Published in J Biol Chem on February 12, 2004
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood (2009) 1.59
Genetic variation in the prostaglandin E2 pathway is associated with primary graft dysfunction. Am J Respir Crit Care Med (2014) 1.51
PAI-1 inhibits neutrophil efferocytosis. Proc Natl Acad Sci U S A (2008) 1.27
Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis. Am J Physiol Renal Physiol (2009) 0.94
Functional structure of the somatomedin B domain of vitronectin. Protein Sci (2007) 0.92
Plasminogen activator inhibitor type 1 regulates microglial motility and phagocytic activity. J Neuroinflammation (2012) 0.91
Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands. J Biol Chem (2008) 0.91
The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice. Blood (2011) 0.90
Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia. Arterioscler Thromb Vasc Biol (2009) 0.89
Inhibition of neutrophil apoptosis by PAI-1. Am J Physiol Lung Cell Mol Physiol (2011) 0.87
Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk. Arterioscler Thromb Vasc Biol (2014) 0.83
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A (2013) 0.82
The vitronectin-binding domain of plasminogen activator inhibitor-1 plays an important functional role in lipopolysaccharide-induced lethality in mice. J Thromb Haemost (2012) 0.78
Heparin alters viral serpin, serp-1, anti-thrombolytic activity to anti-thrombotic activity. Open Biochem J (2008) 0.77
Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts. Lab Invest (2014) 0.75
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke. Nat Med (2008) 3.64
Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein. J Clin Invest (2003) 3.41
Endotoxemia and sepsis mortality reduction by non-anticoagulant activated protein C. J Exp Med (2007) 3.35
Exosomes released from macrophages infected with intracellular pathogens stimulate a proinflammatory response in vitro and in vivo. Blood (2007) 2.92
Association between conformational mutations in neuroserpin and onset and severity of dementia. Lancet (2002) 2.02
Structure and function of the plasminogen/plasmin system. Thromb Haemost (2005) 2.02
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J Clin Invest (2009) 1.86
Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF. J Biol Chem (2002) 1.81
A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics. Blood (2005) 1.81
The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med (2005) 1.66
Endocytic receptor LRP together with tPA and PAI-1 coordinates Mac-1-dependent macrophage migration. EMBO J (2006) 1.66
Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation (2008) 1.62
Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture. Blood (2009) 1.59
A missense mutation in the sodium phosphate co-transporter Slc34a1 impairs phosphate homeostasis. J Am Soc Nephrol (2008) 1.51
FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse. Thromb Haemost (2002) 1.49
Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis. Blood (2007) 1.48
Regulation of seizure spreading by neuroserpin and tissue-type plasminogen activator is plasminogen-independent. J Clin Invest (2002) 1.44
A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis. J Clin Invest (2003) 1.42
Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest (2010) 1.41
Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency. Blood (2006) 1.38
ADP-ribosylation factor 6 regulates tumorigenic and invasive properties in vivo. Cancer Res (2009) 1.37
Plasminogen receptors: the sine qua non of cell surface plasminogen activation. Front Biosci (2005) 1.36
The efficacy of activated protein C in murine endotoxemia is dependent on integrin CD11b. J Clin Invest (2010) 1.36
Retracted Endogenous EPCR/aPC-PAR1 signaling prevents inflammation-induced vascular leakage and lethality. Blood (2009) 1.36
Early platelet dysfunction: an unrecognized role in the acute coagulopathy of trauma. J Am Coll Surg (2012) 1.35
Rapid selection of Drosophila S2 cells with the puromycin resistance gene. Biotechniques (2003) 1.35
A cardioprotective role for the endothelial protein C receptor in lipopolysaccharide-induced endotoxemia in the mouse. Blood (2004) 1.35
Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke. Circulation (2002) 1.34
A soluble Fn14-Fc decoy receptor reduces infarct volume in a murine model of cerebral ischemia. Am J Pathol (2005) 1.31
Transcriptional profiling of the transition from normal intestinal epithelia to adenomas and carcinomas in the APCMin/+ mouse. Physiol Genomics (2003) 1.26
Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha. FASEB J (2006) 1.24
A PAI-1 mutant, PAI-1R, slows progression of diabetic nephropathy. J Am Soc Nephrol (2008) 1.24
Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39. J Clin Invest (2009) 1.22
Plasma levels of bradykinin are suppressed in factor XII-deficient mice. Thromb Haemost (2006) 1.21
The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications. Blood (2009) 1.21
Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function. J Neurochem (2008) 1.21
A single plasmid transfection that offers a significant advantage associated with puromycin selection in Drosophila Schneider S2 cells expressing heterologous proteins. Cytotechnology (2008) 1.21
Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases. J Biol Chem (2011) 1.20
Mice with a severe deficiency in protein C display prothrombotic and proinflammatory phenotypes and compromised maternal reproductive capabilities. J Clin Invest (2005) 1.17
Plasminogen activator inhibitor-1 in tumor growth, angiogenesis and vascular remodeling. Curr Pharm Des (2003) 1.14
New functions for an old enzyme: nonhemostatic roles for tissue-type plasminogen activator in the central nervous system. Exp Biol Med (Maywood) (2004) 1.14
Regulation of nuclear receptor transcriptional activity by a novel DEAD box RNA helicase (DP97). J Biol Chem (2002) 1.12
A protein C deficiency exacerbates inflammatory and hypotensive responses in mice during polymicrobial sepsis in a cecal ligation and puncture model. Am J Pathol (2004) 1.11
Endothelial protein C receptor-assisted transport of activated protein C across the mouse blood-brain barrier. J Cereb Blood Flow Metab (2008) 1.10
Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. J Biol Chem (2007) 1.09
Enhanced in vitro proliferation of aortic endothelial cells from plasminogen activator inhibitor-1-deficient mice. J Biol Chem (2003) 1.08
Impaired fibrinolysis in multiple sclerosis: a role for tissue plasminogen activator inhibitors. Brain (2003) 1.07
Old dogs and new tricks: proteases, inhibitors, and cell migration. Sci STKE (2003) 1.06
A trimeric HIV-1 fusion peptide construct which does not self-associate in aqueous solution and which has 15-fold higher membrane fusion rate. J Am Chem Soc (2004) 1.05
A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. J Biol Chem (2006) 1.05
Plasminogen inhibits TNFalpha-induced apoptosis in monocytes. Blood (2006) 1.04
Acyl-enzyme complexes between tissue-type plasminogen activator and neuroserpin are short-lived in vitro. J Biol Chem (2002) 1.04
Thrombospondin 1--a regulator of adenoma growth and carcinoma progression in the APC(Min/+) mouse model. Carcinogenesis (2003) 1.04
The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans. Brain (2012) 1.04
Neuroserpin: a selective inhibitor of tissue-type plasminogen activator in the central nervous system. Thromb Haemost (2004) 1.04
Oligomeric beta-structure of the membrane-bound HIV-1 fusion peptide formed from soluble monomers. Biophys J (2004) 1.04
Plasminogen activator inhibitor-1: the double-edged sword in apoptosis. Thromb Haemost (2008) 1.03
Progressive ankylosis (Ank) protein is expressed by neurons and Ank immunohistochemical reactivity is increased by limbic seizures. Lab Invest (2003) 1.03
Blood component therapy in trauma guided with the utilization of the perfusionist and thromboelastography. J Extra Corpor Technol (2011) 1.02
Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns. J Neurosci (2009) 1.02
PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury. J Pathol (2012) 1.02
Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination. J Biomed Biotechnol (2012) 1.01
Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling. J Biol Chem (2010) 1.01
Generation of genetically-altered mice producing very low levels of coagulation factorVII. Thromb Haemost (2005) 1.00
Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing. Am J Pathol (2006) 1.00
Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system? Trends Cardiovasc Med (2004) 0.99
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif. J Am Chem Soc (2007) 0.99
Tissue plasminogen activator and neuroserpin are widely expressed in the human central nervous system. Thromb Haemost (2004) 0.97
Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis. J Vasc Surg (2011) 0.97
Fibrinogen stabilizes placental-maternal attachment during embryonic development in the mouse. Am J Pathol (2002) 0.96
Platelet dysfunction is an early marker for traumatic brain injury-induced coagulopathy. Neurocrit Care (2013) 0.96
Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation. Proc Natl Acad Sci U S A (2011) 0.96
Characterization of streptokinases from group A Streptococci reveals a strong functional relationship that supports the coinheritance of plasminogen-binding M protein and cluster 2b streptokinase. J Biol Chem (2012) 0.96
Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. J Biol Chem (2004) 0.96
A natural inactivating mutation in the CovS component of the CovRS regulatory operon in a pattern D Streptococcal pyogenes strain influences virulence-associated genes. J Biol Chem (2013) 0.95
The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin. J Biol Chem (2007) 0.95
A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis. J Biol Chem (2005) 0.94
Subtype-selective antagonism of N-methyl-D-aspartate receptor ion channels by synthetic conantokin peptides. Neuropharmacology (2007) 0.94
Mechanisms underlying the antifibrotic properties of noninhibitory PAI-1 (PAI-1R) in experimental nephritis. Am J Physiol Renal Physiol (2009) 0.94
The low density lipoprotein receptor-related protein modulates protease activity in the brain by mediating the cellular internalization of both neuroserpin and neuroserpin-tissue-type plasminogen activator complexes. J Biol Chem (2003) 0.94
Plasminogen activator inhibitor-1 potentiates LPS-induced neutrophil activation through a JNK-mediated pathway. Thromb Haemost (2006) 0.93
Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent. Curr Drug Targets (2007) 0.93
The fibrinolytic system in dissemination and matrix protein deposition during a mycobacterium infection. Am J Pathol (2003) 0.93
A single amino acid replacement results in the Ca2+-induced self-assembly of a helical conantokin-based peptide. Biochemistry (2004) 0.93
Antimetastatic potential of PAI-1-specific RNA aptamers. Oligonucleotides (2009) 0.93