Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity.

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Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25

Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89

The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92

Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science (2001) 7.85

Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev (1993) 7.79

Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae. Genetics (1987) 7.05

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Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38

An unusual form of transcriptional silencing in yeast ribosomal DNA. Genes Dev (1997) 6.00

Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci U S A (2005) 5.34

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae. Nature (1997) 4.57

Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast. Genes Dev (1997) 4.31

Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci U S A (2000) 3.94

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Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J (1997) 3.54

Longevity regulation by Drosophila Rpd3 deacetylase and caloric restriction. Science (2002) 2.87

JNK signaling confers tolerance to oxidative stress and extends lifespan in Drosophila. Dev Cell (2003) 2.86

Association of CBP/p300 acetylase and thymine DNA glycosylase links DNA repair and transcription. Mol Cell (2002) 2.69

Trithorax and dCBP acting in a complex to maintain expression of a homeotic gene. Science (2001) 2.61

Drosophila CBP is a co-activator of cubitus interruptus in hedgehog signalling. Nature (1997) 2.33

Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell (2002) 1.81

Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300. Mol Cell (2001) 1.70

The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. Genetics (2003) 1.63

A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Genetics (2002) 1.63

Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis. Nature (2001) 1.55

The post-translational modifications of proliferating cell nuclear antigen: acetylation, not phosphorylation, plays an important role in the regulation of its function. J Biol Chem (2004) 1.39

Functional interaction between the coactivator Drosophila CREB-binding protein and ASH1, a member of the trithorax group of chromatin modifiers. Mol Cell Biol (2000) 1.32

Acetylation regulates the DNA end-trimming activity of DNA polymerase beta. Mol Cell (2002) 1.22

Specific age-related signatures in Drosophila body parts transcriptome. BMC Genomics (2006) 1.22

DNA damage-induced translocation of the Werner helicase is regulated by acetylation. J Biol Chem (2002) 1.19

Sir2 mediates apoptosis through JNK-dependent pathways in Drosophila. Proc Natl Acad Sci U S A (2008) 1.19

Sirtuins, nuclear hormone receptor acetylation and transcriptional regulation. Trends Endocrinol Metab (2007) 1.11

A genetic screen of the Drosophila X chromosome for mutations that modify Deformed function. Genetics (1998) 1.10

Comparative analysis of position-effect variegation mutations in Drosophila melanogaster delineates the targets of modifiers. Genetics (1998) 1.04

Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system. Mol Cell Biol (2008) 1.04

p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpoint. J Biol Chem (2007) 1.02

Drosophila dCBP is involved in establishing the DNA replication checkpoint. Mol Cell Biol (2006) 0.97

The interaction between the coactivator dCBP and Modulo, a chromatin-associated factor, affects segmentation and melanotic tumor formation in Drosophila. Proc Natl Acad Sci U S A (2002) 0.88

Drosophila longevity is not affected by heterochromatin-mediated gene silencing. Aging Cell (2005) 0.87