Reprint: Good laboratory practice: preventing introduction of bias at the bench.

Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79

RODENT STROKE MODEL GUIDELINES FOR PRECLINICAL STROKE TRIALS (1ST EDITION). J Exp Stroke Transl Med (2009) 1.49

Bringing rigour to translational medicine. Nat Rev Neurol (2013) 1.16

Dealing with publication bias in translational stroke research. J Exp Stroke Transl Med (2009) 1.08

Authorization of Animal Experiments Is Based on Confidence Rather than Evidence of Scientific Rigor. PLoS Biol (2016) 0.82

A call for transparent reporting to optimize the predictive value of preclinical research. Nature (2012) 14.63

Time to treatment with intravenous alteplase and outcome in stroke: an updated pooled analysis of ECASS, ATLANTIS, NINDS, and EPITHET trials. Lancet (2010) 12.21

Endovascular therapy for ischemic stroke with perfusion-imaging selection. N Engl J Med (2015) 12.06

Stroke. Lancet (2008) 9.51

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol (2008) 9.02

Carotid artery stenting compared with endarterectomy in patients with symptomatic carotid stenosis (International Carotid Stenting Study): an interim analysis of a randomised controlled trial. Lancet (2010) 7.62

Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke (2014) 7.48

Telmisartan to prevent recurrent stroke and cardiovascular events. N Engl J Med (2008) 7.25

1,026 experimental treatments in acute stroke. Ann Neurol (2006) 7.23

Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke (2009) 6.79

Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med (2003) 6.57

Can animal models of disease reliably inform human studies? PLoS Med (2010) 6.27

Early decompressive surgery in malignant infarction of the middle cerebral artery: a pooled analysis of three randomised controlled trials. Lancet Neurol (2007) 6.15

Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med (2008) 6.08

Publication bias in reports of animal stroke studies leads to major overstatement of efficacy. PLoS Biol (2010) 5.58

The angiotensin-receptor blocker candesartan for treatment of acute stroke (SCAST): a randomised, placebo-controlled, double-blind trial. Lancet (2011) 5.17

Pooling of animal experimental data reveals influence of study design and publication bias. Stroke (2004) 4.37

Blood pressure and clinical outcomes in the International Stroke Trial. Stroke (2002) 3.94

Randomized trial of intraarterial infusion of urokinase within 6 hours of middle cerebral artery stroke: the middle cerebral artery embolism local fibrinolytic intervention trial (MELT) Japan. Stroke (2007) 3.93

Stroke-induced immunodeficiency promotes spontaneous bacterial infections and is mediated by sympathetic activation reversal by poststroke T helper cell type 1-like immunostimulation. J Exp Med (2003) 3.89

Surgical decompression for space-occupying cerebral infarction (the Hemicraniectomy After Middle Cerebral Artery infarction with Life-threatening Edema Trial [HAMLET]): a multicentre, open, randomised trial. Lancet Neurol (2009) 3.89

Evidence for the efficacy of NXY-059 in experimental focal cerebral ischaemia is confounded by study quality. Stroke (2008) 3.87

How can we improve the pre-clinical development of drugs for stroke? Trends Neurosci (2007) 3.67

Early dual versus mono antiplatelet therapy for acute non-cardioembolic ischemic stroke or transient ischemic attack: an updated systematic review and meta-analysis. Circulation (2013) 3.57

Central nervous system injury-induced immune deficiency syndrome. Nat Rev Neurosci (2005) 3.45

Very early mobilization after stroke fast-tracks return to walking: further results from the phase II AVERT randomized controlled trial. Stroke (2010) 3.43

Treatment of brain arteriovenous malformations: a systematic review and meta-analysis. JAMA (2011) 3.40

New ischaemic brain lesions on MRI after stenting or endarterectomy for symptomatic carotid stenosis: a substudy of the International Carotid Stenting Study (ICSS). Lancet Neurol (2010) 3.35

Good laboratory practice: preventing introduction of bias at the bench. Stroke (2008) 3.27

Predicting long-term outcome after acute ischemic stroke: a simple index works in patients from controlled clinical trials. Stroke (2008) 3.21

Systematic review and metaanalysis of the efficacy of FK506 in experimental stroke. J Cereb Blood Flow Metab (2005) 3.20

Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke (2008) 2.98

Hypothermia in animal models of acute ischaemic stroke: a systematic review and meta-analysis. Brain (2007) 2.94

Can we improve the statistical analysis of stroke trials? Statistical reanalysis of functional outcomes in stroke trials. Stroke (2007) 2.86

The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. Lancet Neurol (2009) 2.78

Rivaroxaban compared with warfarin in patients with atrial fibrillation and previous stroke or transient ischaemic attack: a subgroup analysis of ROCKET AF. Lancet Neurol (2012) 2.77

Improving the translational hit of experimental treatments in multiple sclerosis. Mult Scler (2010) 2.73

Evaluation of excess significance bias in animal studies of neurological diseases. PLoS Biol (2013) 2.70

Clinical significance of fluid-attenuated inversion recovery vascular hyperintensities in transient ischemic attack. Stroke (2013) 2.68

Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials. Stroke (2008) 2.58

Bone marrow-derived progenitor cells modulate vascular reendothelialization and neointimal formation: effect of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibition. Arterioscler Thromb Vasc Biol (2002) 2.54

High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension (2003) 2.52

Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol (2007) 2.46

Preventive antibacterial therapy in acute ischemic stroke: a randomized controlled trial. PLoS One (2008) 2.39

Clinical practice. Secondary prevention after ischemic stroke or transient ischemic attack. N Engl J Med (2012) 2.39

An alpha-syntrophin-dependent pool of AQP4 in astroglial end-feet confers bidirectional water flow between blood and brain. Proc Natl Acad Sci U S A (2003) 2.37

Granulocyte colony-stimulating factor in patients with acute ischemic stroke: results of the AX200 for Ischemic Stroke trial. Stroke (2013) 2.36

Association between hormone replacement therapy and subsequent arterial and venous vascular events: a meta-analysis. Eur Heart J (2008) 2.36

Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow Metab (2003) 2.34

Notes from the field: Heartland virus disease - United States, 2012-2013. MMWR Morb Mortal Wkly Rep (2014) 2.33

Efficacy of nitric oxide, with or without continuing antihypertensive treatment, for management of high blood pressure in acute stroke (ENOS): a partial-factorial randomised controlled trial. Lancet (2014) 2.31

Improving outcome after stroke: overcoming the translational roadblock. Cerebrovasc Dis (2008) 2.26

Diffusion- and perfusion-weighted MRI response to thrombolysis in stroke. Ann Neurol (2002) 2.25

Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke (2007) 2.25

Systolic blood pressure after intravenous antihypertensive treatment and clinical outcomes in hyperacute intracerebral hemorrhage: the stroke acute management with urgent risk-factor assessment and improvement-intracerebral hemorrhage study. Stroke (2013) 2.23

Neuronal overexpression of cyclooxygenase-2 increases cerebral infarction. Ann Neurol (2003) 2.22

Physical activity improves long-term stroke outcome via endothelial nitric oxide synthase-dependent augmentation of neovascularization and cerebral blood flow. Circ Res (2006) 2.21

Terutroban versus aspirin in patients with cerebral ischaemic events (PERFORM): a randomised, double-blind, parallel-group trial. Lancet (2011) 2.16

Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia. Ann Neurol (2004) 2.14

Treatment of space-occupying cerebral infarction. Crit Care Med (2003) 2.14

The Avoid Stroke as Soon as Possible (ASAP) general practice stroke audit. Med J Aust (2002) 2.13

Systematic review and stratified meta-analysis of the efficacy of interleukin-1 receptor antagonist in animal models of stroke. J Stroke Cerebrovasc Dis (2009) 2.12

Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke. Stroke (2007) 2.10

2016 European Guidelines on cardiovascular disease prevention in clinical practice: The Sixth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of 10 societies and by invited experts)Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR). Eur Heart J (2016) 2.09

Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study. Lancet Neurol (2008) 2.07

Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain (2009) 2.06

Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis. Crit Care Med (2014) 2.05

Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model. J Neurosci (2002) 2.05

HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke (2005) 2.04

Refining the definition of the malignant profile: insights from the DEFUSE-EPITHET pooled data set. Stroke (2011) 2.03

Should the MATCH results be extrapolated to all stroke patients and affect ongoing trials evaluating clopidogrel plus aspirin? Stroke (2004) 2.02

RAPID automated patient selection for reperfusion therapy: a pooled analysis of the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET) and the Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution (DEFUSE) Study. Stroke (2011) 2.01

Predicting clinical outcomes after thrombolysis using the iScore: results from the Virtual International Stroke Trials Archive. Stroke (2013) 2.01

Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow Metab (2005) 2.01

Effective prophylaxis for deep venous thrombosis after stroke: both low-dose anticoagulation and stockings for most cases. Stroke (2004) 2.00