) 2.57
Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell (2003) 2.54
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and Jun. Proc Natl Acad Sci U S A (1999) 2.48
NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes. Immunol Today (1994) 2.43
NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity (2001) 2.38
GATA transcription factors in the developing and adult heart. Cardiovasc Res (2004) 2.30
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemia. Nat Med (2007) 2.28
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science (1997) 2.25
Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes. Cell Calcium (2007) 2.23
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2. J Exp Med (2001) 2.22
Integration of Notch 1 and calcineurin/NFAT signaling pathways in keratinocyte growth and differentiation control. Dev Cell (2005) 2.21
NFAT proteins: emerging roles in cancer progression. Nat Rev Cancer (2009) 2.18
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development. Immunity (1998) 2.16
NFAT signaling in vertebrate development. Curr Opin Genet Dev (2001) 2.15
The transcription factor NFAT4 is involved in the generation and survival of T cells. Immunity (1998) 2.13
Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J (2006) 2.06
Phase II trial of infusional fluorouracil, leucovorin, mitomycin, and dipyridamole in locally advanced unresectable pancreatic adenocarcinoma: SWOG S9700. J Clin Oncol (2007) 2.00
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosis. Immunity (2002) 1.94
NFATc3, a lymphoid-specific NFATc family member that is calcium-regulated and exhibits distinct DNA binding specificity. J Biol Chem (1995) 1.91
Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J Biol Chem (1996) 1.91
Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2. J Biol Chem (2004) 1.88
Cabin 1, a negative regulator for calcineurin signaling in T lymphocytes. Immunity (1998) 1.85
Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol (2004) 1.82
Genome-wide DNA methylation analysis reveals novel epigenetic changes in chronic lymphocytic leukemia. Epigenetics (2012) 1.80
Dichloroacetate induces apoptosis in endometrial cancer cells. Gynecol Oncol (2008) 1.79
NFATc2-mediated repression of cyclin-dependent kinase 4 expression. Mol Cell (2002) 1.79
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. Mol Cell Biol (2004) 1.78
MicroRNA-199b targets the nuclear kinase Dyrk1a in an auto-amplification loop promoting calcineurin/NFAT signalling. Nat Cell Biol (2010) 1.74
A similar DNA-binding motif in NFAT family proteins and the Rel homology region. J Biol Chem (1995) 1.70
A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblasts. J Biol Chem (2003) 1.68
Non-coding RNAs in cardiac remodeling and heart failure. Circ Res (2013) 1.66
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl. Cancer Cell (2010) 1.64
Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood (2004) 1.62
Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes. Mol Cell Biol (1996) 1.61
The calcineurin-NFAT-angiopoietin-2 signaling axis in lung endothelium is critical for the establishment of lung metastases. Cell Rep (2013) 1.61
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2. J Biol Chem (2006) 1.55
Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors. Mol Cell Biol (2008) 1.52
The role of NFATp in cyclosporin A-sensitive tumor necrosis factor-alpha gene transcription. J Biol Chem (1994) 1.52
Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity. J Immunol (2012) 1.51
Phosphorylation of NFATc4 by p38 mitogen-activated protein kinases. Mol Cell Biol (2002) 1.50
Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survival. Blood (2005) 1.49
TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways. Oncogene (2007) 1.48
Interaction of calcineurin with a domain of the transcription factor NFAT1 that controls nuclear import. Proc Natl Acad Sci U S A (1996) 1.47
Wnt-5a/Ca2+-induced NFAT activity is counteracted by Wnt-5a/Yes-Cdc42-casein kinase 1alpha signaling in human mammary epithelial cells. Mol Cell Biol (2006) 1.45
Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas. Blood (2006) 1.43
The osmoprotective function of the NFAT5 transcription factor in T cell development and activation. J Immunol (2002) 1.43
NF-AT-AP-1 and Rel-bZIP: hybrid vigor and binding under the influence. Cell (1994) 1.43
Promiscuous partnerships in Ewing's sarcoma. Cancer Genet (2011) 1.41
Characterization of Nfatc1 regulation identifies an enhancer required for gene expression that is specific to pro-valve endocardial cells in the developing heart. Development (2005) 1.40
The unexpected effect of cyclosporin A on CD56+CD16- and CD56+CD16+ natural killer cell subpopulations. Blood (2007) 1.39
Identification of amino acid residues and protein kinases involved in the regulation of NFATc subcellular localization. J Biol Chem (2000) 1.39
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc Natl Acad Sci U S A (2004) 1.37
Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cells. Oncogene (2005) 1.36
Interaction between NFκB and NFAT coordinates cardiac hypertrophy and pathological remodeling. Circ Res (2012) 1.35
Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation. J Biol Chem (2004) 1.32
The NFATc2 gene is involved in a novel cloned translocation in a Ewing sarcoma variant that couples its function in immunology to oncology. Clin Cancer Res (2009) 1.31
Kaempferol inhibits angiogenesis and VEGF expression through both HIF dependent and independent pathways in human ovarian cancer cells. Nutr Cancer (2009) 1.31
Genistein, a dietary isoflavone, down-regulates the MDM2 oncogene at both transcriptional and posttranslational levels. Cancer Res (2005) 1.30
Nuclear factor of activated T cells balances angiogenesis activation and inhibition. J Exp Med (2004) 1.30
Selective activation of the transcription factor NFAT1 by calcium microdomains near Ca2+ release-activated Ca2+ (CRAC) channels. J Biol Chem (2011) 1.29
The calcineurin/NFAT signaling pathway: a novel therapeutic target in leukemia and solid tumors. Cell Cycle (2007) 1.27
A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virus. Blood (2005) 1.27
RYBP predicts survival of patients with non-small cell lung cancer and regulates tumor cell growth and the response to chemotherapy. Cancer Lett (2015) 0.82
A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study. J Chromatogr B Analyt Technol Biomed Life Sci (2014) 0.81
Selective cytotoxicity, inhibition of cell cycle progression, and induction of apoptosis in human breast cancer cells by sesquiterpenoids from Inula lineariifolia Turcz. Eur J Med Chem (2013) 0.80
Oral delivery of anti-MDM2 inhibitor SP141-loaded FcRn-targeted nanoparticles to treat breast cancer and metastasis. J Control Release (2016) 0.77
Anticancer 20(R)-dammarane-3β,12β,20,25-tetrol-loaded polymeric micelles: Preparation, quantification and pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci (2016) 0.75