Published in J Cell Mol Med on March 27, 2009
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Pen2 and presenilin-1 modulate the dynamic equilibrium of presenilin-1 and presenilin-2 gamma-secretase complexes. J Biol Chem (2008) 1.20
Ubiquilin regulates presenilin endoproteolysis and modulates gamma-secretase components, Pen-2 and nicastrin. Biochem J (2005) 1.14
Passive calcium leak via translocon is a first step for iPLA2-pathway regulated store operated channels activation. FASEB J (2006) 1.13
Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels. Cell Calcium (2006) 1.12
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Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry. Pflugers Arch (2006) 0.98
Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor. J Biol Chem (2000) 0.98
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The N-terminus of presenilin-2 increases single channel activity of brain ryanodine receptors through direct protein-protein interaction. Cell Calcium (2008) 0.96
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The overexpression of presenilin2 and Alzheimer's-disease-linked presenilin2 variants influences TRPC6-enhanced Ca2+ entry into HEK293 cells. Cell Signal (2005) 0.90
The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores. Neurobiol Dis (2004) 0.90
Presenilins and Alzheimer disease: the calcium conspiracy. Nat Neurosci (2006) 0.88
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB J (2006) 0.87
Defective signal transduction in B lymphocytes lacking presenilin proteins. Proc Natl Acad Sci U S A (2008) 0.86
gamma-Secretase complexes containing N- and C-terminal fragments of different presenilin origin retain normal gamma-secretase activity. J Neurochem (2005) 0.86
Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction. J Biol Chem (2003) 0.83
Interplay of the Ca2+-binding protein DREAM with presenilin in neuronal Ca2+ signaling. J Biol Chem (2008) 0.82
Presenilin endoproteolysis mediated by an aspartyl protease activity pharmacologically distinct from gamma-secretase. J Neurochem (2003) 0.81
Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation. J Neurosci Res (2005) 0.78
No endogenous A beta production in presenilin-deficient fibroblasts. Nat Cell Biol (2002) 0.78
BAX and BAK regulation of endoplasmic reticulum Ca2+: a control point for apoptosis. Science (2003) 9.55
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Impaired permeability to Ins(1,4,5)P3 in a mutant connexin underlies recessive hereditary deafness. Nat Cell Biol (2004) 2.70
Fluorescence resonance energy transfer-based analysis of cAMP dynamics in live neonatal rat cardiac myocytes reveals distinct functions of compartmentalized phosphodiesterases. Circ Res (2004) 2.58
Ca2+ hot spots on the mitochondrial surface are generated by Ca2+ mobilization from stores, but not by activation of store-operated Ca2+ channels. Mol Cell (2010) 2.48
Stable interactions between mitochondria and endoplasmic reticulum allow rapid accumulation of calcium in a subpopulation of mitochondria. J Biol Chem (2003) 2.28
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Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway. Circ Res (2005) 1.91
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Direct in vivo monitoring of sarcoplasmic reticulum Ca2+ and cytosolic cAMP dynamics in mouse skeletal muscle. J Cell Biol (2006) 1.82
Mitochondrial pH monitored by a new engineered green fluorescent protein mutant. J Biol Chem (2003) 1.74
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CXCR4-CCR5: a couple modulating T cell functions. Proc Natl Acad Sci U S A (2008) 1.47
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Ca2+ oscillation frequency decoding in cardiac cell hypertrophy: role of calcineurin/NFAT as Ca2+ signal integrators. Proc Natl Acad Sci U S A (2008) 1.34
Compartmentalisation of cAMP and Ca(2+) signals. Curr Opin Cell Biol (2002) 1.33
Regulation of endoplasmic reticulum Ca2+ dynamics by proapoptotic BCL-2 family members. Biochem Pharmacol (2003) 1.30
Calcium signaling in a low calcium environment: how the intracellular malaria parasite solves the problem. J Cell Biol (2003) 1.28
Glutamate-mediated cytosolic calcium oscillations regulate a pulsatile prostaglandin release from cultured rat astrocytes. J Physiol (2003) 1.27
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Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk. Proc Natl Acad Sci U S A (2011) 1.22
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Presenilin mutations linked to familial Alzheimer's disease reduce endoplasmic reticulum and Golgi apparatus calcium levels. Cell Calcium (2006) 1.12
Calcium elevation in mitochondria is the main Ca2+ requirement for mitochondrial permeability transition pore (mPTP) opening. J Biol Chem (2009) 1.11
H2O2 in plant peroxisomes: an in vivo analysis uncovers a Ca(2+)-dependent scavenging system. Plant J (2010) 1.10
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Mitochondrial matrix pH controls oxidative phosphorylation and metabolism-secretion coupling in INS-1E clonal beta cells. FASEB J (2010) 0.94
Reduction of Ca2+ stores and capacitative Ca2+ entry is associated with the familial Alzheimer's disease presenilin-2 T122R mutation and anticipates the onset of dementia. Neurobiol Dis (2005) 0.93
Perspectives on: SGP symposium on mitochondrial physiology and medicine: the pathophysiology of LETM1. J Gen Physiol (2012) 0.92
High content analysis of gamma-secretase activity reveals variable dominance of presenilin mutations linked to familial Alzheimer's disease. Biochim Biophys Acta (2008) 0.92
Bothrops snake myotoxins induce a large efflux of ATP and potassium with spreading of cell damage and pain. Proc Natl Acad Sci U S A (2010) 0.92
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Structural, functional, and bioinformatics studies reveal a new snake venom homologue phospholipase A₂ class. Proteins (2010) 0.90
Ca(2+) signalling in the Golgi apparatus. Cell Calcium (2011) 0.90
A role for calcium in Bcl-2 action? Biochimie (2002) 0.90
The presenilin 2 M239I mutation associated with familial Alzheimer's disease reduces Ca2+ release from intracellular stores. Neurobiol Dis (2004) 0.90
Calcium dynamics in the peroxisomal lumen of living cells. J Biol Chem (2008) 0.88
Ca2+ and cAMP cross-talk in mitochondria. J Physiol (2013) 0.87
Chromatin-modifying agents in anti-cancer therapy. Biochimie (2012) 0.86
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Ca2+ dysregulation in neurons from transgenic mice expressing mutant presenilin 2. Aging Cell (2012) 0.83