Published in PLoS One on March 24, 2009
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet (1998) 40.97
Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet (2001) 22.46
The genetical structure of populations. Ann Eugen (1951) 15.13
A model of mutation appropriate to estimate the number of electrophoretically detectable alleles in a finite population. Genet Res (1973) 13.08
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. Nat Genet (2009) 9.45
Estimation of pairwise relatedness with molecular markers. Genetics (1999) 7.60
The estimation of pairwise relationships. Ann Hum Genet (1975) 6.87
Recent human effective population size estimated from linkage disequilibrium. Genome Res (2007) 6.79
Genetic information given by a relative. Biometrics (1972) 4.84
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene. Am J Hum Genet (2006) 4.22
Measurement of inbreeding from the frequency of marriages between persons of the same surname. Eugen Q (1965) 3.88
Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet (2004) 3.83
An estimator for pairwise relatedness using molecular markers. Genetics (2002) 3.69
Measures of human population structure show heterogeneity among genomic regions. Genome Res (2005) 3.68
A polygenic basis for late-onset disease. Trends Genet (2003) 2.05
Localization and identification of human quantitative trait loci: king harvest has surely come. Curr Opin Genet Dev (2004) 1.68
Random and nonrandom inbreeding. Eugen Q (1965) 0.99
An extension of the probability approach to genetic relationships: one locus. Theor Popul Biol (1974) 0.89
Big data: The future of biocuration. Nature (2008) 10.81
The SRA protein Np95 mediates epigenetic inheritance by recruiting Dnmt1 to methylated DNA. Nature (2007) 8.17
Mapping human genetic diversity in Asia. Science (2009) 7.40
Integrative annotation of 21,037 human genes validated by full-length cDNA clones. PLoS Biol (2004) 7.17
CIBEX: center for information biology gene expression database. C R Biol (2004) 6.16
The transcriptional network that controls growth arrest and differentiation in a human myeloid leukemia cell line. Nat Genet (2009) 6.02
DDBJ in preparation for overview of research activities behind data submissions. Nucleic Acids Res (2006) 6.02
DDBJ launches a new archive database with analytical tools for next-generation sequence data. Nucleic Acids Res (2009) 5.89
Biased biological functions of horizontally transferred genes in prokaryotic genomes. Nat Genet (2004) 5.49
The genome sequence and structure of rice chromosome 1. Nature (2002) 4.99
The Rice Annotation Project Database (RAP-DB): 2008 update. Nucleic Acids Res (2007) 4.23
Metabolic efficiency and amino acid composition in the proteomes of Escherichia coli and Bacillus subtilis. Proc Natl Acad Sci U S A (2002) 4.22
The dynamic genome of Hydra. Nature (2010) 4.00
Phylogenetic analysis of the complete genome of 18 Norwalk-like viruses. Virology (2002) 3.79
DDBJ progress report. Nucleic Acids Res (2010) 3.34
DDBJ dealing with mass data produced by the second generation sequencer. Nucleic Acids Res (2008) 3.24
Curated genome annotation of Oryza sativa ssp. japonica and comparative genome analysis with Arabidopsis thaliana. Genome Res (2007) 3.13
The DNA Data Bank of Japan launches a new resource, the DDBJ Omics Archive of functional genomics experiments. Nucleic Acids Res (2011) 3.05
The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res (2008) 3.04
Endogenous non-retroviral RNA virus elements in mammalian genomes. Nature (2010) 2.91
The Rice Annotation Project Database (RAP-DB): hub for Oryza sativa ssp. japonica genome information. Nucleic Acids Res (2006) 2.90
Arabidopsis transcriptome analysis under drought, cold, high-salinity and ABA treatment conditions using a tiling array. Plant Cell Physiol (2008) 2.84
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Behçet's disease susceptibility loci. Nat Genet (2010) 2.74
The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet (2009) 2.73
Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. Development (2008) 2.53
Exploration and grading of possible genes from 183 bacterial strains by a common protocol to identification of new genes: Gene Trek in Prokaryote Space (GTPS). DNA Res (2006) 2.51
DDBJ working on evaluation and classification of bacterial genes in INSDC. Nucleic Acids Res (2006) 2.50
High-risk HLA allele mismatch combinations responsible for severe acute graft-versus-host disease and implication for its molecular mechanism. Blood (2007) 2.46
Evidence of en bloc duplication in vertebrate genomes. Nat Genet (2002) 2.30
High-throughput DNA typing of HLA-A, -B, -C, and -DRB1 loci by a PCR-SSOP-Luminex method in the Japanese population. Immunogenetics (2005) 2.19
Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates. Genome Biol (2003) 2.19
Polycomb limits the neurogenic competence of neural precursor cells to promote astrogenic fate transition. Neuron (2009) 2.16
The origin and evolution of porcine reproductive and respiratory syndrome viruses. Mol Biol Evol (2005) 2.09
Comparative complete genome sequence analysis of the amino acid replacements responsible for the thermostability of Corynebacterium efficiens. Genome Res (2003) 2.07
The H-Invitational Database (H-InvDB), a comprehensive annotation resource for human genes and transcripts. Nucleic Acids Res (2007) 2.07
A large variation in the rates of synonymous substitution for RNA viruses and its relationship to a diversity of viral infection and transmission modes. Mol Biol Evol (2004) 2.07
A comparison of the molecular clock of hepatitis C virus in the United States and Japan predicts that hepatocellular carcinoma incidence in the United States will increase over the next two decades. Proc Natl Acad Sci U S A (2002) 2.02
SAM domain polymerization links subnuclear clustering of PRC1 to gene silencing. Dev Cell (2013) 1.97
Towards BioDBcore: a community-defined information specification for biological databases. Nucleic Acids Res (2010) 1.97
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. Nat Genet (2013) 1.93
Rate of evolution in brain-expressed genes in humans and other primates. PLoS Biol (2007) 1.87
Role of SOX17 in hematopoietic development from human embryonic stem cells. Blood (2012) 1.86
Multiple candidate gene analysis identifies alpha-synuclein as a susceptibility gene for sporadic Parkinson's disease. Hum Mol Genet (2006) 1.83
Meta-analysis confirms the LCE3C_LCE3B deletion as a risk factor for psoriasis in several ethnic groups and finds interaction with HLA-Cw6. J Invest Dermatol (2010) 1.82
FGFR-related gene nou-darake restricts brain tissues to the head region of planarians. Nature (2002) 1.80
Transcriptional interferences in cis natural antisense transcripts of humans and mice. Genetics (2007) 1.79
Systems medicine and integrated care to combat chronic noncommunicable diseases. Genome Med (2011) 1.78
Mutations of ARX are associated with striking pleiotropy and consistent genotype-phenotype correlation. Hum Mutat (2004) 1.76
Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Dev Biol (2009) 1.62
Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signals. J Mol Med (Berl) (2005) 1.62
The evolutionary position of nematodes. BMC Evol Biol (2002) 1.60
Genetics of Behçet disease inside and outside the MHC. Ann Rheum Dis (2009) 1.55
Diversity of preferred nucleotide sequences around the translation initiation codon in eukaryote genomes. Nucleic Acids Res (2007) 1.52
Complete heart block associated with device closure of perimembranous ventricular septal defects. J Thorac Cardiovasc Surg (2008) 1.47
Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man. Immunol Rev (2002) 1.47
Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma. Brain Dev (2010) 1.45
HLA mismatch combinations associated with decreased risk of relapse: implications for the molecular mechanism. Blood (2008) 1.44
Comparative sequencing of human and chimpanzee MHC class I regions unveils insertions/deletions as the major path to genomic divergence. Proc Natl Acad Sci U S A (2003) 1.43
Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucoma. Invest Ophthalmol Vis Sci (2008) 1.43
Histone H2A mono-ubiquitination is a crucial step to mediate PRC1-dependent repression of developmental genes to maintain ES cell identity. PLoS Genet (2012) 1.40
Hepatoblastoma in a patient with sotos syndrome. J Pediatr (2009) 1.40
Rhesus macaque class I duplicon structures, organization, and evolution within the alpha block of the major histocompatibility complex. Mol Biol Evol (2004) 1.40
Experimental evidence of core modification in the near drip-line nucleus 23O. Phys Rev Lett (2002) 1.40
The GTOP database in 2009: updated content and novel features to expand and deepen insights into protein structures and functions. Nucleic Acids Res (2008) 1.39
Mental retardation, spasticity, basal ganglia calcification, cerebral white matter lesions, multiple endocrine defects, telangiectasia and atrophic skin: a new syndrome? Brain Dev (2007) 1.39
The Human Anatomic Gene Expression Library (H-ANGEL), the H-Inv integrative display of human gene expression across disparate technologies and platforms. Nucleic Acids Res (2005) 1.39
Origin and evolutionary process of the CNS elucidated by comparative genomics analysis of planarian ESTs. Proc Natl Acad Sci U S A (2003) 1.38
A web-based interactive developmental table for the ascidian Ciona intestinalis, including 3D real-image embryo reconstructions: I. From fertilized egg to hatching larva. Dev Dyn (2007) 1.38
Elevation of serum KL-6 levels during treatment with tumor necrosis factor-α inhibitor in patients with psoriasis. J Dermatol (2014) 1.38
Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity. Genetics (2006) 1.37
Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. Hum Mol Genet (2005) 1.36
Pioglitazone prevents alcohol-induced fatty liver in rats through up-regulation of c-Met. Gastroenterology (2004) 1.35
Large-scale identification and characterization of alternative splicing variants of human gene transcripts using 56,419 completely sequenced and manually annotated full-length cDNAs. Nucleic Acids Res (2006) 1.34
Evola: Ortholog database of all human genes in H-InvDB with manual curation of phylogenetic trees. Nucleic Acids Res (2007) 1.32
Evolution of complex structures: minicollagens shape the cnidarian nematocyst. Trends Genet (2008) 1.29
Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility. Ophthalmology (2010) 1.28
Genome-wide analysis of endogenous abscisic acid-mediated transcription in dry and imbibed seeds of Arabidopsis using tiling arrays. Plant J (2010) 1.28
Investigation of protein functions through data-mining on integrated human transcriptome database, H-Invitational database (H-InvDB). Gene (2005) 1.27
Extended gene map reveals tripartite motif, C-type lectin, and Ig superfamily type genes within a subregion of the chicken MHC-B affecting infectious disease. J Immunol (2007) 1.27
Epidemiology of acute encephalopathy in Japan, with emphasis on the association of viruses and syndromes. Brain Dev (2011) 1.26
Comparative genomics of bidirectional gene pairs and its implications for the evolution of a transcriptional regulation system. Gene (2005) 1.26
Alternative splicing in human transcriptome: functional and structural influence on proteins. Gene (2006) 1.26
Effects of HLA allele and killer immunoglobulin-like receptor ligand matching on clinical outcome in leukemia patients undergoing transplantation with T-cell-replete marrow from an unrelated donor. Biol Blood Marrow Transplant (2007) 1.26
Towards BioDBcore: a community-defined information specification for biological databases. Database (Oxford) (2011) 1.24
Comparative genomic analysis of two avian (quail and chicken) MHC regions. J Immunol (2004) 1.24
SLURP-2, a novel member of the human Ly-6 superfamily that is up-regulated in psoriasis vulgaris. Genomics (2003) 1.24