Published in Proc Natl Acad Sci U S A on June 17, 2008
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Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. Hum Mol Genet (2008) 2.05
Minibrain/Dyrk1a regulates food intake through the Sir2-FOXO-sNPF/NPY pathway in Drosophila and mammals. PLoS Genet (2012) 1.20
Dose-dependency of resveratrol in providing health benefits. Dose Response (2010) 1.11
G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity. PLoS Genet (2014) 1.06
A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. PLoS Genet (2010) 1.06
SIRT1 deficiency downregulates PTEN/JNK/FOXO1 pathway to block reactive oxygen species-induced apoptosis in mouse embryonic stem cells. Stem Cells Dev (2011) 1.02
A potent and selective Sirtuin 1 inhibitor alleviates pathology in multiple animal and cell models of Huntington's disease. Hum Mol Genet (2014) 1.01
Increased expression of Drosophila Sir2 extends life span in a dose-dependent manner. Aging (Albany NY) (2013) 1.00
Resveratrol and red wine, healthy heart and longevity. Heart Fail Rev (2010) 0.96
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Drosophila Sirt2/mammalian SIRT3 deacetylates ATP synthase β and regulates complex V activity. J Cell Biol (2014) 0.90
Resveratrol prevention of oxidative stress damage to lens epithelial cell cultures is mediated by forkhead box O activity. Invest Ophthalmol Vis Sci (2011) 0.89
dSir2 and longevity in Drosophila. Exp Gerontol (2010) 0.88
Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila. Aging (Albany NY) (2013) 0.87
Sirt1's complex roles in neuroprotection. Cell Mol Neurobiol (2009) 0.84
Side chain specificity of ADP-ribosylation by a sirtuin. FEBS J (2009) 0.83
Erratum to: resveratrol and red wine, healthy heart and longevity. Heart Fail Rev (2011) 0.81
When is Sirt1 activity bad for dying neurons? Front Cell Neurosci (2013) 0.81
The effects of Rpd3 on fly metabolism, health, and longevity. Exp Gerontol (2016) 0.80
Modulation of insulin/IGFs pathways by sirtuin-7 inhibition in drug-induced chemoreistance. Diagn Pathol (2014) 0.77
The Benefits of Calorie Restriction and Calorie Restriction Mimetics as Related to the Eye. Open Longev Sci (2009) 0.77
Heterochromatin-mediated gene silencing is not affected by Drosophila CBP activity. J Hered (2009) 0.76
Altered Sirtuin 7 Expression is Associated with Early Stage Breast Cancer. Breast Cancer (Auckl) (2015) 0.76
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol (1992) 34.17
Resveratrol improves health and survival of mice on a high-calorie diet. Nature (2006) 20.91
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell (2006) 19.16
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature (2003) 17.52
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science (2004) 17.38
Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell (2001) 15.05
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature (2001) 14.44
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev (1999) 14.43
Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature (2004) 10.36
Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A (2004) 9.25
Mammalian SIRT1 represses forkhead transcription factors. Cell (2004) 8.89
Expression of baculovirus P35 prevents cell death in Drosophila. Development (1994) 7.16
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev (1995) 5.55
Substrate-specific activation of sirtuins by resveratrol. J Biol Chem (2005) 5.28
Sirt1 regulates aging and resistance to oxidative stress in the heart. Circ Res (2007) 5.23
Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell (1996) 5.13
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling. Cell (2005) 4.64
Sir2 blocks extreme life-span extension. Cell (2005) 4.25
Programmed cell death during Drosophila embryogenesis. Development (1993) 4.24
Drosophila p53 binds a damage response element at the reaper locus. Cell (2000) 3.92
Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J (2002) 3.16
The DrosDel deletion collection: a Drosophila genomewide chromosomal deficiency resource. Genetics (2007) 3.08
Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech Ageing Dev (2007) 2.75
Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol Cell Biol (2004) 2.75
Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr Biol (2002) 2.54
Expression of Drosophila FOXO regulates growth and can phenocopy starvation. BMC Dev Biol (2003) 1.92
Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development (1993) 1.85
Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination. Cell (2002) 1.81
Puckered, a Drosophila MAPK phosphatase, ensures cell viability by antagonizing JNK-induced apoptosis. Development (2005) 1.65
The Drosophila melanogaster sir2+ gene is nonessential and has only minor effects on position-effect variegation. Genetics (2003) 1.63
A Drosophila homologue of Sir2 modifies position-effect variegation but does not affect life span. Genetics (2002) 1.63
Foxo and Fos regulate the decision between cell death and survival in response to UV irradiation. EMBO J (2006) 1.63
A cloning method to identify caspases and their regulators in yeast: identification of Drosophila IAP1 as an inhibitor of the Drosophila caspase DCP-1. Proc Natl Acad Sci U S A (1999) 1.55
Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss. Genetics (1997) 1.53
Reaper-mediated inhibition of DIAP1-induced DTRAF1 degradation results in activation of JNK in Drosophila. Nat Cell Biol (2002) 1.31
Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics (2005) 1.26
Gene deletions by ends-in targeting in Drosophila melanogaster. Genetics (2004) 1.20
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum Mol Genet (2007) 1.12
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes. J Neurosci (2007) 1.06
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS. Nature (2007) 7.74
Trichostatin A increases SMN expression and survival in a mouse model of spinal muscular atrophy. J Clin Invest (2007) 3.11
Life extension in Drosophila by feeding a drug. Proc Natl Acad Sci U S A (2002) 2.57
A multicenter study of glucocerebrosidase mutations in dementia with Lewy bodies. JAMA Neurol (2013) 2.32
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Deletion at ITPR1 underlies ataxia in mice and spinocerebellar ataxia 15 in humans. PLoS Genet (2007) 2.09
Splice mutation in the iron-sulfur cluster scaffold protein ISCU causes myopathy with exercise intolerance. Am J Hum Genet (2008) 1.84
Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr Biol (2005) 1.77
A candidate gene for autoimmune myasthenia gravis. Neurology (2012) 1.44
Evaluation of optical coherence tomography retinal thickness parameters for use in clinical trials for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci (2009) 1.36
Nck beta interacts with tyrosine-phosphorylated disabled 1 and redistributes in Reelin-stimulated neurons. Mol Cell Biol (2003) 1.34
Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein. Genes Dev (2003) 1.33
Quantitative subanalysis of optical coherence tomography after treatment with ranibizumab for neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci (2008) 1.33
Individual histone deacetylases in Drosophila modulate transcription of distinct genes. Genomics (2005) 1.26
Nicotinic regulation of CREB activation in hippocampal neurons by glutamatergic and nonglutamatergic pathways. Mol Cell Neurosci (2002) 1.24
Relationship between optical coherence tomography retinal parameters and visual acuity in neovascular age-related macular degeneration. Ophthalmology (2008) 1.15
The Drosophila homolog of Down's syndrome critical region 1 gene regulates learning: implications for mental retardation. Proc Natl Acad Sci U S A (2003) 1.14
Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat Neurosci (2005) 1.14
Mitochondrial matrix Ca2+ as an intrinsic signal regulating mitochondrial motility in axons. Proc Natl Acad Sci U S A (2011) 1.12
Histone deacetylases suppress CGG repeat-induced neurodegeneration via transcriptional silencing in models of fragile X tremor ataxia syndrome. PLoS Genet (2010) 1.11
A novel subfamily of zinc finger genes involved in embryonic development. J Cell Biochem (2004) 1.10
Regulation of lifespan by histone deacetylase. Ageing Res Rev (2002) 1.09
Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome. Proc Natl Acad Sci U S A (2009) 1.08
DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis. EMBO J (2012) 1.00
Nlz1/Znf703 acts as a repressor of transcription. BMC Dev Biol (2008) 0.99
Overexpression of frataxin in the mitochondria increases resistance to oxidative stress and extends lifespan in Drosophila. FEBS Lett (2008) 0.97
Spinocerebellar ataxia type 20. Cerebellum (2005) 0.87
Spinocerebellar ataxia type 15. Cerebellum (2005) 0.86
Effect of ranibizumab retreatment frequency on neurosensory retinal volume in neovascular amd. Retina (2009) 0.85
Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci (2013) 0.85
Establishment of a Shigella sonnei human challenge model in Thailand. Vaccine (2012) 0.84
Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiol Dis (2013) 0.83
Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4. Mech Dev (2002) 0.81
Nebula/DSCR1 upregulation delays neurodegeneration and protects against APP-induced axonal transport defects by restoring calcineurin and GSK-3β signaling. PLoS Genet (2013) 0.81
Relationship between angiographic and optical coherence tomographic (OCT) parameters for quantifying choroidal neovascular lesions. Graefes Arch Clin Exp Ophthalmol (2009) 0.80
Miro, MCU, and calcium: bridging our understanding of mitochondrial movement in axons. Front Cell Neurosci (2013) 0.79
Dynamic expression and regulation by Fgf8 and Pou2 of the zebrafish LIM-only gene, lmo4. Gene Expr Patterns (2002) 0.77
Progress in molecular biology and translational science. Animal models of human disease. Preface. Prog Mol Biol Transl Sci (2011) 0.76
Identification of recombinant alleles using quantitative real-time PCR implications for Gaucher disease. J Mol Diagn (2011) 0.75