Published in Cancer Res on April 14, 2009
AMPK as a metabolic tumor suppressor: control of metabolism and cell growth. Future Oncol (2010) 2.11
Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner. J Cell Mol Med (2011) 1.93
The role of adiponectin in cancer: a review of current evidence. Endocr Rev (2012) 1.78
Paracrine and endocrine effects of adipose tissue on cancer development and progression. Endocr Rev (2011) 1.65
A 25-year prospective study of plasma adiponectin and leptin concentrations and prostate cancer risk and survival. Clin Chem (2009) 1.41
Molecular pathways: adiponectin and leptin signaling in cancer. Clin Cancer Res (2013) 1.37
Interleukin-6 and its receptor, key players in hepatobiliary inflammation and cancer. Transl Gastrointest Cancer (2012) 1.26
Targeting energy metabolic and oncogenic signaling pathways in triple-negative breast cancer by a novel adenosine monophosphate-activated protein kinase (AMPK) activator. J Biol Chem (2011) 1.10
Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnol (2011) 1.09
Site-specific activation of AKT protects cells from death induced by glucose deprivation. Oncogene (2013) 1.08
Gene and protein expression markers of response to combined antiangiogenic and epidermal growth factor targeted therapy in renal cell carcinoma. Ann Oncol (2010) 1.08
Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling. Oncotarget (2014) 0.96
Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling. J Biol Chem (2009) 0.93
Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells. J Biol Chem (2013) 0.91
PP2A function toward mitotic kinases and substrates during the cell cycle. BMB Rep (2013) 0.86
Activation of AMP-activated protein kinase stimulates Na+,K+-ATPase activity in skeletal muscle cells. J Biol Chem (2012) 0.85
Serum leptin, adiponectin and endometrial cancer risk in Chinese women. J Gynecol Oncol (2013) 0.84
Integral role of PTP1B in adiponectin-mediated inhibition of oncogenic actions of leptin in breast carcinogenesis. Neoplasia (2013) 0.83
A Pak1-PP2A-ERM signaling axis mediates F-actin rearrangement and degranulation in mast cells. Exp Hematol (2012) 0.83
Reduction in Ki-67 in benign breast tissue of high-risk women with the lignan secoisolariciresinol diglycoside. Cancer Prev Res (Phila) (2010) 0.82
AMPK as a potential anticancer target - friend or foe? Curr Pharm Des (2014) 0.82
Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget (2013) 0.82
Deciphering the roles of the constitutive androstane receptor in energy metabolism. Acta Pharmacol Sin (2014) 0.82
Time course expression of Foxo transcription factors in skeletal muscle following corticosteroid administration. J Appl Physiol (1985) (2009) 0.82
Evolving role of adiponectin in cancer-controversies and update. Cancer Biol Med (2016) 0.81
Globular adiponectin enhances invasion in human breast cancer cells. Oncol Lett (2015) 0.78
Liraglutide reduces lipogenetic signals in visceral adipose of db/db mice with AMPK activation and Akt suppression. Drug Des Devel Ther (2015) 0.76
Linking adiponectin and autophagy in the regulation of breast cancer metastasis. J Mol Med (Berl) (2014) 0.76
AMPKα1 deletion in fibroblasts promotes tumorigenesis in athymic nude mice by p52-mediated elevation of erythropoietin and CDK2. Oncotarget (2016) 0.75
Active β-catenin is regulated by the PTEN/PI3 kinase pathway: a role for protein phosphatase PP2A. Genes Cancer (2016) 0.75
UBP43 (USP18) specifically removes ISG15 from conjugated proteins. J Biol Chem (2002) 3.52
UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity. EMBO J (2006) 2.84
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure. J Clin Invest (2004) 2.76
Role of ISG15 protease UBP43 (USP18) in innate immunity to viral infection. Nat Med (2004) 2.59
Protein ISGylation modulates the JAK-STAT signaling pathway. Genes Dev (2003) 2.24
High-throughput immunoblotting. Ubiquitiin-like protein ISG15 modifies key regulators of signal transduction. J Biol Chem (2003) 2.24
VDUP1 upregulated by TGF-beta1 and 1,25-dihydorxyvitamin D3 inhibits tumor cell growth by blocking cell-cycle progression. Oncogene (2003) 2.08
Inhibitory effect and mechanism on antiproliferation of isoatriplicolide tiglate (PCAC) from Paulownia Coreana. Molecules (2012) 1.94
RORalpha attenuates Wnt/beta-catenin signaling by PKCalpha-dependent phosphorylation in colon cancer. Mol Cell (2010) 1.78
Negative regulation of hypoxic responses via induced Reptin methylation. Mol Cell (2010) 1.68
Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea--a report from the Korean Breast Cancer Society. J Clin Oncol (2007) 1.62
Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading. Mol Cell (2012) 1.59
Roles of sumoylation of a reptin chromatin-remodelling complex in cancer metastasis. Nat Cell Biol (2006) 1.52
Thyroid gland rupture after blunt cervical trauma. J Ultrasound Med (2006) 1.51
EZH2 generates a methyl degron that is recognized by the DCAF1/DDB1/CUL4 E3 ubiquitin ligase complex. Mol Cell (2012) 1.48
Macrophage inhibitory cytokine-1 induces the invasiveness of gastric cancer cells by up-regulating the urokinase-type plasminogen activator system. Cancer Res (2003) 1.45
Epigallocatechin-3-gallate enhances CD8+ T cell-mediated antitumor immunity induced by DNA vaccination. Cancer Res (2007) 1.43
The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer (2010) 1.39
Big mitogen-activated protein kinase 1/extracellular signal-regulated kinase 5 signaling pathway is essential for tumor-associated angiogenesis. Cancer Res (2005) 1.33
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. EMBO Rep (2009) 1.30
Macrophage inhibitory cytokine-1 activates AKT and ERK-1/2 via the transactivation of ErbB2 in human breast and gastric cancer cells. Carcinogenesis (2008) 1.27
Expression of NDRG2 is related to tumor progression and survival of gastric cancer patients through Fas-mediated cell death. Exp Mol Med (2007) 1.24
Expression and regulation of NDRG2 (N-myc downstream regulated gene 2) during the differentiation of dendritic cells. FEBS Lett (2003) 1.23
Suppression of NF-kappaB activity by NDRG2 expression attenuates the invasive potential of highly malignant tumor cells. Carcinogenesis (2009) 1.21
A novel adipokine CTRP1 stimulates aldosterone production. FASEB J (2008) 1.20
Prognostic factors for patients with bone-only metastasis in breast cancer. Yonsei Med J (2013) 1.18
NDRG2 suppresses cell proliferation through down-regulation of AP-1 activity in human colon carcinoma cells. Int J Cancer (2009) 1.18
TrkC plays an essential role in breast tumor growth and metastasis. Carcinogenesis (2010) 1.18
Berberine-induced AMPK activation inhibits the metastatic potential of melanoma cells via reduction of ERK activity and COX-2 protein expression. Biochem Pharmacol (2011) 1.17
ISG15 modification of ubiquitin E2 Ubc13 disrupts its ability to form thioester bond with ubiquitin. Biochem Biophys Res Commun (2005) 1.17
Bone morphogenetic protein-4 induced by NDRG2 expression inhibits MMP-9 activity in breast cancer cells. Biochem Biophys Res Commun (2009) 1.12
SOCS1 induced by NDRG2 expression negatively regulates STAT3 activation in breast cancer cells. Biochem Biophys Res Commun (2007) 1.11
DNA gyrase is involved in chloroplast nucleoid partitioning. Plant Cell (2004) 1.09
Up-regulation of Mac-2 binding protein by hTERT in gastric cancer. Int J Cancer (2007) 1.08
SUMO-specific protease SUSP4 positively regulates p53 by promoting Mdm2 self-ubiquitination. Nat Cell Biol (2006) 1.06
Adiponectin is a negative regulator of NK cell cytotoxicity. J Immunol (2006) 1.06
The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3- cotransport isoform 3. J Biol Chem (2002) 1.06
Clear cell hidradenoma of the axilla: a case report with literature review. Korean J Radiol (2010) 1.05
Effects of acupuncture on chronic corticosterone-induced depression-like behavior and expression of neuropeptide Y in the rats. Neurosci Lett (2009) 1.04
Apolipoprotein A-I induces IL-10 and PGE2 production in human monocytes and inhibits dendritic cell differentiation and maturation. Biochem Biophys Res Commun (2005) 1.04
A proinflammatory cytokine interleukin-32beta promotes the production of an anti-inflammatory cytokine interleukin-10. Immunology (2008) 1.03
SUMOylation of pontin chromatin-remodeling complex reveals a signal integration code in prostate cancer cells. Proc Natl Acad Sci U S A (2007) 1.03
Upregulation of Bcl-2 is associated with cisplatin-resistance via inhibition of Bax translocation in human bladder cancer cells. Cancer Lett (2005) 1.03
Shear-wave elastography of invasive breast cancer: correlation between quantitative mean elasticity value and immunohistochemical profile. Breast Cancer Res Treat (2013) 1.01
Phase II randomized trial of neoadjuvant metformin plus letrozole versus placebo plus letrozole for estrogen receptor positive postmenopausal breast cancer (METEOR). BMC Cancer (2014) 1.00
ADP-ribosylation factor 4 small GTPase mediates epidermal growth factor receptor-dependent phospholipase D2 activation. J Biol Chem (2002) 1.00
Microarray analysis reveals that Type I interferon strongly increases the expression of immune-response related genes in Ubp43 (Usp18) deficient macrophages. Biochem Biophys Res Commun (2007) 0.99
Increase in CIP2A expression is associated with doxorubicin resistance. FEBS Lett (2011) 0.99
Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer SK-OV-3 cells. Life Sci (2007) 0.99
Forerunner genes contiguous to RB1 contribute to the development of in situ neoplasia. Proc Natl Acad Sci U S A (2007) 0.98
The molecular mechanisms of vitamin C on cell cycle regulation in B16F10 murine melanoma. J Cell Biochem (2007) 0.97
DNA damage-induced RORα is crucial for p53 stabilization and increased apoptosis. Mol Cell (2011) 0.97
c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Biochem Biophys Res Commun (2005) 0.97
Understanding the development of human bladder cancer by using a whole-organ genomic mapping strategy. Lab Invest (2008) 0.96
Loss of TBK1 induces epithelial-mesenchymal transition in the breast cancer cells by ERα downregulation. Cancer Res (2013) 0.96
Serum starvation induces G1 arrest through suppression of Skp2-CDK2 and CDK4 in SK-OV-3 cells. Int J Oncol (2008) 0.96
Induction of thioredoxin is required for nodule development to reduce reactive oxygen species levels in soybean roots. Plant Physiol (2005) 0.96
SUMOylation of RORalpha potentiates transcriptional activation function. Biochem Biophys Res Commun (2008) 0.96
Tid1, a cochaperone of the heat shock 70 protein and the mammalian counterpart of the Drosophila tumor suppressor l(2)tid, is critical for early embryonic development and cell survival. Mol Cell Biol (2004) 0.95
Protein profiling and identification of modulators regulated by the E7 oncogene in the C33A cell line by proteomics and genomics. Proteomics (2004) 0.95
LOXL2 expression is associated with invasiveness and negatively influences survival in breast cancer patients. Breast Cancer Res Treat (2013) 0.95
T lymphocytes and dendritic cells are activated by the deletion of peroxiredoxin II (Prx II) gene. Immunol Lett (2005) 0.94
Up-regulation of Bfl-1/A1 via NF-kappaB activation in cisplatin-resistant human bladder cancer cell line. Cancer Lett (2004) 0.94
Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1 expression in adipose tissue. FEBS Lett (2006) 0.93
A critical role for Romo1-derived ROS in cell proliferation. Biochem Biophys Res Commun (2008) 0.93
Inhibitory effect of jaceosidin isolated from Artemisiaargyi on the function of E6 and E7 oncoproteins of HPV 16. J Ethnopharmacol (2005) 0.93
The difference in prognostic factors between early recurrence and late recurrence in estrogen receptor-positive breast cancer: nodal stage differently impacts early and late recurrence. PLoS One (2013) 0.93
Antiobesity effect of baicalin involves the modulations of proadipogenic and antiadipogenic regulators of the adipogenesis pathway. Phytother Res (2009) 0.92
p34SEI-1 inhibits apoptosis through the stabilization of the X-linked inhibitor of apoptosis protein: p34SEI-1 as a novel target for anti-breast cancer strategies. Cancer Res (2009) 0.92
Serum deprivation-induced reactive oxygen species production is mediated by Romo1. Apoptosis (2010) 0.92
Standardized uptake value of ¹⁸F-fluorodeoxyglucose positron emission tomography for prediction of tumor recurrence in breast cancer beyond tumor burden. Breast Cancer Res (2014) 0.91
Enhanced antitumor activity of vitamin C via p53 in cancer cells. Free Radic Biol Med (2012) 0.91