Published in J Biol Chem on March 16, 2009
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Presenilins in synaptic function and disease. Trends Mol Med (2011) 1.02
Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons. Proc Natl Acad Sci U S A (2013) 0.94
Impaired neurotransmitter release in Alzheimer's and Parkinson's diseases. Neurodegener Dis (2010) 0.90
Regulation of mitochondrial permeability transition pore by PINK1. Mol Neurodegener (2012) 0.90
Gene network inference and biochemical assessment delineates GPCR pathways and CREB targets in small intestinal neuroendocrine neoplasia. PLoS One (2011) 0.86
Polycystin-1 regulates amphiregulin expression through CREB and AP1 signalling: implications in ADPKD cell proliferation. J Mol Med (Berl) (2012) 0.85
Presenilin-1 Dependent Neurogenesis Regulates Hippocampal Learning and Memory. PLoS One (2015) 0.81
Presenilin controls CBP levels in the adult Drosophila central nervous system. PLoS One (2010) 0.79
Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function. Int J Alzheimers Dis (2010) 0.78
Diminished CRE-Induced Plasticity is Linked to Memory Deficits in Familial Alzheimer's Disease Mice. J Alzheimers Dis (2015) 0.77
Presenilin 1 is necessary for neuronal, but not glial, EGFR expression and neuroprotection via γ-secretase-independent transcriptional mechanisms. FASEB J (2015) 0.76
Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem (2013) 0.75
The molecular biology of memory storage: a dialogue between genes and synapses. Science (2001) 11.85
Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell (1989) 11.41
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol (2001) 10.69
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway. Science (2001) 4.81
Skeletal and CNS defects in Presenilin-1-deficient mice. Cell (1997) 4.50
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci U S A (1996) 4.13
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Nat Neurosci (1998) 3.33
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A (2006) 3.30
CREB required for the stability of new and reactivated fear memories. Nat Neurosci (2002) 3.28
What turns CREB on? Cell Signal (2004) 3.03
Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling. Proc Natl Acad Sci U S A (2002) 2.57
Total inactivation of gamma-secretase activity in presenilin-deficient embryonic stem cells. Nat Cell Biol (2000) 2.53
Induction of CRE-mediated gene expression by stimuli that generate long-lasting LTP in area CA1 of the hippocampus. Neuron (1996) 2.47
Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations. Proc Natl Acad Sci U S A (1999) 2.20
The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res (1996) 2.09
Activity-dependent regulation of synaptic clustering in a hippocampal culture system. Proc Natl Acad Sci U S A (1999) 1.97
Presenilin-1 regulates neuronal differentiation during neurogenesis. Development (2000) 1.90
Ca2+ -stimulated adenylyl cyclases regulate ERK-dependent activation of MSK1 during fear conditioning. Neuron (2007) 1.90
A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. J Biol Chem (1999) 1.87
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling. J Biol Chem (2005) 1.61
Genetic analysis of Mint/X11 proteins: essential presynaptic functions of a neuronal adaptor protein family. J Neurosci (2006) 1.61
A nine-transmembrane domain topology for presenilin 1. J Biol Chem (2005) 1.52
The presenilins and Alzheimer's disease. Hum Mol Genet (1997) 1.43
Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised. J Biol Chem (2001) 1.43
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem (2004) 1.33
Impaired phosphorylation of cyclic AMP response element binding protein in the hippocampus of dementia of the Alzheimer type. Brain Res (1999) 1.24
Peroxisome proliferator-activated receptor beta (delta)-dependent regulation of ubiquitin C expression contributes to attenuation of skin carcinogenesis. J Biol Chem (2004) 1.23
Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist (2005) 1.21
Wild-type but not FAD mutant presenilin-1 prevents neuronal degeneration by promoting phosphatidylinositol 3-kinase neuroprotective signaling. J Neurosci (2008) 1.16
Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener (2008) 1.14
Down-regulation of cAMP-dependent protein kinase by over-activated calpain in Alzheimer disease brain. J Neurochem (2007) 1.10
Unequal crossover generates variation in ubiquitin coding unit number at the human UbC polyubiquitin locus. Am J Hum Genet (1989) 0.99
Overexpression of three ubiquitin genes in mouse epidermal tumors is associated with enhanced cellular proliferation and stress. Cell Growth Differ (1992) 0.98
Activated cAMP-response element-binding protein regulates neuronal expression of presenilin-1. J Biol Chem (2000) 0.96
Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2. J Neurosci Res (2004) 0.93
Topology of the C-terminal fragment of human presenilin 1. Biochemistry (2005) 0.91
Regulation of CRE-dependent transcription by presenilins: prospects for therapy of Alzheimer's disease. Trends Pharmacol Sci (2005) 0.89
Presenilin acts as a positive regulator of basal level activity of ERK through the Raf-MEK1 signaling pathway. Biochem Biophys Res Commun (2005) 0.88
Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism. Neurosci Lett (2008) 0.80
Steady-state increase of cAMP-response element binding protein, Rac, and PAK signaling in presenilin-deficient neurons. J Neurochem (2007) 0.79
PINK1 is selectively stabilized on impaired mitochondria to activate Parkin. PLoS Biol (2010) 11.85
alpha-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol (2002) 6.64
Mitochondrial dysfunction and oxidative damage in parkin-deficient mice. J Biol Chem (2004) 4.86
Experimental observation of the quantum anomalous Hall effect in a magnetic topological insulator. Science (2013) 4.69
Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress. Proc Natl Acad Sci U S A (2008) 4.50
Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. J Biol Chem (2003) 4.36
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron (2004) 4.21
Representativeness of the Patient-Reported Outcomes Measurement Information System Internet panel. J Clin Epidemiol (2010) 4.18
Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP. Neuron (2005) 3.83
Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice. Proc Natl Acad Sci U S A (2007) 3.50
The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A (2006) 3.30
Nigrostriatal dopaminergic deficits and hypokinesia caused by inactivation of the familial Parkinsonism-linked gene DJ-1. Neuron (2005) 3.30
Regulation of cholesterol and sphingomyelin metabolism by amyloid-beta and presenilin. Nat Cell Biol (2005) 2.91
Effects of metformin versus glipizide on cardiovascular outcomes in patients with type 2 diabetes and coronary artery disease. Diabetes Care (2012) 2.84
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J (2010) 2.82
gamma-secretase functions through Notch signaling to maintain skin appendages but is not required for their patterning or initial morphogenesis. Dev Cell (2004) 2.68
A pilot study of circulating miRNAs as potential biomarkers of early stage breast cancer. PLoS One (2010) 2.64
Notch activation induces apoptosis in neural progenitor cells through a p53-dependent pathway. Dev Biol (2004) 2.59
Changing the skill-mix of the health care workforce. J Health Serv Res Policy (2004) 2.45
Presenilins are essential for regulating neurotransmitter release. Nature (2009) 2.39
Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A (2010) 2.34
Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex. Neuron (2008) 2.31
R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice. Proc Natl Acad Sci U S A (2009) 2.28
Association between the various mutations in viral core promoter region to different stages of hepatitis B, ranging of asymptomatic carrier state to hepatocellular carcinoma. Am J Gastroenterol (2010) 2.20
LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res (2008) 2.09
Nasal intermittent positive pressure ventilation with heliox in premature infants with respiratory distress syndrome: a randomized controlled trial. Indian Pediatr (2014) 2.07
Postnatal deletion of Numb/Numblike reveals repair and remodeling capacity in the subventricular neurogenic niche. Cell (2006) 2.06
A clustered plasticity model of long-term memory engrams. Nat Rev Neurosci (2006) 2.06
admetSAR: a comprehensive source and free tool for assessment of chemical ADMET properties. J Chem Inf Model (2012) 2.04
Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol (2007) 1.94
Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity. Nat Neurosci (2009) 1.93
Amyloid-independent mechanisms in Alzheimer's disease pathogenesis. J Neurosci (2010) 1.93
Activation of telomerase by human cytomegalovirus. J Natl Cancer Inst (2009) 1.92
Role of acetylation and extracellular location of heat shock protein 90alpha in tumor cell invasion. Cancer Res (2008) 1.88
Update from the 2011 International Schwannomatosis Workshop: From genetics to diagnostic criteria. Am J Med Genet A (2013) 1.72
GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J Biol Chem (2005) 1.72
Spectrum of heart disease associated with murine and human GATA4 mutation. J Mol Cell Cardiol (2007) 1.71
PTEN-inducible kinase 1 (PINK1)/Park6 is indispensable for normal heart function. Proc Natl Acad Sci U S A (2011) 1.70
Conditional activation of β-catenin signaling in mice leads to severe defects in intervertebral disc tissue. Arthritis Rheum (2012) 1.67
A multicenter, double-blind, randomized, controlled phase III clinical trial of chicken type II collagen in rheumatoid arthritis. Arthritis Res Ther (2009) 1.65
(α-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano (2012) 1.61
Conditional inactivation of presenilin 1 prevents amyloid accumulation and temporarily rescues contextual and spatial working memory impairments in amyloid precursor protein transgenic mice. J Neurosci (2005) 1.53
ROS-dependent regulation of Parkin and DJ-1 localization during oxidative stress in neurons. Hum Mol Genet (2012) 1.42
Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease. Nat Cell Biol (2009) 1.41
NOTCH signaling in skeletal progenitors is critical for fracture repair. J Clin Invest (2016) 1.41
Racial/Ethnic disparities in ART adherence in the United States: findings from the MACH14 study. J Acquir Immune Defic Syndr (2012) 1.41
A Cdc20-APC ubiquitin signaling pathway regulates presynaptic differentiation. Science (2009) 1.40
Escherichia coli O86 O-antigen biosynthetic gene cluster and stepwise enzymatic synthesis of human blood group B antigen tetrasaccharide. J Am Chem Soc (2005) 1.38
A regulatory network involving Foxn4, Mash1 and delta-like 4/Notch1 generates V2a and V2b spinal interneurons from a common progenitor pool. Development (2007) 1.37
Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet (2011) 1.37
Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. Am J Hum Genet (2013) 1.37
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures. J Neural Transm (Vienna) (2011) 1.35
Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway. Mol Neurodegener (2012) 1.34
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci (2011) 1.34
Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. J Biol Chem (2004) 1.33
Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis. PLoS One (2011) 1.33
A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem (2010) 1.28
IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines. J Neurooncol (2010) 1.27
Clinical features of schwannomatosis: a retrospective analysis of 87 patients. Oncologist (2012) 1.27
Value of serum glycated albumin and high-sensitivity C-reactive protein levels in the prediction of presence of coronary artery disease in patients with type 2 diabetes. Cardiovasc Diabetol (2006) 1.25
Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol (2008) 1.24
Absence of dopaminergic neuronal degeneration and oxidative damage in aged DJ-1-deficient mice. Mol Neurodegener (2007) 1.24
Conditional forebrain inactivation of nicastrin causes progressive memory impairment and age-related neurodegeneration. J Neurosci (2009) 1.23
The roles of kinases in familial Parkinson's disease. J Neurosci (2007) 1.22
Presenilins in the developing, adult, and aging cerebral cortex. Neuroscientist (2005) 1.21
Loss of SUFU function in familial multiple meningioma. Am J Hum Genet (2012) 1.21
Gene expression changes in response to aging compared to heat stress, oxidative stress and ionizing radiation in Drosophila melanogaster. Aging (Albany NY) (2012) 1.21
A multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of paclitaxel-carboplatin alone or with endostar for advanced non-small cell lung cancer. J Thorac Oncol (2011) 1.19
Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy. Aging (Albany NY) (2009) 1.19
Notch1 signaling influences v2 interneuron and motor neuron development in the spinal cord. Dev Neurosci (2006) 1.17
CREB binding protein is required for both short-term and long-term memory formation. J Neurosci (2010) 1.14
Presenilins are required for maintenance of neural stem cells in the developing brain. Mol Neurodegener (2008) 1.14
Role of presenilin-1 in cortical lamination and survival of Cajal-Retzius neurons. Dev Biol (2005) 1.13
Notch1 and 2 cooperate in limb ectoderm to receive an early Jagged2 signal regulating interdigital apoptosis. Dev Biol (2005) 1.13
Impaired dopamine release and synaptic plasticity in the striatum of parkin-/- mice. J Neurochem (2009) 1.12
DNA methylation-mediated repression of miR-886-3p predicts poor outcome of human small cell lung cancer. Cancer Res (2013) 1.11
Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One (2010) 1.10
A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase. Chem Commun (Camb) (2009) 1.09
Alterations of the p16(INK4) locus in human malignant mesothelial tumors. Carcinogenesis (2002) 1.09
Effect of eIF3a on response of lung cancer patients to platinum-based chemotherapy by regulating DNA repair. Clin Cancer Res (2011) 1.08
Trans-dominant negative effects of pathogenic PSEN1 mutations on γ-secretase activity and Aβ production. J Neurosci (2013) 1.08
Adverse drug events: database construction and in silico prediction. J Chem Inf Model (2013) 1.08
Conditional deletion of Notch1 and Notch2 genes in excitatory neurons of postnatal forebrain does not cause neurodegeneration or reduction of Notch mRNAs and proteins. J Biol Chem (2012) 1.07
Antisilencing role of the RNA-directed DNA methylation pathway and a histone acetyltransferase in Arabidopsis. Proc Natl Acad Sci U S A (2012) 1.07
IL-6 augments the invasiveness of U87MG human glioblastoma multiforme cells via up-regulation of MMP-2 and fascin-1. Oncol Rep (2010) 1.06
Exploring coumarin egress channels in human cytochrome P450 2A6 by random acceleration and steered molecular dynamics simulations. Proteins (2011) 1.06
The value of autofluorescence bronchoscopy combined with white light bronchoscopy compared with white light alone in the diagnosis of intraepithelial neoplasia and invasive lung cancer: a meta-analysis. J Thorac Oncol (2011) 1.04
Classification of cytochrome P450 inhibitors and noninhibitors using combined classifiers. J Chem Inf Model (2011) 1.04
Heterogeneity among studies in rates of decline of antiretroviral therapy adherence over time: results from the multisite adherence collaboration on HIV 14 study. J Acquir Immune Defic Syndr (2013) 1.03