Published in PLoS Genet on July 01, 2015
Therapeutic Benefit of Selective Inhibition of p110α PI3-Kinase in Pancreatic Neuroendocrine Tumors. Clin Cancer Res (2016) 0.76
Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells. Sci Signal (2016) 0.75
Loss of PI3K p110α in the Adipose Tissue Results in Infertility and Delayed Puberty Onset in Male Mice. Biomed Res Int (2017) 0.75
OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis. Sci Rep (2016) 0.75
Small copy-number variations involving genes of the FGF pathway in differences in sex development. Hum Genome Var (2017) 0.75
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res (1995) 12.21
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell (2011) 7.32
The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol (2010) 6.28
Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene. Genes Dev (2001) 6.15
Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature (2008) 6.04
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice. Science (2002) 6.01
PTEN-deficient cancers depend on PIK3CB. Proc Natl Acad Sci U S A (2008) 3.87
Oocyte-specific deletion of Pten causes premature activation of the primordial follicle pool. Science (2008) 3.80
Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature (2006) 3.71
Development of PI3K inhibitors: lessons learned from early clinical trials. Nat Rev Clin Oncol (2013) 3.57
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci U S A (2004) 3.48
Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci (2005) 3.45
Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev (2009) 3.35
Angiogenesis selectively requires the p110alpha isoform of PI3K to control endothelial cell migration. Nature (2008) 3.19
P110delta, a novel phosphoinositide 3-kinase in leukocytes. Proc Natl Acad Sci U S A (1997) 3.09
The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma. Proc Natl Acad Sci U S A (2008) 2.81
Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase. Mamm Genome (2002) 2.79
Essential role for the p110delta phosphoinositide 3-kinase in the allergic response. Nature (2004) 2.73
Rhox: a new homeobox gene cluster. Cell (2005) 2.62
Phosphoinositide 3-kinase p110beta activity: key role in metabolism and mammary gland cancer but not development. Sci Signal (2008) 2.19
Kit/stem cell factor receptor-induced activation of phosphatidylinositol 3'-kinase is essential for male fertility. Nat Genet (2000) 2.18
Point mutation in kit receptor tyrosine kinase reveals essential roles for kit signaling in spermatogenesis and oogenesis without affecting other kit responses. EMBO J (2000) 2.13
Life with a single isoform of Akt: mice lacking Akt2 and Akt3 are viable but display impaired glucose homeostasis and growth deficiencies. Mol Cell Biol (2006) 2.03
A chemical screen in diverse breast cancer cell lines reveals genetic enhancers and suppressors of sensitivity to PI3K isoform-selective inhibition. Biochem J (2008) 1.96
PI3Kβ plays a critical role in neutrophil activation by immune complexes. Sci Signal (2011) 1.95
Spermatid differentiation requires the assembly of a cell polarity complex downstream of junctional adhesion molecule-C. Nature (2004) 1.88
Sertoli and granulosa cell-specific Cre recombinase activity in transgenic mice. Genesis (2002) 1.87
Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development (2003) 1.80
Somatic cells regulate maternal mRNA translation and developmental competence of mouse oocytes. Nat Cell Biol (2013) 1.65
Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Mol Endocrinol (2004) 1.62
Androgen receptor roles in spermatogenesis and fertility: lessons from testicular cell-specific androgen receptor knockout mice. Endocr Rev (2009) 1.55
G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness. Sci Signal (2012) 1.38
Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis. J Clin Invest (2011) 1.37
Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair. Proc Natl Acad Sci U S A (2010) 1.37
The effect of a sertoli cell-selective knockout of the androgen receptor on testicular gene expression in prepubertal mice. Mol Endocrinol (2005) 1.34
Phenotyping male infertility in the mouse: how to get the most out of a 'non-performer'. Hum Reprod Update (2009) 1.22
Regulation of ectoplasmic specialization dynamics in the seminiferous epithelium by focal adhesion-associated proteins in testosterone-suppressed rat testes. Endocrinology (2004) 1.20
Tissue- and cell-specific functions of the androgen receptor revealed through conditional knockout models in mice. Mol Cell Endocrinol (2011) 1.18
Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival. Mol Cell Biol (2011) 1.14
Peptide growth factors and preimplantation development. Hum Reprod Update (1997) 1.13
Phosphoinositide 3-OH kinase p85alpha and p110beta are essential for androgen receptor transactivation and tumor progression in prostate cancers. Oncogene (2008) 1.13
Role of androgen and gonadotrophins in the development and function of the Sertoli cells and Leydig cells: data from mutant and genetically modified mice. Mol Cell Endocrinol (2008) 1.08
Essential role of the p110beta subunit of phosphoinositide 3-OH kinase in male fertility. Mol Biol Cell (2010) 1.07
Loss of androgen receptor binding to selective androgen response elements causes a reproductive phenotype in a knockin mouse model. Proc Natl Acad Sci U S A (2007) 1.06
Spermatogenesis and sertoli cell activity in mice lacking sertoli cell receptors for follicle-stimulating hormone and androgen. Endocrinology (2008) 1.05
Both p110α and p110β isoforms of PI3K can modulate the impact of loss-of-function of the PTEN tumour suppressor. Biochem J (2012) 1.03
Development and function of the adult generation of Leydig cells in mice with Sertoli cell-selective or total ablation of the androgen receptor. Endocrinology (2005) 1.03
Gab2 is involved in differential phosphoinositide 3-kinase signaling by two splice forms of c-Kit. J Biol Chem (2008) 0.99
Twice upon a time: PI3K's secret double life exposed. Trends Biochem Sci (2009) 0.98
PI3K keeps the balance between metabolism and cancer. Adv Biol Regul (2012) 0.94
Regulation of Sertoli-germ cell adhesion and sperm release by FSH and nonclassical testosterone signaling. Mol Endocrinol (2010) 0.93
The potential roles for embryotrophic ligands in preimplantation embryo development. Hum Reprod Update (2008) 0.91
Effect of lysophosphatidic acid on the preimplantation development of mouse embryos. FEBS Lett (1994) 0.89
Isoform-selective induction of human p110δ PI3K expression by TNFα: identification of a new and inducible PIK3CD promoter. Biochem J (2012) 0.86
Early effects of Sertoli cell-selective androgen receptor ablation on testicular gene expression. Int J Androl (2009) 0.86
Constitutive PtdIns(3,4,5)P3 synthesis promotes the development and survival of early mammalian embryos. Development (2007) 0.85
Phosphoinositide 3-kinase p110δ mediates estrogen- and FSH-stimulated ovarian follicle growth. Mol Endocrinol (2013) 0.84
Temporal role of Sertoli cell androgen receptor expression in spermatogenic development. Mol Endocrinol (2012) 0.84
FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells. Mol Cell Endocrinol (2009) 0.83
Transfection with steroid-responsive reporter constructs shows glucocorticoid rather than androgen responsiveness in cultured Sertoli cells. J Steroid Biochem Mol Biol (2006) 0.83
Stable transfection of the rat follicle-stimulating hormone receptor complementary DNA into an immortalized murine Sertoli cell line. Mol Cell Endocrinol (1998) 0.82
Autocrine androgen action is essential for Leydig cell maturation and function, and protects against late-onset Leydig cell apoptosis in both mice and men. FASEB J (2014) 0.81
Maternal phosphatidylinositol 3-kinase signalling is crucial for embryonic genome activation and preimplantation embryogenesis. EMBO Rep (2010) 0.80
Receptor binding properties of 125I-hFSH prepared by enzymatic iodination. J Clin Endocrinol Metab (1974) 0.76
Acute versus chronic loss of mammalian Azi1/Cep131 results in distinct ciliary phenotypes. PLoS Genet (2013) 0.98
Germ cell-specific targeting of DICER or DGCR8 reveals a novel role for endo-siRNAs in the progression of mammalian spermatogenesis and male fertility. PLoS One (2014) 0.91
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study. J Allergy Clin Immunol (2016) 0.88
Sertoli cells maintain Leydig cell number and peritubular myoid cell activity in the adult mouse testis. PLoS One (2014) 0.80
Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation. Mol Cancer Ther (2016) 0.76
Modelling the Structure and Dynamics of Biological Pathways. PLoS Biol (2016) 0.75