Published in Annu Rev Phytopathol on January 01, 2010
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
CRISPR-Cas systems for editing, regulating and targeting genomes. Nat Biotechnol (2014) 9.18
Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol (2011) 8.34
TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol (2012) 7.01
A transcription activator-like effector toolbox for genome engineering. Nat Protoc (2012) 6.81
De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci U S A (2011) 6.12
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors. Proc Natl Acad Sci U S A (2010) 5.65
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Res (2011) 4.75
The crystal structure of TAL effector PthXo1 bound to its DNA target. Science (2012) 3.69
Structural basis for sequence-specific recognition of DNA by TAL effectors. Science (2012) 3.64
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Assembly of designer TAL effectors by Golden Gate cloning. PLoS One (2011) 3.05
Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc Natl Acad Sci U S A (2012) 2.53
Engineering synthetic TAL effectors with orthogonal target sites. Nucleic Acids Res (2012) 2.25
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res (2012) 2.14
A ligation-independent cloning technique for high-throughput assembly of transcription activator–like effector genes. Nat Biotechnol (2013) 1.98
Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci (2012) 1.89
Quantitative analysis of TALE-DNA interactions suggests polarity effects. Nucleic Acids Res (2013) 1.88
Two new complete genome sequences offer insight into host and tissue specificity of plant pathogenic Xanthomonas spp. J Bacteriol (2011) 1.80
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci Rep (2013) 1.73
Single molecule real-time sequencing of Xanthomonas oryzae genomes reveals a dynamic structure and complex TAL (transcription activator-like) effector gene relationships. Microb Genom (2015) 1.72
Targeted transcriptional repression using a chimeric TALE-SRDX repressor protein. Plant Mol Biol (2011) 1.57
Rapid and highly efficient construction of TALE-based transcriptional regulators and nucleases for genome modification. Plant Mol Biol (2012) 1.55
The TAL effector PthA4 interacts with nuclear factors involved in RNA-dependent processes including a HMG protein that selectively binds poly(U) RNA. PLoS One (2012) 1.44
Targeting G with TAL effectors: a comparison of activities of TALENs constructed with NN and NK repeat variable di-residues. PLoS One (2012) 1.38
Transcription activator-like effector hybrids for conditional control and rewiring of chromosomal transgene expression. Sci Rep (2012) 1.37
Dissection of TALE-dependent gene activation reveals that they induce transcription cooperatively and in both orientations. PLoS One (2017) 1.37
TALEs of genome targeting. Nat Biotechnol (2011) 1.35
Precision editing of large animal genomes. Adv Genet (2012) 1.34
Regulation of bacterial virulence by Csr (Rsm) systems. Microbiol Mol Biol Rev (2015) 1.26
Crystal structure of a TALE protein reveals an extended N-terminal DNA binding region. Cell Res (2012) 1.26
Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS One (2013) 1.26
Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers. Nucleic Acids Res (2014) 1.25
Highly efficient bi-allelic mutation rates using TALENs in Xenopus tropicalis. Biol Open (2012) 1.24
TAL effectors: highly adaptable phytobacterial virulence factors and readily engineered DNA-targeting proteins. Trends Cell Biol (2013) 1.24
Recognition of methylated DNA by TAL effectors. Cell Res (2012) 1.23
Human pluripotent stem cells: an emerging model in developmental biology. Development (2013) 1.22
Targeted mutagenesis of Arabidopsis thaliana using engineered TAL effector nucleases. G3 (Bethesda) (2013) 1.19
Intervention of Phytohormone Pathways by Pathogen Effectors. Plant Cell (2014) 1.14
Nuclear jasmonate and salicylate signaling and crosstalk in defense against pathogens. Front Plant Sci (2013) 1.12
Targeting DNA With Fingers and TALENs. Mol Ther Nucleic Acids (2012) 1.12
Targeted genome engineering techniques in Drosophila. Methods (2014) 1.09
Synthetic gene expression perturbation systems with rapid, tunable, single-gene specificity in yeast. Nucleic Acids Res (2012) 1.09
Genome-wide mutagenesis of Xanthomonas axonopodis pv. citri reveals novel genetic determinants and regulation mechanisms of biofilm formation. PLoS One (2011) 1.07
Newer gene editing technologies toward HIV gene therapy. Viruses (2013) 1.07
An improved method for TAL effectors DNA-binding sites prediction reveals functional convergence in TAL repertoires of Xanthomonas oryzae strains. PLoS One (2013) 1.07
Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One (2013) 1.06
Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs. PLoS One (2013) 1.05
Advanced genetic tools for plant biotechnology. Nat Rev Genet (2013) 1.04
Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comput Biol (2013) 1.04
Two- and three-input TALE-based AND logic computation in embryonic stem cells. Nucleic Acids Res (2013) 1.03
Structure of the AvrBs3-DNA complex provides new insights into the initial thymine-recognition mechanism. Acta Crystallogr D Biol Crystallogr (2013) 1.01
Exploitation of eukaryotic subcellular targeting mechanisms by bacterial effectors. Nat Rev Microbiol (2013) 1.00
An efficient strategy for TALEN-mediated genome engineering in Drosophila. Nucleic Acids Res (2013) 0.99
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat Protoc (2013) 0.99
New multilocus variable-number tandem-repeat analysis tool for surveillance and local epidemiology of bacterial leaf blight and bacterial leaf streak of rice caused by Xanthomonas oryzae. Appl Environ Microbiol (2014) 0.99
TAL effectors: function, structure, engineering and applications. Curr Opin Struct Biol (2012) 0.99
Synthetic epigenetics-towards intelligent control of epigenetic states and cell identity. Clin Epigenetics (2015) 0.99
Draft genome sequence of Xanthomonas fragariae reveals reductive evolution and distinct virulence-related gene content. BMC Genomics (2013) 0.98
Chromatin configuration as a battlefield in plant-bacteria interactions. Plant Physiol (2011) 0.97
SAPTA: a new design tool for improving TALE nuclease activity. Nucleic Acids Res (2014) 0.96
RNA-Seq of early-infected poplar leaves by the rust pathogen Melampsora larici-populina uncovers PtSultr3;5, a fungal-induced host sulfate transporter. PLoS One (2012) 0.95
On the front line: structural insights into plant-pathogen interactions. Nat Rev Microbiol (2013) 0.95
Molecular dynamics simulations of DNA-free and DNA-bound TAL effectors. PLoS One (2013) 0.94
Targeted genome modification technologies and their applications in crop improvements. Plant Cell Rep (2013) 0.93
High-Quality Draft Genome Sequence of the Xanthomonas translucens pv. cerealis Pathotype Strain CFBP 2541. Genome Announc (2015) 0.93
Characterization and DNA-binding specificities of Ralstonia TAL-like effectors. Mol Plant (2013) 0.92
Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases. Stem Cells Transl Med (2014) 0.92
Activities and specificities of homodimeric TALENs in Saccharomyces cerevisiae. Curr Genet (2013) 0.92
Programmable DNA-binding proteins from Burkholderia provide a fresh perspective on the TALE-like repeat domain. Nucleic Acids Res (2014) 0.92
Efficient TALEN construction for Bombyx mori gene targeting. PLoS One (2013) 0.90
Pathotype and genetic diversity amongst Indian isolates of Xanthomonas oryzae pv. oryzae. PLoS One (2013) 0.90
Genomic analysis of Xanthomonas translucens pathogenic on wheat and barley reveals cross-kingdom gene transfer events and diverse protein delivery systems. PLoS One (2014) 0.90
Single-cell analyses of regulatory network perturbations using enhancer-targeting TALEs suggest novel roles for PU.1 during haematopoietic specification. Development (2014) 0.89
Epidemiological and Evolutionary Outcomes in Gene-for-Gene and Matching Allele Models. Front Plant Sci (2016) 0.89
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS One (2014) 0.88
Repeat 1 of TAL effectors affects target specificity for the base at position zero. Nucleic Acids Res (2014) 0.88
TAL effectors and activation of predicted host targets distinguish Asian from African strains of the rice pathogen Xanthomonas oryzae pv. oryzicola while strict conservation suggests universal importance of five TAL effectors. Front Plant Sci (2015) 0.87
Predicting promoters targeted by TAL effectors in plant genomes: from dream to reality. Front Plant Sci (2013) 0.87
Comparative genomic and transcriptome analyses of pathotypes of Xanthomonas citri subsp. citri provide insights into mechanisms of bacterial virulence and host range. BMC Genomics (2013) 0.87
Mechanisms and ecological consequences of plant defence induction and suppression in herbivore communities. Ann Bot (2015) 0.87
Revisiting the TALE repeat. Protein Cell (2014) 0.86
Genome-editing technologies and their potential application in horticultural crop breeding. Hortic Res (2015) 0.86
A TALE of transposition: Tn3-like transposons play a major role in the spread of pathogenicity determinants of Xanthomonas citri and other xanthomonads. MBio (2015) 0.86
Complete decoding of TAL effectors for DNA recognition. Cell Res (2014) 0.85
Genome-Wide Identification and Validation of Reference Genes in Infected Tomato Leaves for Quantitative RT-PCR Analyses. PLoS One (2015) 0.85
Bacterial delivery of TALEN proteins for human genome editing. PLoS One (2014) 0.85
Go in for the kill. Virulence (2014) 0.85
TAL effectors specificity stems from negative discrimination. PLoS One (2013) 0.85
A do-it-yourself protocol for simple transcription activator-like effector assembly. Biol Proced Online (2013) 0.85
High‑efficiency system for construction and evaluation of customized TALENs for silkworm genome editing. Mol Genet Genomics (2013) 0.85
Claudin-2 knockout by TALEN-mediated gene targeting in MDCK cells: claudin-2 independently determines the leaky property of tight junctions in MDCK cells. PLoS One (2015) 0.84
Induction of pluripotency by defined factors. Proc Jpn Acad Ser B Phys Biol Sci (2014) 0.84
Precision genetic modifications: a new era in molecular biology and crop improvement. Planta (2014) 0.83
Direct observation of TALE protein dynamics reveals a two-state search mechanism. Nat Commun (2015) 0.83
TAL effectors: tools for DNA targeting. Brief Funct Genomics (2014) 0.83
A Safeguard System for Induced Pluripotent Stem Cell-Derived Rejuvenated T Cell Therapy. Stem Cell Reports (2015) 0.82
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
A bacterial effector acts as a plant transcription factor and induces a cell size regulator. Science (2007) 4.27
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Insights into genome plasticity and pathogenicity of the plant pathogenic bacterium Xanthomonas campestris pv. vesicatoria revealed by the complete genome sequence. J Bacteriol (2005) 3.12
Detailed analysis of the DNA recognition motifs of the Xanthomonas type III effectors AvrBs3 and AvrBs3Deltarep16. Plant J (2009) 2.44
Recognition of AvrBs3-like proteins is mediated by specific binding to promoters of matching pepper Bs3 alleles. Plant Physiol (2009) 2.13
How Xanthomonas type III effectors manipulate the host plant. Curr Opin Microbiol (2009) 2.11
Type III-dependent translocation of the Xanthomonas AvrBs3 protein into the plant cell. Mol Microbiol (2002) 1.77
The xanthomonas type III effector protein AvrBs3 modulates plant gene expression and induces cell hypertrophy in the susceptible host. Mol Plant Microbe Interact (2002) 1.67
Regulation and secretion of Xanthomonas virulence factors. FEMS Microbiol Rev (2009) 1.64
Port of entry--the type III secretion translocon. Trends Microbiol (2002) 1.58
Getting across--bacterial type III effector proteins on their way to the plant cell. EMBO J (2002) 1.53
Two novel type III-secreted proteins of Xanthomonas campestris pv. vesicatoria are encoded within the hrp pathogenicity island. J Bacteriol (2002) 1.53
Characterization of AvrBs3-like effectors from a Brassicaceae pathogen reveals virulence and avirulence activities and a protein with a novel repeat architecture. Mol Plant Microbe Interact (2005) 1.49
Specific binding of the Xanthomonas campestris pv. vesicatoria AraC-type transcriptional activator HrpX to plant-inducible promoter boxes. J Bacteriol (2006) 1.45
Common infection strategies of plant and animal pathogenic bacteria. Curr Opin Plant Biol (2003) 1.41
Functional analysis of HrpF, a putative type III translocon protein from Xanthomonas campestris pv. vesicatoria. J Bacteriol (2002) 1.33
Type III effector proteins from the plant pathogen Xanthomonas and their role in the interaction with the host plant. J Plant Physiol (2005) 1.29
Expression levels of avrBs3-like genes affect recognition specificity in tomato Bs4- but not in pepper Bs3-mediated perception. Mol Plant Microbe Interact (2005) 1.27
Dimerization of the bacterial effector protein AvrBs3 in the plant cell cytoplasm prior to nuclear import. Plant J (2005) 1.27
Genome-wide transcriptome analysis of the plant pathogen Xanthomonas identifies sRNAs with putative virulence functions. Nucleic Acids Res (2011) 1.25
Who comes first? How plant pathogenic bacteria orchestrate type III secretion. Curr Opin Microbiol (2006) 1.22
A novel family of plasmid-transferred anti-sense ncRNAs. RNA Biol (2010) 1.18
XopC and XopJ, two novel type III effector proteins from Xanthomonas campestris pv. vesicatoria. J Bacteriol (2003) 1.13
The type III-dependent Hrp pilus is required for productive interaction of Xanthomonas campestris pv. vesicatoria with pepper host plants. J Bacteriol (2005) 1.11
New type III effectors from Xanthomonas campestris pv. vesicatoria trigger plant reactions dependent on a conserved N-myristoylation motif. Mol Plant Microbe Interact (2007) 1.11
HpaB from Xanthomonas campestris pv. vesicatoria acts as an exit control protein in type III-dependent protein secretion. Mol Microbiol (2004) 1.10
TAL effectors--pathogen strategies and plant resistance engineering. New Phytol (2014) 1.08
Suppression of the AvrBs1-specific hypersensitive response by the YopJ effector homolog AvrBsT from Xanthomonas depends on a SNF1-related kinase. New Phytol (2010) 1.07
Functional characterization of the Xcs and Xps type II secretion systems from the plant pathogenic bacterium Xanthomonas campestris pv vesicatoria. New Phytol (2010) 1.07
Computational predictions provide insights into the biology of TAL effector target sites. PLoS Comput Biol (2013) 1.04
A pathogen type III effector with a novel E3 ubiquitin ligase architecture. PLoS Pathog (2013) 0.99
Targeting of two effector protein classes to the type III secretion system by a HpaC- and HpaB-dependent protein complex from Xanthomonas campestris pv. vesicatoria. Mol Microbiol (2006) 0.99
Basal defenses induced in pepper by lipopolysaccharides are suppressed by Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact (2004) 0.95
Analysis of new type III effectors from Xanthomonas uncovers XopB and XopS as suppressors of plant immunity. New Phytol (2012) 0.95
Characterization of the nonconserved hpaB-hrpF region in the hrp pathogenicity island from Xanthomonas campestris pv. vesicatoria. Mol Plant Microbe Interact (2007) 0.93
HpaC controls substrate specificity of the Xanthomonas type III secretion system. PLoS Pathog (2008) 0.93
Visualization of novel virulence activities of the Xanthomonas type III effectors AvrBs1, AvrBs3 and AvrBs4. Mol Plant Pathol (2009) 0.91
HpaA from Xanthomonas is a regulator of type III secretion. Mol Microbiol (2008) 0.90
Genomic approaches in Xanthomonas campestris pv. vesicatoria allow fishing for virulence genes. J Biotechnol (2003) 0.89
Small RNA sX13: a multifaceted regulator of virulence in the plant pathogen Xanthomonas. PLoS Pathog (2013) 0.89
Membrane topology of conserved components of the type III secretion system from the plant pathogen Xanthomonas campestris pv. vesicatoria. Microbiology (2010) 0.86
Refinement of the Xanthomonas campestris pv. vesicatoria hrpD and hrpE operon structure. Mol Plant Microbe Interact (2007) 0.83
Type III secretion chaperones ShcS1 and ShcO1 from Pseudomonas syringae pv. tomato DC3000 bind more than one effector. Microbiology (2005) 0.81
Host-microbe interactions: ever increasing complexity. Curr Opin Microbiol (2011) 0.80
Regulated nuclear targeting of cauliflower mosaic virus. J Gen Virol (2002) 0.77
Physical delimitation of the pepper Bs3 resistance gene specifying recognition of the AvrBs3 protein from Xanthomonas campestris pv. vesicatoria. Theor Appl Genet (2006) 0.76