Published in Intensive Care Med on March 05, 2009
An updated meta-analysis to understand the variable efficacy of drotrecogin alfa (activated) in severe sepsis and septic shock. Minerva Anestesiol (2012) 1.44
Activated protein C action in inflammation. Br J Haematol (2009) 0.98
Control groups in recent septic shock trials: a systematic review. Intensive Care Med (2016) 0.92
Year in review in Intensive Care Medicine 2009: I. Pneumonia and infections, sepsis, outcome, acute renal failure and acid base, nutrition and glycaemic control. Intensive Care Med (2010) 0.89
The efficacy of activated protein C for the treatment of sepsis: incorporating observational evidence with a Bayesian approach. BMJ Open (2015) 0.80
Growing insights into the potential benefits and risks of activated protein C administration in sepsis: a review of preclinical and clinical studies. Biologics (2009) 0.79
Why activated protein C was not successful in severe sepsis and septic shock: are we still tilting at windmills? Curr Infect Dis Rep (2013) 0.76
Case report: perioperative use of protein c concentrate for protein C deficiency in THA. Clin Orthop Relat Res (2009) 0.75
Vasopressor requirement during targeted temperature management for out-of-hospital cardiac arrest caused by acute myocardial infarction without cardiogenic shock. Clin Exp Emerg Med (2016) 0.75
An update on activated protein C (xigris) in the management of sepsis. P T (2010) 0.75
Managing septic shock. F1000 Med Rep (2010) 0.75
Prone positioning in severe acute respiratory distress syndrome. N Engl J Med (2013) 12.37
Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med (2012) 11.48
A communication strategy and brochure for relatives of patients dying in the ICU. N Engl J Med (2007) 10.13
Drotrecogin alfa (activated) in adults with septic shock. N Engl J Med (2012) 9.19
Albumin replacement in patients with severe sepsis or septic shock. N Engl J Med (2014) 7.07
Early use of polymyxin B hemoperfusion in abdominal septic shock: the EUPHAS randomized controlled trial. JAMA (2009) 6.55
Risk of post-traumatic stress symptoms in family members of intensive care unit patients. Am J Respir Crit Care Med (2005) 6.52
Screening by chest radiograph and lung cancer mortality: the Prostate, Lung, Colorectal, and Ovarian (PLCO) randomized trial. JAMA (2011) 6.45
Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: further evidence for survival and safety and implications for early treatment. Crit Care Med (2005) 3.85
12-h pretreatment with methylprednisolone versus placebo for prevention of postextubation laryngeal oedema: a randomised double-blind trial. Lancet (2007) 3.80
A multicenter study of septic shock due to candidemia: outcomes and predictors of mortality. Intensive Care Med (2014) 3.56
Consensus on circulatory shock and hemodynamic monitoring. Task force of the European Society of Intensive Care Medicine. Intensive Care Med (2014) 3.37
Prophylactic heparin in patients with severe sepsis treated with drotrecogin alfa (activated). Am J Respir Crit Care Med (2007) 3.34
Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients: a randomized controlled trial. JAMA (2010) 3.20
The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material. Intensive Care Med (2012) 3.18
Challenges in end-of-life care in the ICU. Statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003. Intensive Care Med (2004) 3.16
Usefulness of transcranial echography in patients with decompressive craniectomy: a comparison with computed tomography scan. Crit Care Med (2012) 3.10
Challenges in end-of-life care in the ICU: statement of the 5th International Consensus Conference in Critical Care: Brussels, Belgium, April 2003: executive summary. Crit Care Med (2004) 2.95
In-hospital cardiac arrest: incidence, prognosis and possible measures to improve survival. Intensive Care Med (2006) 2.72
Short- and long-term outcome in elderly patients after out-of-hospital cardiac arrest: a cohort study. Crit Care Med (2014) 2.70
Acute kidney injury in patients with acute lung injury: impact of fluid accumulation on classification of acute kidney injury and associated outcomes. Crit Care Med (2011) 2.55
Evaluation of patient skin breakdown and comfort with a new face mask for non-invasive ventilation: a multi-center study. Intensive Care Med (2002) 2.46
Predictors of intensive care unit refusal in French intensive care units: a multiple-center study. Crit Care Med (2005) 2.40
Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. Clin Infect Dis (2009) 2.39
The Italian ECMO network experience during the 2009 influenza A(H1N1) pandemic: preparation for severe respiratory emergency outbreaks. Intensive Care Med (2011) 2.28
Epidemiology and outcome of thrombocytopenic patients in the intensive care unit: results of a prospective multicenter study. Intensive Care Med (2013) 2.16
Benefit of an early and systematic imaging procedure after cardiac arrest: insights from the PROCAT (Parisian Region Out of Hospital Cardiac Arrest) registry. Resuscitation (2012) 2.13
Nasal high-flow versus Venturi mask oxygen therapy after extubation. Effects on oxygenation, comfort, and clinical outcome. Am J Respir Crit Care Med (2014) 2.05
Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med (2003) 2.05
Euthanasia, therapeutic obstinacy or something else? An Italian case. Intensive Care Med (2005) 2.03
Impact of obesity in mechanically ventilated patients: a prospective study. Intensive Care Med (2008) 2.00
Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: a 5-year multicenter observational survey. Crit Care Med (2011) 1.96
Temporal changes in management and outcome of septic shock in patients with malignancies in the intensive care unit. Crit Care Med (2008) 1.89
Selected medical errors in the intensive care unit: results of the IATROREF study: parts I and II. Am J Respir Crit Care Med (2009) 1.85
Refusal of intensive care unit admission due to a full unit: impact on mortality. Am J Respir Crit Care Med (2012) 1.84
A meta-analysis of complications and mortality of extracorporeal membrane oxygenation. Crit Care Resusc (2013) 1.77
Prone position: can we move from better oxygenation to better survival? Crit Care Med (2005) 1.77
Systemic inflammatory response and progression to severe sepsis in critically ill infected patients. Am J Respir Crit Care Med (2004) 1.72
Infectious complications in out-of-hospital cardiac arrest patients in the therapeutic hypothermia era. Crit Care Med (2011) 1.68
Is hypothermia after cardiac arrest effective in both shockable and nonshockable patients?: insights from a large registry. Circulation (2011) 1.63
CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm (2012) 1.63
Noninvasive ventilation after early extubation in patients recovering from hypoxemic acute respiratory failure: a single-centre feasibility study. Intensive Care Med (2012) 1.63
Out-of-hospital cardiac arrest from brain cause: epidemiology, clinical features, and outcome in a multicenter cohort*. Crit Care Med (2015) 1.62
Risk factors for acute kidney injury in critically ill patients receiving high intravenous doses of colistin methanesulfonate and/or other nephrotoxic antibiotics: a retrospective cohort study. Crit Care (2013) 1.60
Biological evaluation of perioperative cardiac stress: a two-way approach. Crit Care Med (2006) 1.60
Diagnostic accuracy of passive leg raising for prediction of fluid responsiveness in adults: systematic review and meta-analysis of clinical studies. Intensive Care Med (2010) 1.58
Impact of case volume on survival of septic shock in patients with malignancies. Crit Care Med (2012) 1.58
Plasma-induced endothelial oxidative stress is related to the severity of septic shock. Crit Care Med (2007) 1.57
Noninvasive positive-pressure ventilation with different interfaces in patients with respiratory failure after abdominal surgery: a matched-control study. Respir Care (2007) 1.57
A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease. Crit Care Med (2010) 1.56
Ventilator-associated pneumonia: current status and future recommendations. J Clin Monit Comput (2010) 1.54
A multicenter multinational study of abdominal candidiasis: epidemiology, outcomes and predictors of mortality. Intensive Care Med (2015) 1.54
Blood glucose level and outcome after cardiac arrest: insights from a large registry in the hypothermia era. Intensive Care Med (2014) 1.51
Non-invasive ventilation delivered by conventional interfaces and helmet in the emergency department. Eur J Emerg Med (2003) 1.51
Online vs live methods for teaching difficult airway management to anesthesiology residents. Intensive Care Med (2005) 1.51
Characteristics and determinants of outcome of hospital-acquired bloodstream infections in intensive care units: the EUROBACT International Cohort Study. Intensive Care Med (2012) 1.47
Levels of vancomycin in the cerebral interstitial fluid after severe head injury. Intensive Care Med (2006) 1.46
Coagulopathy after successful cardiopulmonary resuscitation following cardiac arrest: implication of the protein C anticoagulant pathway. J Am Coll Cardiol (2005) 1.43
In-hospital cardiac arrest: survival depends mainly on the effectiveness of the emergency response. Resuscitation (2004) 1.41
High Level of Endotoxemia Following Out-of-Hospital Cardiac Arrest Is Associated With Severity and Duration of Postcardiac Arrest Shock. Crit Care Med (2015) 1.41
Perioperative management of antiplatelet therapy in patients with coronary stents undergoing cardiac and non-cardiac surgery: a consensus document from Italian cardiological, surgical and anaesthesiological societies. EuroIntervention (2014) 1.41
Antibiotic usage and risk of colonization and infection with antibiotic-resistant bacteria: a hospital population-based study. Antimicrob Agents Chemother (2009) 1.40
Acquiring procedural skills in ICUs: a prospective multicenter study*. Crit Care Med (2014) 1.40
Immunonutrients in critically ill patients: an analysis of the most recent literature. Minerva Anestesiol (2015) 1.39
Noninvasive ventilation options in pediatric myasthenia gravis. Paediatr Anaesth (2005) 1.39
Early diagnosis of candidemia in intensive care unit patients with sepsis: a prospective comparison of (1→3)-β-D-glucan assay, Candida score, and colonization index. Crit Care (2011) 1.38
Morphogenesis of the branching reef coral Madracis mirabilis. Proc Biol Sci (2005) 1.38
High-flow nasal cannula oxygen during endotracheal intubation in hypoxemic patients: a randomized controlled clinical trial. Intensive Care Med (2015) 1.36
Receptor interactions involved in adenoviral-mediated gene delivery after systemic administration in non-human primates. Hum Gene Ther (2003) 1.33
The epidemiology of acute respiratory failure in critically ill patients(*). Chest (2002) 1.29
Intensive care unit mortality after cardiac arrest: the relative contribution of shock and brain injury in a large cohort. Intensive Care Med (2013) 1.27
Transforming growth factor-beta: a mediator of cell regulation in acute respiratory distress syndrome. Crit Care Med (2003) 1.26
High dose tigecycline in critically ill patients with severe infections due to multidrug-resistant bacteria. Crit Care (2014) 1.25
Clinical outcomes of Pseudomonas aeruginosa pneumonia in intensive care unit patients. Intensive Care Med (2013) 1.24
Efficacy and safety of non-invasive ventilation in the treatment of acute cardiogenic pulmonary edema--a systematic review and meta-analysis. Crit Care (2006) 1.23
Hydroxyethyl starch for intravenous volume replacement: more harm than benefit. JAMA (2013) 1.22
Detrimental role of delayed antibiotic administration and penicillin-nonsusceptible strains in adult intensive care unit patients with pneumococcal meningitis: the PNEUMOREA prospective multicenter study. Crit Care Med (2006) 1.20
Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation (2011) 1.18
Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation. BJU Int (2006) 1.16
Noninvasive vs invasive ventilation in COPD patients with severe acute respiratory failure deemed to require ventilatory assistance. Intensive Care Med (2004) 1.15
Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016. Crit Care Med (2017) 1.15
Diagnosis of invasive aspergillosis by a commercial real-time PCR assay for Aspergillus DNA in bronchoalveolar lavage fluid samples from high-risk patients compared to a galactomannan enzyme immunoassay. J Clin Microbiol (2011) 1.15
Discovery of a novel enzymatic cleavage site for botulinum neurotoxin F5. FEBS Lett (2011) 1.13
Noninvasive versus conventional ventilation to treat hypercapnic encephalopathy in chronic obstructive pulmonary disease. Intensive Care Med (2007) 1.12
Determinants of recovery from severe posterior reversible encephalopathy syndrome. PLoS One (2012) 1.11
A prospective, blinded evaluation of indexes proposed to predict weaning from mechanical ventilation. Intensive Care Med (2004) 1.10
Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3. Vaccine (2009) 1.09
Epidemiology and outcome of severe pneumococcal pneumonia admitted to intensive care unit: a multicenter study. Crit Care (2012) 1.09
A low-dose remifentanil infusion is well tolerated for sedation in mechanically ventilated, critically-ill patients. Can J Anaesth (2002) 1.09
Timing and causes of death in septic shock. Ann Intensive Care (2015) 1.09
Coronary angiography after cardiac arrest: useful for whom? Intensive Care Med (2015) 1.08
Levosimendan in Cardiac Surgery. N Engl J Med (2017) 1.06
Buffered crystalloids and acid-base state: still searching the optimal balance? Minerva Anestesiol (2015) 1.06
Effects of PEEP on the intracranial system of patients with head injury and subarachnoid hemorrhage: the role of respiratory system compliance. J Trauma (2005) 1.06
Accuracy of plethysmographic indices as predictors of fluid responsiveness in mechanically ventilated adults: a systematic review and meta-analysis. Intensive Care Med (2012) 1.03