Published in J Cell Biol on April 13, 2009
Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature (2009) 6.74
Plasma membrane contributes to the formation of pre-autophagosomal structures. Nat Cell Biol (2010) 6.41
Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab (2010) 5.82
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes. J Cell Biol (2009) 3.71
The dynamic nature of autophagy in cancer. Genes Dev (2011) 3.57
Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses. Immunity (2010) 2.52
Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. Proc Natl Acad Sci U S A (2012) 2.14
Exit from the Golgi is required for the expansion of the autophagosomal phagophore in yeast Saccharomyces cerevisiae. Mol Biol Cell (2010) 2.10
Distinct autophagosomal-lysosomal fusion mechanism revealed by thapsigargin-induced autophagy arrest. Mol Cell (2011) 2.09
Lysosomal proteolysis inhibition selectively disrupts axonal transport of degradative organelles and causes an Alzheimer's-like axonal dystrophy. J Neurosci (2011) 2.09
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Lysosomal transmembrane protein LAPTM4B promotes autophagy and tolerance to metabolic stress in cancer cells. Cancer Res (2011) 1.73
Membrane delivery to the yeast autophagosome from the Golgi-endosomal system. Mol Biol Cell (2010) 1.61
Systematic identification of molecular subtype-selective vulnerabilities in non-small-cell lung cancer. Cell (2013) 1.60
Drosophila acinus encodes a novel regulator of endocytic and autophagic trafficking. Development (2010) 1.55
Rubicon controls endosome maturation as a Rab7 effector. Proc Natl Acad Sci U S A (2010) 1.55
Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol Biol Cell (2010) 1.55
Autophagy receptors link myosin VI to autophagosomes to mediate Tom1-dependent autophagosome maturation and fusion with the lysosome. Nat Cell Biol (2012) 1.50
Multivesicular bodies mature from the trans-Golgi network/early endosome in Arabidopsis. Plant Cell (2011) 1.47
Autophagy proteins control goblet cell function by potentiating reactive oxygen species production. EMBO J (2013) 1.47
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A dual function of V0-ATPase a1 provides an endolysosomal degradation mechanism in Drosophila melanogaster photoreceptors. J Cell Biol (2010) 1.38
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Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol (2010) 1.34
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A mammalian autophagosome maturation mechanism mediated by TECPR1 and the Atg12-Atg5 conjugate. Mol Cell (2012) 1.26
Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. J Cell Biol (2010) 1.24
The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev (2014) 1.21
Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis. Cell Host Microbe (2016) 1.21
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Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem (2009) 1.17
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The elimination of accumulated and aggregated proteins: a role for aggrephagy in neurodegeneration. Neurobiol Dis (2010) 1.12
Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS One (2010) 1.12
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Autophagy modulates cell migration and β1 integrin membrane recycling. Cell Cycle (2013) 1.04
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Dissecting the role of COPI complexes in influenza virus infection. J Virol (2012) 0.99
Rab11 facilitates cross-talk between autophagy and endosomal pathway through regulation of Hook localization. Mol Biol Cell (2013) 0.98
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COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis. Nat Genet (2015) 0.96
Bi-allelic CLPB mutations cause cataract, renal cysts, nephrocalcinosis and 3-methylglutaconic aciduria, a novel disorder of mitochondrial protein disaggregation. J Inherit Metab Dis (2015) 0.96
Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PLoS One (2013) 0.94
Genetic inactivation of COPI coatomer separately inhibits vesicular stomatitis virus entry and gene expression. J Virol (2011) 0.93
Proteomic analysis of endocytic vesicles: Rab1a regulates motility of early endocytic vesicles. J Cell Sci (2011) 0.92
Autophagy initiation by ULK complex assembly on ER tubulovesicular regions marked by ATG9 vesicles. Nat Commun (2016) 0.92
Endocytosis and autophagy: exploitation or cooperation? Cold Spring Harb Perspect Biol (2014) 0.91
Calcium-permeable ion channels in control of autophagy and cancer. Front Physiol (2013) 0.91
Dopamine receptor D3 regulates endocytic sorting by a Prazosin-sensitive interaction with the coatomer COPI. Proc Natl Acad Sci U S A (2012) 0.89
Defective macroautophagic turnover of brain lipids in the TgCRND8 Alzheimer mouse model: prevention by correcting lysosomal proteolytic deficits. Brain (2014) 0.89
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A role of autophagy in PTP4A3-driven cancer progression. Autophagy (2014) 0.85
A role for myocilin in receptor-mediated endocytosis. PLoS One (2013) 0.84
ARF1 localizes to the golgi and the trans-golgi network. Plant Cell (2011) 0.84
Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases. Neurol Res Int (2012) 0.84
Molecular pathways for intracellular cholesterol accumulation: common pathogenic mechanisms in Niemann-Pick disease Type C and cystic fibrosis. Arch Biochem Biophys (2011) 0.83
ArfGAP3 regulates the transport of cation-independent mannose 6-phosphate receptor in the post-Golgi compartment. Curr Biol (2013) 0.83
Tumor-specific silencing of COPZ2 gene encoding coatomer protein complex subunit ζ 2 renders tumor cells dependent on its paralogous gene COPZ1. Proc Natl Acad Sci U S A (2011) 0.83
Abortive autophagy induces endoplasmic reticulum stress and cell death in cancer cells. PLoS One (2012) 0.83
BPIFB3 regulates autophagy and coxsackievirus B replication through a noncanonical pathway independent of the core initiation machinery. MBio (2014) 0.82
Silkworm coatomers and their role in tube expansion of posterior silkgland. PLoS One (2010) 0.81
A genome-scale screen reveals context-dependent ovarian cancer sensitivity to miRNA overexpression. Mol Syst Biol (2015) 0.80
Autophagy dysregulation in cell culture and animals models of spinal muscular atrophy. Mol Cell Neurosci (2014) 0.80
Adenovirus RID-alpha activates an autonomous cholesterol regulatory mechanism that rescues defects linked to Niemann-Pick disease type C. J Cell Biol (2009) 0.78
Characterization of growth suppressive functions of a splice variant of cyclin D2. PLoS One (2013) 0.78
Golgi Fragmentation in ALS Motor Neurons. New Mechanisms Targeting Microtubules, Tethers, and Transport Vesicles. Front Neurosci (2015) 0.78
Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors. Sci Rep (2016) 0.78
Origin of the Autophagosomal Membrane in Plants. Front Plant Sci (2016) 0.77
Decreased function of survival motor neuron protein impairs endocytic pathways. Proc Natl Acad Sci U S A (2016) 0.77
Blockade of irradiation-induced autophagosome formation impairs proliferation but does not enhance cell death in HCT-116 human colorectal carcinoma cells. Int J Oncol (2012) 0.77
Physiological Functions of the COPI Complex in Higher Plants. Mol Cells (2015) 0.77
α-COP binding to the survival motor neuron protein SMN is required for neuronal process outgrowth. Hum Mol Genet (2015) 0.77
Mitochondrial Quality Control and Disease: Insights into Ischemia-Reperfusion Injury. Mol Neurobiol (2017) 0.76
Necrotic cell death and neurodegeneration: The involvement of endocytosis and intracellular trafficking. Worm (2012) 0.76
Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking. Cell Rep (2016) 0.76
Crystal structure of truncated human coatomer protein complex subunit ζ1 (Copζ1). Acta Crystallogr F Struct Biol Commun (2017) 0.75
Role of Coatomer Protein I in Virus Replication. J Virol Antivir Res (2012) 0.75
Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones. Cell Biol Toxicol (2016) 0.75
Discovery Proteomics Identifies a Molecular Link between the Coatomer Protein Complex I and Androgen Receptor-dependent Transcription. J Biol Chem (2016) 0.75
A functional endosomal pathway is necessary for lysosome biogenesis in Drosophila. BMC Cell Biol (2016) 0.75
Identification of novel cancer therapeutic targets using a designed and pooled shRNA library screen. Sci Rep (2017) 0.75
Endosomal system genetics and autism spectrum disorders: A literature review. Neurosci Biobehav Rev (2016) 0.75
Components of the SNARE-containing regulon are co-regulated in root cells undergoing defense. Plant Signal Behav (2016) 0.75
Identification of thyroid tumor cell vulnerabilities through a siRNA-based functional screening. Oncotarget (2015) 0.75
SNAPping off Golgi membranes for autophagosome formation. Cell Cycle (2012) 0.75
The nascent polypeptide-associated complex is essential for autophagic flux. Autophagy (2014) 0.75
Chemotactic G protein-coupled receptors control cell migration by repressing autophagosome biogenesis. Autophagy (2016) 0.75
Autophagy fights disease through cellular self-digestion. Nature (2008) 33.83
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem (2007) 21.73
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Autophagosome formation: core machinery and adaptations. Nat Cell Biol (2007) 13.59
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Autophagy is activated for cell survival after endoplasmic reticulum stress. Mol Cell Biol (2006) 8.89
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science (2005) 7.98
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Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell (1991) 5.10
siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. J Biol Chem (2007) 4.33
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30
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