Rules for making human tumor cells.

Advances in understanding cancer genomes through second-generation sequencing. Nat Rev Genet (2010) 10.15

An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell (2009) 10.09

Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones (2005) 5.22

Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Sci Transl Med (2009) 4.71

Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci (2010) 3.17

Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev (2004) 2.75

Evolution of cooperation among tumor cells. Proc Natl Acad Sci U S A (2006) 2.63

Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol (2011) 2.48

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production. Proc Natl Acad Sci U S A (2007) 2.34

Protein kinase CK2 in health and disease: CK2: a key player in cancer biology. Cell Mol Life Sci (2009) 2.21

Defined factors induce reprogramming of gastrointestinal cancer cells. Proc Natl Acad Sci U S A (2009) 2.11

The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest (2008) 2.11

The tumor suppressor PP2A Abeta regulates the RalA GTPase. Cell (2007) 2.10

Regulation of human p53 activity and cell localization by alternative splicing. Mol Cell Biol (2004) 2.01

Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood (2006) 1.98

Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93

Sustained regression of tumors upon MYC inactivation requires p53 or thrombospondin-1 to reverse the angiogenic switch. Proc Natl Acad Sci U S A (2006) 1.89

Patient-derived xenografts for individualized care in advanced sarcoma. Cancer (2014) 1.82

miR-22 represses cancer progression by inducing cellular senescence. J Cell Biol (2011) 1.78

Frequencies of NRAS and BRAF mutations increase from the radial to the vertical growth phase in cutaneous melanoma. J Invest Dermatol (2009) 1.71

The Li-Fraumeni syndrome (LFS): a model for the initiation of p53 signatures in the distal Fallopian tube. J Pathol (2010) 1.70

DNA replication fidelity and cancer. Semin Cancer Biol (2010) 1.69

Cancer stem cells and human malignant melanoma. Pigment Cell Melanoma Res (2008) 1.65

c-Myc depletion inhibits proliferation of human tumor cells at various stages of the cell cycle. Oncogene (2007) 1.59

A systematic search for downstream mediators of tumor suppressor function of p53 reveals a major role of BTG2 in suppression of Ras-induced transformation. Genes Dev (2006) 1.58

Angiostatin regulates the expression of antiangiogenic and proapoptotic pathways via targeted inhibition of mitochondrial proteins. Blood (2009) 1.57

Genetic alteration and gene expression modulation during cancer progression. Mol Cancer (2004) 1.50

RAP80 and RNF8, key players in the recruitment of repair proteins to DNA damage sites. Cancer Lett (2008) 1.50

Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation. Genes Dev (2004) 1.48

Retracted Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. Cancer Res (2010) 1.46

Cancer and the immortal strand hypothesis. Genetics (2006) 1.45

Anti cancer effects of curcumin: cycle of life and death. Cell Div (2008) 1.45

Modeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes. Genes Dev (2010) 1.42

Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6. Mol Cell Biol (2007) 1.41

APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells. Sci Rep (2012) 1.40

Epithelial tissues have varying degrees of susceptibility to Kras(G12D)-initiated tumorigenesis in a mouse model. PLoS One (2011) 1.38

Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol (2009) 1.33

Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene. Blood (2007) 1.32

Clonal heterogeneity in the 5q- syndrome: p53 expressing progenitors prevail during lenalidomide treatment and expand at disease progression. Haematologica (2009) 1.31

Cause and consequences of genetic and epigenetic alterations in human cancer. Curr Genomics (2008) 1.31

Targeted therapy for metastatic renal cell carcinoma. Br J Cancer (2006) 1.29

Immune recognition of self in immunity against cancer. J Clin Invest (2004) 1.27

Molecular characterization of spontaneous mesenchymal stem cell transformation. PLoS One (2008) 1.26

BALB/c and C57BL6 mouse strains vary in their ability to heal corneal epithelial debridement wounds. Exp Eye Res (2008) 1.23

Selective inactivation of a Fas-associated death domain protein (FADD)-dependent apoptosis and autophagy pathway in immortal epithelial cells. Mol Biol Cell (2005) 1.21

Simian virus 40 small T antigen activates AMPK and triggers autophagy to protect cancer cells from nutrient deprivation. J Virol (2009) 1.20

Decorin antagonizes the angiogenic network: concurrent inhibition of Met, hypoxia inducible factor 1α, vascular endothelial growth factor A, and induction of thrombospondin-1 and TIMP3. J Biol Chem (2011) 1.20

Depurinating estrogen-DNA adducts in the etiology and prevention of breast and other human cancers. Future Oncol (2010) 1.18

A novel LZAP-binding protein, NLBP, inhibits cell invasion. J Biol Chem (2010) 1.17

Stochastic elimination of cancer cells. Proc Biol Sci (2003) 1.16

Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol Cancer (2010) 1.16

Activation of the aryl-hydrocarbon receptor inhibits invasive and metastatic features of human breast cancer cells and promotes breast cancer cell differentiation. Mol Endocrinol (2009) 1.16

Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events. PLoS One (2011) 1.15

Degradation of tyrosine phosphatase PTPN3 (PTPH1) by association with oncogenic human papillomavirus E6 proteins. J Virol (2006) 1.14

New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells (2008) 1.13

HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. Blood (2010) 1.13

High-resolution analysis of genetic stability of human adipose tissue stem cells cultured to senescence. J Cell Mol Med (2008) 1.12

Telomeres, telomerase, and tumorigenesis--a review. MedGenMed (2004) 1.11

Chromosomal translocations involving the MLL gene: molecular mechanisms. DNA Repair (Amst) (2006) 1.11

Targeting the tumor microenvironment: focus on angiogenesis. J Oncol (2011) 1.09

The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view. Phys Biol (2011) 1.09

Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia. Haematologica (2013) 1.08

Creating oral squamous cancer cells: a cellular model of oral-esophageal carcinogenesis. Proc Natl Acad Sci U S A (2005) 1.05

Effects of the sesquiterpene lactone parthenolide on prostate tumor-initiating cells: An integrated molecular profiling approach. Prostate (2009) 1.05

Apoptosis and colorectal cancer. Gut (2004) 1.05

The mysterious steps in carcinogenesis. Br J Cancer (2009) 1.04

Differential control of Notch1 gene transcription by Klf4 and Sp3 transcription factors in normal versus cancer-derived keratinocytes. PLoS One (2010) 1.03

Large animal models of hematopoietic stem cell gene therapy. Gene Ther (2010) 1.03

A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS Lett (2007) 1.03

Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction. Methods Mol Biol (2009) 1.02

Smad phosphoisoform signaling specificity: the right place at the right time. Carcinogenesis (2011) 1.02

The skin: a home to multiple classes of epithelial progenitor cells. Stem Cell Rev (2008) 1.02

A role for the retinoblastoma protein as a regulator of mouse osteoblast cell adhesion: implications for osteogenesis and osteosarcoma formation. PLoS One (2010) 1.02

Integration site selection by retroviral vectors: molecular mechanism and clinical consequences. Hum Gene Ther (2008) 1.01

Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway. Oncogene (2009) 1.01

Identifying molecular drivers of gastric cancer through next-generation sequencing. Cancer Lett (2012) 1.01

Cancer: looking for simplicity and finding complexity. Cancer Cell Int (2006) 1.01

Haploinsufficiency of Anx7 tumor suppressor gene and consequent genomic instability promotes tumorigenesis in the Anx7(+/-) mouse. Proc Natl Acad Sci U S A (2003) 1.01

Clinical relevance of Ephs and ephrins in cancer: lessons from breast, colorectal, and lung cancer profiling. Semin Cell Dev Biol (2011) 1.00

In vivo multiplexed interrogation of amplified genes identifies GAB2 as an ovarian cancer oncogene. Proc Natl Acad Sci U S A (2014) 0.99

Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. Clin Cancer Res (2013) 0.98

Deletion of the PDZ motif of HPV16 E6 preventing immortalization and anchorage-independent growth in human tonsil epithelial cells. Head Neck (2008) 0.98

Cancer models in Caenorhabditis elegans. Dev Dyn (2010) 0.98

Invasion of normal human fibroblasts induced by v-Fos is independent of proliferation, immortalization, and the tumor suppressors p16INK4a and p53. Mol Cell Biol (2004) 0.97

Cyclin E and SV40 small T antigen cooperate to bypass quiescence and contribute to transformation by activating CDK2 in human fibroblasts. J Biol Chem (2008) 0.96

The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity. Mol Aspects Med (2013) 0.96

Malignant transformation of non-neoplastic Barrett's epithelial cells through well-defined genetic manipulations. PLoS One (2010) 0.95

AMPKα2 Suppresses Murine Embryonic Fibroblast Transformation and Tumorigenesis. Genes Cancer (2012) 0.94

Biosafety assessment of site-directed transgene integration in human umbilical cord-lining cells. Mol Ther (2010) 0.94

Transcriptionally targeted gene therapy to detect and treat cancer. Trends Mol Med (2003) 0.94

Increased expression of PITX2 transcription factor contributes to ovarian cancer progression. PLoS One (2012) 0.94

Extracting consistent knowledge from highly inconsistent cancer gene data sources. BMC Bioinformatics (2010) 0.94

MOZ-mediated repression of p16(INK) (4) (a) is critical for the self-renewal of neural and hematopoietic stem cells. Stem Cells (2014) 0.93

Oncoproteomic profiling with antibody microarrays. Genome Med (2009) 0.92

Stochastic dynamics of cancer initiation. Phys Biol (2011) 0.91

Overexpression of a novel regulator of p120 catenin, NLBP, promotes lung adenocarcinoma proliferation. Cell Cycle (2013) 0.90

Boolean modeling and fault diagnosis in oxidative stress response. BMC Genomics (2012) 0.90

A new view of carcinogenesis and an alternative approach to cancer therapy. Mol Med (2009) 0.90

Endogenous Voltage Potentials and the Microenvironment: Bioelectric Signals that Reveal, Induce and Normalize Cancer. J Clin Exp Oncol (2013) 0.90

Novel oncogene-induced metastatic prostate cancer cell lines define human prostate cancer progression signatures. Cancer Res (2012) 0.89

Hallmarks of cancer: the next generation. Cell (2011) 140.01

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

The basics of epithelial-mesenchymal transition. J Clin Invest (2009) 32.82

Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell (2004) 31.38

Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature (2007) 21.53

Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer (2009) 18.53

Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell (2005) 18.20

An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors. Nat Genet (2008) 17.67

Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature (2007) 15.20

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell (2008) 14.80

A perspective on cancer cell metastasis. Science (2011) 13.31

Retracted A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell (2009) 10.51

Tumor metastasis: molecular insights and evolving paradigms. Cell (2011) 10.34

A progression puzzle. Nature (2002) 9.56

Lentivirus-delivered stable gene silencing by RNAi in primary cells. RNA (2003) 8.07

Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A (2004) 7.96

Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res (2008) 7.91

Ras oncogenes: split personalities. Nat Rev Mol Cell Biol (2008) 7.91

miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol (2010) 6.67

Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A (2010) 6.15

Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state. Proc Natl Acad Sci U S A (2011) 5.53

Modelling the molecular circuitry of cancer. Nat Rev Cancer (2002) 5.43

Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A (2007) 5.24

Cancer stem cells: mirage or reality? Nat Med (2009) 5.20

The signals and pathways activating cellular senescence. Int J Biochem Cell Biol (2004) 5.00

Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol (2010) 4.80

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell (2011) 4.79

Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol (2002) 4.77

Slug and Sox9 cooperatively determine the mammary stem cell state. Cell (2012) 4.77

The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nat Genet (2005) 4.70

Stromal fibroblasts in cancer: a novel tumor-promoting cell type. Cell Cycle (2006) 4.67

Transformation of different human breast epithelial cell types leads to distinct tumor phenotypes. Cancer Cell (2007) 4.30

Species- and cell type-specific requirements for cellular transformation. Cancer Cell (2004) 4.25

Cancer stem cells and epithelial-mesenchymal transition: concepts and molecular links. Semin Cancer Biol (2012) 3.98

The epigenetics of epithelial-mesenchymal plasticity in cancer. Nat Med (2013) 3.96

Exploring a new twist on tumor metastasis. Cancer Res (2006) 3.96

Systemic endocrine instigation of indolent tumor growth requires osteopontin. Cell (2008) 3.95

Immortalization and transformation of primary human airway epithelial cells by gene transfer. Oncogene (2002) 3.80

Growth-inhibitory and tumor- suppressive functions of p53 depend on its repression of CD44 expression. Cell (2008) 3.75

The Spemann organizer gene, Goosecoid, promotes tumor metastasis. Proc Natl Acad Sci U S A (2006) 3.64

Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell (2013) 3.61

Retracted Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell (2003) 3.56

Telomerase maintains telomere structure in normal human cells. Cell (2003) 3.29

Opinion: Comparative biology of mouse versus human cells: modelling human cancer in mice. Nat Rev Cancer (2003) 3.23

Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res (2007) 3.04

Autocrine TGF-beta and stromal cell-derived factor-1 (SDF-1) signaling drives the evolution of tumor-promoting mammary stromal myofibroblasts. Proc Natl Acad Sci U S A (2010) 3.03

Telomeres: cancer to human aging. Annu Rev Cell Dev Biol (2006) 2.88

Telomerase contributes to tumorigenesis by a telomere length-independent mechanism. Proc Natl Acad Sci U S A (2002) 2.82

Integrin beta1-focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs. Proc Natl Acad Sci U S A (2009) 2.75

Tumor-host interactions: a far-reaching relationship. J Clin Oncol (2010) 2.48

Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia (2010) 2.38

When cells get stressed: an integrative view of cellular senescence. J Clin Invest (2004) 2.37

A mouse model of human breast cancer metastasis to human bone. Cancer Res (2005) 2.24

Adaptation versus selection: the origins of metastatic behavior. Cancer Res (2007) 2.08

Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet (2008) 2.03

Taking the study of cancer cell survival to a new dimension. Cell (2002) 2.03

Human tumors instigate granulin-expressing hematopoietic cells that promote malignancy by activating stromal fibroblasts in mice. J Clin Invest (2011) 1.96

Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell (2013) 1.86

IGF-2 is a mediator of prolactin-induced morphogenesis in the breast. Dev Cell (2002) 1.79

Phenotypic plasticity and epithelial-mesenchymal transitions in cancer and normal stem cells? Int J Cancer (2011) 1.79

Erosion of the telomeric single-strand overhang at replicative senescence. Nat Genet (2003) 1.78

Retracted Concomitant suppression of three target genes can explain the impact of a microRNA on metastasis. Genes Dev (2009) 1.74

Cell plasticity and heterogeneity in cancer. Clin Chem (2012) 1.74

MicroRNAs in malignant progression. Cell Cycle (2007) 1.74

Retracted Concurrent suppression of integrin alpha5, radixin, and RhoA phenocopies the effects of miR-31 on metastasis. Cancer Res (2010) 1.73

Cancer-stimulated mesenchymal stem cells create a carcinoma stem cell niche via prostaglandin E2 signaling. Cancer Discov (2012) 1.71

Systemic stromal effects of estrogen promote the growth of estrogen receptor-negative cancers. Cancer Res (2007) 1.66

MicroRNAs: Crucial multi-tasking components in the complex circuitry of tumor metastasis. Cell Cycle (2009) 1.63

Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos. Mol Cell Biol (2003) 1.59

miR-31: a crucial overseer of tumor metastasis and other emerging roles. Cell Cycle (2010) 1.51

The outgrowth of micrometastases is enabled by the formation of filopodium-like protrusions. Cancer Discov (2012) 1.45

Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A (2008) 1.41

Retracted Activation of miR-31 function in already-established metastases elicits metastatic regression. Genes Dev (2011) 1.40

An integrin-linked machinery of cytoskeletal regulation that enables experimental tumor initiation and metastatic colonization. Cancer Cell (2013) 1.36

Metastatic colonization: settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin Cancer Biol (2010) 1.36

Roles for microRNAs in the regulation of cell adhesion molecules. J Cell Sci (2011) 1.25

Heterogeneity of stromal fibroblasts in tumors. Cancer Biol Ther (2007) 1.21

Chemokine networks and breast cancer metastasis. Breast Dis (2007) 1.17

AACR special conference on epithelial-mesenchymal transition and cancer progression and treatment. Cancer Res (2010) 1.17

Coevolution in the tumor microenvironment. Nat Genet (2008) 1.16

Senescence: does it all happen at the ends? Oncogene (2002) 0.98

High efficiency creation of human monoclonal antibody-producing hybridomas. J Immunol Methods (2004) 0.94

Assaying microRNA loss-of-function phenotypes in mammalian cells: emerging tools and their potential therapeutic utility. RNA Biol (2009) 0.90

Of mice and (wo)men: mouse models of breast cancer metastasis to bone. J Bone Miner Res (2010) 0.89

Functional genomics and the breast cancer problem. Cancer Cell (2002) 0.86

Cancer cell of origin: spotlight on luminal progenitors. Cell Stem Cell (2010) 0.83

Filling the mosaic of p53 actions: p53 represses RHAMM expression. Cell Cycle (2008) 0.82

Is metastasis predetermined? Mol Oncol (2007) 0.81

Cancer Biology and Therapy: the road ahead. Cancer Biol Ther (2002) 0.81

Poised with purpose: cell plasticity enhances tumorigenicity. Cell Cycle (2013) 0.81

Metastasis suppression: a role of the Dice(r). Genome Biol (2010) 0.78

Retrospective: Judah Folkman (1933-2008). Science (2008) 0.77

Addendum: A breast cancer stem cell niche supported by juxtacrine signalling from monocytes and macrophages. Nat Cell Biol (2015) 0.76

Health for life. Your lifestyle, your genes, and cancer. Newsweek (2008) 0.75

All You Need Is Mentorship. Cell (2016) 0.75