PubRank

Susan Lindquist

Author PubWeight™ 259.73‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Hsp90 as a capacitor of phenotypic variation. Nature 2002 8.90
2 Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell 2007 8.84
3 Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science 2006 7.72
4 HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol 2010 7.16
5 Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011 6.56
6 A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell 2009 6.20
7 Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 2005 5.04
8 Increase in activity during calorie restriction requires Sirt1. Science 2005 4.90
9 Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science 2003 4.45
10 A neuronal isoform of the aplysia CPEB has prion-like properties. Cell 2003 4.16
11 Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science 2004 4.01
12 Prions as adaptive conduits of memory and inheritance. Nat Rev Genet 2005 3.97
13 Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet 2009 3.59
14 A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A 2008 3.46
15 Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell 2012 3.44
16 The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A 2007 3.39
17 A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast 2007 3.30
18 Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science 2013 3.15
19 Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet 2009 3.06
20 Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science 2002 3.05
21 HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell 2012 2.94
22 α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol 2010 2.93
23 Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature 2012 2.89
24 Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science 2013 2.79
25 Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science 2010 2.68
26 Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science 2011 2.66
27 A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A 2007 2.62
28 Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science 2013 2.61
29 Prion switching in response to environmental stress. PLoS Biol 2008 2.61
30 Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A 2006 2.59
31 Prion recognition elements govern nucleation, strain specificity and species barriers. Nature 2007 2.57
32 Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A 2009 2.35
33 Prions as protein-based genetic elements. Annu Rev Microbiol 2002 2.21
34 Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech 2009 2.16
35 Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell 2006 2.14
36 Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell 2006 2.09
37 High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A 2011 2.03
38 Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays 2004 2.02
39 Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci 2012 2.00
40 Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science 2002 1.99
41 The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A 2007 1.99
42 A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol 2011 1.95
43 Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A 2006 1.92
44 Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets 2009 1.91
45 Fitness trade-offs restrict the evolution of resistance to amphotericin B. PLoS Biol 2013 1.88
46 Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet 2010 1.88
47 Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci U S A 2008 1.88
48 HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci U S A 2008 1.87
49 Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science 2013 1.85
50 Widespread regulation of translation by elongation pausing in heat shock. Mol Cell 2013 1.85
51 A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci U S A 2006 1.85
52 Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science 2010 1.84
53 Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J 2008 1.82
54 Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev 2008 1.81
55 The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J 2011 1.80
56 Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nat Struct Mol Biol 2007 1.77
57 Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet 2006 1.77
58 Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci U S A 2006 1.76
59 Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A 2010 1.73
60 Prions, protein homeostasis, and phenotypic diversity. Trends Cell Biol 2010 1.63
61 Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A 2004 1.62
62 An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component. J Cell Biol 2012 1.60
63 Blessings in disguise: biological benefits of prion-like mechanisms. Trends Cell Biol 2013 1.56
64 Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell 2007 1.56
65 The prion protein knockout mouse: a phenotype under challenge. Prion 2007 1.51
66 Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Vis Exp 2008 1.50
67 Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell 2011 1.49
68 Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron 2009 1.49
69 Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nat Rev Neurosci 2010 1.46
70 Mechanisms of protein-folding diseases at a glance. Dis Model Mech 2014 1.45
71 HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci U S A 2008 1.45
72 Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A 2010 1.43
73 A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev 2009 1.43
74 Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods 2013 1.41
75 Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol 2003 1.41
76 Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels. PLoS One 2007 1.39
77 Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell 2013 1.38
78 Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J Clin Invest 2008 1.38
79 Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nat Struct Mol Biol 2009 1.35
80 Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nat Biotechnol 2013 1.33
81 Motor mechanism for protein threading through Hsp104. Mol Cell 2009 1.33
82 Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet 2013 1.32
83 Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol 2011 1.31
84 Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region. Mol Biol Cell 2004 1.29
85 ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data. Nucleic Acids Res 2011 1.28
86 Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. PLoS One 2008 1.26
87 Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest 2012 1.25
88 Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. J Neurosci 2009 1.24
89 Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A 2008 1.20
90 Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol 2009 1.19
91 Amyloid deposits: protection against toxic protein species? Cell Cycle 2009 1.18
92 Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci 2007 1.15
93 Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity 2008 1.14
94 Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers. Nat Commun 2012 1.12
95 Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs. Proc Natl Acad Sci U S A 2008 1.06
96 Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proc Natl Acad Sci U S A 2011 1.06
97 Conversion of a yeast prion protein to an infectious form in bacteria. Proc Natl Acad Sci U S A 2010 1.06
98 Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms. J Biol Chem 2011 1.04
99 Optical trapping with high forces reveals unexpected behaviors of prion fibrils. Nat Struct Mol Biol 2010 1.04
100 The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration. Exp Gerontol 2008 1.04
101 Prion formation by a yeast GLFG nucleoporin. Prion 2012 1.04
102 Conserved features of intermediates in amyloid assembly determine their benign or toxic states. Proc Natl Acad Sci U S A 2012 1.03
103 Prion pathogenesis is independent of caspase-12. Prion 2007 1.03
104 Biochemical, cell biological, and genetic assays to analyze amyloid and prion aggregation in yeast. Methods Enzymol 2010 1.02
105 A method for probing the mutational landscape of amyloid structure. Bioinformatics 2011 1.01
106 Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity. ACS Chem Biol 2012 0.98
107 Context dependent neuroprotective properties of prion protein (PrP). Prion 2009 0.95
108 Prion formation and polyglutamine aggregation are controlled by two classes of genes. PLoS Genet 2011 0.95
109 Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases. Proc Natl Acad Sci U S A 2013 0.94
110 The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. PLoS One 2009 0.94
111 Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions. J Biol Chem 2007 0.92
112 Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study. Hum Mol Genet 2011 0.91
113 Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures. Proc Natl Acad Sci U S A 2012 0.91
114 Structure-activity relationships for withanolides as inducers of the cellular heat-shock response. J Med Chem 2014 0.88
115 Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates. Bioorg Med Chem Lett 2011 0.87
116 Navigating the ClpB channel to solution. Nat Struct Mol Biol 2005 0.86
117 STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions. Proteins 2011 0.85
118 Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles. Bioorg Med Chem Lett 2012 0.85
119 Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity. Proc Natl Acad Sci U S A 2014 0.84
120 From yeast to patient neurons and back again: powerful new discovery platform. Mov Disord 2014 0.83
121 Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein. Neuroimage 2009 0.83
122 Using yeast to understand protein folding diseases: an interview with Susan Lindquist by Kristin Kain. Dis Model Mech 2008 0.83
123 A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin. J Cell Sci 2009 0.82
124 Hsp90 and chromatin: where is the link? Cell Cycle 2003 0.81
125 Evidence that alpha-synuclein does not inhibit phospholipase D. Biochemistry 2009 0.81
126 ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans. Beilstein J Org Chem 2013 0.81
127 Physical properties of polymorphic yeast prion amyloid fibers. Biophys J 2011 0.80
128 A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier. PLoS Genet 2011 0.80
129 Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease. Drug Discov Today Technol 2013 0.80
130 Illuminating aggregate heterogeneity in neurodegenerative disease. Nat Methods 2007 0.79
131 TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast. PLoS One 2011 0.77
132 Interview: Protein folding and studies of neurodegenerative diseases. J Vis Exp 2008 0.76
133 Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity. Proc Natl Acad Sci U S A 2014 0.76