Published in Proc Natl Acad Sci U S A on March 04, 2009
Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. Genes Dev (2009) 4.29
TRIM proteins and cancer. Nat Rev Cancer (2011) 2.84
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PML nuclear bodies. Cold Spring Harb Perspect Biol (2010) 2.44
Regulation of E2Fs and senescence by PML nuclear bodies. Genes Dev (2011) 1.25
CCAAT/enhancer binding protein beta regulates stem cell activity and specifies luminal cell fate in the mammary gland. Stem Cells (2010) 1.08
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol (2012) 1.07
Targeting promyelocytic leukemia protein: a means to regulating PML nuclear bodies. Int J Biol Sci (2009) 1.03
The epigenetic landscape of mammary gland development and functional differentiation. J Mammary Gland Biol Neoplasia (2010) 1.02
Paternal RLIM/Rnf12 is a survival factor for milk-producing alveolar cells. Cell (2012) 0.97
RUNX1, a transcription factor mutated in breast cancer, controls the fate of ER-positive mammary luminal cells. Elife (2014) 0.96
The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3. Genes Dev (2012) 0.95
Role of the promyelocytic leukaemia protein in cell death regulation. Cell Death Dis (2012) 0.90
USP11 regulates PML stability to control Notch-induced malignancy in brain tumours. Nat Commun (2014) 0.88
Atbf1 regulates pubertal mammary gland development likely by inhibiting the pro-proliferative function of estrogen-ER signaling. PLoS One (2012) 0.86
Evidence for a multipotent mammary progenitor with pregnancy-specific activity. Breast Cancer Res (2013) 0.83
The role of PML in hematopoietic and leukemic stem cell maintenance. Int J Hematol (2014) 0.80
A Long-Lived Luminal Subpopulation Enriched with Alveolar Progenitors Serves as Cellular Origin of Heterogeneous Mammary Tumors. Stem Cell Reports (2015) 0.77
Tumor suppressive pathways in the control of neurogenesis. Cell Mol Life Sci (2012) 0.76
Myogenic differentiation triggers PML nuclear body loss and DAXX relocalization to chromocentres. Cell Death Dis (2017) 0.75
Tip30 controls differentiation of murine mammary luminal progenitor to estrogen receptor-positive luminal cell through regulating FoxA1 expression. Cell Death Dis (2014) 0.75
Purification and unique properties of mammary epithelial stem cells. Nature (2006) 15.98
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1. J Cell Biol (1999) 5.83
Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies. Nat Rev Mol Cell Biol (2007) 5.79
Stat5a is mandatory for adult mammary gland development and lactogenesis. Genes Dev (1997) 5.57
GATA-3 maintains the differentiation of the luminal cell fate in the mammary gland. Cell (2006) 4.98
Deconstructing a disease: RARalpha, its fusion partners, and their roles in the pathogenesis of acute promyelocytic leukemia. Blood (1999) 4.58
Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell (2008) 3.87
Role of PML in cell growth and the retinoic acid pathway. Science (1998) 3.82
PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75
PML and PML nuclear bodies: implications in antiviral defence. Biochimie (2007) 3.26
A PMLRARalpha transgene initiates murine acute promyelocytic leukemia. Proc Natl Acad Sci U S A (1997) 3.20
Loss of the tumor suppressor PML in human cancers of multiple histologic origins. J Natl Cancer Inst (2004) 3.17
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
Transcriptional induction of the PML growth suppressor gene by interferons is mediated through an ISRE and a GAS element. Oncogene (1995) 2.50
Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver. Mol Cell Biol (2001) 2.44
The PML growth-suppressor has an altered expression in human oncogenesis. Oncogene (1995) 2.23
PML protein expression in hematopoietic and acute promyelocytic leukemia cells. Blood (1993) 1.82
PML nuclear bodies and apoptosis. Oncogene (2004) 1.66
PML nuclear bodies are general targets for inflammation and cell proliferation. Cancer Res (1995) 1.54
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (2003) 1.48
The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development (2007) 1.46
New insights into the role of PML in tumour suppression. Cell Res (2008) 1.22
The Stat family of transcription factors have diverse roles in mammary gland development. Semin Cell Dev Biol (2008) 1.22
Heterogeneous nuclear expression of the promyelocytic leukemia (PML) protein in normal and neoplastic human tissues. Am J Pathol (1996) 1.11
A novel cell culture model for studying differentiation and apoptosis in the mouse mammary gland. Breast Cancer Res (2000) 1.01
Histone deacetylase inhibitors suppress IFNalpha-induced up-regulation of promyelocytic leukemia protein. Blood (2006) 0.97
The promyelocytic leukemia protein functions as a negative regulator of IFN-gamma signaling. Proc Natl Acad Sci U S A (2006) 0.95
Developing a mammary gland is a stat affair. J Mammary Gland Biol Neoplasia (1997) 0.94
Cell type- and differentiation stage-dependent expression of PML domains in rat, detected by monoclonal antibody HIS55. Exp Cell Res (1995) 0.89
Expression and role of PML gene in normal adult hematopoiesis: functional interaction between PML and Rb proteins in erythropoiesis. Oncogene (1999) 0.87
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Generation of a functional mammary gland from a single stem cell. Nature (2006) 18.30
A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy. Cell (2007) 5.85
Progesterone induces adult mammary stem cell expansion. Nature (2010) 4.69
Steroid hormone receptor status of mouse mammary stem cells. J Natl Cancer Inst (2006) 4.47
Transcriptome analysis of the normal human mammary cell commitment and differentiation process. Cell Stem Cell (2008) 3.87
A method for quantifying normal human mammary epithelial stem cells with in vivo regenerative ability. Nat Med (2008) 3.64
Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest (2009) 3.55
Mammary development in the embryo and adult: a journey of morphogenesis and commitment. Development (2008) 2.69
Ptpn11/Shp2 acts as a tumor suppressor in hepatocellular carcinogenesis. Cancer Cell (2011) 2.46
Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injury. Circ Res (2004) 2.45
Endogenous purification reveals GREB1 as a key estrogen receptor regulatory factor. Cell Rep (2013) 2.37
Epigenetic analysis of the Dlk1-Gtl2 imprinted domain on mouse chromosome 12: implications for imprinting control from comparison with Igf2-H19. Hum Mol Genet (2002) 2.33
Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression. Breast Cancer Res (2003) 2.29
Stat3 controls lysosomal-mediated cell death in vivo. Nat Cell Biol (2011) 2.28
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration. J Biol Chem (2002) 2.28
Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med (2010) 2.23
Stat3 regulates microtubules by antagonizing the depolymerization activity of stathmin. J Cell Biol (2006) 2.21
Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland. Breast Cancer Res (2012) 2.18
The E3 ubiquitin ligase Itch controls the protein stability of p63. Proc Natl Acad Sci U S A (2006) 2.01
Mutational switch of an IL-6 response to an interferon-gamma-like response. Proc Natl Acad Sci U S A (2002) 1.96
Interaction between mutant ataxin-1 and PQBP-1 affects transcription and cell death. Neuron (2002) 1.95
As(2)O(3) enhances retroviral reverse transcription and counteracts Ref1 antiviral activity. J Virol (2003) 1.94
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Res (2013) 1.92
TAp63 and DeltaNp63 in cancer and epidermal development. Cell Cycle (2007) 1.84
SUMO-1 protease-1 regulates gene transcription through PML. Mol Cell (2002) 1.80
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3. Proc Natl Acad Sci U S A (2003) 1.80
A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction. Aging (Albany NY) (2010) 1.70
Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology (2009) 1.64
Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci. Mol Cell Biol (2007) 1.62
Ups and downs: the STAT1:STAT3 seesaw of Interferon and gp130 receptor signalling. Semin Cell Dev Biol (2008) 1.62
The STAT3 isoforms alpha and beta have unique and specific functions. Nat Immunol (2004) 1.62
Alpha interferon induces long-lasting refractoriness of JAK-STAT signaling in the mouse liver through induction of USP18/UBP43. Mol Cell Biol (2009) 1.61
Constitutively active Stat3 enhances neu-mediated migration and metastasis in mammary tumors via upregulation of Cten. Cancer Res (2010) 1.60
Critical role for Stat3 in T-dependent terminal differentiation of IgG B cells. Blood (2005) 1.60
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary gland. Development (2003) 1.48
Epithelial-to-mesenchymal transition confers resistance to apoptosis in three murine mammary epithelial cell lines. Differentiation (2006) 1.48
A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J Biol Chem (2005) 1.47
The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development. Development (2007) 1.46
Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity. J Gen Virol (2013) 1.41
C/EBP beta gene inactivation causes both impaired and enhanced gene expression and inverse regulation of IL-12 p40 and p35 mRNAs in macrophages. J Immunol (2002) 1.41
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition. Nat Cell Biol (2005) 1.37
Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol (2009) 1.37
Defective thermoregulation, impaired lipid metabolism, but preserved adrenergic induction of gene expression in brown fat of mice lacking C/EBPbeta. Biochem J (2005) 1.35
The genes induced by signal transducer and activators of transcription (STAT)3 and STAT5 in mammary epithelial cells define the roles of these STATs in mammary development. Mol Endocrinol (2005) 1.33
Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis. Cytokine (2004) 1.31
Nucleocytoplasmic shuttling of persistently activated STAT3. J Cell Sci (2007) 1.31
Killing a cancer: what are the alternatives? Nat Rev Cancer (2012) 1.30
The nystagmus-associated FRMD7 gene regulates neuronal outgrowth and development. Hum Mol Genet (2009) 1.30
The tumor suppressor Pml regulates cell fate in the developing neocortex. Nat Neurosci (2009) 1.30
Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control. Dev Biol (2007) 1.28
STAT1 and STAT3 in tumorigenesis: A matter of balance. JAKSTAT (2012) 1.27
Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med (2004) 1.24
TGFβ induces the formation of tumour-initiating cells in claudinlow breast cancer. Nat Commun (2012) 1.23
Key signalling nodes in mammary gland development and cancer. Signalling downstream of PI3 kinase in mammary epithelium: a play in 3 Akts. Breast Cancer Res (2010) 1.22
Characterisation of microRNA expression in post-natal mouse mammary gland development. BMC Genomics (2009) 1.21
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch. Proc Natl Acad Sci U S A (2007) 1.19
IL-6, IL-17 and STAT3: a holy trinity in auto-immunity? Front Biosci (Landmark Ed) (2012) 1.18
Mammary-specific deletion of parathyroid hormone-related protein preserves bone mass during lactation. J Clin Invest (2003) 1.18
Calcium-dependent dephosphorylation of the histone chaperone DAXX regulates H3.3 loading and transcription upon neuronal activation. Neuron (2012) 1.18
Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology (2010) 1.17
Isolation of mouse mammary epithelial subpopulations: a comparison of leading methods. J Mammary Gland Biol Neoplasia (2012) 1.17
Genome-wide discovery of functional transcription factor binding sites by comparative genomics: the case of Stat3. Proc Natl Acad Sci U S A (2009) 1.16
Analysis of SOCS-3 promoter responses to interferon gamma. J Biol Chem (2004) 1.08
Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem (2007) 1.08
Poxvirus targeting of E3 ligase β-TrCP by molecular mimicry: a mechanism to inhibit NF-κB activation and promote immune evasion and virulence. PLoS Pathog (2013) 1.08
Mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol (2010) 1.08
Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. Biochemistry (2006) 1.08
Conditional deletion of Stat3 in mammary epithelium impairs the acute phase response and modulates immune cell numbers during post-lactational regression. J Pathol (2012) 1.07
PML interacts with Myc, and Myc target gene expression is altered in PML-null fibroblasts. Oncogene (2005) 1.06
Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway. J Biol Chem (2003) 1.05
Inhibition of autophagy: a new strategy to enhance sensitivity of chronic myeloid leukemia stem cells to tyrosine kinase inhibitors. Leuk Lymphoma (2011) 1.05
IKKbeta/2 induces TWEAK and apoptosis in mammary epithelial cells. Development (2006) 1.05
The role of the N-terminal domain in dimerization and nucleocytoplasmic shuttling of latent STAT3. J Cell Sci (2011) 1.05
A multifunctional 3D co-culture system for studies of mammary tissue morphogenesis and stem cell biology. PLoS One (2011) 1.04
Stat3 and the inflammation/acute phase response in involution and breast cancer. J Mammary Gland Biol Neoplasia (2009) 1.03
Microarray analysis of the involution switch. J Mammary Gland Biol Neoplasia (2003) 1.03
AIRE's CARD revealed, a new structure for central tolerance provokes transcriptional plasticity. J Biol Chem (2007) 1.03
Postpartum remodeling, lactation, and breast cancer risk: summary of a National Cancer Institute-sponsored workshop. J Natl Cancer Inst (2012) 1.02
Anti-HIV drugs and the mitochondria. Biochim Biophys Acta (2006) 1.01
Regulation of the p73 protein stability and degradation. Biochem Biophys Res Commun (2005) 1.00
Cutting edge: inherent and acquired resistance to radiation-induced apoptosis in B cells: a pivotal role for STAT3. J Immunol (2006) 1.00
Of alphas and betas: distinct and overlapping functions of STAT3 isoforms. Front Biosci (2008) 0.99
Vaccinia virus protein C4 inhibits NF-κB activation and promotes virus virulence. J Gen Virol (2012) 0.97
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3. EMBO J (2006) 0.97
Tyk2 and Stat3 regulate brown adipose tissue differentiation and obesity. Cell Metab (2012) 0.97
Endogenous leukemia inhibitory factor attenuates endotoxin response. Lab Invest (2005) 0.97
Mapping the IkappaB kinase beta (IKKbeta)-binding interface of the B14 protein, a vaccinia virus inhibitor of IKKbeta-mediated activation of nuclear factor kappaB. J Biol Chem (2011) 0.97
Vaccinia protein F12 has structural similarity to kinesin light chain and contains a motor binding motif required for virion export. PLoS Pathog (2010) 0.97
The dimensional assessment of personality in pathologic and social gamblers: the role of novelty seeking and self-transcendence. Compr Psychiatry (2006) 0.96
A dual role for oncostatin M signaling in the differentiation and death of mammary epithelial cells in vivo. Mol Endocrinol (2008) 0.96