Published in Nat Rev Cancer on July 01, 2005
Nitric oxide and peroxynitrite in health and disease. Physiol Rev (2007) 15.49
Nuclear FAK promotes cell proliferation and survival through FERM-enhanced p53 degradation. Mol Cell (2008) 3.31
Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol (2010) 3.27
Structural basis for the autoinhibition of focal adhesion kinase. Cell (2007) 3.18
Invadopodia: specialized cell structures for cancer invasion. Clin Exp Metastasis (2006) 3.05
Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics. J Cell Biol (2007) 2.79
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
FAK in cancer: mechanistic findings and clinical applications. Nat Rev Cancer (2014) 2.46
Inside the human cancer tyrosine phosphatome. Nat Rev Cancer (2011) 2.38
A small molecule inhibitor, 1,2,4,5-benzenetetraamine tetrahydrochloride, targeting the y397 site of focal adhesion kinase decreases tumor growth. J Med Chem (2008) 2.31
Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis. Adv Drug Deliv Rev (2010) 2.21
Genome-wide DNA copy number analysis in pancreatic cancer using high-density single nucleotide polymorphism arrays. Oncogene (2007) 2.14
Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling. Proc Natl Acad Sci U S A (2011) 2.13
PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments. Cancer Biol Ther (2010) 2.10
Nonlinear modelling of cancer: bridging the gap between cells and tumours. Nonlinearity (2010) 2.08
Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells. Cancer Res (2009) 2.04
Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. PLoS Pathog (2007) 2.01
The extracellular matrix modulates the hallmarks of cancer. EMBO Rep (2014) 1.88
Dasatinib sensitizes KRAS mutant colorectal tumors to cetuximab. Oncogene (2010) 1.88
Computer simulation of glioma growth and morphology. Neuroimage (2007) 1.83
Mammary epithelial-specific disruption of focal adhesion kinase retards tumor formation and metastasis in a transgenic mouse model of human breast cancer. Am J Pathol (2008) 1.82
A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer. Cell Cycle (2009) 1.79
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis. PLoS One (2010) 1.60
Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis. Cancer Lett (2009) 1.59
SRC: a century of science brought to the clinic. Neoplasia (2010) 1.58
Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression. Cancer Res (2008) 1.54
Transforming growth factor beta induces clustering of HER2 and integrins by activating Src-focal adhesion kinase and receptor association to the cytoskeleton. Cancer Res (2009) 1.53
p53 regulates FAK expression in human tumor cells. Mol Carcinog (2008) 1.52
Nonreceptor tyrosine kinases in prostate cancer. Neoplasia (2007) 1.50
Src-dependent phosphorylation of ASAP1 regulates podosomes. Mol Cell Biol (2007) 1.48
FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell (2009) 1.47
FERM control of FAK function: implications for cancer therapy. Cell Cycle (2008) 1.43
FAK and IGF-IR interact to provide survival signals in human pancreatic adenocarcinoma cells. Carcinogenesis (2008) 1.43
Endothelial FAK is required for tumour angiogenesis. EMBO Mol Med (2010) 1.38
Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis. J Theor Biol (2010) 1.37
Merlin deficiency predicts FAK inhibitor sensitivity: a synthetic lethal relationship. Sci Transl Med (2014) 1.34
Grb2 signaling in cell motility and cancer. Expert Opin Ther Targets (2008) 1.32
FAK engages multiple pathways to maintain survival of fibroblasts and epithelia: differential roles for paxillin and p130Cas. J Cell Sci (2009) 1.29
MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression. PLoS One (2012) 1.27
RhoC promotes metastasis via activation of the Pyk2 pathway in prostate cancer. Cancer Res (2008) 1.27
Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity. Cell (2015) 1.26
RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas. Cancer Discov (2013) 1.25
Hyaluronan and hyaluronidase in genitourinary tumors. Front Biosci (2008) 1.24
CD98 expression modulates intestinal homeostasis, inflammation, and colitis-associated cancer in mice. J Clin Invest (2011) 1.23
Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling. J Clin Invest (2009) 1.22
FAK phosphorylation at Tyr-925 regulates cross-talk between focal adhesion turnover and cell protrusion. Mol Biol Cell (2011) 1.22
Turnover of focal adhesions and cancer cell migration. Int J Cell Biol (2012) 1.22
Focal adhesion kinase and p53 signal transduction pathways in cancer. Front Biosci (Landmark Ed) (2010) 1.20
Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway. Oncogene (2009) 1.19
Multiple paxillin binding sites regulate FAK function. J Mol Signal (2008) 1.19
Intrinsic chemoresistance to gemcitabine is associated with constitutive and laminin-induced phosphorylation of FAK in pancreatic cancer cell lines. Mol Cancer (2009) 1.18
Activation of platelet-activating factor receptor and pleiotropic effects on tyrosine phospho-EGFR/Src/FAK/paxillin in ovarian cancer. Cancer Res (2008) 1.17
Tumor cell migration in complex microenvironments. Cell Mol Life Sci (2012) 1.16
Tenascin C induces epithelial-mesenchymal transition-like change accompanied by SRC activation and focal adhesion kinase phosphorylation in human breast cancer cells. Am J Pathol (2011) 1.16
Integrin signaling, cell survival, and anoikis: distinctions, differences, and differentiation. J Signal Transduct (2011) 1.14
Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer. IUBMB Life (2010) 1.12
Implanted adipose progenitor cells as physicochemical regulators of breast cancer. Proc Natl Acad Sci U S A (2012) 1.12
The heterochronic microRNA let-7 inhibits cell motility by regulating the genes in the actin cytoskeleton pathway in breast cancer. Mol Cancer Res (2013) 1.11
Small molecule chloropyramine hydrochloride (C4) targets the binding site of focal adhesion kinase and vascular endothelial growth factor receptor 3 and suppresses breast cancer growth in vivo. J Med Chem (2009) 1.11
Integrin β5 contributes to the tumorigenic potential of breast cancer cells through the Src-FAK and MEK-ERK signaling pathways. Oncogene (2012) 1.11
Growth activation alone is not sufficient to cause metastatic thyroid cancer in a mouse model of follicular thyroid carcinoma. Endocrinology (2010) 1.11
Disrupting the scaffold to improve focal adhesion kinase-targeted cancer therapeutics. Sci Signal (2013) 1.10
CNTO 95, a fully human anti alphav integrin antibody, inhibits cell signaling, migration, invasion, and spontaneous metastasis of human breast cancer cells. Clin Exp Metastasis (2007) 1.10
Function of focal adhesion kinase scaffolding to mediate endophilin A2 phosphorylation promotes epithelial-mesenchymal transition and mammary cancer stem cell activities in vivo. J Biol Chem (2012) 1.10
Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation. BMC Struct Biol (2007) 1.09
Small interference RNA targeting Krüppel-like factor 8 inhibits the renal carcinoma 786-0 cells growth in vitro and in vivo. J Cancer Res Clin Oncol (2010) 1.08
Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol Cell Biol (2011) 1.07
FAK is involved in invasion and metastasis of hepatocellular carcinoma. Clin Exp Metastasis (2010) 1.07
Global gene expression analysis identifies PDEF transcriptional networks regulating cell migration during cancer progression. Mol Biol Cell (2008) 1.06
Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer. Nat Commun (2011) 1.06
Nuclear FAK: a new mode of gene regulation from cellular adhesions. Mol Cells (2013) 1.06
Role of receptor for hyaluronic acid-mediated motility (RHAMM) in low molecular weight hyaluronan (LMWHA)-mediated fibrosarcoma cell adhesion. J Biol Chem (2011) 1.05
Focal adhesion kinase and endothelial cell apoptosis. Microvasc Res (2011) 1.05
Distinct FAK activities determine progenitor and mammary stem cell characteristics. Cancer Res (2013) 1.04
Targeted inhibition of prostate cancer metastases with an RNA aptamer to prostate-specific membrane antigen. Mol Ther (2014) 1.04
Targeting Pyk2 for therapeutic intervention. Expert Opin Ther Targets (2010) 1.04
PTTG induces EMT through integrin αVβ3-focal adhesion kinase signaling in lung cancer cells. Oncogene (2011) 1.03
Emerging roles of nodal and Cripto-1: from embryogenesis to breast cancer progression. Breast Dis (2008) 1.03
Focal adhesion kinase regulates pathogen-killing capability and life span of neutrophils via mediating both adhesion-dependent and -independent cellular signals. J Immunol (2009) 1.03
Lung cancer cell migration is regulated via repressing growth factor PTN/RPTP β/ζ signaling by menin. Oncogene (2010) 1.03
Identification of vitronectin as an extrinsic inducer of cancer stem cell differentiation and tumor formation. Stem Cells (2010) 1.03
Organization and post-transcriptional processing of focal adhesion kinase gene. BMC Genomics (2006) 1.03
Functional kinomics identifies candidate therapeutic targets in head and neck cancer. Clin Cancer Res (2014) 1.03
The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence. Br J Cancer (2007) 1.02
An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers. J Clin Invest (2011) 1.02
Hyalurondiase: both a tumor promoter and suppressor. Semin Cancer Biol (2008) 1.02
Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J Virol (2006) 1.01
Global evaluation of Eph receptors and ephrins in lung adenocarcinomas identifies EphA4 as an inhibitor of cell migration and invasion. Mol Cancer Ther (2012) 1.01
A network-based biomarker approach for molecular investigation and diagnosis of lung cancer. BMC Med Genomics (2011) 1.01
Impact of heat-shock protein 90 on cancer metastasis. Future Oncol (2009) 1.00
Endogenous angiogenesis inhibitor blocks tumor growth via direct and indirect effects on tumor microenvironment. Am J Pathol (2011) 1.00
Compensatory function of Pyk2 protein in the promotion of focal adhesion kinase (FAK)-null mammary cancer stem cell tumorigenicity and metastatic activity. J Biol Chem (2011) 1.00
A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src. Mol Biol Cell (2011) 1.00
Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion. Mol Cancer (2010) 1.00
Paxillin-Y118 phosphorylation contributes to the control of Src-induced anchorage-independent growth by FAK and adhesion. BMC Cancer (2009) 0.99
The direct effect of focal adhesion kinase (FAK), dominant-negative FAK, FAK-CD and FAK siRNA on gene expression and human MCF-7 breast cancer cell tumorigenesis. BMC Cancer (2009) 0.99
KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. J Cell Biol (2012) 0.99
miRNA-mRNA correlation-network modules in human prostate cancer and the differences between primary and metastatic tumor subtypes. PLoS One (2012) 0.99
Involvement of focal adhesion kinase in cellular invasion of head and neck squamous cell carcinomas via regulation of MMP-2 expression. Br J Cancer (2008) 0.98
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol (2009) 8.63
Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth. Cancer Cell (2011) 3.19
Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc Natl Acad Sci U S A (2009) 3.08
Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression. Proc Natl Acad Sci U S A (2007) 2.64
Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling. Nat Cell Biol (2002) 2.50
Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev (2004) 2.49
Focal adhesion and actin dynamics: a place where kinases and proteases meet to promote invasion. Trends Cell Biol (2004) 2.46
v-Src's hold over actin and cell adhesions. Nat Rev Mol Cell Biol (2002) 2.40
E-cadherin-integrin crosstalk in cancer invasion and metastasis. J Cell Sci (2013) 2.23
Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex. Nat Cell Biol (2007) 2.18
RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev Cell (2004) 2.13
Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival. Blood (2011) 2.11
The calpain system and cancer. Nat Rev Cancer (2011) 2.10
Autophagic targeting of Src promotes cancer cell survival following reduced FAK signalling. Nat Cell Biol (2011) 2.07
Src and FAK signalling controls adhesion fate and the epithelial-to-mesenchymal transition. Curr Opin Cell Biol (2005) 1.85
Dasatinib inhibits the development of metastases in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology (2010) 1.81
Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream of Wnt/c-Myc signaling. Dev Cell (2010) 1.79
Src and focal adhesion kinase as therapeutic targets in cancer. Curr Opin Pharmacol (2008) 1.69
A novel role for FAK as a protease-targeting adaptor protein: regulation by p42 ERK and Src. Curr Biol (2003) 1.67
Identification of potential biomarkers for measuring inhibition of Src kinase activity in colon cancer cells following treatment with dasatinib. Mol Cancer Ther (2006) 1.66
Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors. Clin Cancer Res (2009) 1.63
The membrane targeting and spatial activation of Src, Yes and Fyn is influenced by palmitoylation and distinct RhoB/RhoD endosome requirements. J Cell Sci (2007) 1.57
Inhibition of calpain stabilises podosomes and impairs dendritic cell motility. J Cell Sci (2006) 1.47
SRC family kinase activity is up-regulated in hormone-refractory prostate cancer. Clin Cancer Res (2009) 1.47
LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology (2010) 1.47
Identification of Src-specific phosphorylation site on focal adhesion kinase: dissection of the role of Src SH2 and catalytic functions and their consequences for tumor cell behavior. Cancer Res (2005) 1.45
Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53. Cancer Res (2011) 1.44
Endosomal trafficking of Src tyrosine kinase. Trends Cell Biol (2008) 1.43
Role of discoidin domain receptors 1 and 2 in human smooth muscle cell-mediated collagen remodeling: potential implications in atherosclerosis and lymphangioleiomyomatosis. Am J Pathol (2004) 1.39
Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Mol Biol Cell (2004) 1.39
Critical role for lipid raft-associated Src kinases in activation of PI3K-Akt signalling. Cell Signal (2006) 1.38
Calpain: a role in cell transformation and migration. Int J Biochem Cell Biol (2002) 1.37
Src kinase modulates the activation, transport and signalling dynamics of fibroblast growth factor receptors. EMBO Rep (2007) 1.36
A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Curr Biol (2010) 1.34
Stage specific lymph node metastasis mapping in radical cystectomy specimens. J Urol (2004) 1.33
Epigenetic downregulation of human disabled homolog 2 switches TGF-beta from a tumor suppressor to a tumor promoter. J Clin Invest (2010) 1.30
Focal adhesion kinase as a potential target in oncology. Expert Opin Pharmacother (2003) 1.28
The IpaC carboxyterminal effector domain mediates Src-dependent actin polymerization during Shigella invasion of epithelial cells. PLoS Pathog (2009) 1.26
Real-time study of E-cadherin and membrane dynamics in living animals: implications for disease modeling and drug development. Cancer Res (2009) 1.25
Comparison of methods for image-based profiling of cellular morphological responses to small-molecule treatment. J Biomol Screen (2013) 1.19
Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chem Biol (2009) 1.18
Expression of kinase-defective mutants of c-Src in human metastatic colon cancer cells decreases Bcl-xL and increases oxaliplatin- and Fas-induced apoptosis. J Biol Chem (2004) 1.16
High-content phenotypic profiling of drug response signatures across distinct cancer cells. Mol Cancer Ther (2010) 1.13
AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Mol Cell Biol (2006) 1.12
Quantitative in vivo imaging of the effects of inhibiting integrin signaling via Src and FAK on cancer cell movement: effects on E-cadherin dynamics. Cancer Res (2010) 1.12
Advances in Rho-dependent actin regulation and oncogenic transformation. Curr Opin Genet Dev (2002) 1.12
Src-dependent phosphorylation of Scar1 promotes its association with the Arp2/3 complex. Cell Motil Cytoskeleton (2006) 1.10
Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells. EMBO Rep (2012) 1.09
Two-color photoactivatable probe for selective tracking of proteins and cells. J Biol Chem (2010) 1.08
Loss of Scar/WAVE complex promotes N-WASP- and FAK-dependent invasion. Curr Biol (2012) 1.05
The SRC-induced mesenchymal state in late-stage colon cancer cells. Cells Tissues Organs (2005) 1.03
Endothelial heparan sulfate 6-O-sulfation levels regulate angiogenic responses of endothelial cells to fibroblast growth factor 2 and vascular endothelial growth factor. J Biol Chem (2012) 1.02
Is expression or activation of Src kinase associated with cancer-specific survival in ER-, PR- and HER2-negative breast cancer patients? Am J Pathol (2009) 1.01
Src kinase inhibitors: promising cancer therapeutics? Crit Rev Oncog (2012) 1.01
Src/FAK-mediated regulation of E-cadherin as a mechanism for controlling collective cell movement: insights from in vivo imaging. Cell Adh Migr (2011) 1.00
Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of src in pancreatic cancer. Cancer Res (2013) 0.99
The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells. Int J Cancer (2011) 0.96
FGF/heparin differentially regulates Schwann cell and olfactory ensheathing cell interactions with astrocytes: a role in astrocytosis. J Neurosci (2007) 0.95
Recruitment of phosphoinositide 3-kinase defines a positive contribution of tyrosine kinase signaling to E-cadherin function. J Biol Chem (2004) 0.94
A novel Src kinase inhibitor reduces tumour formation in a skin carcinogenesis model. Carcinogenesis (2008) 0.94
Synthetic heparan sulfate oligosaccharides inhibit endothelial cell functions essential for angiogenesis. PLoS One (2010) 0.94
Tetrasaccharide iteration synthesis of a heparin-like dodecasaccharide and radiolabelling for in vivo tissue distribution studies. Nat Commun (2013) 0.93
HER2 overcomes PTEN (loss)-induced senescence to cause aggressive prostate cancer. Proc Natl Acad Sci U S A (2011) 0.92
N-cadherin differentially determines Schwann cell and olfactory ensheathing cell adhesion and migration responses upon contact with astrocytes. Mol Cell Neurosci (2005) 0.91
FRS2-dependent SRC activation is required for fibroblast growth factor receptor-induced phosphorylation of Sprouty and suppression of ERK activity. J Cell Sci (2004) 0.91
Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res (2012) 0.90
Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Res (2007) 0.90
Kindlin-1 regulates mitotic spindle formation by interacting with integrins and Plk-1. Nat Commun (2013) 0.89
Methodologies for estimating cumulative human exposures to current-use pyrethroid pesticides. J Expo Sci Environ Epidemiol (2010) 0.89