Published in Cell Mol Life Sci on June 01, 2009
Emergence of protein kinase CK2 as a key target in cancer therapy. Biofactors (2010) 1.46
Dynamic regulation of a metabolic multi-enzyme complex by protein kinase CK2. J Biol Chem (2010) 1.36
Overexpression of nuclear protein kinase CK2 α catalytic subunit (CK2α) as a poor prognosticator in human colorectal cancer. PLoS One (2011) 1.26
Proteomic characterization of novel alternative splice variant proteins in human epidermal growth factor receptor 2/neu-induced breast cancers. Cancer Res (2010) 1.25
CK2 modulation of NF-kappaB, TP53, and the malignant phenotype in head and neck cancer by anti-CK2 oligonucleotides in vitro or in vivo via sub-50-nm nanocapsules. Clin Cancer Res (2010) 1.16
Protein kinase CK2 regulates cytoskeletal reorganization during ionizing radiation-induced senescence of human mesenchymal stem cells. Cancer Res (2009) 1.08
Cytotoxic activity of the casein kinase 2 inhibitor CX-4945 against T-cell acute lymphoblastic leukemia: targeting the unfolded protein response signaling. Leukemia (2013) 1.02
Inhibition of CK2α down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med (2013) 1.01
ck2-dependent phosphorylation of progesterone receptors (PR) on Ser81 regulates PR-B isoform-specific target gene expression in breast cancer cells. Mol Cell Biol (2011) 1.00
Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One (2012) 0.99
SCFFbxo9 and CK2 direct the cellular response to growth factor withdrawal via Tel2/Tti1 degradation and promote survival in multiple myeloma. Nat Cell Biol (2013) 0.98
Effects of notch signaling on regulation of myeloid cell differentiation in cancer. Cancer Res (2013) 0.97
Activation of protein kinase CK2 attenuates FOXO3a functioning in a PML-dependent manner: implications in human prostate cancer. Cell Death Dis (2013) 0.95
Systemic administration of antisense oligonucleotides simultaneously targeting CK2α and α' subunits reduces orthotopic xenograft prostate tumors in mice. Mol Cell Biochem (2011) 0.94
Protein kinase CK2 is a central regulator of topoisomerase I hyperphosphorylation and camptothecin sensitivity in cancer cell lines. Biochemistry (2011) 0.94
A proteomic study of myosin II motor proteins during tumor cell migration. J Mol Biol (2011) 0.93
The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies. Front Pharmacol (2015) 0.92
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels. Haematologica (2014) 0.91
Novel mechanism by which histone deacetylase inhibitors facilitate topoisomerase IIα degradation in hepatocellular carcinoma cells. Hepatology (2011) 0.90
Identification of a novel function of CX-4945 as a splicing regulator. PLoS One (2014) 0.89
Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci (2012) 0.88
Effects of the CK2 inhibitors CX-4945 and CX-5011 on drug-resistant cells. PLoS One (2012) 0.88
Role of phosphorylation in progesterone receptor signaling and specificity. Mol Cell Endocrinol (2011) 0.88
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90. Mol Cancer (2011) 0.87
Preclinical evaluation of cyclin dependent kinase 11 and casein kinase 2 survival kinases as RNA interference targets for triple negative breast cancer therapy. Breast Cancer Res (2015) 0.87
CK2-dependent phosphorylation of occludin regulates the interaction with ZO-proteins and tight junction integrity. Cell Commun Signal (2013) 0.86
Overlapping kinetochore targets of CK2 and Aurora B kinases in mitotic regulation. Mol Biol Cell (2011) 0.86
Nuclear hormone receptor corepressor promotes esophageal cancer cell invasion by transcriptional repression of interferon-γ-inducible protein 10 in a casein kinase 2-dependent manner. Mol Biol Cell (2012) 0.86
Kinome profiling of myxoid liposarcoma reveals NF-kappaB-pathway kinase activity and casein kinase II inhibition as a potential treatment option. Mol Cancer (2010) 0.86
Treatment of cultured human astrocytes and vascular endothelial cells with protein kinase CK2 inhibitors induces early changes in cell shape and cytoskeleton. Mol Cell Biochem (2010) 0.86
Single-step inline hydroxyapatite enrichment facilitates identification and quantitation of phosphopeptides from mass-limited proteomes with MudPIT. J Proteome Res (2012) 0.86
Inhibition of protein kinase II (CK2) prevents induced signal transducer and activator of transcription (STAT) 1/3 and constitutive STAT3 activation. Oncotarget (2014) 0.85
Protein kinase CK2 inhibition induces cell death via early impact on mitochondrial function. J Cell Biochem (2014) 0.85
CK2-mediated hyperphosphorylation of topoisomerase I targets serine 506, enhances topoisomerase I-DNA binding, and increases cellular camptothecin sensitivity. PLoS One (2012) 0.84
Therapeutic CK2 inhibition attenuates diverse prosurvival signaling cascades and decreases cell viability in human breast cancer cells. Oncotarget (2014) 0.84
Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival. BMC Urol (2011) 0.84
Mechanism and efficacy of sub-50-nm tenfibgen nanocapsules for cancer cell-directed delivery of anti-CK2 RNAi to primary and metastatic squamous cell carcinoma. Mol Cancer Ther (2014) 0.83
BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation. Cell Cycle (2015) 0.83
CK2α, over-expressed in human malignant pleural mesothelioma, regulates the Hedgehog signaling pathway in mesothelioma cells. J Exp Clin Cancer Res (2014) 0.83
Phosphorylation of the anaphase-promoting complex/Cdc27 is involved in TGF-beta signaling. J Biol Chem (2011) 0.83
Programmed cell death 5 mediates HDAC3 decay to promote genotoxic stress response. Nat Commun (2015) 0.83
Inhibition of protein kinase CK2 with the clinical-grade small ATP-competitive compound CX-4945 or by RNA interference unveils its role in acute myeloid leukemia cell survival, p53-dependent apoptosis and daunorubicin-induced cytotoxicity. J Hematol Oncol (2013) 0.82
Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One (2010) 0.82
Tenfibgen-DMAT Nanocapsule Delivers CK2 Inhibitor DMAT to Prostate Cancer Xenograft Tumors Causing Inhibition of Cell Proliferation. Mol Cell Pharmacol (2015) 0.81
Protein kinase CK2 inactivates PRH/Hhex using multiple mechanisms to de-repress VEGF-signalling genes and promote cell survival. Nucleic Acids Res (2012) 0.81
Regulation of ceramide synthase by casein kinase 2-dependent phosphorylation in Saccharomyces cerevisiae. J Biol Chem (2014) 0.81
A chemogenomic screening identifies CK2 as a target for pro-senescence therapy in PTEN-deficient tumours. Nat Commun (2015) 0.81
Molecules that target nucleophosmin for cancer treatment: an update. Oncotarget (2016) 0.81
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin. Proc Natl Acad Sci U S A (2012) 0.81
Isomeric mono-, di-, and tri-bromobenzo-1H-triazoles as inhibitors of human protein kinase CK2α. PLoS One (2012) 0.80
Different Persistence of the Cellular Effects Promoted by Protein Kinase CK2 Inhibitors CX-4945 and TDB. Biomed Res Int (2015) 0.79
CK2-NCoR signaling cascade promotes prostate tumorigenesis. Oncotarget (2013) 0.79
Tenfibgen ligand nanoencapsulation delivers bi-functional anti-CK2 RNAi oligomer to key sites for prostate cancer targeting using human xenograft tumors in mice. PLoS One (2014) 0.79
Nanoparticle-based targeted therapeutics in head-and-neck cancer. Int J Med Sci (2015) 0.79
Nuclear Immunolocalization of Hexamerins in the Fat Body of Metamorphosing Honey Bees. Insects (2012) 0.79
The Phosphorylation of PDX-1 by Protein Kinase CK2 Is Crucial for Its Stability. Pharmaceuticals (Basel) (2016) 0.79
Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks. Pharmaceuticals (Basel) (2017) 0.79
D11-Mediated Inhibition of Protein Kinase CK2 Impairs HIF-1α-Mediated Signaling in Human Glioblastoma Cells. Pharmaceuticals (Basel) (2017) 0.79
CK2 Molecular Targeting-Tumor Cell-Specific Delivery of RNAi in Various Models of Cancer. Pharmaceuticals (Basel) (2017) 0.78
Epigenetics in myeloid derived suppressor cells: a sheathed sword towards cancer. Oncotarget (2016) 0.78
The New Role for an Old Kinase: Protein Kinase CK2 Regulates Metal Ion Transport. Pharmaceuticals (Basel) (2016) 0.78
Presynaptic CK2 promotes synapse organization and stability by targeting Ankyrin2. J Cell Biol (2014) 0.77
Focus on molecules: protein kinase CK2. Exp Eye Res (2010) 0.77
Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation. PLoS One (2014) 0.77
CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia (2014) 0.77
Targeting CK2-driven non-oncogene addiction in B-cell tumors. Oncogene (2016) 0.77
The human adenovirus type 5 E1B 55-kilodalton protein is phosphorylated by protein kinase CK2. J Virol (2011) 0.77
The heat-shock, or HSF1-mediated proteotoxic stress, response in cancer: from proteomic stability to oncogenesis. Philos Trans R Soc Lond B Biol Sci (2018) 0.76
Drosophila casein kinase 2 (CK2) promotes warts protein to suppress Yorkie protein activity for growth control. J Biol Chem (2014) 0.76
Generation and quantitative proteomics analysis of CK2α/α'((-/-)) cells. Sci Rep (2017) 0.76
Targeting protein kinase CK2 suppresses bladder cancer cell survival via the glucose metabolic pathway. Oncotarget (2016) 0.76
Autophagosome-mediated EGFR down-regulation induced by the CK2 inhibitor enhances the efficacy of EGFR-TKI on EGFR-mutant lung cancer cells with resistance by T790M. PLoS One (2014) 0.76
Topoisomerase-I PS506 as a Dual Function Cancer Biomarker. PLoS One (2015) 0.76
Developments in the use of nanocapsules in oncology. Braz J Med Biol Res (2013) 0.76
Identification and characterization of a novel gene, c1orf109, encoding a CK2 substrate that is involved in cancer cell proliferation. J Biomed Sci (2012) 0.75
CK2 abrogates the inhibitory effects of PRH/HHEX on prostate cancer cell migration and invasion and acts through PRH to control cell proliferation. Oncogenesis (2017) 0.75
RP1 is a phosphorylation target of CK2 and is involved in cell adhesion. PLoS One (2013) 0.75
Protein kinase CK2 in development and differentiation. Biomed Rep (2016) 0.75
Phosphorylation of apoptosis repressor with caspase recruitment domain by protein kinase CK2 contributes to chemotherapy resistance by inhibiting doxorubicin induced apoptosis. Oncotarget (2015) 0.75
Protein Kinase CK2α Maintains Extracellular Signal-regulated Kinase (ERK) Activity in a CK2α Kinase-independent Manner to Promote Resistance to Inhibitors of RAF and MEK but Not ERK in BRAF Mutant Melanoma. J Biol Chem (2016) 0.75
Quantitative proteomic analysis revealed 4-(methylnitrosamino)-1-(3-pyridinyl)-1-butanone-induced up-regulation of 20S proteasome in cultured human fibroblast cells. J Proteome Res (2012) 0.75
Casein Kinase 2 controls the survival of normal thymic and leukemic γδ T-cells via promotion of AKT signaling. Leukemia (2016) 0.75
Use of a special Brazilian red-light emitting railroad worm Luciferase in bioassays of NEK7 protein Kinase and Creatine Kinase. BMC Biochem (2017) 0.75
Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta (2017) 0.75
CX4945 suppresses the growth of castration-resistant prostate cancer cells by reducing AR-V7 expression. World J Urol (2017) 0.75
Inhibition of protein kinase CK2 sensitizes non-small cell lung cancer cells to cisplatin via upregulation of PML. Mol Cell Biochem (2017) 0.75
Protein kinase CK2 regulates redox homeostasis through NF-κB and Bcl-xL in cardiomyoblasts. Mol Cell Biochem (2017) 0.75
A fragment-based approach leading to the discovery of a novel binding site and the selective CK2 inhibitor CAM4066. Bioorg Med Chem (2017) 0.75
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Protein kinase A RIalpha antisense inhibition of PC3M prostate cancer cell growth: Bcl-2 hyperphosphorylation, Bax up-regulation, and Bad-hypophosphorylation. Clin Cancer Res (2002) 1.55
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