Prions, protein homeostasis, and phenotypic diversity.

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease. Brain Res (2012) 3.00

The amyloid state and its association with protein misfolding diseases. Nat Rev Mol Cell Biol (2014) 2.99

Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature (2012) 2.89

Aneuploidy causes proteotoxic stress in yeast. Genes Dev (2012) 1.66

Fitness landscape transformation through a single amino acid change in the rho terminator. PLoS Genet (2012) 1.59

A novel single-cell screening platform reveals proteome plasticity during yeast stress responses. J Cell Biol (2013) 1.56

Transmissible proteins: expanding the prion heresy. Cell (2012) 1.49

Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A (2010) 1.43

Prion hypothesis: the end of the controversy? Trends Biochem Sci (2010) 1.40

Implications of the prion-related Q/N domains in TDP-43 and FUS. Prion (2011) 1.25

A size threshold limits prion transmission and establishes phenotypic diversity. Science (2010) 1.18

High-resolution structure of infectious prion protein: the final frontier. Nat Struct Mol Biol (2012) 1.09

TDP-43: the relationship between protein aggregation and neurodegeneration in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. FEBS J (2011) 1.09

High natural prevalence of a fungal prion. Proc Natl Acad Sci U S A (2012) 1.09

Cellular strategies for regulating functional and nonfunctional protein aggregation. Cell Rep (2012) 1.08

Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease. Brain Res (2016) 1.08

Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB). Proc Natl Acad Sci U S A (2011) 1.06

Emergence and natural selection of drug-resistant prions. Mol Biosyst (2010) 1.05

An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists. Cell (2014) 1.04

Genomic clustering and homology between HET-S and the NWD2 STAND protein in various fungal genomes. PLoS One (2012) 1.03

[SWI], the prion formed by the chromatin remodeling factor Swi1, is highly sensitive to alterations in Hsp70 chaperone system activity. PLoS Genet (2011) 1.03

Does the central dogma still stand? Biol Direct (2012) 1.02

Prokaryotic chaperones support yeast prions and thermotolerance and define disaggregation machinery interactions. Genetics (2012) 0.99

Prion-like nuclear aggregation of TDP-43 during heat shock is regulated by HSP40/70 chaperones. Hum Mol Genet (2013) 0.99

Yeast prions: structure, biology, and prion-handling systems. Microbiol Mol Biol Rev (2015) 0.98

Engineering enhanced protein disaggregases for neurodegenerative disease. Prion (2015) 0.96

Hsp104 drives "protein-only" positive selection of Sup35 prion strains encoding strong [PSI(+)]. Chem Biol (2012) 0.95

Discovering putative prion sequences in complete proteomes using probabilistic representations of Q/N-rich domains. BMC Genomics (2013) 0.95

Sex, prions, and plasmids in yeast. Proc Natl Acad Sci U S A (2012) 0.94

Dictyostelium discoideum has a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation. Proc Natl Acad Sci U S A (2015) 0.93

Luminidependens (LD) is an Arabidopsis protein with prion behavior. Proc Natl Acad Sci U S A (2016) 0.90

The sensitive [SWI (+)] prion: new perspectives on yeast prion diversity. Prion (2011) 0.87

Mitochondrion-mediated cell death: dissecting yeast apoptosis for a better understanding of neurodegeneration. Front Oncol (2012) 0.85

Paramutation: just a curiosity or fine tuning of gene expression in the next generation? Curr Genomics (2011) 0.85

Yeast prions assembly and propagation: contributions of the prion and non-prion moieties and the nature of assemblies. Prion (2011) 0.84

Amyloid-associated activity contributes to the severity and toxicity of a prion phenotype. Nat Commun (2014) 0.83

Extracellular environment modulates the formation and propagation of particular amyloid structures. Mol Microbiol (2014) 0.82

Non-genetic individuality in Escherichia coli motor switching. Phys Biol (2011) 0.82

Potential roles for prions and protein-only inheritance in cancer. Cancer Metastasis Rev (2012) 0.82

RNA-binding proteins with prion-like domains in health and disease. Biochem J (2017) 0.81

The [Het-s] prion, an amyloid fold as a cell death activation trigger. PLoS Pathog (2012) 0.81

Defining the limits: Protein aggregation and toxicity in vivo. Crit Rev Biochem Mol Biol (2014) 0.81

Wild yeast harbour a variety of distinct amyloid structures with strong prion-inducing capabilities. Mol Microbiol (2014) 0.81

Purification of hsp104, a protein disaggregase. J Vis Exp (2011) 0.81

Conformational analysis of misfolded protein aggregation by FRET and live-cell imaging techniques. Int J Mol Sci (2015) 0.80

Pernicious pathogens or expedient elements of inheritance: the significance of yeast prions. PLoS Pathog (2014) 0.80

Nucleobindin 1 caps human islet amyloid polypeptide protofibrils to prevent amyloid fibril formation. J Mol Biol (2012) 0.79

Disparate Mutations Confer Therapeutic Gain of Hsp104 Function. ACS Chem Biol (2015) 0.79

Use of yeast as a system to study amyloid toxicity. Methods (2010) 0.79

Patterns of [PSI (+) ] aggregation allow insights into cellular organization of yeast prion aggregates. Prion (2012) 0.78

The copper transport-associated protein Ctr4 can form prion-like epigenetic determinants in Schizosaccharomyces pombe. Microb Cell (2017) 0.78

More than just trash bins? Potential roles for extracellular vesicles in the vertical and horizontal transmission of yeast prions. Curr Genet (2015) 0.76

The heat shock response is modulated by and interferes with toxic effects of scrapie prion protein and amyloid β. J Biol Chem (2012) 0.75

Disentangling genetic and epigenetic determinants of ultrafast adaptation. Mol Syst Biol (2016) 0.75

Prion-like characteristics of the bacterial protein Microcin E492. Sci Rep (2017) 0.75

Epigenetic inheritance, prions and evolution. J Genet (2017) 0.75

A prolonged chronological lifespan is an unexpected benefit of the [PSI+] prion in yeast. PLoS One (2017) 0.75

Protein misfolding, functional amyloid, and human disease. Annu Rev Biochem (2006) 22.87

Adapting proteostasis for disease intervention. Science (2008) 13.22

[URE3] as an altered URE2 protein: evidence for a prion analog in Saccharomyces cerevisiae. Science (1994) 10.94

Phenotypic diversity, population growth, and information in fluctuating environments. Science (2005) 8.21

Support for the prion hypothesis for inheritance of a phenotypic trait in yeast. Science (1996) 7.24

A yeast prion provides a mechanism for genetic variation and phenotypic diversity. Nature (2000) 6.65

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev (2008) 6.18

Nucleated conformational conversion and the replication of conformational information by a prion determinant. Science (2000) 6.16

Flexible nets. The roles of intrinsic disorder in protein interaction networks. FEBS J (2005) 5.36

Self-seeded fibers formed by Sup35, the protein determinant of [PSI+], a heritable prion-like factor of S. cerevisiae. Cell (1997) 5.24

The physical basis of how prion conformations determine strain phenotypes. Nature (2006) 4.77

Rnq1: an epigenetic modifier of protein function in yeast. Mol Cell (2000) 4.62

Diverse RNA-binding proteins interact with functionally related sets of RNAs, suggesting an extensive regulatory system. PLoS Biol (2008) 4.34

A neuronal isoform of the aplysia CPEB has prion-like properties. Cell (2003) 4.16

Prions as adaptive conduits of memory and inheritance. Nat Rev Genet (2005) 3.97

Experimental evolution of bet hedging. Nature (2009) 3.92

The protein product of the het-s heterokaryon incompatibility gene of the fungus Podospora anserina behaves as a prion analog. Proc Natl Acad Sci U S A (1997) 3.85

FLO1 is a variable green beard gene that drives biofilm-like cooperation in budding yeast. Cell (2008) 3.76

Epigenetics for ecologists. Ecol Lett (2007) 3.48

Multiple Gln/Asn-rich prion domains confer susceptibility to induction of the yeast [PSI(+)] prion. Cell (2001) 3.29

Molecular basis of a yeast prion species barrier. Cell (2000) 3.27

The prion's elusive reason for being. Annu Rev Neurosci (2008) 3.23

Microbial cell individuality and the underlying sources of heterogeneity. Nat Rev Microbiol (2006) 3.18

Is genetic evolution predictable? Science (2009) 3.10

Bacterial persistence: a model of survival in changing environments. Genetics (2005) 2.97

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits. Nature (2004) 2.87

Polymorphism in the intermediates and products of amyloid assembly. Curr Opin Struct Biol (2007) 2.75

Prion switching in response to environmental stress. PLoS Biol (2008) 2.61

Yeast prions [URE3] and [PSI+] are diseases. Proc Natl Acad Sci U S A (2005) 2.45

Is evolvability evolvable? Nat Rev Genet (2008) 2.45

Oligopeptide-repeat expansions modulate 'protein-only' inheritance in yeast. Nature (1999) 2.43

Newly identified prion linked to the chromatin-remodeling factor Swi1 in Saccharomyces cerevisiae. Nat Genet (2008) 2.43

Interactions among prions and prion "strains" in yeast. Proc Natl Acad Sci U S A (2002) 2.42

Prion generation in vitro: amyloid of Ure2p is infectious. EMBO J (2005) 2.42

Prions of fungi: inherited structures and biological roles. Nat Rev Microbiol (2007) 2.38

Robustness: mechanisms and consequences. Trends Genet (2009) 2.27

Dependence and independence of [PSI(+)] and [PIN(+)]: a two-prion system in yeast? EMBO J (2000) 2.23

Evolutionary conservation of prion-forming abilities of the yeast Sup35 protein. Mol Microbiol (2000) 2.23

Antagonistic interactions between yeast [PSI(+)] and [URE3] prions and curing of [URE3] by Hsp70 protein chaperone Ssa1p but not by Ssa2p. Mol Cell Biol (2002) 2.19

Translation termination efficiency can be regulated in Saccharomyces cerevisiae by environmental stress through a prion-mediated mechanism. EMBO J (1999) 2.14

Extrachromosomal psi+ determinant suppresses nonsense mutations in yeast. J Bacteriol (1979) 2.13

Epigenetic control of polyamines by the prion [PSI+]. Nat Cell Biol (2008) 1.99

Prion properties of the Sup35 protein of yeast Pichia methanolica. EMBO J (2000) 1.94

Analysis of the generation and segregation of propagons: entities that propagate the [PSI+] prion in yeast. Genetics (2003) 1.91

The yeast global transcriptional co-repressor protein Cyc8 can propagate as a prion. Nat Cell Biol (2009) 1.87

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J (2008) 1.82

Yeast [PSI+] "prions" that are crosstransmissible and susceptible beyond a species barrier through a quasi-prion state. Mol Cell (2001) 1.70

A method to assess compositional bias in biological sequences and its application to prion-like glutamine/asparagine-rich domains in eukaryotic proteomes. Genome Biol (2003) 1.61

Reciprocal regulation of anaerobic and aerobic cell wall mannoprotein gene expression in Saccharomyces cerevisiae. J Bacteriol (2001) 1.57

A non-Q/N-rich prion domain of a foreign prion, [Het-s], can propagate as a prion in yeast. Mol Cell (2007) 1.43

The evolution of bet-hedging adaptations to rare scenarios. Theor Popul Biol (2007) 1.43

A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev (2009) 1.43

Appearance and propagation of polyglutamine-based amyloids in yeast: tyrosine residues enable polymer fragmentation. J Biol Chem (2008) 1.38

Stress and prions: lessons from the yeast model. FEBS Lett (2007) 1.38

Prion protein remodelling confers an immediate phenotypic switch. Nature (2005) 1.37

Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae. Genetics (1998) 1.36

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nat Struct Mol Biol (2009) 1.35

Reversion from suppression to nonsuppression in SUQ5 [psi+] strains of yeast: the classificaion of mutations. Genetics (1980) 1.35

Promoter-dependent roles for the Srb10 cyclin-dependent kinase and the Hda1 deacetylase in Tup1-mediated repression in Saccharomyces cerevisiae. Mol Biol Cell (2004) 1.34

The spontaneous appearance rate of the yeast prion [PSI+] and its implications for the evolution of the evolvability properties of the [PSI+] system. Genetics (2009) 1.31

Prion protein repeat expansion results in increased aggregation and reveals phenotypic variability. Mol Cell Biol (2007) 1.31

Retracted A prion of yeast metacaspase homolog (Mca1p) detected by a genetic screen. Proc Natl Acad Sci U S A (2009) 1.25

The conversion of 3' UTRs into coding regions. Mol Biol Evol (2006) 1.24

The yeast prion [URE3] can be greatly induced by a functional mutated URE2 allele. EMBO J (2000) 1.21

Complex adaptations can drive the evolution of the capacitor [PSI], even with realistic rates of yeast sex. PLoS Genet (2009) 1.15

Genetic and epigenetic mechanisms underlying cell-surface variability in protozoa and fungi. Annu Rev Genet (2009) 1.12

Prion variants and species barriers among Saccharomyces Ure2 proteins. Genetics (2009) 1.10

Genetic interactions between [PSI+] and nonstop mRNA decay affect phenotypic variation. Proc Natl Acad Sci U S A (2005) 1.09

Amyloid-a state in many guises: survival of the fittest fibril fold. Protein Sci (2007) 1.06

The [PSI+] prion of Saccharomyces cerevisiae can be propagated by an Hsp104 orthologue from Candida albicans. Eukaryot Cell (2006) 1.03

Prion proteostasis: Hsp104 meets its supporting cast. Prion (2008) 1.02

Novel non-Mendelian determinant involved in the control of translation accuracy in Saccharomyces cerevisiae. Genetics (2002) 1.01

Ssa1 overexpression and [PIN(+)] variants cure [PSI(+)] by dilution of aggregates. J Mol Biol (2009) 0.95

The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion. PLoS One (2009) 0.94

Reporter assay systems for [URE3] detection and analysis. Methods (2006) 0.92

Yeast prions: evolution of the prion concept. Prion (2007) 0.89

Nitrogen source and the retrograde signalling pathway affect detection, not generation, of the [URE3] prion. Yeast (2006) 0.77

Hsp90 as a capacitor of phenotypic variation. Nature (2002) 8.90

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis. Cell (2007) 8.84

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models. Science (2006) 7.72

HSP90 at the hub of protein homeostasis: emerging mechanistic insights. Nat Rev Mol Cell Biol (2010) 7.16

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell (2011) 6.56

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins. Cell (2009) 6.20

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science (2005) 5.04

Increase in activity during calorie restriction requires Sirt1. Science (2005) 4.90

Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (2003) 4.45

A neuronal isoform of the aplysia CPEB has prion-like properties. Cell (2003) 4.16

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers. Science (2004) 4.01

Prions as adaptive conduits of memory and inheritance. Nat Rev Genet (2005) 3.97

Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity. Nat Genet (2009) 3.59

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity. Proc Natl Acad Sci U S A (2008) 3.46

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. Cell (2012) 3.44

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis. Proc Natl Acad Sci U S A (2007) 3.39

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae. Yeast (2007) 3.30

Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish. Science (2013) 3.15

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity. Nat Genet (2009) 3.06

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol. Science (2002) 3.05

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers. Cell (2012) 2.94

α-Synuclein: membrane interactions and toxicity in Parkinson's disease. Annu Rev Cell Dev Biol (2010) 2.93

Prions are a common mechanism for phenotypic inheritance in wild yeasts. Nature (2012) 2.89

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state. Science (2013) 2.79

Hsp90 and environmental stress transform the adaptive value of natural genetic variation. Science (2010) 2.68

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast. Science (2011) 2.66

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures. Proc Natl Acad Sci U S A (2007) 2.62

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons. Science (2013) 2.61

A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis. Nature (2013) 2.61

Prion switching in response to environmental stress. PLoS Biol (2008) 2.61

Flanking sequences profoundly alter polyglutamine toxicity in yeast. Proc Natl Acad Sci U S A (2006) 2.59

Prion recognition elements govern nucleation, strain specificity and species barriers. Nature (2007) 2.57

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc Natl Acad Sci U S A (2009) 2.35

Prions as protein-based genetic elements. Annu Rev Microbiol (2002) 2.21

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Dis Model Mech (2009) 2.16

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities. Mol Cell (2006) 2.14

Genetic architecture of Hsp90-dependent drug resistance. Eukaryot Cell (2006) 2.09

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer. Proc Natl Acad Sci U S A (2011) 2.03

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance. Bioessays (2004) 2.02

Retracted SIRT1 protects against α-synuclein aggregation by activating molecular chaperones. J Neurosci (2012) 2.00

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol. Science (2002) 1.99

The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases. Proc Natl Acad Sci U S A (2007) 1.99

A yeast model of FUS/TLS-dependent cytotoxicity. PLoS Biol (2011) 1.95

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal. Proc Natl Acad Sci U S A (2006) 1.92

Inhibiting the transcription factor HSF1 as an anticancer strategy. Expert Opin Ther Targets (2009) 1.91

Fitness trade-offs restrict the evolution of resistance to amphotericin B. PLoS Biol (2013) 1.88

Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms. Annu Rev Genet (2010) 1.88

Chaperone-dependent amyloid assembly protects cells from prion toxicity. Proc Natl Acad Sci U S A (2008) 1.88

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits. Proc Natl Acad Sci U S A (2008) 1.87

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science (2013) 1.85

Widespread regulation of translation by elongation pausing in heat shock. Mol Cell (2013) 1.85

A network of protein interactions determines polyglutamine toxicity. Proc Natl Acad Sci U S A (2006) 1.85

Epigenetics in the extreme: prions and the inheritance of environmentally acquired traits. Science (2010) 1.84

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions. EMBO J (2008) 1.82

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity. Genes Dev (2008) 1.81

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication. EMBO J (2011) 1.80

Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity. Nat Struct Mol Biol (2007) 1.77

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum Mol Genet (2006) 1.77

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis. Proc Natl Acad Sci U S A (2006) 1.76

Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A (2010) 1.73

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody. Proc Natl Acad Sci U S A (2004) 1.62

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component. J Cell Biol (2012) 1.60

Blessings in disguise: biological benefits of prion-like mechanisms. Trends Cell Biol (2013) 1.56

Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104. Cell (2007) 1.56

Cooperation of molecular chaperones with the ubiquitin/proteasome system. Biochim Biophys Acta (2004) 1.53

BAG-2 acts as an inhibitor of the chaperone-associated ubiquitin ligase CHIP. Mol Biol Cell (2005) 1.52

The prion protein knockout mouse: a phenotype under challenge. Prion (2007) 1.51

Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis. J Vis Exp (2008) 1.50

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice. Neuron (2009) 1.49

Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins. Mol Cell (2011) 1.49

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast? Nat Rev Neurosci (2010) 1.46

Mechanisms of protein-folding diseases at a glance. Dis Model Mech (2014) 1.45

HSP90-buffered genetic variation is common in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2008) 1.45

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation. Proc Natl Acad Sci U S A (2010) 1.43

A heritable switch in carbon source utilization driven by an unusual yeast prion. Genes Dev (2009) 1.43

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition. Nat Methods (2013) 1.41

Prion protein gene polymorphisms in Saccharomyces cerevisiae. Mol Microbiol (2003) 1.41

Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels. PLoS One (2007) 1.39

Heritable remodeling of yeast multicellularity by an environmentally responsive prion. Cell (2013) 1.38

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease. J Clin Invest (2008) 1.38

Protein disorder, prion propensities, and self-organizing macromolecular collectives. Biochim Biophys Acta (2013) 1.36

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+]. Nat Struct Mol Biol (2009) 1.35

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells. Nat Biotechnol (2013) 1.33

Motor mechanism for protein threading through Hsp104. Mol Cell (2009) 1.33

Transgenerational epigenetic inheritance: how important is it? Nat Rev Genet (2013) 1.32

Using the heat-shock response to discover anticancer compounds that target protein homeostasis. ACS Chem Biol (2011) 1.31

Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates. Mol Biol Cell (2012) 1.29

Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region. Mol Biol Cell (2004) 1.29

ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data. Nucleic Acids Res (2011) 1.28

Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities. PLoS One (2008) 1.26

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis. J Clin Invest (2012) 1.25

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. J Neurosci (2009) 1.24

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease. Proc Natl Acad Sci U S A (2008) 1.20

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models. Nat Chem Biol (2009) 1.19

Amyloid deposits: protection against toxic protein species? Cell Cycle (2009) 1.18

Filament formation by metabolic enzymes is a specific adaptation to an advanced state of cellular starvation. Elife (2014) 1.17

Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo. J Neurosci (2007) 1.15

Lymphotoxin-dependent prion replication in inflammatory stromal cells of granulomas. Immunity (2008) 1.14

Identification of VCP/p97, carboxyl terminus of Hsp70-interacting protein (CHIP), and amphiphysin II interaction partners using membrane-based human proteome arrays. Mol Cell Proteomics (2005) 1.13