Published in Stem Cell Res on May 08, 2008
Stage-specific signaling through TGFβ family members and WNT regulates patterning and pancreatic specification of human pluripotent stem cells. Development (2011) 2.82
Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38
Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells. Nat Biotechnol (2011) 2.08
Transcriptomes of the major human pancreatic cell types. Diabetologia (2011) 1.90
Epigenetic regulation of the DLK1-MEG3 microRNA cluster in human type 2 diabetic islets. Cell Metab (2013) 1.49
Novel Observations From Next-Generation RNA Sequencing of Highly Purified Human Adult and Fetal Islet Cell Subsets. Diabetes (2015) 1.21
Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell (2010) 1.13
MicroRNA expression in alpha and beta cells of human pancreatic islets. PLoS One (2013) 1.08
Human islets contain four distinct subtypes of β cells. Nat Commun (2016) 1.03
Single-Cell Transcriptomics of the Human Endocrine Pancreas. Diabetes (2016) 0.99
Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol (2011) 0.93
Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation. PLoS One (2013) 0.92
Proteomic profiling of cardiac tissue by isolation of nuclei tagged in specific cell types (INTACT). Development (2014) 0.92
Urocortin 3 marks mature human primary and embryonic stem cell-derived pancreatic alpha and beta cells. PLoS One (2012) 0.91
Integration of ATAC-seq and RNA-seq identifies human alpha cell and beta cell signature genes. Mol Metab (2016) 0.91
Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function. Cell Metab (2016) 0.90
Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm (2011) 0.88
In vitro multilineage differentiation and self-renewal of single pancreatic colony-forming cells from adult C57BL/6 mice. Stem Cells Dev (2014) 0.85
Transcriptional and epigenetic regulation in human islets. Diabetologia (2013) 0.82
Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism. Sci Rep (2016) 0.81
Creating new β cells: cellular transmutation by genomic alchemy. J Clin Invest (2013) 0.81
Pretargeting vs. direct targeting of human betalox5 islet cells subcutaneously implanted in mice using an anti-human islet cell antibody. Nucl Med Biol (2012) 0.81
Single cell transcriptomes identify human islet cell signatures and reveal cell-type-specific expression changes in type 2 diabetes. Genome Res (2016) 0.80
Maturation of stem cell-derived beta-cells guided by the expression of urocortin 3. Rev Diabet Stud (2014) 0.80
The pancreatic β-cell transcriptome and integrated-omics. Curr Opin Endocrinol Diabetes Obes (2014) 0.76
TGF-β1 promotes acinar to ductal metaplasia of human pancreatic acinar cells. Sci Rep (2016) 0.76
Functional proteomics screen enables enrichment of distinct cell types from human pancreatic islets. PLoS One (2015) 0.75
Novel surface markers directed against adult human gallbladder. Stem Cell Res (2015) 0.75
Rapid, high efficiency isolation of pancreatic ß-cells. Sci Rep (2015) 0.75
β-cell replacement sources for type 1 diabetes: a focus on pancreatic ductal cells. Ther Adv Endocrinol Metab (2016) 0.75
Functional and Metabolomic Consequences of ATP-dependent Potassium Channel Inactivation in Human Islets. Diabetes (2017) 0.75
Beyond the Protein-Coding Sequence: Noncoding RNAs in the Pathogenesis of Type 2 Diabetes. Rev Diabet Stud (2016) 0.75
Reprogramming human gallbladder cells into insulin-producing β-like cells. PLoS One (2017) 0.75
Epigenetics in formation, function, and failure of the endocrine pancreas. Mol Metab (2017) 0.75
Biallelic inactivation of BRCA2 in Fanconi anemia. Science (2002) 9.31
Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature (2003) 6.92
The Fanconi anaemia/BRCA pathway. Nat Rev Cancer (2003) 5.89
Robust expansion of human hepatocytes in Fah-/-/Rag2-/-/Il2rg-/- mice. Nat Biotechnol (2007) 5.04
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration. Nature (2013) 4.94
S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51. Blood (2002) 4.27
Generation and regeneration of cells of the liver and pancreas. Science (2008) 4.21
Myelomonocytic cells are sufficient for therapeutic cell fusion in liver. Nat Med (2004) 3.77
Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice. Genes Dev (2003) 3.58
Stem cells and liver regeneration. Gastroenterology (2009) 3.40
The ploidy conveyor of mature hepatocytes as a source of genetic variation. Nature (2010) 3.27
The origin and liver repopulating capacity of murine oval cells. Proc Natl Acad Sci U S A (2003) 2.99
AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat Genet (2003) 2.81
The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell (2003) 2.71
Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential. Genes Dev (2011) 2.53
Epigenomic plasticity enables human pancreatic α to β cell reprogramming. J Clin Invest (2013) 2.38
Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. Cell Stem Cell (2012) 2.26
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathway. Mol Cell Biol (2004) 2.20
Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev (2011) 2.17
Myeloid lineage progenitors give rise to vascular endothelium. Proc Natl Acad Sci U S A (2006) 2.13
Large-scale molecular characterization of adeno-associated virus vector integration in mouse liver. J Virol (2005) 2.09
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatin. Blood (2004) 2.08
Kinetics of liver repopulation after bone marrow transplantation. Am J Pathol (2002) 1.85
The potential of human allogeneic juvenile chondrocytes for restoration of articular cartilage. Am J Sports Med (2010) 1.83
Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity (2013) 1.83
Bone marrow-derived cells fuse with normal and transformed intestinal stem cells. Proc Natl Acad Sci U S A (2006) 1.82
Therapeutic liver reconstitution with murine cells isolated long after death. Gastroenterology (2010) 1.78
Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. Cancer Cell (2008) 1.75
Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway. J Exp Med (2011) 1.74
Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype. Am J Hum Genet (2007) 1.67
Surface markers for the murine oval cell response. Hepatology (2008) 1.65
In vivo correction of murine hereditary tyrosinemia type I by phiC31 integrase-mediated gene delivery. Mol Ther (2005) 1.59
Production of pluripotent stem cells by oocyte-assisted reprogramming: joint statement with signatories. Natl Cathol Bioeth Q (2005) 1.57
Mutations in PHF6 are associated with Börjeson-Forssman-Lehmann syndrome. Nat Genet (2002) 1.57
Gene therapy of metachromatic leukodystrophy reverses neurological damage and deficits in mice. J Clin Invest (2006) 1.54
Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. J Clin Invest (2012) 1.52
Generation of monoclonal antibodies specific for cell surface molecules expressed on early mouse endoderm. Stem Cells (2009) 1.43
Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency. Hum Mutat (2003) 1.42
Adeno-associated virus gene repair corrects a mouse model of hereditary tyrosinemia in vivo. Hepatology (2010) 1.41
In vivo correction of murine tyrosinemia type I by DNA-mediated transposition. Mol Ther (2002) 1.39
Seeking consensus: a clarification and defense of altered nuclear transfer. Hastings Cent Rep (2006) 1.39
Clonal tracing of Sox9+ liver progenitors in mouse oval cell injury. Hepatology (2014) 1.32
Frequent aneuploidy among normal human hepatocytes. Gastroenterology (2011) 1.30
Fancd2-/- mice have hematopoietic defects that can be partially corrected by resveratrol. Blood (2010) 1.29
Ploidy reductions in murine fusion-derived hepatocytes. PLoS Genet (2009) 1.28
Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. Cancer Res (2010) 1.26
Aneuploidy as a mechanism for stress-induced liver adaptation. J Clin Invest (2012) 1.23
Tempol protects against oxidative damage and delays epithelial tumor onset in Fanconi anemia mice. Cancer Res (2008) 1.22
Natural gene therapy in monozygotic twins with Fanconi anemia. Blood (2006) 1.20
Heterozygosity for p53 (Trp53+/-) accelerates epithelial tumor formation in fanconi anemia complementation group D2 (Fancd2) knockout mice. Cancer Res (2005) 1.17
Non-invasive stem cell therapy in a rat model for retinal degeneration and vascular pathology. PLoS One (2010) 1.17
Fancd2 functions in a double strand break repair pathway that is distinct from non-homologous end joining. Hum Mol Genet (2005) 1.15
Therapeutic intervention in mice deficient for succinate semialdehyde dehydrogenase (gamma-hydroxybutyric aciduria). J Pharmacol Exp Ther (2002) 1.13
Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol (2010) 1.11
Attenuation of the formation of DNA-repair foci containing RAD51 in Fanconi anaemia. Carcinogenesis (2002) 1.10
BRCA1 interacts directly with the Fanconi anemia protein FANCA. Hum Mol Genet (2002) 1.10
Pillars article: Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994. 264: 703-707. J Immunol (2014) 1.08
Helper-independent and AAV-ITR-independent chromosomal integration of double-stranded linear DNA vectors in mice. Mol Ther (2003) 1.08
Ribosomal DNA integrating rAAV-rDNA vectors allow for stable transgene expression. Mol Ther (2012) 1.08
Chromosomal integration of adenoviral vector DNA in vivo. J Virol (2010) 1.07
Response to "Can 'humanized' mice improve drug development in the 21st century?". Trends Pharmacol Sci (2013) 1.07
Gene therapy of Fanconi anemia: preclinical efficacy using lentiviral vectors. Blood (2002) 1.07
In vivo genetic selection of renal proximal tubules. Mol Ther (2005) 1.05
p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology (2013) 1.05
Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism. Mol Cell Biol (2002) 1.02
Hematopoietic stem cells contribute to lymphatic endothelium. PLoS One (2008) 1.01
Fanconi anemia group A and C double-mutant mice: functional evidence for a multi-protein Fanconi anemia complex. Exp Hematol (2002) 1.01
Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents. Biochem Pharmacol (2003) 1.00
Clinical scale expanded adult pluripotent stem cells prevent graft-versus-host disease. Cell Immunol (2008) 0.98
SV40 large T-antigen disturbs the formation of nuclear DNA-repair foci containing MRE11. Oncogene (2002) 0.98
Efficient production of Fah-null heterozygote pigs by chimeric adeno-associated virus-mediated gene knockout and somatic cell nuclear transfer. Hepatology (2011) 0.97
Low therapeutic threshold for hepatocyte replacement in murine phenylketonuria. Mol Ther (2005) 0.96
CXCR4 induction in hematopoietic progenitor cells from Fanca(-/-), -c(-/-), and -d2(-/-) mice. Exp Hematol (2008) 0.96
Generation of islet-like cells from mouse gall bladder by direct ex vivo reprogramming. Stem Cell Res (2013) 0.95
Signaling networks in hepatic oval cell activation. Stem Cell Res (2008) 0.93
AAV vectors containing rDNA homology display increased chromosomal integration and transgene persistence. Mol Ther (2012) 0.93
Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol (2011) 0.93
New potential cell source for hepatocyte transplantation: discarded livers from metabolic disease liver transplants. Stem Cell Res (2013) 0.92
Liver repair by intra- and extrahepatic progenitors. Stem Cell Rev (2005) 0.92
Liver-directed adenoviral gene transfer in murine succinate semialdehyde dehydrogenase deficiency. Mol Ther (2004) 0.91
Validation of Fanconi anemia complementation Group A assignment using molecular analysis. Genet Med (2009) 0.91
Interstrand crosslink-induced radials form between non-homologous chromosomes, but are absent in sex chromosomes. DNA Repair (Amst) (2004) 0.91
AAV-mediated gene targeting is significantly enhanced by transient inhibition of nonhomologous end joining or the proteasome in vivo. Hum Gene Ther (2012) 0.90
Murine succinate semialdehyde dehydrogenase deficiency. Ann Neurol (2003) 0.90
Donor marker infidelity in transgenic hematopoietic stem cells. Stem Cells (2005) 0.90
The novel monoclonal antibody HPC2 and N-cadherin distinguish pancreatic ductal adenocarcinoma from cholangiocarcinoma. Hum Pathol (2012) 0.88
Sustained phosphorylation of Bid is a marker for resistance to Fas-induced apoptosis during chronic liver diseases. Gastroenterology (2006) 0.88
Chronic liver disease in murine hereditary tyrosinemia type 1 induces resistance to cell death. Hepatology (2004) 0.88
Human islet cell MORF/cMORF pretargeting in a xenogeneic murine transplant model. Mol Pharm (2011) 0.88
CDX2 in the formation of the trophectoderm lineage in primate embryos. Dev Biol (2009) 0.86