Published in Nature on April 30, 2003
The primary cilium: a signalling centre during vertebrate development. Nat Rev Genet (2010) 8.81
Planar cell polarity signaling: from fly development to human disease. Annu Rev Genet (2008) 3.43
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles. Nat Cell Biol (2008) 3.07
Wnt7a activates the planar cell polarity pathway to drive the symmetric expansion of satellite stem cells. Cell Stem Cell (2009) 3.02
Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development (2006) 2.96
Principles of planar polarity in animal development. Development (2011) 2.94
Wnt5a functions in planar cell polarity regulation in mice. Dev Biol (2007) 2.85
Smaller inner ear sensory epithelia in Neurog 1 null mice are related to earlier hair cell cycle exit. Dev Dyn (2005) 2.71
Coupling between hydrodynamic forces and planar cell polarity orients mammalian motile cilia. Nat Cell Biol (2010) 2.67
The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet (2006) 2.56
Frizzled6 controls hair patterning in mice. Proc Natl Acad Sci U S A (2004) 2.54
Convergent extension, planar-cell-polarity signalling and initiation of mouse neural tube closure. Development (2007) 2.45
Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation. Dev Cell (2007) 2.41
Regulation of polarized extension and planar cell polarity in the cochlea by the vertebrate PCP pathway. Nat Genet (2005) 2.36
Review series: The cell biology of hearing. J Cell Biol (2010) 2.29
Murine dishevelled 3 functions in redundant pathways with dishevelled 1 and 2 in normal cardiac outflow tract, cochlea, and neural tube development. PLoS Genet (2008) 2.29
The mammalian Scribble polarity protein regulates epithelial cell adhesion and migration through E-cadherin. J Cell Biol (2005) 2.28
Genetics of human neural tube defects. Hum Mol Genet (2009) 2.28
The mother centriole plays an instructive role in defining cell geometry. PLoS Biol (2007) 2.04
Linking genes underlying deafness to hair-bundle development and function. Nat Neurosci (2009) 1.95
Strange as it may seem: the many links between Wnt signaling, planar cell polarity, and cilia. Genes Dev (2011) 1.94
Genetic interaction between members of the Vangl family causes neural tube defects in mice. Proc Natl Acad Sci U S A (2008) 1.90
Sec24b selectively sorts Vangl2 to regulate planar cell polarity during neural tube closure. Nat Cell Biol (2009) 1.80
Wnt signaling in myogenesis. Trends Cell Biol (2012) 1.79
Planar cell polarity protein Celsr1 regulates endothelial adherens junctions and directed cell rearrangements during valve morphogenesis. Dev Cell (2013) 1.70
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol (2007) 1.66
A focused and efficient genetic screening strategy in the mouse: identification of mutations that disrupt cortical development. PLoS Biol (2004) 1.64
Cilia orientation and the fluid mechanics of development. Curr Opin Cell Biol (2008) 1.62
Planar cell polarity signaling in vertebrates. Bioessays (2007) 1.62
Disruption of fibroblast growth factor receptor 3 signaling results in defects in cellular differentiation, neuronal patterning, and hearing impairment. Dev Dyn (2007) 1.61
A quest for the mechanism regulating global planar cell polarity of tissues. Trends Cell Biol (2009) 1.60
A two-step mechanism underlies the planar polarization of regenerating sensory hair cells. Proc Natl Acad Sci U S A (2006) 1.59
Microtubules enable the planar cell polarity of airway cilia. Curr Biol (2012) 1.59
Pronephric tubulogenesis requires Daam1-mediated planar cell polarity signaling. J Am Soc Nephrol (2011) 1.55
Morphogenesis of the node and notochord: the cellular basis for the establishment and maintenance of left-right asymmetry in the mouse. Dev Dyn (2008) 1.50
Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. PLoS One (2010) 1.49
Canonical wnt signaling is required for pancreatic carcinogenesis. Cancer Res (2013) 1.49
Neurulation in the cranial region--normal and abnormal. J Anat (2005) 1.47
Polarity protein alterations in carcinoma: a focus on emerging roles for polarity regulators. Curr Opin Genet Dev (2010) 1.40
The Wnt coreceptor Ryk regulates Wnt/planar cell polarity by modulating the degradation of the core planar cell polarity component Vangl2. J Biol Chem (2012) 1.39
Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int (2016) 1.39
Planar cell polarity signaling, cilia and polarized ciliary beating. Curr Opin Cell Biol (2010) 1.37
Order from disorder: Self-organization in mammalian hair patterning. Proc Natl Acad Sci U S A (2006) 1.37
PTK7 is essential for polarized cell motility and convergent extension during mouse gastrulation. Development (2009) 1.36
Subcellular localization of frizzled receptors, mediated by their cytoplasmic tails, regulates signaling pathway specificity. PLoS Biol (2004) 1.33
Impaired neural development caused by inducible expression of Axin in transgenic mice. Mech Dev (2006) 1.32
Mouse prickle1, the homolog of a PCP gene, is essential for epiblast apical-basal polarity. Proc Natl Acad Sci U S A (2009) 1.29
Regulation of PCDH15 function in mechanosensory hair cells by alternative splicing of the cytoplasmic domain. Development (2011) 1.27
Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes. Development (2010) 1.26
Atypical cadherins Celsr1-3 differentially regulate migration of facial branchiomotor neurons in mice. J Neurosci (2010) 1.25
Eya1 gene dosage critically affects the development of sensory epithelia in the mammalian inner ear. Hum Mol Genet (2008) 1.25
Epidermal wound repair is regulated by the planar cell polarity signaling pathway. Dev Cell (2010) 1.25
Planar cell polarity: keeping hairs straight is not so simple. Cold Spring Harb Perspect Biol (2010) 1.24
The small GTPase Rac1 regulates auditory hair cell morphogenesis. J Neurosci (2009) 1.24
The planar polarity pathway promotes coordinated cell migration during Drosophila oogenesis. Development (2007) 1.23
Primary cilia in planar cell polarity regulation of the inner ear. Curr Top Dev Biol (2008) 1.23
Comparison of phenotypes between different vangl2 mutants demonstrates dominant effects of the Looptail mutation during hair cell development. PLoS One (2012) 1.22
A protein complex of SCRIB, NOS1AP and VANGL1 regulates cell polarity and migration, and is associated with breast cancer progression. Oncogene (2011) 1.20
Sfrp controls apicobasal polarity and oriented cell division in developing gut epithelium. PLoS Genet (2009) 1.19
Myosin II regulates extension, growth and patterning in the mammalian cochlear duct. Development (2009) 1.19
The cell biology of planar cell polarity. J Cell Biol (2014) 1.19
Line up and listen: Planar cell polarity regulation in the mammalian inner ear. Semin Cell Dev Biol (2009) 1.18
Regulation of PCP by the Fat signaling pathway. Genes Dev (2013) 1.17
Functional interactions between Fat family cadherins in tissue morphogenesis and planar polarity. Development (2012) 1.17
The plane facts of PCP in the CNS. Neuron (2008) 1.17
Shaping the mammalian auditory sensory organ by the planar cell polarity pathway. Int J Dev Biol (2007) 1.17
Molecular mechanisms of inner ear development. Cold Spring Harb Perspect Biol (2012) 1.16
Loss of the Drosophila cell polarity regulator Scribbled promotes epithelial tissue overgrowth and cooperation with oncogenic Ras-Raf through impaired Hippo pathway signaling. BMC Dev Biol (2011) 1.15
Wnt5a regulates ventral midbrain morphogenesis and the development of A9-A10 dopaminergic cells in vivo. PLoS One (2008) 1.14
Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2. Development (2009) 1.14
Otic mesenchyme cells regulate spiral ganglion axon fasciculation through a Pou3f4/EphA4 signaling pathway. Neuron (2012) 1.14
Primary cilium migration depends on G-protein signalling control of subapical cytoskeleton. Nat Cell Biol (2013) 1.13
Distinct apical and basolateral mechanisms drive planar cell polarity-dependent convergent extension of the mouse neural plate. Dev Cell (2014) 1.12
WNTs in the neonatal mouse uterus: potential regulation of endometrial gland development. Biol Reprod (2010) 1.12
Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain. J Cell Biol (2009) 1.11
Planar cell polarity signaling: coordination of cellular orientation across tissues. Wiley Interdiscip Rev Dev Biol (2013) 1.11
Kif3a regulates planar polarization of auditory hair cells through both ciliary and non-ciliary mechanisms. Development (2011) 1.10
Alternative Wnt pathways and receptors. Cold Spring Harb Perspect Biol (2012) 1.09
Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B. Hum Mol Genet (2010) 1.07
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila. Genetics (2004) 1.07
A Myo6 mutation destroys coordination between the myosin heads, revealing new functions of myosin VI in the stereocilia of mammalian inner ear hair cells. PLoS Genet (2008) 1.07
Hey2 functions in parallel with Hes1 and Hes5 for mammalian auditory sensory organ development. BMC Dev Biol (2008) 1.07
The novel mouse mutant, chuzhoi, has disruption of Ptk7 protein and exhibits defects in neural tube, heart and lung development and abnormal planar cell polarity in the ear. BMC Dev Biol (2010) 1.06
When whorls collide: the development of hair patterns in frizzled 6 mutant mice. Development (2010) 1.06
Chato, a KRAB zinc-finger protein, regulates convergent extension in the mouse embryo. Development (2008) 1.06
Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol (2012) 1.06
Is left-right asymmetry a form of planar cell polarity? Development (2009) 1.04
The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors. Dev Biol (2009) 1.03
Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse. Genetics (2011) 1.02
Planar cell polarity signaling in the Drosophila eye. Curr Top Dev Biol (2010) 1.02
Erbin controls dendritic morphogenesis by regulating localization of delta-catenin. J Neurosci (2008) 1.02
Inner ear supporting cells: rethinking the silent majority. Semin Cell Dev Biol (2013) 1.01
Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions. Curr Biol (2010) 1.01
Scribble is required for normal epithelial cell-cell contacts and lumen morphogenesis in the mammalian lung. Dev Biol (2012) 1.01
The emerging role of Wnt/PCP signaling in organ formation. Zebrafish (2009) 1.00
Regulation of cochlear convergent extension by the vertebrate planar cell polarity pathway is dependent on p120-catenin. Development (2012) 1.00
The mouse Wnt/PCP protein Vangl2 is necessary for migration of facial branchiomotor neurons, and functions independently of Dishevelled. Dev Biol (2012) 1.00
A novel GTP-binding protein-adaptor protein complex responsible for export of Vangl2 from the trans Golgi network. Elife (2013) 1.00
Wnt to build a tube: contributions of Wnt signaling to epithelial tubulogenesis. Dev Dyn (2010) 1.00
Cilia, Wnt signaling, and the cytoskeleton. Cilia (2012) 0.99
A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res (2003) 12.94
Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res (2005) 11.23
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med (2006) 9.68
Onset and progression in inherited ALS determined by motor neurons and microglia. Science (2006) 9.42
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature (2012) 8.31
Mammalian mutagenesis using a highly mobile somatic Sleeping Beauty transposon system. Nature (2005) 6.20
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet (2003) 5.92
Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell (2004) 5.04
RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res (2004) 4.41
A transposon-based genetic screen in mice identifies genes altered in colorectal cancer. Science (2009) 4.16
New genes involved in cancer identified by retroviral tagging. Nat Genet (2002) 4.14
Identification of an organelle receptor for myosin-Va. Nat Cell Biol (2002) 4.06
Genome-wide single-nucleotide polymorphism analysis defines haplotype patterns in mouse. Proc Natl Acad Sci U S A (2003) 3.93
Melanocytes and the microphthalmia transcription factor network. Annu Rev Genet (2004) 3.78
The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat Immunol (2008) 3.55
Bcl11a is essential for normal lymphoid development. Nat Immunol (2003) 3.48
A conditional transposon-based insertional mutagenesis screen for genes associated with mouse hepatocellular carcinoma. Nat Biotechnol (2009) 3.44
Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice. Proc Natl Acad Sci U S A (2002) 3.33
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells. Blood (2005) 2.93
Math1 regulates development of the sensory epithelium in the mammalian cochlea. Nat Neurosci (2004) 2.93
Parkinson's disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci (2006) 2.85
Hermansky-Pudlak syndrome type 7 (HPS-7) results from mutant dysbindin, a member of the biogenesis of lysosome-related organelles complex 1 (BLOC-1). Nat Genet (2003) 2.78
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion. Science (2010) 2.77
Asymmetric localization of Vangl2 and Fz3 indicate novel mechanisms for planar cell polarity in mammals. J Neurosci (2006) 2.73
Region-specific saturation germline mutagenesis in mice using the Sleeping Beauty transposon system. Nat Methods (2005) 2.70
Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Hum Mol Genet (2003) 2.64
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals. EMBO J (2004) 2.55
Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea. Proc Natl Acad Sci U S A (2008) 2.52
Synaptic defects in ataxia mice result from a mutation in Usp14, encoding a ubiquitin-specific protease. Nat Genet (2002) 2.46
Harnessing transposons for cancer gene discovery. Nat Rev Cancer (2010) 2.44
Myosin-1a is critical for normal brush border structure and composition. Mol Biol Cell (2005) 2.44
Persistent amyloidosis following suppression of Abeta production in a transgenic model of Alzheimer disease. PLoS Med (2005) 2.43
Development of tonotopy in the auditory periphery. Hear Res (2011) 2.32
Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development (2003) 2.18
Efficient Cre-loxP-induced mitotic recombination in mouse embryonic stem cells. Nat Genet (2001) 2.14
From placode to polarization: new tunes in inner ear development. Development (2004) 2.12
Gene therapy insertional mutagenesis insights. Science (2004) 1.99
Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. Neurobiol Dis (2002) 1.96
Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2. PLoS One (2011) 1.93
Cooperating cancer-gene identification through oncogenic-retrovirus-induced insertional mutagenesis. Blood (2005) 1.91
Tumor suppressor gene identification using retroviral insertional mutagenesis in Blm-deficient mice. EMBO J (2006) 1.88
A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res (2009) 1.86
Sleeping Beauty mutagenesis reveals cooperating mutations and pathways in pancreatic adenocarcinoma. Proc Natl Acad Sci U S A (2012) 1.82
Zic2 patterns binocular vision by specifying the uncrossed retinal projection. Cell (2003) 1.81
Cell of origin strongly influences genetic selection in a mouse model of T-ALL. Blood (2011) 1.78
Transcription profiling of inner ears from Pou4f3(ddl/ddl) identifies Gfi1 as a target of the Pou4f3 deafness gene. Hum Mol Genet (2004) 1.73
Response and resistance to MEK inhibition in leukaemias initiated by hyperactive Ras. Nature (2009) 1.72
Mitf and Tfe3, two members of the Mitf-Tfe family of bHLH-Zip transcription factors, have important but functionally redundant roles in osteoclast development. Proc Natl Acad Sci U S A (2002) 1.70
Coincident thresholds of mutant protein for paralytic disease and protein aggregation caused by restrictively expressed superoxide dismutase cDNA. Neurobiol Dis (2005) 1.69
Inhibitors of differentiation and DNA binding (Ids) regulate Math1 and hair cell formation during the development of the organ of Corti. J Neurosci (2006) 1.68
Hearing loss and retarded cochlear development in mice lacking type 2 iodothyronine deiodinase. Proc Natl Acad Sci U S A (2004) 1.68
Noncanonical Wnt signaling and neural polarity. Annu Rev Neurosci (2006) 1.63
Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation. Hum Mol Genet (2005) 1.63
Zfp423 is required for normal cerebellar development. Mol Cell Biol (2006) 1.62