Published in Dev Biol on February 13, 2008
A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. J Clin Invest (2010) 2.06
Phenotypic impact of genomic structural variation: insights from and for human disease. Nat Rev Genet (2013) 1.98
Myocardial lineage development. Circ Res (2010) 1.98
Genetics of congenital heart disease: the glass half empty. Circ Res (2013) 1.90
22q11 deletion syndrome: a role for TBX1 in pharyngeal and cardiovascular development. Pediatr Cardiol (2010) 1.44
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
The neural crest in cardiac congenital anomalies. Differentiation (2012) 1.17
Role of mesodermal FGF8 and FGF10 overlaps in the development of the arterial pole of the heart and pharyngeal arch arteries. Circ Res (2009) 1.15
Of mice and men: molecular genetics of congenital heart disease. Cell Mol Life Sci (2013) 1.10
Tbx1 controls cardiac neural crest cell migration during arch artery development by regulating Gbx2 expression in the pharyngeal ectoderm. Development (2009) 1.09
Genotype and cardiovascular phenotype correlations with TBX1 in 1,022 velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. Hum Mutat (2011) 1.05
A new heart for a new head in vertebrate cardiopharyngeal evolution. Nature (2015) 1.04
Regulation of skin aging and heart development by TAp63. Cell Death Differ (2011) 1.02
Understanding the role of Tbx1 as a candidate gene for 22q11.2 deletion syndrome. Curr Allergy Asthma Rep (2013) 0.98
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis (2009) 0.97
Decreased levels of embryonic retinoic acid synthesis accelerate recovery from arterial growth delay in a mouse model of DiGeorge syndrome. Circ Res (2010) 0.94
Cardiac outflow tract anomalies. Wiley Interdiscip Rev Dev Biol (2013) 0.92
Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis. Proc Natl Acad Sci U S A (2012) 0.92
NK4 antagonizes Tbx1/10 to promote cardiac versus pharyngeal muscle fate in the ascidian second heart field. PLoS Biol (2013) 0.92
Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol (2010) 0.91
Identification of a Tbx1/Tbx2/Tbx3 genetic pathway governing pharyngeal and arterial pole morphogenesis. Hum Mol Genet (2011) 0.91
Hes1 expression is reduced in Tbx1 null cells and is required for the development of structures affected in 22q11 deletion syndrome. Dev Biol (2010) 0.91
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. J Proteome Res (2009) 0.89
Endothelial neuropilin disruption in mice causes DiGeorge syndrome-like malformations via mechanisms distinct to those caused by loss of Tbx1. PLoS One (2012) 0.87
Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet (2014) 0.85
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
Tbx1 is required for second heart field proliferation in zebrafish. Dev Dyn (2013) 0.84
DiGeorge syndrome gene tbx1 functions through wnt11r to regulate heart looping and differentiation. PLoS One (2013) 0.83
TCreERT2, a transgenic mouse line for temporal control of Cre-mediated recombination in lineages emerging from the primitive streak or tail bud. PLoS One (2013) 0.83
Loss of Wnt5a disrupts second heart field cell deployment and may contribute to OFT malformations in DiGeorge syndrome. Hum Mol Genet (2014) 0.83
Mammalian TBX1 preferentially binds and regulates downstream targets via a tandem T-site repeat. PLoS One (2014) 0.82
AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol (2014) 0.81
Heart fields and cardiac morphogenesis. Cold Spring Harb Perspect Med (2014) 0.81
The inferred cardiogenic gene regulatory network in the mammalian heart. PLoS One (2014) 0.80
Novel TBX1 loss-of-function mutation causes isolated conotruncal heart defects in Chinese patients without 22q11.2 deletion. BMC Med Genet (2014) 0.79
Regulation and evolution of cardiopharyngeal cell identity and behavior: insights from simple chordates. Curr Opin Genet Dev (2015) 0.79
Tbx5 and Osr1 interact to regulate posterior second heart field cell cycle progression for cardiac septation. J Mol Cell Cardiol (2015) 0.78
Heparan Sulfate Biosynthesis Enzyme, Ext1, Contributes to Outflow Tract Development of Mouse Heart via Modulation of FGF Signaling. PLoS One (2015) 0.77
Whole-Genome Sequencing and Integrative Genomic Analysis Approach on Two 22q11.2 Deletion Syndrome Family Trios for Genotype to Phenotype Correlations. Hum Mutat (2015) 0.76
Reduced dosage of β-catenin provides significant rescue of cardiac outflow tract anomalies in a Tbx1 conditional null mouse model of 22q11.2 deletion syndrome. PLoS Genet (2017) 0.75
Heterogeneity in the Segmental Development of the Aortic Tree: Impact on Management of Genetically Triggered Aortic Aneurysms. Aorta (Stamford) (2014) 0.75
TBX1 Represses Vegfr2 Gene Expression and Enhances the Cardiac Fate of VEGFR2+ Cells. PLoS One (2015) 0.75
Epithelial tension in the second heart field promotes mouse heart tube elongation. Nat Commun (2017) 0.75
Ciona as a Simple Chordate Model for Heart Development and Regeneration. J Cardiovasc Dev Dis (2016) 0.75
A 3 base pair deletion in TBX1 leads to reduced protein expression and transcriptional activity. Sci Rep (2017) 0.75
Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development. Dis Model Mech (2016) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart. Dev Cell (2003) 8.00
Requirement of the transcription factor GATA4 for heart tube formation and ventral morphogenesis. Genes Dev (1997) 6.52
GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature (2003) 6.40
Chromosome 22-specific low copy repeats and the 22q11.2 deletion syndrome: genomic organization and deletion endpoint analysis. Hum Mol Genet (2000) 6.21
A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell (2001) 5.77
Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev (1995) 5.53
Building the mammalian heart from two sources of myocardial cells. Nat Rev Genet (2005) 5.51
TBX1 is responsible for cardiovascular defects in velo-cardio-facial/DiGeorge syndrome. Cell (2001) 4.60
Role of TBX1 in human del22q11.2 syndrome. Lancet (2003) 4.45
Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Nature (2001) 4.41
DiGeorge syndrome phenotype in mice mutant for the T-box gene, Tbx1. Nat Genet (2001) 4.35
A new syndrome involving cleft palate, cardiac anomalies, typical facies, and learning disabilities: velo-cardio-facial syndrome. Cleft Palate J (1978) 4.23
The right ventricle, outflow tract, and ventricular septum comprise a restricted expression domain within the secondary/anterior heart field. Dev Biol (2005) 3.58
Expression of the T-box family genes, Tbx1-Tbx5, during early mouse development. Dev Dyn (1996) 3.34
Tbx5 associates with Nkx2-5 and synergistically promotes cardiomyocyte differentiation. Nat Genet (2001) 3.14
Inactivation of FGF8 in early mesoderm reveals an essential role in kidney development. Development (2005) 2.82
Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol Cell Biol (1994) 2.63
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Modulation of cardiac growth and development by HOP, an unusual homeodomain protein. Cell (2002) 2.53
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Morphogenesis of the right ventricle requires myocardial expression of Gata4. J Clin Invest (2005) 2.50
GATA transcription factors in the developing and adult heart. Cardiovasc Res (2004) 2.30
Embryonic retinoic acid synthesis is essential for heart morphogenesis in the mouse. Development (2001) 2.25
Molecular definition of the 22q11 deletions in velo-cardio-facial syndrome. Am J Hum Genet (1995) 2.19
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor. Development (1997) 2.07
Chamber-specific cardiac expression of Tbx5 and heart defects in Holt-Oram syndrome. Dev Biol (1999) 2.05
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A (2006) 2.03
GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression. Mol Cell Biol (1998) 2.00
The clonal origin of myocardial cells in different regions of the embryonic mouse heart. Dev Cell (2004) 2.00
Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Hum Mol Genet (2004) 1.95
T-box genes coordinate regional rates of proliferation and regional specification during cardiogenesis. Development (2005) 1.92
Dose-dependent interaction of Tbx1 and Crkl and locally aberrant RA signaling in a model of del22q11 syndrome. Dev Cell (2006) 1.83
Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development (2006) 1.82
Mutation in myosin heavy chain 6 causes atrial septal defect. Nat Genet (2005) 1.76
Tbx1 regulates fibroblast growth factors in the anterior heart field through a reinforcing autoregulatory loop involving forkhead transcription factors. Development (2004) 1.75
Congenital heart defects in Fgfr2-IIIb and Fgf10 mutant mice. Cardiovasc Res (2006) 1.73
Transcriptional regulation of vertebrate cardiac morphogenesis. Circ Res (2002) 1.72
The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells. Mol Cell Biol (1994) 1.70
The Xenopus GATA-4/5/6 genes are associated with cardiac specification and can regulate cardiac-specific transcription during embryogenesis. Dev Biol (1996) 1.63
The anterior heart-forming field: voyage to the arterial pole of the heart. Trends Genet (2002) 1.62
Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol (2006) 1.55
Ventricular expression of tbx5 inhibits normal heart chamber development. Dev Biol (2000) 1.52
A caudorostral wave of RALDH2 conveys anteroposterior information to the cardiac field. Development (2003) 1.51
Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. Dev Biol (1998) 1.49
Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development (2006) 1.49
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development (2005) 1.46
Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Development (2003) 1.36
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development (2006) 1.34
Patterns of expression in the developing myocardium: towards a morphologically integrated transcriptional model. Cardiovasc Res (1998) 1.34
Expression of the atrial-specific myosin heavy chain AMHC1 and the establishment of anteroposterior polarity in the developing chicken heart. Development (1994) 1.31
Inhibition of transcription factor GATA-4 expression blocks in vitro cardiac muscle differentiation. Mol Cell Biol (1995) 1.30
Molecular inroads into the anterior heart field. Trends Cardiovasc Med (2005) 1.30
T-box binding sites are required for activity of a cardiac GATA-4 enhancer. Dev Biol (2004) 1.25
Identification of a novel nuclear localization signal in Tbx1 that is deleted in DiGeorge syndrome patients harboring the 1223delC mutation. Hum Mol Genet (2005) 1.19
Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. Hum Mol Genet (2001) 1.19
Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for development of the pharynx. Mol Cell Biol (2001) 1.17
Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol (2005) 1.10
Retinoid signaling and cardiac anteroposterior segmentation. Genesis (2001) 1.07
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet (2006) 1.06
Retinoic acid is required in the mouse embryo for left-right asymmetry determination and heart morphogenesis. Development (1999) 1.05
A retinoic acid-inducible transgenic marker of sino-atrial development in the mouse heart. Development (1999) 1.01
Common arterial trunk associated with a homeodomain mutation of NKX2.6. Hum Mol Genet (2005) 1.00
Retinoid signaling required for normal heart development regulates GATA-4 in a pathway distinct from cardiomyocyte differentiation. Dev Biol (1999) 0.97
Tbx1 is required for proper neural crest migration and to stabilize spatial patterns during middle and inner ear development. Mech Dev (2005) 0.96
Phenotypic characterization of the murine Nkx2.6 homeobox gene by gene targeting. Mol Cell Biol (2000) 0.94
Expression of NK-2 class homeobox gene Nkx2-6 in foregut endoderm and heart. Mech Dev (1998) 0.90
Nkx2.6 expression is transiently and specifically restricted to the branchial region of pharyngeal-stage mouse embryos. Mech Dev (1997) 0.87
TBX5, a gene mutated in Holt-Oram syndrome, is regulated through a GC box and T-box binding elements (TBEs). J Cell Biochem (2004) 0.81
Chromosomal microarray versus karyotyping for prenatal diagnosis. N Engl J Med (2012) 4.97
Genomic disorders on 22q11. Am J Hum Genet (2002) 2.63
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Diabetes lowers aerobic capacity in heart failure. J Am Coll Cardiol (2005) 2.07
Microduplication and triplication of 22q11.2: a highly variable syndrome. Am J Hum Genet (2005) 2.05
Full spectrum of malformations in velo-cardio-facial syndrome/DiGeorge syndrome mouse models by altering Tbx1 dosage. Hum Mol Genet (2004) 1.95
Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo. Blood (2011) 1.79
A hybrid blob-slice model for accurate and efficient detection of fluorescence labeled nuclei in 3D. BMC Bioinformatics (2010) 1.69
Shuffling of genes within low-copy repeats on 22q11 (LCR22) by Alu-mediated recombination events during evolution. Genome Res (2003) 1.62
Inactivation of Tbx1 in the pharyngeal endoderm results in 22q11DS malformations. Development (2006) 1.49
Suppression of neural fate and control of inner ear morphogenesis by Tbx1. Development (2004) 1.41
A Tbx1-Six1/Eya1-Fgf8 genetic pathway controls mammalian cardiovascular and craniofacial morphogenesis. J Clin Invest (2011) 1.39
Tbx1 affects asymmetric cardiac morphogenesis by regulating Pitx2 in the secondary heart field. Development (2006) 1.34
Frequent translocations occur between low copy repeats on chromosome 22q11.2 (LCR22s) and telomeric bands of partner chromosomes. Hum Mol Genet (2003) 1.17
Behavior of mice with mutations in the conserved region deleted in velocardiofacial/DiGeorge syndrome. Neurogenetics (2006) 1.14
Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet (2006) 1.13
T-genes and limb bud development. Am J Med Genet A (2006) 1.11
Dual embryonic origin of the mammalian otic vesicle forming the inner ear. Development (2011) 1.07
Dissection of Tbx1 and Fgf interactions in mouse models of 22q11DS suggests functional redundancy. Hum Mol Genet (2006) 1.06
Genetic modifiers of the physical malformations in velo-cardio-facial syndrome/DiGeorge syndrome. Dev Disabil Res Rev (2008) 1.00
Mutations in GJB2, GJB6, and mitochondrial DNA are rare in African American and Caribbean Hispanic individuals with hearing impairment. Am J Med Genet A (2007) 0.98
Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol (2008) 0.96
Enhanced maternal origin of the 22q11.2 deletion in velocardiofacial and DiGeorge syndromes. Am J Hum Genet (2013) 0.96
Traffic of genetic information between segmental duplications flanking the typical 22q11.2 deletion in velo-cardio-facial syndrome/DiGeorge syndrome. Genome Res (2005) 0.95
Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol (2009) 0.94
Afp::mCherry, a red fluorescent transgenic reporter of the mouse visceral endoderm. Genesis (2011) 0.93
Hominoid lineage specific amplification of low-copy repeats on 22q11.2 (LCR22s) associated with velo-cardio-facial/digeorge syndrome. Hum Mol Genet (2007) 0.92
Mesodermal Tbx1 is required for patterning the proximal mandible in mice. Dev Biol (2010) 0.91
Mutational analysis of HOXA2 and SIX2 in a Bronx population with isolated microtia. Int J Pediatr Otorhinolaryngol (2010) 0.91
Canonical Wnt signaling modulates Tbx1, Eya1, and Six1 expression, restricting neurogenesis in the otic vesicle. Dev Dyn (2010) 0.90
Tetratricopeptide repeat domain 7A (TTC7A) mutation in a newborn with multiple intestinal atresia and combined immunodeficiency. J Clin Immunol (2014) 0.88
AT-rich repeats associated with chromosome 22q11.2 rearrangement disorders shape human genome architecture on Yq12. Genome Res (2007) 0.85
Spectrum of elastin sequence variants and cardiovascular phenotypes in 49 patients with Williams-Beuren syndrome. Am J Med Genet A (2013) 0.84
Cleft palate, retrognathia and congenital heart disease in velo-cardio-facial syndrome: a phenotype correlation study. Int J Pediatr Otorhinolaryngol (2011) 0.84
Live imaging fluorescent proteins in early mouse embryos. Methods Enzymol (2012) 0.82
GJB2 mutation spectrum in 209 hearing impaired individuals of predominantly Caribbean Hispanic and African descent. Int J Pediatr Otorhinolaryngol (2010) 0.81
Association between autism spectrum disorder in individuals with velocardiofacial (22q11.2 deletion) syndrome and PRODH and COMT genotypes. Psychiatr Genet (2014) 0.81
Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. Dev Dyn (2012) 0.79
Overt cleft palate phenotype and TBX1 genotype correlations in velo-cardio-facial/DiGeorge/22q11.2 deletion syndrome patients. Am J Med Genet A (2012) 0.79
Genetic evaluation of American minority pediatric cochlear implant recipients. Int J Pediatr Otorhinolaryngol (2008) 0.78
A candidate gene approach to identify modifiers of the palatal phenotype in 22q11.2 deletion syndrome patients. Int J Pediatr Otorhinolaryngol (2012) 0.77
Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol (2013) 0.76
Correction: A Novel C-Terminal CIB2 (Calcium and Integrin Binding Protein 2) Mutation Associated with Non-Syndromic Hearing Loss in a Hispanic Family. PLoS One (2015) 0.75
A conditional mutant allele for analysis of Mixl1 function in the mouse. Genesis (2014) 0.75
A cornucopia of delights for the mouse fancier. Genome Biol (2007) 0.75
Social media and dissemination: impressions of fish pedicures following a case of onychomadesis. Dermatol Online J (2020) 0.75
A novel, single nucleotide polymorphism-based assay to detect 22q11 deletions. Genet Test (2007) 0.75