Published in Genesis on March 01, 2009
Bmp signaling regulates myocardial differentiation from cardiac progenitors through a MicroRNA-mediated mechanism. Dev Cell (2010) 1.49
22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development. Pediatr Cardiol (2010) 1.44
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
Partitioning the heart: mechanisms of cardiac septation and valve development. Development (2012) 1.13
Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome. Curr Allergy Asthma Rep (2013) 0.98
Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet (2014) 0.85
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
TBX1 protein interactions and microRNA-96-5p regulation controls cell proliferation during craniofacial and dental development: implications for 22q11.2 deletion syndrome. Hum Mol Genet (2015) 0.84
Tbx1 modulates endodermal and mesodermal differentiation from mouse induced pluripotent stem cells. Stem Cells Dev (2014) 0.79
Biallelic expression of Tbx1 protects the embryo from developmental defects caused by increased receptor tyrosine kinase signaling. Dev Dyn (2012) 0.78
Ectopic TBX1 suppresses thymic epithelial cell differentiation and proliferation during thymus organogenesis. Development (2014) 0.78
Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol (2013) 0.76
A 3 base pair deletion in TBX1 leads to reduced protein expression and transcriptional activity. Sci Rep (2017) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Role of TBX1 in human del22q11.2 syndrome. Lancet (2003) 4.45
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet (2001) 4.35
Congenital heart disease in mice deficient for the DiGeorge syndrome region. Nature (1999) 2.60
Required, tissue-specific roles for Fgf8 in outflow tract formation and remodeling. Development (2006) 2.41
Chromosomal microdeletions: dissecting del22q11 syndrome. Nat Rev Genet (2001) 2.32
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Hum Mol Genet (2004) 1.95
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (2004) 1.75
In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet (2007) 1.59
Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol (2004) 1.46
Identification of downstream genetic pathways of Tbx1 in the second heart field. Dev Biol (2008) 1.39
Dissecting contiguous gene defects: TBX1. Curr Opin Genet Dev (2005) 1.30
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis (2007) 1.24
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet (2006) 1.06
The 22q11.2 deletion syndrome: a gene dosage perspective. ScientificWorldJournal (2006) 0.88
TFEB links autophagy to lysosomal biogenesis. Science (2011) 8.87
A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB. EMBO J (2012) 5.03
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol (2013) 2.62
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development (2006) 1.82
In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet (2007) 1.59
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development (2005) 1.57
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development (2005) 1.46
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Great vessel development requires biallelic expression of Chd7 and Tbx1 in pharyngeal ectoderm in mice. J Clin Invest (2009) 1.40
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development (2006) 1.31
TBX1 is required for inner ear morphogenesis. Hum Mol Genet (2003) 1.30
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet (2006) 1.27
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis (2007) 1.24
Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol (2006) 1.10
Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol (2005) 1.10
Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol (2006) 1.07
Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis (2005) 1.06
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta. Circ Res (2007) 1.02
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet (2012) 1.02
Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm. Dev Dyn (2007) 0.97
Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95
Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet (2005) 0.94
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol (2010) 0.94
Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol (2009) 0.94
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome (2010) 0.91
Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol (2010) 0.90
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. J Proteome Res (2009) 0.89
Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome. Semin Cell Dev Biol (2006) 0.88
Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol (2010) 0.86
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol (2007) 0.84
14-3-3ε plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol (2012) 0.83
Manipulation of endogenous regulatory elements and transgenic analyses of the Tbx1 gene. Mamm Genome (2010) 0.82
Generating and modifying DiGeorge syndrome-like phenotypes in model organisms: is there a common genetic pathway? Trends Genet (2003) 0.81
A deficiency in the region homologous to human 17q21.33-q23.2 causes heart defects in mice. Genetics (2006) 0.81
Ece1 and Tbx1 define distinct pathways to aortic arch morphogenesis. Dev Dyn (2003) 0.78
Fate map of serotonin transporter-expressing cells in developing mouse heart. Genesis (2007) 0.78
Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol (2013) 0.76