Published in Nat Commun on January 01, 2012
PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes. Nature (2014) 1.82
Chemical biology strategies for posttranslational control of protein function. Chem Biol (2014) 1.07
Physiological and environmental control of yeast prions. FEMS Microbiol Rev (2013) 0.97
Asparagine repeats in Plasmodium falciparum proteins: good for nothing? PLoS Pathog (2013) 0.96
Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC Genomics (2013) 0.95
Dictyostelium discoideum has a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation. Proc Natl Acad Sci U S A (2015) 0.93
A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites. Nat Commun (2014) 0.92
Deconvoluting heme biosynthesis to target blood-stage malaria parasites. Elife (2015) 0.86
A Non-enveloped Virus Hijacks Host Disaggregation Machinery to Translocate across the Endoplasmic Reticulum Membrane. PLoS Pathog (2015) 0.85
Towards a comprehensive Plasmodium falciparum merozoite cell surface and secreted recombinant protein library. Malar J (2014) 0.83
Overexpression, Purification and Characterisation of the Plasmodium falciparum Hsp70-z (PfHsp70-z) Protein. PLoS One (2015) 0.80
Small molecule screen for candidate antimalarials targeting Plasmodium Kinesin-5. J Biol Chem (2014) 0.79
Plasmodium falciparum erythrocytic stage parasites require the putative autophagy protein PfAtg7 for normal growth. PLoS One (2013) 0.79
The Social Amoeba Dictyostelium discoideum Is Highly Resistant to Polyglutamine Aggregation. J Biol Chem (2015) 0.78
Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony. Nat Microbiol (2017) 0.77
Aminoacylation of Plasmodium falciparum tRNA(Asn) and insights in the synthesis of asparagine repeats. J Biol Chem (2013) 0.77
Plasmodial HSP70s are functionally adapted to the malaria parasite life cycle. Front Mol Biosci (2015) 0.76
Possible roles of amyloids in malaria pathophysiology. Future Sci OA (2015) 0.75
1. In Vitro and In Vivo Activity of Sulfur-Containing Linear Bisphosphonates against Apicomplexan Parasites. Antimicrob Agents Chemother (2016) 0.75
Evidence that the Malaria Parasite Plasmodium falciparum Putative Rhoptry Protein 2 Localizes to the Golgi Apparatus throughout the Erythrocytic Cycle. PLoS One (2015) 0.75
Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Phenotypic Screens Identify Parasite Genetic Factors Associated with Malarial Fever Response in Plasmodium falciparum piggyBac Mutants. mSphere (2016) 0.75
Plasmodium falciparum Hsp70-z, an Hsp110 homologue, exhibits independent chaperone activity and interacts with Hsp70-1 in a nucleotide-dependent fashion. Cell Stress Chaperones (2016) 0.75
Investigating the Roles of the C-Terminal Domain of Plasmodium falciparum GyrA. PLoS One (2015) 0.75
Expansion of Lysine-rich Repeats in Plasmodium Proteins Generates Novel Localization Sequences That Target the Periphery of the Host Erythrocyte. J Biol Chem (2016) 0.75
The Exported Chaperone PfHsp70x Is Dispensable for the Plasmodium falciparum Intraerythrocytic Life Cycle. mSphere (2017) 0.75
Hsp90 as a capacitor for morphological evolution. Nature (1998) 13.60
[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. Science (1994) 10.94
Molecular chaperones in protein folding and proteostasis. Nature (2011) 8.63
Improving the photostability of bright monomeric orange and red fluorescent proteins. Nat Methods (2008) 8.41
Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science (1996) 7.24
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20
MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell (2011) 5.91
A critical role for amino-terminal glutamine/asparagine repeats in the formation and propagation of a yeast prion. Cell (1998) 4.25
Amyloid-like aggregates sequester numerous metastable proteins with essential cellular functions. Cell (2011) 3.98
Yeast [PSI+] prion aggregates are formed by small Sup35 polymers fragmented by Hsp104. J Biol Chem (2003) 3.53
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (2010) 3.27
Amyloid-binding compounds maintain protein homeostasis during ageing and extend lifespan. Nature (2011) 3.20
An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods (2007) 3.01
Plasmodium biology: genomic gleanings. Cell (2003) 2.89
Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding. Cell (2008) 2.80
Negative selection of Plasmodium falciparum reveals targeted gene deletion by double crossover recombination. Int J Parasitol (2002) 2.70
Aplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation. Cell (2010) 2.65
Molecular chaperones of the Hsp110 family act as nucleotide exchange factors of Hsp70s. EMBO J (2006) 2.58
Chaperone network in the yeast cytosol: Hsp110 is revealed as an Hsp70 nucleotide exchange factor. EMBO J (2006) 2.45
Insights into Hsp70 chaperone activity from a crystal structure of the yeast Hsp110 Sse1. Cell (2007) 2.36
Chaperones in control of protein disaggregation. EMBO J (2008) 2.01
Structure of the Hsp110:Hsc70 nucleotide exchange machine. Mol Cell (2008) 1.96
Plasticity in chromosome number and testing of essential genes in Leishmania by targeting. Proc Natl Acad Sci U S A (1993) 1.88
The role of Plasmodium falciparum food vacuole plasmepsins. J Biol Chem (2004) 1.75
Physical limits of cells and proteomes. Proc Natl Acad Sci U S A (2011) 1.71
Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum. J Cell Biol (2004) 1.69
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A (2009) 1.62
The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase. Nat Chem Biol (2010) 1.59
Binding mode of Thioflavin T and other molecular probes in the context of amyloid fibrils-current status. J Chem Biol (2009) 1.55
Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Vis Exp (2008) 1.50
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49
Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci U S A (2011) 1.46
Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem (2008) 1.43
Hyper-expansion of asparagines correlates with an abundance of proteins with prion-like domains in Plasmodium falciparum. Mol Biochem Parasitol (2004) 1.39
A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila. Genetics (2010) 1.32
Yeast dihydroorotate dehydrogenase as a new selectable marker for Plasmodium falciparum transfection. Mol Biochem Parasitol (2011) 1.24
Fatty acid acylation regulates trafficking of the unusual Plasmodium falciparum calpain to the nucleolus. Mol Microbiol (2009) 1.23
Low-complexity regions in Plasmodium falciparum: missing links in the evolution of an extreme genome. Mol Biol Evol (2010) 1.23
Mechanisms of the Hsp70 chaperone system. Biochem Cell Biol (2010) 1.23
Protein folding and aggregation in bacteria. Cell Mol Life Sci (2010) 1.10
Plasmodium protein phosphatase 2C dephosphorylates translation elongation factor 1beta and inhibits its PKC-mediated nucleotide exchange activity in vitro. Mol Microbiol (2001) 1.08
Protein aggregation and polyasparagine-mediated cellular toxicity in Saccharomyces cerevisiae. Prion (2007) 0.95
The yeast Hsp110, Sse1p, exhibits high-affinity peptide binding. FEBS Lett (2008) 0.95
Interaction of the Hsp110 molecular chaperones from S. cerevisiae with substrate protein. J Mol Biol (2010) 0.94
Hsp90 as a capacitor of phenotypic variation. Nature (2002) 8.90
Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84
Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72
HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56
A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20
Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science (2005) 5.04
Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90
Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (2003) 4.45
A neuronal isoform of the aplysia CPEB has prion-like properties. Cell (2003) 4.16
Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science (2004) 4.01
Prions as adaptive conduits of memory and inheritance. Nat Rev Genet (2005) 3.97
Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet (2009) 3.59
A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A (2008) 3.46
Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell (2012) 3.44
The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39
A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (2007) 3.30
Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science (2013) 3.15
Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet (2009) 3.06
Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science (2002) 3.05
An FKBP destabilization domain modulates protein levels in Plasmodium falciparum. Nat Methods (2007) 3.01
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94
α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol (2010) 2.93
Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature (2012) 2.89
Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79
Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science (2010) 2.68
Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66
A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A (2007) 2.62
Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61
Prion switching in response to environmental stress. PLoS Biol (2008) 2.61
Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A (2006) 2.59
Prion recognition elements govern nucleation, strain specificity and species barriers. Nature (2007) 2.57
Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems. Proc Natl Acad Sci U S A (2006) 2.43
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A (2009) 2.35
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine. Proc Natl Acad Sci U S A (2002) 2.24
Prions as protein-based genetic elements. Annu Rev Microbiol (2002) 2.21
Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16
Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell (2006) 2.14
Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell (2006) 2.09
High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A (2011) 2.03
Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays (2004) 2.02
Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother (2005) 2.00
Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00
Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science (2002) 1.99
The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A (2007) 1.99
Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature (2010) 1.97
A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A (2006) 1.92
Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets (2009) 1.91
Fitness trade-offs restrict the evolution of resistance to amphotericin B. PLoS Biol (2013) 1.88
Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet (2010) 1.88
Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci U S A (2008) 1.88
HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci U S A (2008) 1.87
Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85
Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85
A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci U S A (2006) 1.85
Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science (2010) 1.84
Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J (2008) 1.82
Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev (2008) 1.81
The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80
Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nat Struct Mol Biol (2007) 1.77
Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet (2006) 1.77
Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci U S A (2006) 1.76
The role of Plasmodium falciparum food vacuole plasmepsins. J Biol Chem (2004) 1.75
Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A (2010) 1.73
A role for falcilysin in transit peptide degradation in the Plasmodium falciparum apicoplast. Mol Microbiol (2006) 1.71
Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum. J Cell Biol (2004) 1.69
Biological roles of proteases in parasitic protozoa. Annu Rev Biochem (2001) 1.66
Prions, protein homeostasis, and phenotypic diversity. Trends Cell Biol (2010) 1.63
A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradation. J Biol Chem (2004) 1.63
Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A (2004) 1.62
A calpain unique to alveolates is essential in Plasmodium falciparum and its knockdown reveals an involvement in pre-S-phase development. Proc Natl Acad Sci U S A (2009) 1.62
An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component. J Cell Biol (2012) 1.60
Valganciclovir therapy for immune recovery uveitis complicated by macular edema. Am J Ophthalmol (2004) 1.57
Blessings in disguise: biological benefits of prion-like mechanisms. Trends Cell Biol (2013) 1.56
Results of silicone oil removal in patients with cytomegalovirus retinitis related retinal detachments. Am J Ophthalmol (2005) 1.56
Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell (2007) 1.56
The prion protein knockout mouse: a phenotype under challenge. Prion (2007) 1.51
Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Vis Exp (2008) 1.50
Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49
Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron (2009) 1.49
Characterization of plasmepsin V, a membrane-bound aspartic protease homolog in the endoplasmic reticulum of Plasmodium falciparum. Mol Biochem Parasitol (2005) 1.48
Validation of isoleucine utilization targets in Plasmodium falciparum. Proc Natl Acad Sci U S A (2011) 1.46
Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag. Proc Natl Acad Sci U S A (2011) 1.46
Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nat Rev Neurosci (2010) 1.46
Mechanisms of protein-folding diseases at a glance. Dis Model Mech (2014) 1.45
HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.45
Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A (2010) 1.43
A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev (2009) 1.43
Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem (2008) 1.43
Interference with heme binding to histidine-rich protein-2 as an antimalarial strategy. Chem Biol (2002) 1.42
Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods (2013) 1.41
Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol (2003) 1.41
Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels. PLoS One (2007) 1.39
Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell (2013) 1.38
Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J Clin Invest (2008) 1.38
Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nat Struct Mol Biol (2009) 1.35