Published in J Clin Invest on April 20, 2009
The immunology of stroke: from mechanisms to translation. Nat Med (2011) 6.53
Immune cell regulation by autocrine purinergic signalling. Nat Rev Immunol (2011) 2.94
The neutrophil in vascular inflammation. Nat Med (2011) 2.84
The resolution of inflammation. Nat Rev Immunol (2012) 1.58
cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem (2010) 1.11
NTPDase1 governs P2X7-dependent functions in murine macrophages. Eur J Immunol (2010) 1.09
New insights regarding the regulation of chemotaxis by nucleotides, adenosine, and their receptors. Purinergic Signal (2012) 1.04
CD39 expression on T lymphocytes correlates with severity of disease in patients with chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk (2011) 0.99
Cardiac to cancer: connecting connexins to clinical opportunity. FEBS Lett (2014) 0.96
Transgenic over expression of ectonucleotide triphosphate diphosphohydrolase-1 protects against murine myocardial ischemic injury. J Mol Cell Cardiol (2011) 0.95
Ectoenzymes in leukocyte migration and their therapeutic potential. Semin Immunopathol (2014) 0.90
Differential macrophage activation alters the expression profile of NTPDase and ecto-5'-nucleotidase. PLoS One (2012) 0.90
The scavenger receptor CD36 contributes to the neurotoxicity of bone marrow-derived monocytes through peroxynitrite production. Neurobiol Dis (2011) 0.89
Molecular pathology of pulmonary surfactants and cytokines in drowning compared with other asphyxiation and fatal hypothermia. Int J Legal Med (2012) 0.88
Tissue-resident ecto-5' nucleotidase (CD73) regulates leukocyte trafficking in the ischemic brain. J Immunol (2012) 0.86
Inflammatory Disequilibrium in Stroke. Circ Res (2016) 0.83
Ectonucleotidases in tumor cells and tumor-associated immune cells: an overview. J Biomed Biotechnol (2012) 0.83
Regulation of innate immunity by the nucleotide pathway in children with idiopathic nephrotic syndrome. Clin Exp Immunol (2011) 0.82
Regulation of ecto-apyrase CD39 (ENTPD1) expression by phosphodiesterase III (PDE3). FASEB J (2013) 0.81
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation. Nat Commun (2015) 0.81
Flow-dependent expression of ectonucleotide tri(di)phosphohydrolase-1 and suppression of atherosclerosis. J Clin Invest (2015) 0.80
The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets. Immunol Rev (2017) 0.80
P2X ion channel receptors and inflammation. Purinergic Signal (2016) 0.79
Lipid metabolism modulation by the P2X7 receptor in the immune system and during the course of infection: new insights into the old view. Purinergic Signal (2011) 0.79
Low-dose levodopa protects nerve cells from oxidative stress and up-regulates expression of pCREB and CD39. PLoS One (2014) 0.78
Inhibition of connexin 43 hemichannel-mediated ATP release attenuates early inflammation during the foreign body response. Tissue Eng Part A (2015) 0.78
CD39 deficiency in murine liver allografts promotes inflammatory injury and immune-mediated rejection. Transpl Immunol (2015) 0.78
Purinergic signaling in early inflammatory events of the foreign body response: modulating extracellular ATP as an enabling technology for engineered implants and tissues. Tissue Eng Part B Rev (2014) 0.78
Expression and function of P2 receptors in hematopoietic stem and progenitor cells. Stem Cell Investig (2015) 0.77
Differential requirement for P2X7R function in IL-17 dependent vs. IL-17 independent cellular immune responses. Am J Transplant (2014) 0.76
Ectonucleotidase CD39-driven control of postinfarction myocardial repair and rupture. JCI Insight (2017) 0.75
Barriers to Radiation-Induced In Situ Tumor Vaccination. Front Immunol (2017) 0.75
Purinergic dysregulation in pulmonary hypertension. Am J Physiol Heart Circ Physiol (2016) 0.75
Emerging role of extracellular nucleotides and adenosine in multiple sclerosis. Purinergic Signal (2011) 0.75
The three Rs: Recruitment, Retention and Residence of leukocytes in the liver. Clin Transl Immunology (2016) 0.75
Ischemic Cerebroprotection Conferred by Myeloid Lineage-Restricted or Global CD39 Transgene Expression. Circulation (2017) 0.75
Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke. Acta Neuropathol (2017) 0.75
Receptors for purines and pyrimidines. Pharmacol Rev (1998) 13.92
F4/80, a monoclonal antibody directed specifically against the mouse macrophage. Eur J Immunol (1981) 12.96
P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury. Nature (2003) 6.04
ATP release guides neutrophil chemotaxis via P2Y2 and A3 receptors. Science (2006) 6.00
P2X receptors as cell-surface ATP sensors in health and disease. Nature (2006) 4.55
Targeted disruption of cd39/ATP diphosphohydrolase results in disordered hemostasis and thromboregulation. Nat Med (1999) 4.44
Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med (2004) 4.16
Nucleotide receptors: an emerging family of regulatory molecules in blood cells. Blood (2001) 3.84
Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. J Exp Med (2003) 3.71
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 3.64
Macrovascular thrombosis is driven by tissue factor derived primarily from the blood vessel wall. Blood (2004) 3.31
Liaisons dangereuses: P2X(7) and the inflammasome. Trends Pharmacol Sci (2007) 3.01
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood (2004) 2.80
Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor. J Biol Chem (1993) 2.50
The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39. J Clin Invest (1997) 2.18
Formation of leukotrienes and other hydroxy acids during platelet-neutrophil interactions in vitro. Biochem Biophys Res Commun (1982) 2.02
Selective inactivation or reconstitution of adenosine A2A receptors in bone marrow cells reveals their significant contribution to the development of ischemic brain injury. Nat Med (2004) 1.93
Methotrexate and sulfasalazine promote adenosine release by a mechanism that requires ecto-5'-nucleotidase-mediated conversion of adenine nucleotides. J Clin Invest (1998) 1.86
Contribution of E-NTPDase1 (CD39) to renal protection from ischemia-reperfusion injury. FASEB J (2007) 1.84
A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood (2005) 1.81
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest (2002) 1.80
Cell-surface enzymes in control of leukocyte trafficking. Nat Rev Immunol (2005) 1.76
Disordered cellular migration and angiogenesis in cd39-null mice. Circulation (2001) 1.70
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1. Blood (2000) 1.69
Neuronal protection in stroke by an sLex-glycosylated complement inhibitory protein. Science (1999) 1.65
Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation. J Clin Invest (1998) 1.64
Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation. J Clin Invest (2004) 1.61
A reproducible model of middle cerebral artery occlusion in mice: hemodynamic, biochemical, and magnetic resonance imaging. J Cereb Blood Flow Metab (1998) 1.58
Pharmacological characterization of the human P2Y11 receptor. Br J Pharmacol (1999) 1.58
Lymphocytic infiltration and expression of intercellular adhesion molecule-1 in photochemically induced ischemia of the rat cortex. J Cereb Blood Flow Metab (1995) 1.50
Dynamics of the inflammatory response after murine spinal cord injury revealed by flow cytometry. J Neurosci Res (2008) 1.42
Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury. Stroke (1999) 1.42
Inhibition of platelet function by recombinant soluble ecto-ADPase/CD39. J Clin Invest (1998) 1.39
Inhibition of platelet function by an aspirin-insensitive endothelial cell ADPase. Thromboregulation by endothelial cells. J Clin Invest (1991) 1.38
Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation (2002) 1.35
Beneficial effects of CD39/ecto-nucleoside triphosphate diphosphohydrolase-1 in murine intestinal ischemia-reperfusion injury. Thromb Haemost (2004) 1.31
CD39 modulates endothelial cell activation and apoptosis. Mol Med (2000) 1.25
Agonists and antagonists acting at P2X receptors: selectivity profiles and functional implications. Naunyn Schmiedebergs Arch Pharmacol (2000) 1.23
CD39/NTPDase-1 activity and expression in normal leukocytes. Thromb Res (2007) 1.22
Analysis of CD39/ATP diphosphohydrolase (ATPDase) expression in endothelial cells, platelets and leukocytes. Thromb Haemost (1999) 1.20
Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke (1994) 1.15
Cloned ligand-gated channels activated by extracellular ATP (P2X receptors). J Membr Biol (1997) 1.10
Contributions of LFA-1 and Mac-1 to brain injury and microvascular dysfunction induced by transient middle cerebral artery occlusion. Am J Physiol Heart Circ Physiol (2004) 1.07
Ecto-5'-nucleotidase activity in T and B lymphocytes from normal subjects and patients with congenital X-linked agammaglobulinemia. J Immunol (1979) 1.07
Soluble purine-converting enzymes circulate in human blood and regulate extracellular ATP level via counteracting pyrophosphatase and phosphotransfer reactions. FASEB J (2003) 1.06
Isolation and flow cytometric characterization of newborn mouse brain-derived microglia maintained in vitro. J Leukoc Biol (1991) 1.04
ATP- and adenosine-mediated signaling in the central nervous system: chronic pain and microglia: involvement of the ATP receptor P2X4. J Pharmacol Sci (2004) 1.03
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1. Br J Pharmacol (2000) 1.02
Neuroprotective effect of SolCD39, a novel platelet aggregation inhibitor, on transient middle cerebral artery occlusion in rats. Stroke (2003) 1.01
A simple qPCR-based method to detect correct insertion of homologous targeting vectors in murine ES cells. Transgenic Res (2007) 1.00
Cell biology. Purinergic chemotaxis. Science (2006) 1.00
Modulation of surface CD11/CD18 glycoproteins (Mo1, LFA-1, p150,95) by human mononuclear phagocytes. Clin Immunol Immunopathol (1988) 0.97
Properties of the novel ATP-gated ionotropic receptor composed of the P2X(1) and P2X(5) isoforms. Mol Pharmacol (1999) 0.97
Stimulation of human neutrophil adhesive properties by adenine nucleotides. J Immunol (1988) 0.92
Nucleotides and cd39: principal modulatory players in hemostasis and thrombosis. Nat Med (1999) 0.90
Hydrolysis of extracellular ATP and immune suppression: humans versus mice. Blood (2008) 0.80
Intracellular localization of Na,K-ATPase alpha2 subunit mutants. Arch Biochem Biophys (1997) 0.78
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 3.64
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41
Plasma interleukin-10 levels and adverse outcomes in acute coronary syndrome. Am J Med (2011) 2.59
Adiponectin is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction in patients presenting with chest pain. Eur Heart J (2006) 2.47
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci U S A (2004) 2.42
Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet (2002) 2.02
Evidence for tissue-resident mesenchymal stem cells in human adult lung from studies of transplanted allografts. J Clin Invest (2007) 1.87
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. J Biol Chem (2002) 1.81
A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood (2005) 1.81
Elucidation of the thromboregulatory role of CD39/ectoapyrase in the ischemic brain. J Clin Invest (2002) 1.80
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J (2006) 1.66
Association of plasma levels of F11 receptor/junctional adhesion molecule-A (F11R/JAM-A) with human atherosclerosis. J Am Coll Cardiol (2007) 1.64
Complement component C3 mediates inflammatory injury following focal cerebral ischemia. Circ Res (2006) 1.63
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2008) 1.62
Mesenchymal stromal cells in bronchoalveolar lavage as predictors of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med (2010) 1.58
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest (2002) 1.44
A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis. J Clin Invest (2003) 1.42
Lung resident mesenchymal stem cells isolated from human lung allografts inhibit T cell proliferation via a soluble mediator. J Immunol (2008) 1.42
Timing of nitric oxide donor supplementation determines endothelin-1 regulation and quality of lung preservation for transplantation. Am J Respir Cell Mol Biol (2002) 1.41
Thrombospondins deployed by thrombopoietic cells determine angiogenic switch and extent of revascularization. J Clin Invest (2006) 1.35
Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Circulation (2002) 1.34
A plasma membrane receptor kinase, GHR1, mediates abscisic acid- and hydrogen peroxide-regulated stomatal movement in Arabidopsis. Plant Cell (2012) 1.33
Role of CD39 (NTPDase-1) in thromboregulation, cerebroprotection, and cardioprotection. Semin Thromb Hemost (2005) 1.32
Usefulness of baseline plasma myeloperoxidase levels as an independent predictor of myocardial infarction at two years in patients presenting with acute coronary syndrome. Am J Cardiol (2007) 1.32
Tissue inhibitor of metalloproteinase-1 (TIMP-1) is an independent predictor of all-cause mortality, cardiac mortality, and myocardial infarction. Am Heart J (2006) 1.31
A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol (2005) 1.31
Brain injury and neurofunctional deficit in neonatal mice with hypoxic-ischemic encephalopathy. Behav Brain Res (2003) 1.31
Metabolic control of excessive extracellular nucleotide accumulation by CD39/ecto-nucleotidase-1: implications for ischemic vascular diseases. J Pharmacol Exp Ther (2003) 1.29
Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha. FASEB J (2006) 1.24
A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J Am Soc Nephrol (2008) 1.24
CD39/NTPDase-1 activity and expression in normal leukocytes. Thromb Res (2007) 1.22
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. J Neurochem (2008) 1.21
Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases. J Biol Chem (2011) 1.20
Central role for aldose reductase pathway in myocardial ischemic injury. FASEB J (2004) 1.19
Endothelial response to hypoxia: physiologic adaptation and pathologic dysfunction. Curr Opin Crit Care (2002) 1.16
Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling. Curr Pharm Des (2003) 1.14
New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system. Exp Biol Med (Maywood) (2004) 1.14
Carbon monoxide rescues ischemic lungs by interrupting MAPK-driven expression of early growth response 1 gene and its downstream target genes. Proc Natl Acad Sci U S A (2006) 1.14
Substitution profile of Delta9-tetrahydrocannabinol, triazolam, hydromorphone, and methylphenidate in humans discriminating Delta9-tetrahydrocannabinol. Psychopharmacology (Berl) (2008) 1.13
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. FASEB J (2002) 1.13
Induction of DNA polymerase beta-dependent base excision repair in response to oxidative stress in vivo. Carcinogenesis (2002) 1.13
Obligatory role for interleukin-13 in obstructive lesion development in airway allografts. Am J Pathol (2006) 1.11
cAMP/CREB-mediated transcriptional regulation of ectonucleoside triphosphate diphosphohydrolase 1 (CD39) expression. J Biol Chem (2010) 1.11
Late measures of brain injury after neonatal hypoxia-ischemia in mice. Stroke (2004) 1.10
Targeting therapeutics to the vascular wall in atherosclerosis--carrier size matters. Atherosclerosis (2011) 1.09
Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. J Biol Chem (2007) 1.09
COX inhibitors and thromboregulation. N Engl J Med (2002) 1.08
Attenuation of DNA polymerase beta-dependent base excision repair and increased DMS-induced mutagenicity in aged mice. Mutat Res (2002) 1.07
Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain (2003) 1.07
Old dogs and new tricks: proteases, inhibitors, and cell migration. Sci STKE (2003) 1.06
Homocysteine inhibits neoangiogenesis in mice through blockade of annexin A2-dependent fibrinolysis. J Clin Invest (2009) 1.04
Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. J Biol Chem (2002) 1.04
Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system. Thromb Haemost (2004) 1.04
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain (2012) 1.04
Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures. Lab Invest (2003) 1.03
Conservation of critical functional domains in murine plasminogen activator inhibitor-1. J Biol Chem (2004) 1.02
Heterotopic vascularized murine cardiac transplantation to study graft arteriopathy. Nat Protoc (2007) 1.02
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J Neurosci (2009) 1.02
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury. J Pathol (2012) 1.02
Electrophilic nitro-fatty acids inhibit vascular inflammation by disrupting LPS-dependent TLR4 signalling in lipid rafts. Cardiovasc Res (2013) 1.01
Ecto-5' nucleotidase (CD73)-mediated adenosine generation and signaling in murine cardiac allograft vasculopathy. Circ Res (2008) 1.01
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. J Biol Chem (2010) 1.01
Low plasma RANTES levels are an independent predictor of cardiac mortality in patients referred for coronary angiography. Arterioscler Thromb Vasc Biol (2007) 1.01
Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing. Am J Pathol (2006) 1.00
Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc Med (2004) 0.99
CD39 expression on T lymphocytes correlates with severity of disease in patients with chronic lymphocytic leukemia. Clin Lymphoma Myeloma Leuk (2011) 0.99
Epithelial interactions and local engraftment of lung-resident mesenchymal stem cells. Am J Respir Cell Mol Biol (2011) 0.98
Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography. Atherosclerosis (2009) 0.98
Suppression of murine cardiac allograft arteriopathy by long-term blockade of CD40-CD154 interactions. Circulation (2002) 0.98
PKCbeta regulates ischemia/reperfusion injury in the lung. J Clin Invest (2004) 0.98
Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost (2004) 0.97
Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. J Vasc Surg (2011) 0.97
Marker expression, behaviors, and responses vary in different lines of conditionally immortalized cultured podocytes. Am J Physiol Renal Physiol (2011) 0.97