Published in Hum Mol Genet on August 15, 2003
Stem cell therapy for the inner ear: recent advances and future directions. Trends Amplif (2012) 1.58
Connecting the ear to the brain: Molecular mechanisms of auditory circuit assembly. Prog Neurobiol (2011) 1.23
Tissue-specific roles of Tbx1 in the development of the outer, middle and inner ear, defective in 22q11DS patients. Hum Mol Genet (2006) 1.13
Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development. Brain Res (2006) 1.12
Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol (2006) 1.10
Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol (2006) 1.07
Extremely discrepant mutation spectrum of SLC26A4 between Chinese patients with isolated Mondini deformity and enlarged vestibular aqueduct. J Transl Med (2011) 1.03
Network topologies and convergent aetiologies arising from deletions and duplications observed in individuals with autism. PLoS Genet (2013) 1.00
A 200-kb region of human chromosome 22q11.2 confers antipsychotic-responsive behavioral abnormalities in mice. Proc Natl Acad Sci U S A (2005) 0.99
A symphony of inner ear developmental control genes. BMC Genet (2010) 0.97
Cooperative function of Tbx1 and Brn4 in the periotic mesenchyme is necessary for cochlea formation. J Assoc Res Otolaryngol (2008) 0.96
Tbx1 and Brn4 regulate retinoic acid metabolic genes during cochlear morphogenesis. BMC Dev Biol (2009) 0.94
Developmental expression patterns of Tbx1, Tbx2, Tbx5, and Tbx20 in Xenopus tropicalis. Dev Dyn (2006) 0.89
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. J Proteome Res (2009) 0.89
Three patients with oculo-auriculo-vertebral spectrum and microdeletion 22q11.2. Am J Med Genet A (2009) 0.88
Chimeric negative regulation of p14ARF and TBX1 by a t(9;22) translocation associated with melanoma, deafness, and DNA repair deficiency. Hum Mutat (2013) 0.87
A noncoding point mutation of Zeb1 causes multiple developmental malformations and obesity in Twirler mice. PLoS Genet (2011) 0.87
In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol (2007) 0.84
Segregating neural and mechanosensory fates in the developing ear: patterning, signaling, and transcriptional control. Cell Tissue Res (2014) 0.83
Single nucleotide polymorphism discovery in TBX1 in individuals with and without 22q11.2 deletion syndrome. Birth Defects Res A Clin Mol Teratol (2010) 0.82
Congenital T cell deficiency in a patient with CHARGE syndrome. J Pediatr (2009) 0.81
Spatiotemporal expression of Zic genes during vertebrate inner ear development. Dev Dyn (2013) 0.80
RIPPLY3 is a retinoic acid-inducible repressor required for setting the borders of the pre-placodal ectoderm. Development (2012) 0.80
Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development. Dev Dyn (2012) 0.79
Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling. Elife (2015) 0.79
Hearing loss in a mouse model of 22q11.2 Deletion Syndrome. PLoS One (2013) 0.79
Hard to swallow: Developmental biological insights into pediatric dysphagia. Dev Biol (2015) 0.78
Conditional and constitutive expression of a Tbx1-GFP fusion protein in mice. BMC Dev Biol (2013) 0.76
Otologic and audiologic findings in 22q11.2 deletion syndrome. Eur Arch Otorhinolaryngol (2016) 0.75
The role of Zic genes in inner ear development in the mouse: Exploring mutant mouse phenotypes. Dev Dyn (2014) 0.75
Spemann organizer gene Goosecoid promotes delamination of neuroblasts from the otic vesicle. Proc Natl Acad Sci U S A (2016) 0.75
Transcriptome-wide comparison of the impact of Atoh1 and miR-183 family on pluripotent stem cells and multipotent otic progenitor cells. PLoS One (2017) 0.75
Genome-wide association and HLA region fine-mapping studies identify susceptibility loci for multiple common infections. Nat Commun (2017) 0.75
The severity of vestibular dysfunction in deafness as a determinant of comorbid hyperactivity or anxiety. J Neurosci (2017) 0.75
Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med (2005) 3.13
T cell costimulation by chemokine receptors. Nat Immunol (2005) 3.00
Neuroepithelial stem cell proliferation requires LIS1 for precise spindle orientation and symmetric division. Cell (2008) 2.68
Tbx1 has a dual role in the morphogenesis of the cardiac outflow tract. Development (2004) 2.62
Acute kidney injury in cirrhosis. Hepatology (2008) 2.43
Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis. Liver Int (2009) 2.27
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity (2010) 2.22
A genetic link between Tbx1 and fibroblast growth factor signaling. Development (2002) 2.18
Orchestration of lymphocyte chemotaxis by mitochondrial dynamics. J Exp Med (2006) 2.10
Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med (2011) 2.06
Tbx1 mutation causes multiple cardiovascular defects and disrupts neural crest and cranial nerve migratory pathways. Hum Mol Genet (2002) 2.04
Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome. Proc Natl Acad Sci U S A (2006) 2.03
A pivotal role for endogenous TGF-beta-activated kinase-1 in the LKB1/AMP-activated protein kinase energy-sensor pathway. Proc Natl Acad Sci U S A (2006) 2.03
CD4+CD25+ regulatory T cells suppress mast cell degranulation and allergic responses through OX40-OX40L interaction. Immunity (2008) 1.95
CD28 and lipid rafts coordinate recruitment of Lck to the immunological synapse of human T lymphocytes. J Immunol (2004) 1.92
Mesodermal expression of Tbx1 is necessary and sufficient for pharyngeal arch and cardiac outflow tract development. Development (2006) 1.82
Filamin-A regulates actin-dependent clustering of HIV receptors. Nat Cell Biol (2007) 1.71
A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2. Blood (2010) 1.67
In vivo response to high-resolution variation of Tbx1 mRNA dosage. Hum Mol Genet (2007) 1.59
Tbx1 expression in pharyngeal epithelia is necessary for pharyngeal arch artery development. Development (2005) 1.57
Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities. Hum Mol Genet (2007) 1.57
CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse. Nat Cell Biol (2006) 1.56
The critical role of agrin in the hematopoietic stem cell niche. Blood (2011) 1.54
CXCR4-CCR5: a couple modulating T cell functions. Proc Natl Acad Sci U S A (2008) 1.47
Timed mutation and cell-fate mapping reveal reiterated roles of Tbx1 during embryogenesis, and a crucial function during segmentation of the pharyngeal system via regulation of endoderm expansion. Development (2005) 1.46
Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A (2007) 1.46
Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries. Cell Res (2013) 1.46
Tbx1 regulates the BMP-Smad1 pathway in a transcription independent manner. PLoS One (2009) 1.41
The 2q23.1 microdeletion syndrome: clinical and behavioural phenotype. Eur J Hum Genet (2009) 1.39
Tbx1 regulates proliferation and differentiation of multipotent heart progenitors. Circ Res (2009) 1.37
Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet (2012) 1.37
Phenotypic characterization of Bbs4 null mice reveals age-dependent penetrance and variable expressivity. Hum Genet (2006) 1.32
Pitx2 promotes development of splanchnic mesoderm-derived branchiomeric muscle. Development (2006) 1.31
Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. Hum Mol Genet (2006) 1.27
The inner side of T cell lipid rafts. Immunol Lett (2004) 1.26
A fate map of Tbx1 expressing cells reveals heterogeneity in the second cardiac field. Genesis (2007) 1.24
Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies. Semin Cell Dev Biol (2010) 1.21
Lipid rafts in lymphocyte activation and migration. Mol Membr Biol (2006) 1.20
Cortical dysplasia of the left temporal lobe might explain severe expressive-language delay in patients with duplication of the Williams-Beuren locus. Eur J Hum Genet (2006) 1.18
Two classes of low-copy repeats comediate a new recurrent rearrangement consisting of duplication at 8p23.1 and triplication at 8p23.2. Hum Mutat (2007) 1.14
Chromosomal rearrangements in Xq and premature ovarian failure: mapping of 25 new cases and review of the literature. Hum Reprod (2006) 1.14
Overexpression of microRNA-206 in the skeletal muscle from myotonic dystrophy type 1 patients. J Transl Med (2010) 1.13
Lipid rafts and T cell receptor signaling: a critical re-evaluation. Eur J Immunol (2002) 1.13
Reciprocal translocations: a trap for cytogenetists? Hum Genet (2005) 1.12
Mouse models of 22q11 deletion syndrome. Biol Psychiatry (2006) 1.11
Distinct dose-dependent cortical neuronal migration and neurite extension defects in Lis1 and Ndel1 mutant mice. J Neurosci (2009) 1.10
Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol (2006) 1.10
Microarray analysis detects differentially expressed genes in the pharyngeal region of mice lacking Tbx1. Dev Biol (2005) 1.10
Tbx1 regulates population, proliferation and cell fate determination of otic epithelial cells. Dev Biol (2006) 1.07
Fgf15 is required for proper morphogenesis of the mouse cardiac outflow tract. Genesis (2005) 1.06
Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice. Brain Res (2010) 1.05
Modulation of human T-cell functions by reactive nitrogen species. Eur J Immunol (2011) 1.03
Peroxisome proliferator-activated receptor-delta upregulates 14-3-3 epsilon in human endothelial cells via CCAAT/enhancer binding protein-beta. Circ Res (2007) 1.02
Transcriptional control in cardiac progenitors: Tbx1 interacts with the BAF chromatin remodeling complex and regulates Wnt5a. PLoS Genet (2012) 1.02
Vav cooperates with CD28 to induce NF-kappaB activation via a pathway involving Rac-1 and mitogen-activated kinase kinase 1. Eur J Immunol (2002) 1.01
Multiple genetic typing of Salmonella Enteritidis phage-types 4, 6, 7, 8 and 13a isolates from animals and humans in the UK. Vet Microbiol (2004) 1.01
Adhesion shapes T cells for prompt and sustained T-cell receptor signalling. EMBO J (2010) 1.00
The splice variant LOXIN inhibits LOX-1 receptor function through hetero-oligomerization. J Mol Cell Cardiol (2007) 1.00
Lymphocyte lipid rafts: structure and function. Curr Opin Immunol (2003) 0.98
Tbx1 regulation of myogenic differentiation in the limb and cranial mesoderm. Dev Dyn (2007) 0.97
Genetic analysis of Down syndrome-associated heart defects in mice. Hum Genet (2011) 0.97
Flotillins are involved in the polarization of primitive and mature hematopoietic cells. PLoS One (2009) 0.97
Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis (2009) 0.97
Microphthalmia with linear skin defects (MLS) syndrome: clinical, cytogenetic, and molecular characterization of 11 cases. Am J Med Genet A (2005) 0.97
Hypoxia-mediated regulation of macrophage functions in pathophysiology. Int Immunol (2012) 0.96
Dysmorphic features, simplified gyral pattern and 7q11.23 duplication reciprocal to the Williams-Beuren deletion. Eur J Hum Genet (2008) 0.95
Mouse models for Down syndrome-associated developmental cognitive disabilities. Dev Neurosci (2011) 0.95
A 2.3 Mb duplication of chromosome 8q24.3 associated with severe mental retardation and epilepsy detected by standard karyotype. Eur J Hum Genet (2005) 0.94
Early thyroid development requires a Tbx1-Fgf8 pathway. Dev Biol (2009) 0.94
Microarray analysis of the Df1 mouse model of the 22q11 deletion syndrome. Hum Genet (2005) 0.94
Tbx1 regulates progenitor cell proliferation in the dental epithelium by modulating Pitx2 activation of p21. Dev Biol (2010) 0.94
Epigenetic control of the critical region for premature ovarian failure on autosomal genes translocated to the X chromosome: a hypothesis. Hum Genet (2007) 0.91
Deficiencies in the region syntenic to human 21q22.3 cause cognitive deficits in mice. Mamm Genome (2010) 0.91
Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro. Int J Biochem Cell Biol (2010) 0.90
Tbx1 regulates Vegfr3 and is required for lymphatic vessel development. J Cell Biol (2010) 0.90
IFN-gamma and R-848 dependent activation of human monocyte-derived dendritic cells by Neisseria meningitidis adhesin A. J Immunol (2007) 0.90
Transcription factor TBX1 overexpression induces downregulation of proteins involved in retinoic acid metabolism: a comparative proteomic analysis. J Proteome Res (2009) 0.89
PERP regulates enamel formation via effects on cell-cell adhesion and gene expression. J Cell Sci (2011) 0.89
Self-antigen presentation by mouse B cells results in regulatory T-cell induction rather than anergy or clonal deletion. Blood (2011) 0.88
Genetic pathways to mammalian heart development: Recent progress from manipulation of the mouse genome. Semin Cell Dev Biol (2006) 0.88
A susceptibility gene for premature ovarian failure (POF) maps to proximal Xq28. Eur J Hum Genet (2004) 0.86
Partial rescue of the Tbx1 mutant heart phenotype by Fgf8: genetic evidence of impaired tissue response to Fgf8. J Mol Cell Cardiol (2010) 0.86
Physiological T cell activation starts and propagates in lipid rafts. Immunol Lett (2004) 0.86
Identification and molecular modelling of a novel familial mutation in the SRY gene implicated in the pure gonadal dysgenesis. Eur J Hum Genet (2006) 0.86
Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells. J Mol Cell Biol (2013) 0.86
Tbx1 is a negative modulator of Mef2c. Hum Mol Genet (2012) 0.84
A patient with duplication (7)(p22.1pter) characterized by array-CGH. Am J Med Genet A (2007) 0.84
In vivo genetic ablation of the periotic mesoderm affects cell proliferation survival and differentiation in the cochlea. Dev Biol (2007) 0.84
Regulatory T cells target chemokine secretion by dendritic cells independently of their capacity to regulate T cell proliferation. J Immunol (2011) 0.84