Published in Mol Cell Biol on June 01, 2005
Structural basis of Wnt recognition by Frizzled. Science (2012) 4.31
A Wnt7b-dependent pathway regulates the orientation of epithelial cell division and establishes the cortico-medullary axis of the mammalian kidney. Development (2009) 2.55
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Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell (2011) 2.23
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
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Wnt7b stimulates embryonic lung growth by coordinately increasing the replication of epithelium and mesenchyme. Development (2008) 1.90
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An FGF-WNT gene regulatory network controls lung mesenchyme development. Dev Biol (2008) 1.78
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Functional interaction between Wnt3 and Frizzled-7 leads to activation of the Wnt/beta-catenin signaling pathway in hepatocellular carcinoma cells. J Hepatol (2008) 1.56
Hairless triggers reactivation of hair growth by promoting Wnt signaling. Proc Natl Acad Sci U S A (2005) 1.41
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Down-regulation of the canonical Wnt β-catenin pathway in the airway epithelium of healthy smokers and smokers with COPD. PLoS One (2011) 1.13
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A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus. Dev Biol (2006) 1.06
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Wntless is required for peripheral lung differentiation and pulmonary vascular development. Dev Biol (2013) 1.03
Comprehensive Wnt-related gene expression during cochlear duct development in chicken. J Comp Neurol (2008) 1.02
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Impact of environmental chemicals on lung development. Environ Health Perspect (2010) 0.94
Wnt ligands signal in a cooperative manner to promote foregut organogenesis. Proc Natl Acad Sci U S A (2012) 0.94
Wnt/Frizzled family members mediate olfactory sensory neuron axon extension. J Comp Neurol (2008) 0.94
The matricellular protein cysteine-rich protein 61 (CCN1/Cyr61) enhances physiological adaptation of retinal vessels and reduces pathological neovascularization associated with ischemic retinopathy. J Biol Chem (2011) 0.94
Estrogenic environmental chemicals and drugs: mechanisms for effects on the developing male urogenital system. J Steroid Biochem Mol Biol (2011) 0.94
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Wnt and FGF mediated epithelial-mesenchymal crosstalk during lung development. Dev Dyn (2014) 0.82
LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One (2012) 0.81
Wnt/β-catenin signaling modulates human airway sensitization induced by β2-adrenoceptor stimulation. PLoS One (2014) 0.80
Airway response to acute mechanical stress in a human bronchial model of stretch. Crit Care (2011) 0.80
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Inhibition of canonical WNT/β-catenin signaling is involved in leflunomide (LEF)-mediated cytotoxic effects on renal carcinoma cells. Oncotarget (2016) 0.78
Lung interstitial cells during alveolarization. Korean J Pediatr (2010) 0.78
Canonical Wnt signaling activity in early stages of chick lung development. PLoS One (2014) 0.77
Identification of embryonic pancreatic genes using Xenopus DNA microarrays. Dev Dyn (2009) 0.77
Linking bronchopulmonary dysplasia to adult chronic lung diseases: role of WNT signaling. Mol Cell Pediatr (2016) 0.77
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Dynamic expression of secreted Frizzled-related protein 3 (sFRP3) in the developing mouse spinal cord and dorsal root ganglia. Neuroscience (2013) 0.76
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Wnt signaling and renal medulla formation. Pediatr Nephrol (2011) 0.75
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LDL-receptor-related proteins in Wnt signal transduction. Nature (2000) 6.94
Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6. Curr Biol (2001) 5.95
Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature (2000) 5.52
Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway. Mol Cell (2001) 5.19
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JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates. EMBO Rep (2001) 3.08
The Wnt/beta-catenin pathway regulates cardiac valve formation. Nature (2003) 2.89
Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 2.88
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Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse. J Cell Biol (2004) 2.57
Wnt5a participates in distal lung morphogenesis. Dev Biol (2002) 2.37
Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis. Development (2001) 2.19
Mesd encodes an LRP5/6 chaperone essential for specification of mouse embryonic polarity. Cell (2003) 1.99
Ligand receptor interactions in the Wnt signaling pathway in Drosophila. J Biol Chem (2002) 1.84
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
A role for the beta-catenin/T-cell factor signaling cascade in vascular remodeling. Circ Res (2002) 1.72
Regulation of Wnt/LRP signaling by distinct domains of Dickkopf proteins. Mol Cell Biol (2002) 1.60
The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell (2003) 1.49
Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev (2001) 1.49
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Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins. J Biol Chem (2003) 1.44
Wnt7b regulates placental development in mice. Dev Biol (2001) 1.37
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Identification of a Wnt-responsive signal transduction pathway in primary endothelial cells. Biochem Biophys Res Commun (1999) 1.27
Multiple mechanisms for Wnt11-mediated repression of the canonical Wnt signaling pathway. J Biol Chem (2004) 1.27
Molecular markers of cardiac endocardial cushion development. Dev Dyn (2003) 1.22
Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Mech Dev (2002) 1.13
LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol (2004) 1.10
Expression of Frizzled genes in developing and postnatal hair follicles. J Invest Dermatol (2004) 1.04
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Chimeric Wnt proteins define the amino-terminus of Wnt-1 as a transformation-specific determinant. Oncogene (1999) 0.98
Involvement of frizzled-10 in Wnt-7a signaling during chick limb development. Dev Growth Differ (2000) 0.89
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Postnatal isl1+ cardioblasts enter fully differentiated cardiomyocyte lineages. Nature (2005) 9.44
Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. Cell Stem Cell (2011) 6.11
Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature (2010) 5.26
The timing of cortical neurogenesis is encoded within lineages of individual progenitor cells. Nat Neurosci (2006) 4.49
Interconversion between intestinal stem cell populations in distinct niches. Science (2011) 4.23
Myocardin is a critical serum response factor cofactor in the transcriptional program regulating smooth muscle cell differentiation. Mol Cell Biol (2003) 3.69
Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm. Development (2007) 3.56
WNT7b mediates macrophage-induced programmed cell death in patterning of the vasculature. Nature (2005) 3.44
beta-Catenin is required for specification of proximal/distal cell fate during lung morphogenesis. J Biol Chem (2003) 3.37
A Gata6-Wnt pathway required for epithelial stem cell development and airway regeneration. Nat Genet (2008) 3.37
PlexinD1 and semaphorin signaling are required in endothelial cells for cardiovascular development. Dev Cell (2004) 3.24
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Wnt7b regulates mesenchymal proliferation and vascular development in the lung. Development (2002) 2.88
FoxP2 expression in avian vocal learners and non-learners. J Neurosci (2004) 2.87
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Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung. Dev Biol (2005) 2.73
Wnt2/2b and beta-catenin signaling are necessary and sufficient to specify lung progenitors in the foregut. Dev Cell (2009) 2.72
Nf1 has an essential role in endothelial cells. Nat Genet (2002) 2.63
Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development. Proc Natl Acad Sci U S A (2008) 2.55
Hop is an unusual homeobox gene that modulates cardiac development. Cell (2002) 2.52
Transcriptional and DNA binding activity of the Foxp1/2/4 family is modulated by heterotypic and homotypic protein interactions. Mol Cell Biol (2004) 2.48
Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development (2008) 2.46
Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron (2008) 2.44
Foxp2 and Foxp1 cooperatively regulate lung and esophagus development. Development (2007) 2.44
Pax3 functions at a nodal point in melanocyte stem cell differentiation. Nature (2005) 2.37
Foxp1 regulates cardiac outflow tract, endocardial cushion morphogenesis and myocyte proliferation and maturation. Development (2004) 2.27
Wnt/beta-catenin signaling directs multiple stages of tooth morphogenesis. Dev Biol (2007) 2.26
Reciprocal requirements for EDA/EDAR/NF-kappaB and Wnt/beta-catenin signaling pathways in hair follicle induction. Dev Cell (2009) 2.17
Wnt/beta-catenin signaling promotes expansion of Isl-1-positive cardiac progenitor cells through regulation of FGF signaling. J Clin Invest (2007) 2.12
Impaired notch signaling promotes de novo squamous cell carcinoma formation. Cancer Res (2006) 2.02
Transcriptional genomics associates FOX transcription factors with human heart failure. Circulation (2006) 2.00
GATA6 is essential for embryonic development of the liver but dispensable for early heart formation. Mol Cell Biol (2005) 2.00
Cardiac outflow tract defects in mice lacking ALK2 in neural crest cells. Development (2004) 1.99
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Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron (2012) 1.86
Wnt signaling regulates smooth muscle precursor development in the mouse lung via a tenascin C/PDGFR pathway. J Clin Invest (2009) 1.83
GATA6 regulates differentiation of distal lung epithelium. Development (2002) 1.82
Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A (2011) 1.76
Hdac1 and Hdac2 act redundantly to control p63 and p53 functions in epidermal progenitor cells. Dev Cell (2010) 1.75
Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proc Natl Acad Sci U S A (2005) 1.70
The three R's of lung health and disease: repair, remodeling, and regeneration. J Clin Invest (2011) 1.68
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium. J Clin Invest (2011) 1.67
Myocardial Notch signaling reprograms cardiomyocytes to a conduction-like phenotype. Circulation (2012) 1.66
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The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium. J Biol Chem (2002) 1.59
Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol (2006) 1.55
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GATA-6 regulates semaphorin 3C and is required in cardiac neural crest for cardiovascular morphogenesis. J Clin Invest (2006) 1.47
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The von Hippel-Lindau Chuvash mutation promotes pulmonary hypertension and fibrosis in mice. J Clin Invest (2010) 1.46
Cre-mediated excision of Fgf8 in the Tbx1 expression domain reveals a critical role for Fgf8 in cardiovascular development in the mouse. Dev Biol (2004) 1.46
Coordination of heart and lung co-development by a multipotent cardiopulmonary progenitor. Nature (2013) 1.42
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proc Natl Acad Sci U S A (2009) 1.41
Distinct functions for Wnt/β-catenin in hair follicle stem cell proliferation and survival and interfollicular epidermal homeostasis. Cell Stem Cell (2013) 1.41
GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. Development (2007) 1.39
Characterization and in vivo pharmacological rescue of a Wnt2-Gata6 pathway required for cardiac inflow tract development. Dev Cell (2010) 1.33
Tie2Cre-mediated inactivation of plexinD1 results in congenital heart, vascular and skeletal defects. Dev Biol (2008) 1.29
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GATA-6 is required for maturation of the lung in late gestation. Am J Physiol Lung Cell Mol Physiol (2002) 1.26
GATA-6 regulates genes promoting synthetic functions in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2004) 1.26
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PIP5KI gamma is required for cardiovascular and neuronal development. Proc Natl Acad Sci U S A (2007) 1.25
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Molecular markers of cardiac endocardial cushion development. Dev Dyn (2003) 1.22
Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature. Arterioscler Thromb Vasc Biol (2008) 1.21
Wnt2 signaling is necessary and sufficient to activate the airway smooth muscle program in the lung by regulating myocardin/Mrtf-B and Fgf10 expression. Dev Biol (2011) 1.19
Melanocyte-like cells in the heart and pulmonary veins contribute to atrial arrhythmia triggers. J Clin Invest (2009) 1.19
Regulation of lung endoderm progenitor cell behavior by miR302/367. Development (2011) 1.14
Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues. Mech Dev (2002) 1.13
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Gata4 and Gata5 cooperatively regulate cardiac myocyte proliferation in mice. J Biol Chem (2009) 1.12
Advanced cardiac morphogenesis does not require heart tube fusion. Science (2004) 1.11
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The neurofibromin GAP-related domain rescues endothelial but not neural crest development in Nf1 mice. J Clin Invest (2006) 1.10
Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development (2012) 1.08