Published in Trends Biochem Sci on April 17, 2009
The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol (2010) 6.28
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
The secret life of kinases: functions beyond catalysis. Cell Commun Signal (2011) 1.13
Classes of phosphoinositide 3-kinases at a glance. J Cell Sci (2014) 0.96
SCF, BDNF, and Gas6 are regulators of growth plate chondrocyte proliferation and differentiation. Mol Endocrinol (2009) 0.91
Identification of components of the host type IA phosphoinositide 3-kinase pathway that promote internalization of Listeria monocytogenes. Infect Immun (2011) 0.91
Novel Role for p110β PI 3-Kinase in Male Fertility through Regulation of Androgen Receptor Activity in Sertoli Cells. PLoS Genet (2015) 0.82
Adipose tissue insulin resistance due to loss of PI3K p110α leads to decreased energy expenditure and obesity. Am J Physiol Endocrinol Metab (2014) 0.82
ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase. J Biol Chem (2009) 0.82
Phosphoinositide 3-kinase γ inhibits cardiac GSK-3 independently of Akt. Sci Signal (2013) 0.81
Phosphoinositide 3-kinaseγ controls the intracellular localization of CpG to limit DNA-PKcs-dependent IL-10 production in macrophages. PLoS One (2011) 0.78
Identification and classification of small molecule kinases: insights into substrate recognition and specificity. BMC Evol Biol (2016) 0.77
Phosphoinositide 3-kinase: friend and foe in cardiovascular disease. Front Pharmacol (2015) 0.77
Role of Host Type IA Phosphoinositide 3-Kinase Pathway Components in Invasin-Mediated Internalization of Yersinia enterocolitica. Infect Immun (2016) 0.76
Scaffolding Function of PI3Kgamma Emerges from Enzyme's Shadow. J Mol Biol (2017) 0.75
Evolutionary history of phosphatidylinositol- 3-kinases: ancestral origin in eukaryotes and complex duplication patterns. BMC Evol Biol (2015) 0.75
Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells. Nat Med (2005) 7.66
Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement. FASEB J (2006) 5.93
Therapeutic potential of endothelial progenitor cells in cardiovascular diseases. Hypertension (2005) 2.03
Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM- and integrin-mediated signaling in platelets. Blood (2009) 1.90
PI3K/AKT signaling pathway and cancer: an updated review. Ann Med (2014) 1.60
Diagnostic and prognostic value of presepsin in the management of sepsis in the emergency department: a multicenter prospective study. Crit Care (2013) 1.55
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Mol Cell (2011) 1.52
Phosphoinositide 3-kinase signalling in the vascular system. Cardiovasc Res (2008) 1.51
Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction. Stem Cells (2009) 1.50
The post-transcriptional gene silencing machinery functions independently of DNA methylation to repress a LINE1-like retrotransposon in Neurospora crassa. Nucleic Acids Res (2005) 1.40
Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. J Endocrinol (2007) 1.35
NADPH oxidases in heart failure: poachers or gamekeepers? Antioxid Redox Signal (2012) 1.27
Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism. Hypertension (2002) 1.23
Targeting PI3K in Cancer: Any Good News? Front Oncol (2013) 1.18
Phosphoinositide 3-kinase gamma gene knockout impairs postischemic neovascularization and endothelial progenitor cell functions. Arterioscler Thromb Vasc Biol (2007) 1.16
Taming the PI3K team to hold inflammation and cancer at bay. Pharmacol Ther (2008) 1.13
PI3K inhibition in inflammation: Toward tailored therapies for specific diseases. Bioessays (2010) 1.11
Hypoxia-regulated therapeutic gene as a preemptive treatment strategy against ischemia/reperfusion tissue injury. Proc Natl Acad Sci U S A (2004) 1.09
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell (2010) 1.07
Negative feedback regulation of Rac in leukocytes from mice expressing a constitutively active phosphatidylinositol 3-kinase gamma. Proc Natl Acad Sci U S A (2007) 0.98
Blockade of phosphatidylinositol 3-kinase PI3Kδ or PI3Kγ reduces IL-17 and ameliorates imiquimod-induced psoriasis-like dermatitis. J Immunol (2012) 0.96
Teratocarcinoma-derived growth factor-1 is upregulated in aldosterone-producing adenomas and increases aldosterone secretion and inhibits apoptosis in vitro. Hypertension (2010) 0.94
Antihypertensive drugs and the sympathetic nervous system. J Cardiovasc Pharmacol (2007) 0.94
Distinct effects of leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure. Circulation (2011) 0.93
Diagnosis and treatment of low-renin hypertension. Clin Endocrinol (Oxf) (2007) 0.91
Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation (2012) 0.91
PI3K kinase and scaffold functions in heart. Ann N Y Acad Sci (2010) 0.89
Mesenchymal stem cells differentiate into renin-producing juxtaglomerular (JG)-like cells under the control of liver X receptor-alpha. J Biol Chem (2010) 0.88
Role and regulation of phosphatidylinositol 3-kinase β in platelet integrin α2β1 signaling. Blood (2011) 0.88
Sustained release of PI3K inhibitor from PHA nanoparticles and in vitro growth inhibition of cancer cell lines. Appl Microbiol Biotechnol (2011) 0.88
Liver X receptor activation reduces angiogenesis by impairing lipid raft localization and signaling of vascular endothelial growth factor receptor-2. Arterioscler Thromb Vasc Biol (2012) 0.86
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation. J Clin Invest (2014) 0.86
PI3Kγ inhibition reduces blood pressure by a vasorelaxant Akt/L-type calcium channel mechanism. Cardiovasc Res (2011) 0.86
The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice. Immunol Lett (2010) 0.85
Myocyte signalling in leucocyte recruitment to the heart. Cardiovasc Res (2014) 0.84
Rule out of acute aortic dissection with plasma matrix metalloproteinase 8 in the emergency department. Crit Care (2013) 0.83
Crossroads of PI3K and Rac pathways. Small GTPases (2015) 0.83
Baroreflex sensitivity correlates with left ventricular morphology and diastolic function in essential hypertension. J Hypertens (2007) 0.83
Early cardiovascular autonomic dysfunction, beta cell function and insulin resistance in obese adolescents. Acta Biomed (2009) 0.82
Ago1 and Ago2 differentially affect cell proliferation, motility and apoptosis when overexpressed in SH-SY5Y neuroblastoma cells. FEBS Lett (2011) 0.81
Nuclear hormone receptors as regulators of the renin-angiotensin-aldosterone system. Hypertension (2008) 0.80
Specific PI3K isoform modulation in heart failure: lessons from transgenic mice. Curr Heart Fail Rep (2011) 0.78
Phosphoinositide 3-kinases in health and disease. Subcell Biochem (2012) 0.78
Therapeutic applications of PI3K inhibitors in cardiovascular diseases. Future Med Chem (2013) 0.77
Primary aldosteronism (PA) and endothelial progenitor cell (EPC) bioavailability. Clin Endocrinol (Oxf) (2008) 0.77
May thrombopoietin be a useful marker of sepsis severity assessment in patients with SIRS entering the emergency department? Clin Chem Lab Med (2014) 0.77
Genetics of primary aldosteronism. J Hypertens (2004) 0.76
Phosphoinositides and cardiovascular diseases. Curr Top Microbiol Immunol (2012) 0.76
Diagnostic performance of emergency transthoracic focus cardiac ultrasound in suspected acute type A aortic dissection. Intern Emerg Med (2014) 0.76
Aldosterone as an independent factor in cerebrovascular damage. Clin Exp Hypertens (2008) 0.75
[ADHD and multimodal intervention]. Ann Ist Super Sanita (2006) 0.75
Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors. Org Biomol Chem (2011) 0.75
Measuring PI3K lipid kinase activity. Methods Mol Biol (2012) 0.75
Bleeding prevalence and transfusion requirement in patients with thrombocytopenia in the emergency department. Clin Chem Lab Med (2014) 0.75
Thrombopoietin as Early Biomarker of Disease Severity in Patients With Acute Pancreatitis. Pancreas (2017) 0.75