Published in Am J Respir Cell Mol Biol on March 27, 2009
Epithelial repair mechanisms in the lung. Am J Physiol Lung Cell Mol Physiol (2010) 3.22
Understanding fibrosis in systemic sclerosis: shifting paradigms, emerging opportunities. Nat Rev Rheumatol (2011) 1.82
Profibrotic role of miR-154 in pulmonary fibrosis. Am J Respir Cell Mol Biol (2012) 1.30
Cigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells. PLoS One (2010) 1.27
Fibrosis in systemic sclerosis: emerging concepts and implications for targeted therapy. Autoimmun Rev (2010) 1.20
Axin pathway activity regulates in vivo pY654-β-catenin accumulation and pulmonary fibrosis. J Biol Chem (2011) 1.17
Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13
A role for Wnt signaling genes in the pathogenesis of impaired lung function in asthma. Am J Respir Crit Care Med (2009) 1.12
Nuclear β-catenin accumulation is associated with increased expression of Nanog protein and predicts poor prognosis of non-small cell lung cancer. J Transl Med (2013) 1.09
Activation of the Wnt/β-catenin signaling pathway by mechanical ventilation is associated with ventilator-induced pulmonary fibrosis in healthy lungs. PLoS One (2011) 1.08
Cellular and molecular mechanisms of chronic inflammation-associated organ fibrosis. Front Immunol (2012) 1.05
Role of Smad2/3 and p38 MAP kinase in TGF-β1-induced epithelial-mesenchymal transition of pulmonary epithelial cells. J Cell Physiol (2011) 1.04
Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis. J Clin Invest (2013) 1.03
Concise review: the relevance of human stem cell-derived organoid models for epithelial translational medicine. Stem Cells (2013) 0.99
RACK1 promotes non-small-cell lung cancer tumorigenicity through activating sonic hedgehog signaling pathway. J Biol Chem (2012) 0.98
CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2011) 0.97
The lens as a model for fibrotic disease. Philos Trans R Soc Lond B Biol Sci (2011) 0.97
Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis. Am J Pathol (2010) 0.95
WNT7B in fibroblastic foci of idiopathic pulmonary fibrosis. Respir Res (2012) 0.94
Expression of canonical WNT/β-CATENIN signaling components in the developing human lung. BMC Dev Biol (2012) 0.92
β-Catenin determines upper airway progenitor cell fate and preinvasive squamous lung cancer progression by modulating epithelial-mesenchymal transition. J Pathol (2012) 0.92
A glimpse of the pathogenetic mechanisms of Wnt/β-catenin signaling in diabetic nephropathy. Biomed Res Int (2013) 0.92
Planar polarity: A new player in both lung development and disease. Organogenesis (2011) 0.90
Overexpression of Sulf2 in idiopathic pulmonary fibrosis. Glycobiology (2013) 0.89
Vitamin D intake and lung cancer risk in the Women's Health Initiative. Am J Clin Nutr (2013) 0.89
The β-catenin pathway contributes to the effects of leptin on SREBP-1c expression in rat hepatic stellate cells and liver fibrosis. Br J Pharmacol (2013) 0.88
Aquaporin 5 regulates cigarette smoke induced emphysema by modulating barrier and immune properties of the epithelium. Tissue Barriers (2013) 0.87
Inhibition of lung cancer cells growth, motility and induction of apoptosis by Klotho, a novel secreted Wnt antagonist, in a dose-dependent manner. Cancer Biol Ther (2012) 0.87
Promoter methylation-mediated silencing of β-catenin enhances invasiveness of non-small cell lung cancer and predicts adverse prognosis. PLoS One (2014) 0.86
Expression of fibroblast growth factor 9 in normal human lung and idiopathic pulmonary fibrosis. J Histochem Cytochem (2013) 0.86
Epithelial N-cadherin and nuclear β-catenin are up-regulated during early development of human lung. BMC Dev Biol (2010) 0.86
Fibrosis in systemic sclerosis: common and unique pathobiology. Fibrogenesis Tissue Repair (2012) 0.85
Regulation of Wnt4 in chronic obstructive pulmonary disease. FASEB J (2013) 0.84
Early activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury. Crit Care (2014) 0.83
Persistence of smoking-induced dysregulation of miRNA expression in the small airway epithelium despite smoking cessation. PLoS One (2015) 0.83
Wif1 hypermethylation as unfavorable prognosis of non-small cell lung cancers with EGFR mutation. Mol Cells (2013) 0.83
Emergence of a Wave of Wnt Signaling that Regulates Lung Alveologenesis by Controlling Epithelial Self-Renewal and Differentiation. Cell Rep (2016) 0.83
Alteration in the Wnt microenvironment directly regulates molecular events leading to pulmonary senescence. Aging Cell (2014) 0.82
Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs. Respir Res (2012) 0.82
ROS-induced endothelial stress contributes to pulmonary fibrosis through pericytes and Wnt signaling. Lab Invest (2015) 0.82
LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One (2012) 0.81
Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells. Dis Model Mech (2015) 0.81
Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation. PLoS One (2014) 0.80
Mechanobiology in lung epithelial cells: measurements, perturbations, and responses. Compr Physiol (2012) 0.80
Airway response to acute mechanical stress in a human bronchial model of stretch. Crit Care (2011) 0.80
Shared gene expression patterns in mesenchymal progenitors derived from lung and epidermis in pulmonary arterial hypertension: identifying key pathways in pulmonary vascular disease. Pulm Circ (2016) 0.79
c-Myc regulates proliferation and Fgf10 expression in airway smooth muscle after airway epithelial injury in mouse. PLoS One (2013) 0.79
Wnt5a attenuates hypoxia-induced pulmonary arteriolar remodeling and right ventricular hypertrophy in mice. Exp Biol Med (Maywood) (2015) 0.78
Tumor necrosis factor-α induces increased lung vascular permeability: a role for GSK3α/β. Eur J Pharmacol (2011) 0.78
A study of the relationship between the Wnt/β-catenin signaling pathway and the gastrointestinal development of rat embryonic and perinatal periods. Exp Ther Med (2013) 0.78
Estimated intake of vitamin D and its interaction with vitamin A on lung cancer risk among smokers. Int J Cancer (2014) 0.78
Inhibition of Wnt/β-catenin signaling suppresses bleomycin-induced pulmonary fibrosis by attenuating the expression of TGF-β1 and FGF-2. Exp Mol Pathol (2016) 0.77
The Wnt/β-catenin signaling pathway regulates the development of airway remodeling in patients with asthma. Exp Mol Med (2015) 0.77
CDX2 serves as a Wnt signaling inhibitor and is frequently methylated in lung cancer. Cancer Biol Ther (2012) 0.77
WNT/β-catenin signaling regulates cigarette smoke-induced airway inflammation via the PPARδ/p38 pathway. Lab Invest (2015) 0.77
Secreted frizzled related proteins inhibit fibrosis in vitro but appear redundant in vivo. Fibrogenesis Tissue Repair (2014) 0.77
Transcriptome Analysis of the Preterm Rabbit Lung after Seven Days of Hyperoxic Exposure. PLoS One (2015) 0.77
Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling. Mol Cell Pediatr (2016) 0.77
Protein kinase GSK3β regulates tumor suppressor Pdcd4 expression in lung cancer cells. Dokl Biochem Biophys (2012) 0.76
Lithium Attenuates TGF-β(1)-Induced Fibroblasts to Myofibroblasts Transition in Bronchial Fibroblasts Derived from Asthmatic Patients. J Allergy (Cairo) (2012) 0.76
Inhibition of β-catenin/p300 interaction proximalizes mouse embryonic lung epithelium. Transl Respir Med (2014) 0.76
Breakdown of Epithelial Barrier Integrity and Overdrive Activation of Alveolar Epithelial Cells in the Pathogenesis of Acute Respiratory Distress Syndrome and Lung Fibrosis. Biomed Res Int (2015) 0.76
Intratracheal instillation of high dose adenoviral vectors is sufficient to induce lung injury and fibrosis in mice. PLoS One (2014) 0.76
Non-canonical WNT signalling in the lung. J Biochem (2015) 0.76
'WNT-er is coming': WNT signalling in chronic lung diseases. Thorax (2017) 0.76
Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases. J Transl Med (2015) 0.75
Prognostic significance of β-catenin expression in patients with non-small cell lung cancer: a meta-analysis. Transl Lung Cancer Res (2017) 0.75
A powerful weighted statistic for detecting group differences of directed biological networks. Sci Rep (2016) 0.75
The Wnt Blows: On the Functional Role of Wnt Signaling in Mycobacterium tuberculosis Infection and Beyond. Front Immunol (2016) 0.75
Wingless: developmentally important genes that respond adversely to smoking. Thorax (2013) 0.75
Potential contribution of alveolar epithelial type I cells to pulmonary fibrosis. Biosci Rep (2017) 0.75
Wnt Signaling in Chronic Rhinosinusitis with Nasal Polyps. Am J Respir Cell Mol Biol (2017) 0.75
Cellular and molecular pathobiology of pulmonary arterial hypertension. J Am Coll Cardiol (2004) 5.79
WNT1-inducible signaling protein-1 mediates pulmonary fibrosis in mice and is upregulated in humans with idiopathic pulmonary fibrosis. J Clin Invest (2009) 3.33
Inhibition and role of let-7d in idiopathic pulmonary fibrosis. Am J Respir Crit Care Med (2010) 3.02
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. PLoS One (2008) 2.94
Genetics and genomics of pulmonary arterial hypertension. J Am Coll Cardiol (2009) 2.31
Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension. Hum Mutat (2006) 2.30
Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am J Physiol Lung Cell Mol Physiol (2006) 2.29
Retracted CXCR2 mediates NADPH oxidase-independent neutrophil extracellular trap formation in cystic fibrosis airway inflammation. Nat Med (2010) 2.17
Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors. J Biol Chem (2009) 2.12
Increased local expression of coagulation factor X contributes to the fibrotic response in human and murine lung injury. J Clin Invest (2009) 1.96
Activation of the WNT/β-catenin pathway attenuates experimental emphysema. Am J Respir Crit Care Med (2010) 1.94
Of flies, mice and men: a systematic approach to understanding the early life origins of chronic lung disease. Thorax (2012) 1.88
The impact of TGF-β on lung fibrosis: from targeting to biomarkers. Proc Am Thorac Soc (2012) 1.74
Hyperoxia modulates TGF-beta/BMP signaling in a mouse model of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol (2006) 1.71
Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? Am J Respir Cell Mol Biol (2004) 1.67
Emphysema diagnosis using X-ray dark-field imaging at a laser-driven compact synchrotron light source. Proc Natl Acad Sci U S A (2012) 1.62
Infiltrated neutrophils acquire novel chemokine receptor expression and chemokine responsiveness in chronic inflammatory lung diseases. J Immunol (2008) 1.56
Caveolin-1 facilitates mechanosensitive protein kinase B (Akt) signaling in vitro and in vivo. Circ Res (2005) 1.55
Genetic basis of pulmonary arterial hypertension: current understanding and future directions. J Am Coll Cardiol (2004) 1.53
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention. Thorax (2010) 1.52
New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis. Lancet (2012) 1.47
Investigation of the antifibrotic effect of IFN-gamma on fibroblasts in a cell culture model of Peyronie's disease. Eur Urol (2007) 1.47
Dysregulated bone morphogenetic protein signaling in monocrotaline-induced pulmonary arterial hypertension. Arterioscler Thromb Vasc Biol (2007) 1.43
Leukocytes induce epithelial to mesenchymal transition after unilateral ureteral obstruction in neonatal mice. Am J Pathol (2007) 1.39
Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types. Am J Respir Cell Mol Biol (2008) 1.31
Chronic lung disease in the preterm infant. Lessons learned from animal models. Am J Respir Cell Mol Biol (2014) 1.28
From arginine methylation to ADMA: a novel mechanism with therapeutic potential in chronic lung diseases. BMC Pulm Med (2009) 1.24
TGF-beta signaling is dynamically regulated during the alveolarization of rodent and human lungs. Dev Dyn (2008) 1.15
The angiotensin II receptor 2 is expressed and mediates angiotensin II signaling in lung fibrosis. Am J Respir Cell Mol Biol (2007) 1.15
Lung-selective gene responses to alveolar hypoxia: potential role for the bone morphogenetic antagonist gremlin in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2008) 1.15
Transforming growth factor-beta signaling across ages: from distorted lung development to chronic obstructive pulmonary disease. Proc Am Thorac Soc (2009) 1.14
Progressive pulmonary fibrosis is mediated by TGF-beta isoform 1 but not TGF-beta3. Int J Biochem Cell Biol (2007) 1.11
Nrf2 induces interleukin-6 (IL-6) expression via an antioxidant response element within the IL-6 promoter. J Biol Chem (2010) 1.09
Innovations in phenotyping of mouse models in the German Mouse Clinic. Mamm Genome (2012) 1.09
Transgelin is a direct target of TGF-beta/Smad3-dependent epithelial cell migration in lung fibrosis. FASEB J (2008) 1.09
Gli1 mediates lung cancer cell proliferation and Sonic Hedgehog-dependent mesenchymal cell activation. PLoS One (2013) 1.08
Functional role and species-specific contribution of arginases in pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2007) 1.07
Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies? Intensive Care Med (2007) 1.06
Pulmonary epithelium is a prominent source of proteinase-activated receptor-1-inducible CCL2 in pulmonary fibrosis. Am J Respir Crit Care Med (2008) 1.06
Pulmonary emphysema diagnosis with a preclinical small-animal X-ray dark-field scatter-contrast scanner. Radiology (2013) 1.05
Receptor for activated C-kinase 1, a novel interaction partner of type II bone morphogenetic protein receptor, regulates smooth muscle cell proliferation in pulmonary arterial hypertension. Circulation (2007) 1.04
Acute cigarette smoke exposure impairs proteasome function in the lung. Am J Physiol Lung Cell Mol Physiol (2012) 1.04
Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype. Eur Respir Rev (2014) 1.04
Transforming growth factor-beta-dependent growth inhibition in primary vascular smooth muscle cells is p38-dependent. J Pharmacol Exp Ther (2005) 1.03
Fhl-1, a new key protein in pulmonary hypertension. Circulation (2008) 1.03
TGF-beta signaling in COPD: deciphering genetic and cellular susceptibilities for future therapeutic regimen. Swiss Med Wkly (2009) 1.02
High throughput determination of TGFβ1/SMAD3 targets in A549 lung epithelial cells. PLoS One (2011) 1.02
TGF-β directs trafficking of the epithelial sodium channel ENaC which has implications for ion and fluid transport in acute lung injury. Proc Natl Acad Sci U S A (2013) 1.01
Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia. J Appl Physiol (1985) (2002) 1.00
Dysregulation of the IL-13 receptor system: a novel pathomechanism in pulmonary arterial hypertension. Am J Respir Crit Care Med (2010) 1.00
Lysyl oxidase activity is dysregulated during impaired alveolarization of mouse and human lungs. Am J Respir Crit Care Med (2009) 1.00
High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner. J Biol Chem (2013) 0.95
Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med (2015) 0.94
Inflammatory and oxidative stress responses of an alveolar epithelial cell line to airborne zinc oxide nanoparticles at the air-liquid interface: a comparison with conventional, submerged cell-culture conditions. Biomed Res Int (2013) 0.94
The role of dimethylarginine dimethylaminohydrolase in idiopathic pulmonary fibrosis. Sci Transl Med (2011) 0.94
Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages. Am J Respir Cell Mol Biol (2013) 0.93
The composition of cigarette smoke determines inflammatory cell recruitment to the lung in COPD mouse models. Clin Sci (Lond) (2014) 0.93
Differential expression of matrix metalloproteinases and their inhibitors in human and mouse lung development. Thromb Haemost (2005) 0.93
Increased protein arginine methylation in chronic hypoxia: role of protein arginine methyltransferases. Am J Respir Cell Mol Biol (2006) 0.92
The chitinase-like protein YKL-40 modulates cystic fibrosis lung disease. PLoS One (2011) 0.92
Overexpression of HSP-72 confers cytoprotection in experimental peritoneal dialysis. Kidney Int (2004) 0.92
Role of von Hippel-Lindau protein in fibroblast proliferation and fibrosis. FASEB J (2011) 0.89
Cigarette smoke-induced disruption of bronchial epithelial tight junctions is prevented by transforming growth factor-β. Am J Respir Cell Mol Biol (2014) 0.89
Zyxin is a transforming growth factor-β (TGF-β)/Smad3 target gene that regulates lung cancer cell motility via integrin α5β1. J Biol Chem (2012) 0.89
Diagnosing and mapping pulmonary emphysema on X-ray projection images: incremental value of grating-based X-ray dark-field imaging. PLoS One (2013) 0.88
Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension. Int J Biochem Cell Biol (2008) 0.87
BDNF/TrkB signaling augments smooth muscle cell proliferation in pulmonary hypertension. Am J Pathol (2012) 0.87
Upregulation of mRNA expression of MCP-1 by TGF-beta1 in fibroblast cells from Peyronie's disease. World J Urol (2008) 0.87
Alterations in the transforming growth factor (TGF)-beta pathway as a potential factor in the pathogenesis of Peyronie's disease. Eur Urol (2006) 0.86
Transcriptional and post-transcriptional regulation of transforming growth factor beta type II receptor expression in osteoblasts. Gene (2002) 0.86
Improved diagnosis of pulmonary emphysema using in vivo dark-field radiography. Invest Radiol (2014) 0.86
Multiplex profiling of cellular invasion in 3D cell culture models. PLoS One (2013) 0.85
Identification of a novel IL-6 isoform binding to the endogenous IL-6 receptor. Am J Respir Cell Mol Biol (2002) 0.85
In Vivo Dark-Field Radiography for Early Diagnosis and Staging of Pulmonary Emphysema. Invest Radiol (2015) 0.84
Protease-mediated release of chemotherapeutics from mesoporous silica nanoparticles to ex vivo human and mouse lung tumors. ACS Nano (2015) 0.84
Temporal and spatial regulation of bone morphogenetic protein signaling in late lung development. Dev Dyn (2007) 0.84
What shall we do with the damaged proteins in lung disease? Ask the proteasome! Eur Respir J (2012) 0.83
Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages. Nanomedicine (Lond) (2012) 0.83
Induction of mesothelial HSP-72 upon in vivo exposure to peritoneal dialysis fluid. Perit Dial Int (2003) 0.83
Subcellular fractionation of TGF-beta1-stimulated lung epithelial cells: a novel proteomic approach for identifying signaling intermediates. Proteomics (2009) 0.83
Mouse nuclear myosin I knock-out shows interchangeability and redundancy of myosin isoforms in the cell nucleus. PLoS One (2013) 0.82
Phosphodiesterase 6 subunits are expressed and altered in idiopathic pulmonary fibrosis. Respir Res (2010) 0.82
Constitutive homo- and hetero-oligomerization of TbetaRII-B, an alternatively spliced variant of the mouse TGF-beta type II receptor. Biochem Biophys Res Commun (2006) 0.82
Quantitative assessment of arginine methylation in free versus protein-incorporated amino acids in vitro and in vivo using protein hydrolysis and high-performance liquid chromatography. Biotechniques (2006) 0.82
Cardiovascular and inflammatory effects of intratracheally instilled ambient dust from Augsburg, Germany, in spontaneously hypertensive rats (SHRs). Part Fibre Toxicol (2010) 0.82
Mast cells mediate malignant pleural effusion formation. J Clin Invest (2015) 0.82
Hypoxia differentially enhances the effects of transforming growth factor-beta isoforms on the synthesis and secretion of glycosaminoglycans by human lung fibroblasts. J Pharmacol Exp Ther (2002) 0.82
Abca3 haploinsufficiency is a risk factor for lung injury induced by hyperoxia or mechanical ventilation in a murine model. Pediatr Res (2013) 0.81
[Pulmonary fibrosis--a therapeutic dilemma?]. Med Klin (Munich) (2006) 0.81
Inflammatory responses to pulmonary application of PEI-based siRNA nanocarriers in mice. Biomaterials (2011) 0.80
Efficient bioactive delivery of aerosolized drugs to human pulmonary epithelial cells cultured in air-liquid interface conditions. Am J Respir Cell Mol Biol (2014) 0.80
An American Thoracic Society Official Research Statement: Future Directions in Lung Fibrosis Research. Am J Respir Crit Care Med (2016) 0.79
Worsening respiratory function in mechanically ventilated intensive care patients: feasibility and value of xenon-enhanced dual energy CT. Eur J Radiol (2012) 0.79
Increased carcinogenic potential of myeloid tumor cells induced by aberrant TGF-beta1-signaling and upregulation of cathepsin B. Biol Chem (2007) 0.78
The quest for the initial lesion in idiopathic pulmonary fibrosis: gene expression differences in IPF fibroblasts. Am J Respir Cell Mol Biol (2010) 0.78
The procoagulant effects of fine particulate matter in vivo. Part Fibre Toxicol (2011) 0.78
Dimethylarginine metabolism during acute and chronic rejection of rat renal allografts. Nephrol Dial Transplant (2010) 0.78
An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol (2017) 0.77
Ventilation imaging of the paranasal sinuses using xenon-enhanced dynamic single-energy CT and dual-energy CT: a feasibility study in a nasal cast. Eur Radiol (2012) 0.77
Transforming growth factor-alpha, a novel mediator of strain-induced vascular remodeling. Circ Res (2006) 0.77