Published in Proc Biol Sci on April 08, 2009
Origins and evolution of antibiotic resistance. Microbiol Mol Biol Rev (2010) 7.35
Challenges of antibacterial discovery. Clin Microbiol Rev (2011) 3.94
In-feed antibiotic effects on the swine intestinal microbiome. Proc Natl Acad Sci U S A (2012) 2.50
Applying insights from biofilm biology to drug development - can a new approach be developed? Nat Rev Drug Discov (2013) 1.82
Extended-Spectrum Beta-Lactamases Producing E. coli in Wildlife, yet Another Form of Environmental Pollution? Front Microbiol (2011) 1.78
The population genetics of antibiotic resistance: integrating molecular mechanisms and treatment contexts. Nat Rev Genet (2010) 1.58
Integron involvement in environmental spread of antibiotic resistance. Front Microbiol (2012) 1.52
What traits are carried on mobile genetic elements, and why? Heredity (Edinb) (2010) 1.49
Management options for reducing the release of antibiotics and antibiotic resistance genes to the environment. Environ Health Perspect (2013) 1.42
The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions. PLoS Genet (2010) 1.36
Transcriptional and antagonistic responses of Pseudomonas fluorescens Pf0-1 to phylogenetically different bacterial competitors. ISME J (2011) 1.27
Evolutionary consequences of antibiotic use for the resistome, mobilome and microbial pangenome. Front Microbiol (2013) 1.17
Resources and biological activities of natural polyphenols. Nutrients (2014) 1.17
RND multidrug efflux pumps: what are they good for? Front Microbiol (2013) 1.11
High levels of antimicrobial resistance among escherichia coli isolates from livestock farms and synanthropic rats and shrews in the Mekong Delta of Vietnam. Appl Environ Microbiol (2014) 1.10
Antimicrobial resistance, virulence factors and genetic diversity of Escherichia coli isolates from household water supply in Dhaka, Bangladesh. PLoS One (2013) 1.09
Concentration-dependent activity of antibiotics in natural environments. Front Microbiol (2013) 1.06
Resistance to broad-spectrum antibiotics in aquatic systems: anthropogenic activities modulate the dissemination of bla(CTX-M)-like genes. Appl Environ Microbiol (2012) 1.06
Geographical variation in antibiotic-resistant Escherichia coli isolates from stool, cow-dung and drinking water. Int J Environ Res Public Health (2012) 1.04
Antibiotic resistance patterns in Escherichia coli from gulls in nine European countries. Infect Ecol Epidemiol (2014) 1.00
Transcriptome profiling defines a novel regulon modulated by the LysR-type transcriptional regulator MexT in Pseudomonas aeruginosa. Nucleic Acids Res (2009) 0.99
Metagenomic frameworks for monitoring antibiotic resistance in aquatic environments. Environ Health Perspect (2013) 0.95
Wastewater as a point source of antibiotic-resistance genes in the sediment of a freshwater lake. ISME J (2014) 0.95
Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world. Front Microbiol (2013) 0.93
Coastal seawater bacteria harbor a large reservoir of plasmid-mediated quinolone resistance determinants in Jiaozhou Bay, China. Microb Ecol (2012) 0.90
Megacities as sources for pathogenic bacteria in rivers and their fate downstream. Int J Microbiol (2010) 0.90
Initial efforts toward the optimization of arylomycins for antibiotic activity. J Med Chem (2011) 0.90
Emergence and spread of antibiotic resistance: setting a parameter space. Ups J Med Sci (2014) 0.90
Tracking pathogen transmission at the human-wildlife interface: banded mongoose and Escherichia coli. Ecohealth (2013) 0.90
Interconnected microbiomes and resistomes in low-income human habitats. Nature (2016) 0.89
Wide variation in antibiotic resistance proteins identified by functional metagenomic screening of a soil DNA library. Appl Environ Microbiol (2012) 0.88
Detection and diversity evaluation of tetracycline resistance genes in grassland-based production systems in Colombia, South america. Front Microbiol (2011) 0.88
Metagenomic profiling of microbial composition and antibiotic resistance determinants in Puget Sound. PLoS One (2012) 0.88
Synthesis and characterization of the arylomycin lipoglycopeptide antibiotics and the crystallographic analysis of their complex with signal peptidase. J Am Chem Soc (2011) 0.88
Antibiotic resistance is the quintessential One Health issue. Trans R Soc Trop Med Hyg (2016) 0.88
Presence of multi-drug resistant pathogenic Escherichia coli in the San Pedro River located in the State of Aguascalientes, Mexico. Front Microbiol (2013) 0.87
Strain-specific transfer of antibiotic resistance from an environmental plasmid to foodborne pathogens. J Biomed Biotechnol (2012) 0.87
Environmental dissemination of antibiotic resistance genes and correlation to anthropogenic contamination with antibiotics. Infect Ecol Epidemiol (2015) 0.85
Lytic phages obscure the cost of antibiotic resistance in Escherichia coli. ISME J (2015) 0.84
Wastewater irrigation increases the abundance of potentially harmful gammaproteobacteria in soils in Mezquital Valley, Mexico. Appl Environ Microbiol (2014) 0.84
Putative connection between zoonotic multiresistant extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in dog feces from a veterinary campus and clinical isolates from dogs. Infect Ecol Epidemiol (2015) 0.83
Antimony resistance and environment: Elusive links to explore during Leishmania life cycle. Int J Parasitol Drugs Drug Resist (2012) 0.83
Reciprocal regulation of resistance-nodulation-division efflux systems and the Cpx two-component system in Vibrio cholerae. Infect Immun (2014) 0.82
Antibiotics in the environment. Ups J Med Sci (2014) 0.82
Synthesis and biological characterization of arylomycin B antibiotics. J Nat Prod (2011) 0.82
Changes in multidrug resistance of enteric bacteria following an intervention to reduce antimicrobial resistance in dairy calves. J Clin Microbiol (2009) 0.80
Chlorinated phenols control the expression of the multidrug resistance efflux pump MexAB-OprM in Pseudomonas aeruginosa by interacting with NalC. Mol Microbiol (2011) 0.80
The importance of growth kinetic analysis in determining bacterial susceptibility against antibiotics and silver nanoparticles. Front Microbiol (2014) 0.79
Substrate-dependent activation of the Vibrio cholerae vexAB RND efflux system requires vexR. PLoS One (2015) 0.79
Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants. Microorganisms (2016) 0.79
Diversity of SCCmec elements in Staphylococci isolated from public washrooms. BMC Microbiol (2015) 0.79
Role of wild birds as carriers of multi-drug resistant Escherichia coli and Escherichia vulneris. Braz J Microbiol (2015) 0.78
Impact of treated wastewater irrigation on antibiotic resistance in the soil microbiome. Environ Sci Pollut Res Int (2013) 0.78
Recovery of plasmid pEMB1, whose toxin-antitoxin system stabilizes an ampicillin resistance-conferring β-lactamase gene in Escherichia coli, from natural environments. Appl Environ Microbiol (2014) 0.78
Differential epigenetic compatibility of qnr antibiotic resistance determinants with the chromosome of Escherichia coli. PLoS One (2012) 0.78
Ecological and temporal constraints in the evolution of bacterial genomes. Genes (Basel) (2011) 0.78
Antibiotic resistance and extended-spectrum β-lactamases in isolated bacteria from seawater of Algiers beaches (Algeria). Microbes Environ (2011) 0.78
Genomic analysis reveals distinct concentration-dependent evolutionary trajectories for antibiotic resistance in Escherichia coli. DNA Res (2014) 0.77
Regulation of an auxiliary, antibiotic-resistant tryptophanyl-tRNA synthetase gene via ribosome-mediated transcriptional attenuation. J Bacteriol (2010) 0.76
A potent synthetic inorganic antibiotic with activity against drug-resistant pathogens. Sci Rep (2017) 0.75
Predation and selection for antibiotic resistance in natural environments. Evol Appl (2016) 0.75
Genotypic diversity, antibiotic resistance and bacteriocin production of enterococci isolated from rhizospheres. Microbes Environ (2012) 0.75
Genotypic and phenotypic detection of efflux pump in Rhodococcus equi. Braz J Microbiol (2014) 0.75
In Silico Gene-Level Evolution Explains Microbial Population Diversity through Differential Gene Mobility. Genome Biol Evol (2015) 0.75
Effect of antibiotics on bacterial populations: a multi-hierachical selection process. F1000Res (2017) 0.75
Eradication of Methicillin-Resistant Staphylococcus aureus and of Enterobacteriaceae Expressing Extended-Spectrum Beta-Lactamases on a Model Pig Farm. Appl Environ Microbiol (2015) 0.75
Whence Resistance? Surg Infect (Larchmt) (2015) 0.75
High Diversity of CTX-M Extended-Spectrum β-Lactamases in Municipal Wastewater and Urban Wetlands. Microb Drug Resist (2015) 0.75
CpxR Activates MexAB-OprM Efflux Pump Expression and Enhances Antibiotic Resistance in Both Laboratory and Clinical nalB-Type Isolates of Pseudomonas aeruginosa. PLoS Pathog (2016) 0.75
Resistance to antimicrobial drugs in different surface waters and wastewaters of Guadeloupe. PLoS One (2017) 0.75
The coevolution of toxin and antitoxin genes drives the dynamics of bacterial addiction complexes and intragenomic conflict. Proc Biol Sci (2012) 0.75
Genomic and Functional Characterization of qnr-Encoding Plasmids from Municipal Wastewater Biosolid Klebsiella pneumoniae Isolates. Front Microbiol (2015) 0.75
Predominance of CTX-M-15 among ESBL Producers from Environment and Fish Gut from the Shores of Lake Victoria in Mwanza, Tanzania. Front Microbiol (2016) 0.75
A Functional Metagenomic Analysis of Tetracycline Resistance in Cheese Bacteria. Front Microbiol (2017) 0.75
Extended-spectrum beta-lactamases: a clinical update. Clin Microbiol Rev (2005) 15.72
The Soil as a Source of Microorganisms Antagonistic to Disease-Producing Bacteria. J Bacteriol (1940) 12.56
Quinolone resistance from a transferable plasmid. Lancet (1998) 11.28
High mutation frequencies among Escherichia coli and Salmonella pathogens. Science (1996) 10.88
Metagenomics: application of genomics to uncultured microorganisms. Microbiol Mol Biol Rev (2004) 10.67
Antibacterial resistance worldwide: causes, challenges and responses. Nat Med (2004) 10.46
Plasmid-linked resistance to inorganic salts in Staphylococcus aureus. J Bacteriol (1968) 9.99
High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection. Science (2000) 9.14
Overview of nosocomial infections caused by gram-negative bacilli. Clin Infect Dis (2005) 9.06
A novel family of potentially mobile DNA elements encoding site-specific gene-integration functions: integrons. Mol Microbiol (1989) 8.71
Bacterial interference caused by autoinducing peptide variants. Science (1997) 7.96
Inactivation of antibiotics and the dissemination of resistance genes. Science (1994) 7.89
Sampling the antibiotic resistome. Science (2006) 7.27
Mechanisms of, and barriers to, horizontal gene transfer between bacteria. Nat Rev Microbiol (2005) 6.55
The role of root exudates in rhizosphere interactions with plants and other organisms. Annu Rev Plant Biol (2006) 6.26
The biological cost of antibiotic resistance. Curr Opin Microbiol (1999) 6.08
Plasmid-determined resistance to antimicrobial drugs and toxic metal ions in bacteria. Microbiol Rev (1983) 5.45
Molecular mechanisms of antibacterial multidrug resistance. Cell (2007) 5.32
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A (1973) 5.20
Multidrug-resistance efflux pumps - not just for resistance. Nat Rev Microbiol (2006) 5.18
Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells. Proc Natl Acad Sci U S A (1986) 5.00
Integrons: agents of bacterial evolution. Nat Rev Microbiol (2006) 4.81
Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria. Clin Microbiol Rev (2006) 4.77
Toxins-antitoxins: plasmid maintenance, programmed cell death, and cell cycle arrest. Science (2003) 4.55
Effects of environment on compensatory mutations to ameliorate costs of antibiotic resistance. Science (2000) 4.48
Bacterial heavy metal resistance: new surprises. Annu Rev Microbiol (1996) 4.28
The antibiotic resistome: the nexus of chemical and genetic diversity. Nat Rev Microbiol (2007) 4.14
Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa. Clin Infect Dis (2006) 3.93
Antibiotics and antibiotic resistance genes in natural environments. Science (2008) 3.77
Mechanisms of solvent tolerance in gram-negative bacteria. Annu Rev Microbiol (2002) 3.50
Bacteria subsisting on antibiotics. Science (2008) 3.47
Resistance mechanisms in Pseudomonas aeruginosa and other nonfermentative gram-negative bacteria. Clin Infect Dis (1998) 3.46
Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species. J Mol Evol (1992) 3.44
Heavy use of prophylactic antibiotics in aquaculture: a growing problem for human and animal health and for the environment. Environ Microbiol (2006) 3.43
Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases. Antimicrob Agents Chemother (1998) 3.37
Analysis of Pseudomonas aeruginosa 4-hydroxy-2-alkylquinolines (HAQs) reveals a role for 4-hydroxy-2-heptylquinoline in cell-to-cell communication. Proc Natl Acad Sci U S A (2004) 3.30
Mutation frequencies and antibiotic resistance. Antimicrob Agents Chemother (2000) 3.27
Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proc Natl Acad Sci U S A (2002) 3.25
Antibiotic resistance found in wild rodents. Nature (1999) 3.20
Origin of plasmid-mediated quinolone resistance determinant QnrA. Antimicrob Agents Chemother (2005) 3.18
Effects of the ccd function of the F plasmid on bacterial growth. J Bacteriol (1985) 3.10
Antibiotics and antibiotic resistance in water environments. Curr Opin Biotechnol (2008) 2.96
On the origin of bacterial resistance to penicillin: comparison of a beta-lactamase and a penicillin target. Science (1986) 2.88
Antibiotics as intermicrobial signaling agents instead of weapons. Proc Natl Acad Sci U S A (2006) 2.80
Antibiotics as signalling molecules. Philos Trans R Soc Lond B Biol Sci (2007) 2.74
Multidrug resistance--a sign of the times. N Engl J Med (1998) 2.68
Influence of the MexAB-OprM multidrug efflux system on quorum sensing in Pseudomonas aeruginosa. J Bacteriol (1998) 2.61
Plasmid-determined beta-lactamases identified in a group of 204 ampicillin-resistant Enterobacteriaceae. J Antimicrob Chemother (1983) 2.54
Antibiotic resistance in Pseudomonas aeruginosa: mechanisms and impact on treatment. Drug Resist Updat (2000) 2.44
Mercury released from dental "silver" fillings provokes an increase in mercury- and antibiotic-resistant bacteria in oral and intestinal floras of primates. Antimicrob Agents Chemother (1993) 2.40
Phylogeny of multidrug transporters. Semin Cell Dev Biol (2001) 2.31
Overexpression of the MexEF-OprN multidrug efflux system affects cell-to-cell signaling in Pseudomonas aeruginosa. J Bacteriol (2001) 2.28
Predicting antibiotic resistance. Nat Rev Microbiol (2007) 2.28
Functional metagenomics reveals diverse beta-lactamases in a remote Alaskan soil. ISME J (2008) 2.17
Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob Agents Chemother (2005) 2.08
Revisiting quorum sensing: Discovery of additional chemical and biological functions for 3-oxo-N-acylhomoserine lactones. Proc Natl Acad Sci U S A (2004) 2.05
Unexpected occurrence of plasmid-mediated quinolone resistance determinants in environmental Aeromonas spp. Emerg Infect Dis (2008) 2.05
Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. Proc Natl Acad Sci U S A (2005) 2.04
Determination of antibiotic hypersensitivity among 4,000 single-gene-knockout mutants of Escherichia coli. J Bacteriol (2008) 2.01
Clinical problems posed by multiresistant nonfermenting gram-negative pathogens. Clin Infect Dis (1998) 1.91
A global view of antibiotic resistance. FEMS Microbiol Rev (2008) 1.83
The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82
Emergence and dissemination of Enterobacteriaceae isolates producing CTX-M-1-like enzymes in Spain are associated with IncFII (CTX-M-15) and broad-host-range (CTX-M-1, -3, and -32) plasmids. Antimicrob Agents Chemother (2006) 1.79
Functional role of bacterial multidrug efflux pumps in microbial natural ecosystems. FEMS Microbiol Rev (2009) 1.79
Antibiotics as signals that trigger specific bacterial responses. Curr Opin Microbiol (2008) 1.73
Environmental and clinical isolates of Pseudomonas aeruginosa show pathogenic and biodegradative properties irrespective of their origin. Environ Microbiol (1999) 1.71
Phylogenetic and physiological diversity of microorganisms isolated from a deep greenland glacier ice core. Appl Environ Microbiol (2004) 1.71
The truth about antibiotics. Int J Med Microbiol (2006) 1.68
Toxin-antitoxin systems are ubiquitous and plasmid-encoded in vancomycin-resistant enterococci. Proc Natl Acad Sci U S A (2006) 1.68
Complex ciprofloxacin resistome revealed by screening a Pseudomonas aeruginosa mutant library for altered susceptibility. Antimicrob Agents Chemother (2008) 1.67
Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis. Mol Microbiol (1994) 1.66
Plasmids of the same Inc groups in Enterobacteria before and after the medical use of antibiotics. Nature (1984) 1.65
Transcription regulation and environmental adaptation in bacteria. Trends Microbiol (2003) 1.63
Crossing over between regions of limited homology in Escherichia coli. RecA-dependent and RecA-independent pathways. Genetics (2002) 1.62
Predictive analysis of transmissible quinolone resistance indicates Stenotrophomonas maltophilia as a potential source of a novel family of Qnr determinants. BMC Microbiol (2008) 1.59
Retracted Mediation of pathogen resistance by exudation of antimicrobials from roots. Nature (2005) 1.59
Are antibiotics naturally antibiotics? J Ind Microbiol Biotechnol (2006) 1.59
Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrob Agents Chemother (1994) 1.59
Expression of multidrug efflux pump SmeDEF by clinical isolates of Stenotrophomonas maltophilia. Antimicrob Agents Chemother (2001) 1.53
Genomic analysis reveals the major driving forces of bacterial life in the rhizosphere. Genome Biol (2007) 1.52
Resident microbiota of the gypsy moth midgut harbors antibiotic resistance determinants. DNA Cell Biol (2009) 1.52
Biological cost of AmpC production for Salmonella enterica serotype Typhimurium. Antimicrob Agents Chemother (2000) 1.50
Environmental selection of antibiotic resistance genes. Environ Microbiol (2001) 1.50
Distribution and physiology of ABC-type transporters contributing to multidrug resistance in bacteria. Microbiol Mol Biol Rev (2007) 1.46
F plasmid ccd mechanism in Escherichia coli. J Bacteriol (1986) 1.44
Sequence of conjugative plasmid pIP1206 mediating resistance to aminoglycosides by 16S rRNA methylation and to hydrophilic fluoroquinolones by efflux. Antimicrob Agents Chemother (2008) 1.44
Coselection for microbial resistance to metals and antibiotics in freshwater microcosms. Environ Microbiol (2006) 1.34
A global gene pool for high-level cephalosporin resistance in commensal Streptococcus species and Streptococcus pneumoniae. J Infect Dis (1997) 1.33
Microcin-mediated interactions between Klebsiella pneumoniae and Escherichia coli strains. J Gen Microbiol (1984) 1.32
Antibacterial resistance, Wayampis Amerindians, French Guyana. Emerg Infect Dis (2004) 1.30
Incidence of class 1 integrons in a quaternary ammonium compound-polluted environment. Antimicrob Agents Chemother (2005) 1.28
Plasmid-mediated quinolone resistance in Aeromonas allosaccharophila recovered from a Swiss lake. J Antimicrob Chemother (2008) 1.25
Transcription modulation of Salmonella enterica serovar Typhimurium promoters by sub-MIC levels of rifampin. J Bacteriol (2006) 1.23
Multiresistance genes of Rhizobium etli CFN42. Mol Plant Microbe Interact (2000) 1.21
The biocide triclosan selects Stenotrophomonas maltophilia mutants that overproduce the SmeDEF multidrug efflux pump. Antimicrob Agents Chemother (2005) 1.17
Potentially multidrug-resistant non-fermentative Gram-negative pathogens causing nosocomial pneumonia. Int J Antimicrob Agents (2006) 1.16
Overexpression of the multidrug efflux pump SmeDEF impairs Stenotrophomonas maltophilia physiology. J Antimicrob Chemother (2004) 1.14
Spatial patterns in antibiotic resistance among stream bacteria: effects of industrial pollution. Appl Environ Microbiol (2000) 1.14
Origins, acquisition and dissemination of antibiotic resistance determinants. Ciba Found Symp (1997) 1.14
Dual effects of MLS antibiotics: transcriptional modulation and interactions on the ribosome. Chem Biol (2004) 1.12