The emerging shape of the ESCRT machinery.

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature (2009) 6.99

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments. J Cell Biol (2008) 4.66

Membrane scission by the ESCRT-III complex. Nature (2009) 4.66

Ubiquitin-binding domains - from structures to functions. Nat Rev Mol Cell Biol (2009) 4.62

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. J Cell Biol (2007) 4.30

Membrane budding and scission by the ESCRT machinery: it's all in the neck. Nat Rev Mol Cell Biol (2010) 4.29

Biological functions and biogenesis of secreted bacterial outer membrane vesicles. Annu Rev Microbiol (2010) 4.13

ESCRT complexes and the biogenesis of multivesicular bodies. Curr Opin Cell Biol (2008) 3.90

The structural biology of HIV assembly. Curr Opin Struct Biol (2008) 3.71

Functional reconstitution of ESCRT-III assembly and disassembly. Cell (2009) 3.52

G protein-coupled receptor sorting to endosomes and lysosomes. Annu Rev Pharmacol Toxicol (2008) 3.49

Helical structures of ESCRT-III are disassembled by VPS4. Science (2008) 3.38

Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol (2009) 3.25

Large-scale proteomics and phosphoproteomics of urinary exosomes. J Am Soc Nephrol (2008) 3.22

Functional anatomy of T cell activation and synapse formation. Annu Rev Immunol (2010) 3.01

A role for the ESCRT system in cell division in archaea. Science (2008) 2.94

Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol (2008) 2.93

Microvesicles as mediators of intercellular communication in cancer--the emerging science of cellular 'debris'. Semin Immunopathol (2011) 2.78

Early endosomes and endosomal coatomer are required for autophagy. J Cell Biol (2009) 2.69

Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? Virology (2007) 2.68

Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell (2010) 2.67

Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc Natl Acad Sci U S A (2009) 2.66

Phagosome maturation: going through the acid test. Nat Rev Mol Cell Biol (2008) 2.53

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43

Differential requirements for Alix and ESCRT-III in cytokinesis and HIV-1 release. Proc Natl Acad Sci U S A (2008) 2.33

SAXS ensemble refinement of ESCRT-III CHMP3 conformational transitions. Structure (2011) 2.24

Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding. Dev Cell (2008) 2.23

Dynamics of ESCRT protein recruitment during retroviral assembly. Nat Cell Biol (2011) 2.23

The ESCRT complexes. Crit Rev Biochem Mol Biol (2010) 2.23

Midbody targeting of the ESCRT machinery by a noncanonical coiled coil in CEP55. Science (2008) 2.23

TWEAK-FN14 signaling induces lysosomal degradation of a cIAP1-TRAF2 complex to sensitize tumor cells to TNFalpha. J Cell Biol (2008) 2.11

Microvesicles and viral infection. J Virol (2011) 2.10

The endosomal system of plants: charting new and familiar territories. Plant Physiol (2008) 2.01

Structural basis for ESCRT-III protein autoinhibition. Nat Struct Mol Biol (2009) 1.98

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). J Proteome Res (2009) 1.97

HECT and RING finger families of E3 ubiquitin ligases at a glance. J Cell Sci (2012) 1.95

Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules. Nat Rev Immunol (2010) 1.93

ALIX-CHMP4 interactions in the human ESCRT pathway. Proc Natl Acad Sci U S A (2008) 1.91

Three-dimensional analysis of budding sites and released virus suggests a revised model for HIV-1 morphogenesis. Cell Host Microbe (2008) 1.91

Computational model of membrane fission catalyzed by ESCRT-III. PLoS Comput Biol (2009) 1.78

Structural basis for autoinhibition of ESCRT-III CHMP3. J Mol Biol (2008) 1.78

Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell (2008) 1.71

Ist1 regulates Vps4 localization and assembly. Mol Biol Cell (2007) 1.68

ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation. EMBO J (2010) 1.66

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer. Histochem Cell Biol (2008) 1.65

Membrane budding. Cell (2010) 1.65

Novel Ist1-Did2 complex functions at a late step in multivesicular body sorting. Mol Biol Cell (2007) 1.63

Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene (2010) 1.60

NEDD4L overexpression rescues the release and infectivity of human immunodeficiency virus type 1 constructs lacking PTAP and YPXL late domains. J Virol (2008) 1.60

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination. J Cell Biol (2011) 1.59

Essential role of ubiquitin and TSG101 protein in formation and function of the central supramolecular activation cluster. Immunity (2010) 1.56

The trypanosome transcriptome is remodelled during differentiation but displays limited responsiveness within life stages. BMC Genomics (2008) 1.56

Understanding the structure and function of the immunological synapse. Cold Spring Harb Perspect Biol (2010) 1.54

Why do cellular proteins linked to K63-polyubiquitin chains not associate with proteasomes? EMBO J (2013) 1.53

No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci (2009) 1.50

Structure and function of the ESCRT-II-III interface in multivesicular body biogenesis. Dev Cell (2009) 1.50

Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly. Mol Biol Cell (2008) 1.46

Cytotoxic immunological synapses. Immunol Rev (2010) 1.45

In vitro budding of intralumenal vesicles into late endosomes is regulated by Alix and Tsg101. Mol Biol Cell (2008) 1.45

Assembly of the AAA ATPase Vps4 on ESCRT-III. Mol Biol Cell (2010) 1.43

Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants. J Cell Sci (2009) 1.42

The ESCRT machinery at a glance. J Cell Sci (2009) 1.41

The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells. J Biol Chem (2009) 1.40

Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex. Dev Cell (2008) 1.40

ESCRTs are everywhere. EMBO J (2015) 1.40

Herpes simplex virus type 1 production requires a functional ESCRT-III complex but is independent of TSG101 and ALIX expression. J Virol (2009) 1.40

Cryo electron tomography of native HIV-1 budding sites. PLoS Pathog (2010) 1.39

A viral nonstructural protein regulates bluetongue virus trafficking and release. J Virol (2009) 1.39

SCAMP3 negatively regulates epidermal growth factor receptor degradation and promotes receptor recycling. Mol Biol Cell (2009) 1.39

Shaping development with ESCRTs. Nat Cell Biol (2011) 1.38

Autophagy in neurodegeneration and development. Biochim Biophys Acta (2008) 1.38

Plasticity of polyubiquitin recognition as lysosomal targeting signals by the endosomal sorting machinery. Mol Biol Cell (2007) 1.37

Structural analysis of HIV-1 maturation using cryo-electron tomography. PLoS Pathog (2010) 1.36

Polyubiquitin binding and disassembly by deubiquitinating enzymes. Chem Rev (2009) 1.36

Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors. Traffic (2010) 1.35

Wortmannin induces homotypic fusion of plant prevacuolar compartments. J Exp Bot (2009) 1.35

Proteomic analysis of secreted membrane vesicles of archaeal Sulfolobus species reveals the presence of endosome sorting complex components. Extremophiles (2008) 1.34

Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p. J Mol Biol (2008) 1.33

Arrestin-2 interacts with the endosomal sorting complex required for transport machinery to modulate endosomal sorting of CXCR4. Mol Biol Cell (2010) 1.32

Regulators of Vps4 ATPase activity at endosomes differentially influence the size and rate of formation of intralumenal vesicles. Mol Biol Cell (2010) 1.32

Extracellular vesicles as an emerging mechanism of cell-to-cell communication. Endocrine (2012) 1.32

MVB-12, a fourth subunit of metazoan ESCRT-I, functions in receptor downregulation. PLoS One (2007) 1.29

A capsid-encoded PPxY-motif facilitates adenovirus entry. PLoS Pathog (2010) 1.29

IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin Immunol (2012) 1.27

Multiple interactions between the ESCRT machinery and arrestin-related proteins: implications for PPXY-dependent budding. J Virol (2010) 1.27

Structural basis of Ist1 function and Ist1-Did2 interaction in the multivesicular body pathway and cytokinesis. Mol Biol Cell (2009) 1.27

Analyses of the recycling receptor, FcRn, in live cells reveal novel pathways for lysosomal delivery. Traffic (2009) 1.24

Hybrid structural model of the complete human ESCRT-0 complex. Structure (2009) 1.23

Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2. J Biol Chem (2009) 1.23

Leucine-rich repeat kinase LRRK1 regulates endosomal trafficking of the EGF receptor. Nat Commun (2011) 1.22

Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes. EMBO J (2008) 1.21

Mechanochemical crosstalk during endocytic vesicle formation. Curr Opin Cell Biol (2009) 1.20

Lysine63-linked ubiquitylation of PIN2 auxin carrier protein governs hormonally controlled adaptation of Arabidopsis root growth. Proc Natl Acad Sci U S A (2012) 1.19

Endocytic pathway is required for Drosophila Toll innate immune signaling. Proc Natl Acad Sci U S A (2010) 1.18

Molecular characterization of proprotein convertase subtilisin/kexin type 9-mediated degradation of the LDLR. J Lipid Res (2012) 1.18

The chromosomal passenger complex controls the function of endosomal sorting complex required for transport-III Snf7 proteins during cytokinesis. Open Biol (2012) 1.17

Biochemical and structural studies of yeast Vps4 oligomerization. J Mol Biol (2008) 1.15

Oncogenic extracellular vesicles in brain tumor progression. Front Physiol (2012) 1.15

Multivesicular bodies in neurons: distribution, protein content, and trafficking functions. Prog Neurobiol (2011) 1.14

Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes. Oncotarget (2015) 1.13

Breaking the chains: structure and function of the deubiquitinases. Nat Rev Mol Cell Biol (2009) 8.85

Bilayered clathrin coats on endosomal vacuoles are involved in protein sorting toward lysosomes. Mol Biol Cell (2002) 3.24

Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation. Autophagy (2010) 2.91

AMSH is an endosome-associated ubiquitin isopeptidase. J Cell Biol (2004) 2.58

Endocytosis: the DUB version. Trends Cell Biol (2006) 2.39

Ubiquitin: same molecule, different degradation pathways. Cell (2010) 2.26

The ubiquitin isopeptidase UBPY regulates endosomal ubiquitin dynamics and is essential for receptor down-regulation. J Biol Chem (2006) 2.17

Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol (2006) 1.76

The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation. J Biol Chem (2007) 1.69

Met/Hepatocyte growth factor receptor ubiquitination suppresses transformation and is required for Hrs phosphorylation. Mol Cell Biol (2005) 1.65

Endosomal dynamics of Met determine signaling output. Mol Biol Cell (2003) 1.55

Deubiquitylases from genes to organism. Physiol Rev (2013) 1.54

Cellular functions of the DUBs. J Cell Sci (2012) 1.45

Emerging roles of deubiquitinases in cancer-associated pathways. IUBMB Life (2010) 1.41

PIKfyve regulation of endosome-linked pathways. Traffic (2009) 1.39

Analysis of articulation between clathrin and retromer in retrograde sorting on early endosomes. Traffic (2009) 1.30

Governance of endocytic trafficking and signaling by reversible ubiquitylation. Dev Cell (2012) 1.29

Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. J Cell Sci (2006) 1.29

Analysis of phosphoinositide binding domain properties within the myotubularin-related protein MTMR3. J Cell Sci (2005) 1.19

Growth factors induce differential phosphorylation profiles of the Hrs-STAM complex: a common node in signalling networks with signal-specific properties. Biochem J (2005) 1.15

Ubiquilin recruits Eps15 into ubiquitin-rich cytoplasmic aggregates via a UIM-UBL interaction. J Cell Sci (2005) 1.14

Recruitment of UBPY and ESCRT exchange drive HD-PTP-dependent sorting of EGFR to the MVB. Curr Biol (2013) 1.09

Hrs function: viruses provide the clue. Trends Cell Biol (2003) 1.04

The met receptor degradation pathway: requirement for Lys48-linked polyubiquitin independent of proteasome activity. J Biol Chem (2004) 0.99

Phosphoinositides and the endocytic pathway. Exp Cell Res (2008) 0.98

Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. J Biol Chem (2012) 0.97

Deubiquitinase activities required for hepatocyte growth factor-induced scattering of epithelial cells. Curr Biol (2009) 0.95

The deubiquitylase USP15 stabilizes newly synthesized REST and rescues its expression at mitotic exit. Cell Cycle (2013) 0.94

Ab initio protein modelling reveals novel human MIT domains. FEBS Lett (2009) 0.91

Isoform-specific localization of the deubiquitinase USP33 to the Golgi apparatus. Traffic (2011) 0.86

Structural variability of the ubiquitin specific protease DUSP-UBL double domains. FEBS Lett (2011) 0.86

Deciphering histone 2A deubiquitination. Genome Biol (2008) 0.83

Regulation of ErbB2 receptor status by the proteasomal DUB POH1. PLoS One (2009) 0.82

Selective protein degradation in cell signalling. Semin Cell Dev Biol (2012) 0.80

USP8 controls the trafficking and sorting of lysosomal enzymes. Traffic (2014) 0.79

Multivesicular bodies. Curr Biol (2008) 0.76

Moving in with ubiquitin. Traffic (2011) 0.75