Published in J Biol Chem on March 24, 2009
Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility. Curr Opin Cell Biol (2009) 1.99
Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA. J Biol Chem (2012) 0.87
ARAP2 signals through Arf6 and Rac1 to control focal adhesion morphology. J Biol Chem (2013) 0.85
AGAP2 regulates retrograde transport between early endosomes and the TGN. J Cell Sci (2010) 0.84
GTP-binding protein-like domain of AGAP1 is protein binding site that allosterically regulates ArfGAP protein catalytic activity. J Biol Chem (2012) 0.83
The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation. Biochem J (2013) 0.82
The roles of PIKE in tumorigenesis. Acta Pharmacol Sin (2013) 0.80
Phosphoinositide 3-kinase enhancer (PIKE) in the brain: is it simply a phosphoinositide 3-kinase/Akt enhancer? Rev Neurosci (2012) 0.78
Allosteric properties of PH domains in Arf regulatory proteins. Cell Logist (2016) 0.76
Direct Functional Interaction of the Kinesin-13 family membrane Kinesin Like Protein 2A (Kif2A) and Arf GAP with GTP-Binding Protein-Like, Ankyrin Repeats and PH domains1 (AGAP1). J Biol Chem (2016) 0.75
Arf proteins in cancer cell migration. Small GTPases (2016) 0.75
Regulators and Effectors of Arf GTPases in Neutrophils. J Immunol Res (2015) 0.75
Cell migration: integrating signals from front to back. Science (2003) 29.13
Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol (2005) 11.74
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice. Nature (1995) 11.06
Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr Opin Cell Biol (2006) 8.52
ARF proteins: roles in membrane traffic and beyond. Nat Rev Mol Cell Biol (2006) 7.75
The role of focal-adhesion kinase in cancer - a new therapeutic opportunity. Nat Rev Cancer (2005) 5.57
Focal adhesion regulation of cell behavior. Biochim Biophys Acta (2004) 3.83
Control of motile and invasive cell phenotypes by focal adhesion kinase. Biochim Biophys Acta (2004) 2.98
Focal adhesions: a nexus for intracellular signaling and cytoskeletal dynamics. Exp Cell Res (2000) 2.91
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol (2004) 2.46
Asymmetric focal adhesion disassembly in motile cells. Curr Opin Cell Biol (2008) 2.28
Arf GAPs: multifunctional proteins that regulate membrane traffic and actin remodelling. Cell Signal (2004) 1.85
The Arf GTPase-activating protein ASAP1 regulates the actin cytoskeleton. Proc Natl Acad Sci U S A (2000) 1.71
Arf GAPs and membrane traffic. J Cell Sci (2006) 1.67
Focal adhesions: what's new inside. Dev Biol (2006) 1.65
Localization and function of Arf family GTPases. Biochem Soc Trans (2005) 1.58
ARAP1: a point of convergence for Arf and Rho signaling. Mol Cell (2002) 1.53
PIKE (phosphatidylinositol 3-kinase enhancer)-A GTPase stimulates Akt activity and mediates cellular invasion. J Biol Chem (2004) 1.47
Arf GAPs as regulators of the actin cytoskeleton. Biol Cell (2007) 1.44
PIKE-A is amplified in human cancers and prevents apoptosis by up-regulating Akt. Proc Natl Acad Sci U S A (2004) 1.43
Mechanisms of focal adhesion kinase regulation. Curr Cancer Drug Targets (2005) 1.40
Phosphoinositide-dependent activation of the ADP-ribosylation factor GTPase-activating protein ASAP1. Evidence for the pleckstrin homology domain functioning as an allosteric site. J Biol Chem (2000) 1.38
DDEF1 is located in an amplified region of chromosome 8q and is overexpressed in uveal melanoma. Clin Cancer Res (2005) 1.30
ASAP1, a gene at 8q24, is associated with prostate cancer metastasis. Cancer Res (2008) 1.29
The association of ASAP1, an ADP ribosylation factor-GTPase activating protein, with focal adhesion kinase contributes to the process of focal adhesion assembly. Mol Biol Cell (2002) 1.28
PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion. Oncogene (2007) 1.23
ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP. J Cell Sci (2006) 1.21
Mislocalization or reduced expression of Arf GTPase-activating protein ASAP1 inhibits cell spreading and migration by influencing Arf1 GTPase cycling. J Biol Chem (2005) 1.18
The Arf GAPs AGAP1 and AGAP2 distinguish between the adaptor protein complexes AP-1 and AP-3. J Cell Sci (2005) 1.14
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12
Regulation of ASAP1 by phospholipids is dependent on the interface between the PH and Arf GAP domains. Cell Signal (2005) 1.00
Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. Genomics (1997) 0.99
Isolation of development and differentiation enhancing factor-like 1 (DDEFL1) as a drug target for hepatocellular carcinomas. Int J Oncol (2004) 0.89
Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med (2013) 8.76
Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2. Cell (2007) 2.65
Mechanical control of morphogenesis by Fat/Dachsous/Four-jointed planar cell polarity pathway. Science (2012) 2.39
Nitric oxide regulates endocytosis by S-nitrosylation of dynamin. Proc Natl Acad Sci U S A (2006) 1.99
Prevalence of idiopathic hypertrophic cardiomyopathy in China: a population-based echocardiographic analysis of 8080 adults. Am J Med (2004) 1.79
Protective effect of milk fat globule-epidermal growth factor-factor VIII after renal ischemia-reperfusion injury in mice. Crit Care Med (2011) 1.58
MiR-21 protected human glioblastoma U87MG cells from chemotherapeutic drug temozolomide induced apoptosis by decreasing Bax/Bcl-2 ratio and caspase-3 activity. Brain Res (2010) 1.56
The G12 family of heterotrimeric G proteins promotes breast cancer invasion and metastasis. Proc Natl Acad Sci U S A (2006) 1.54
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
A role for BARS at the fission step of COPI vesicle formation from Golgi membrane. EMBO J (2005) 1.48
A role for the G12 family of heterotrimeric G proteins in prostate cancer invasion. J Biol Chem (2006) 1.47
Milk fat globule epidermal growth factor 8 attenuates acute lung injury in mice after intestinal ischemia and reperfusion. Am J Respir Crit Care Med (2009) 1.45
Consensus nomenclature for the human ArfGAP domain-containing proteins. J Cell Biol (2008) 1.42
Distinct fermi surface topology and nodeless superconducting gap in a (Tl0.58Rb0.42)Fe1.72Se2 superconductor. Phys Rev Lett (2011) 1.40
Prostaglandin E2 promotes lung cancer cell migration via EP4-betaArrestin1-c-Src signalsome. Mol Cancer Res (2010) 1.32
Androgen receptor activation by G(s) signaling in prostate cancer cells. J Biol Chem (2005) 1.26
Src-dependent tyrosine phosphorylation regulates dynamin self-assembly and ligand-induced endocytosis of the epidermal growth factor receptor. J Biol Chem (2002) 1.24
Passage of chronic wasting disease prion into transgenic mice expressing Rocky Mountain elk (Cervus elaphus nelsoni) PrPC. J Gen Virol (2006) 1.20
Identification of betaArrestin2 as a corepressor of androgen receptor signaling in prostate cancer. Proc Natl Acad Sci U S A (2009) 1.17
Liuwei Dihuang (LWDH), a traditional Chinese medicinal formula, protects against β-amyloid toxicity in transgenic Caenorhabditis elegans. PLoS One (2012) 1.13
ASAP3 is a focal adhesion-associated Arf GAP that functions in cell migration and invasion. J Biol Chem (2008) 1.12
Vp28 of shrimp white spot syndrome virus is involved in the attachment and penetration into shrimp cells. J Biochem Mol Biol (2004) 1.11
Targeting Gbetagamma signaling to inhibit prostate tumor formation and growth. J Biol Chem (2003) 1.11
PGE2 promotes angiogenesis through EP4 and PKA Cγ pathway. Blood (2011) 1.10
Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected]. J Immunol (2009) 1.09
Genetic variation of promoter sequence modulates XBP1 expression and genetic risk for vitiligo. PLoS Genet (2009) 1.07
Bradykinin receptor subtype 1 expression and function in prostate cancer. Cancer Res (2003) 1.07
Expression and function of lysophosphatidic acid LPA1 receptor in prostate cancer cells. Endocrinology (2006) 1.06
MicroRNA-125b-2 confers human glioblastoma stem cells resistance to temozolomide through the mitochondrial pathway of apoptosis. Int J Oncol (2011) 1.04
miR-145 inhibits migration and invasion of glioma stem cells by targeting ABCG2. Neuromolecular Med (2014) 1.04
ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner. J Cell Sci (2004) 1.04
Robustness of topological order and formation of quantum well states in topological insulators exposed to ambient environment. Proc Natl Acad Sci U S A (2012) 1.04
Mutations profile in Chinese patients with hypertrophic cardiomyopathy. Clin Chim Acta (2005) 1.03
Comparison of toad venoms from different Bufo species by HPLC and LC-DAD-MS/MS. J Ethnopharmacol (2010) 1.01
[A quantitative method for simultaneous assay of four flavones with one marker in Radix Scutellariae]. Zhongguo Zhong Yao Za Zhi (2009) 1.01
Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB. Prostate (2004) 1.01
Lysophosphatidic acid-regulated mitogenic ERK signaling in androgen-insensitive prostate cancer PC-3 cells. Int J Cancer (2002) 1.00
BCL10 mediates lipopolysaccharide/toll-like receptor-4 signaling through interaction with Pellino2. J Biol Chem (2004) 1.00
Multiple gene mutations, not the type of mutation, are the modifier of left ventricle hypertrophy in patients with hypertrophic cardiomyopathy. Mol Biol Rep (2013) 0.99
Requirement for direct cross-talk between B1 and B2 kinin receptors for the proliferation of androgen-insensitive prostate cancer PC3 cells. Biochem J (2003) 0.98
Bufadienolides and their antitumor activity. Nat Prod Rep (2011) 0.97
Assays and properties of the Arf GAPs AGAP1, ASAP1, and Arf GAP1. Methods Enzymol (2005) 0.96
Prostaglandin E2 regulates renal cell carcinoma invasion through the EP4 receptor-Rap GTPase signal transduction pathway. J Biol Chem (2011) 0.95
Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction. Biochem Pharmacol (2007) 0.95
Androgens transduce the G alphas-mediated activation of protein kinase A in prostate cells. Cancer Res (2008) 0.95
Regulation of epidermal growth factor receptor internalization by G protein-coupled receptors. Biochemistry (2003) 0.95
Rap1GAP regulates renal cell carcinoma invasion. Cancer Lett (2012) 0.94
ARFGAP1 promotes AP-2-dependent endocytosis. Nat Cell Biol (2011) 0.94
Guanosine phosphate binding protein coupled receptors in prostate cancer: a review. J Urol (2002) 0.94
MicroRNA-21 inhibitor sensitizes human glioblastoma U251 stem cells to chemotherapeutic drug temozolomide. J Mol Neurosci (2012) 0.93
Overview of the quality standard research of traditional Chinese medicine. Front Med (2011) 0.93
Functional differences of miR-125b on the invasion of primary glioblastoma CD133-negative cells and CD133-positive cells. Neuromolecular Med (2012) 0.92
miR-125b inhibitor enhance the chemosensitivity of glioblastoma stem cells to temozolomide by targeting Bak1. Tumour Biol (2014) 0.92
BRAF exon 15 T1799A mutation is common in melanocytic nevi, but less prevalent in cutaneous malignant melanoma, in Chinese Han. J Invest Dermatol (2011) 0.91
Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. J Immunol (2004) 0.91
Aberrant PGE₂ metabolism in bladder tumor microenvironment promotes immunosuppressive phenotype of tumor-infiltrating myeloid cells. Int Immunopharmacol (2011) 0.90
Regulation of Arf6 and ACAP1 signaling by the PTB-domain-containing adaptor protein GULP. Curr Biol (2007) 0.89
Arf1 dissociates from the clathrin adaptor GGA prior to being inactivated by Arf GTPase-activating proteins. J Biol Chem (2002) 0.89
Expansion of CCR8(+) inflammatory myeloid cells in cancer patients with urothelial and renal carcinomas. Clin Cancer Res (2013) 0.88
Milk fat globule EGF factor 8 attenuates sepsis-induced apoptosis and organ injury in alcohol-intoxicated rats. Alcohol Clin Exp Res (2010) 0.88
Isolation and crystallographic identification of four isomers of Sm@C90. J Am Chem Soc (2011) 0.88
Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep (2012) 0.88
Is it necessary to combine detection of anticitrullinated protein antibodies in the diagnosis of rheumatoid arthritis? J Rheumatol (2010) 0.87
Acute activation of β2-adrenergic receptor regulates focal adhesions through βArrestin2- and p115RhoGEF protein-mediated activation of RhoA. J Biol Chem (2012) 0.87
Cisplatin up-regulates the adenosine A(1) receptor in the rat kidney. Eur J Pharmacol (2002) 0.87
Inhibition of shear-induced platelet aggregation in rat by tetramethylpyrazine and salvianolic acid B. Clin Hemorheol Microcirc (2004) 0.87
Salt-resistant homodimeric bactenecin, a cathelicidin-derived antimicrobial peptide. FEBS J (2008) 0.87
Analysis of RGS2 expression and prognostic significance in stage II and III colorectal cancer. Biosci Rep (2010) 0.87
miR-335 promotes cell proliferation by directly targeting Rb1 in meningiomas. J Neurooncol (2012) 0.86
Enhancing apoptotic cell clearance mitigates bacterial translocation and promotes tissue repair after gut ischemia-reperfusion injury. Int J Mol Med (2012) 0.86
Contribution of AZAP-Type Arf GAPs to cancer cell migration and invasion. Adv Cancer Res (2008) 0.86
Blocking cold-inducible RNA-binding protein protects liver from ischemia-reperfusion injury. Shock (2015) 0.86
Dynamin2- and endothelial nitric oxide synthase-regulated invasion of bladder epithelial cells by uropathogenic Escherichia coli. J Cell Biol (2011) 0.86
Interleukin 6 mediates the lysophosphatidic acid-regulated cross-talk between stromal and epithelial prostate cancer cells. J Biol Chem (2004) 0.85
Site-specific gene targeting using transcription activator-like effector (TALE)-based nuclease in Brassica oleracea. J Integr Plant Biol (2013) 0.85
miR-125b inhibitor may enhance the invasion-prevention activity of temozolomide in glioblastoma stem cells by targeting PIAS3. BioDrugs (2014) 0.84
Disappearance of nodal gap across the insulator-superconductor transition in a copper-oxide superconductor. Nat Commun (2013) 0.84
Isolation of a small carbon nanotube: the surprising appearance of D(5h)(1)-C(90). Angew Chem Int Ed Engl (2010) 0.84
A novel locus for disseminated superficial actinic porokeratosis maps to chromosome 16q24.1-24.3. Hum Genet (2010) 0.84
Significance of anti-CCP antibodies in modification of 1987 ACR classification criteria in diagnosis of rheumatoid arthritis. Clin Rheumatol (2009) 0.83
G-protein coupled receptor kinase 5 regulates prostate tumor growth. J Urol (2011) 0.83
Downregulation of ABCG2 protein inhibits migration and invasion in U251 glioma stem cells. Neuroreport (2014) 0.83
miR-125b promotes cell proliferation by directly targeting Lin28 in glioblastoma stem cells with low expression levels of miR-125b. Neuroreport (2014) 0.83
The Arf GAP AGAP2 interacts with β-arrestin2 and regulates β2-adrenergic receptor recycling and ERK activation. Biochem J (2013) 0.82
Identification of pulmonary fissures using a piecewise plane fitting algorithm. Comput Med Imaging Graph (2012) 0.82
Aqueous solutions of uranium(VI) as studied by time-resolved emission spectroscopy: a round-robin test. Appl Spectrosc (2003) 0.82
G protein-coupled receptors provide survival signals in prostate cancer. Clin Prostate Cancer (2002) 0.82
[A quantitative method for simultaneous assay of five ingredients with one marker in Salvia miltiorrhiza]. Zhongguo Zhong Yao Za Zhi (2011) 0.81
Two hundred eight patients with apical hypertrophic cardiomyopathy in china: clinical feature, prognosis, and comparison of pure and mixed forms. Clin Cardiol (2011) 0.81
Isolation and structural characterization of the molecular nanocapsule Sm(2)@D(3d)(822)-C(104). Angew Chem Int Ed Engl (2009) 0.81
Gene-wide characterization of common quantitative trait loci for ABCB1 mRNA expression in normal liver tissues in the Chinese population. PLoS One (2012) 0.81
Receptor-interacting protein kinase 3 deficiency inhibits immune cell infiltration and attenuates organ injury in sepsis. Crit Care (2014) 0.81
Evaluation of 5-fluorouracil released from a foldable capsular vitreous body in vitro and in vivo. Graefes Arch Clin Exp Ophthalmol (2011) 0.81
Upregulation of Kupffer cell α2A-Adrenoceptors and downregulation of MKP-1 mediate hepatic injury in chronic alcohol exposure. Biochem Biophys Res Commun (2011) 0.80