Published in Nat Protoc on January 05, 2012
RNA-guided human genome engineering via Cas9. Science (2013) 48.29
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
Genome engineering using the CRISPR-Cas9 system. Nat Protoc (2013) 15.98
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol (2013) 11.35
TALENs: a widely applicable technology for targeted genome editing. Nat Rev Mol Cell Biol (2012) 7.01
A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun (2012) 3.60
Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic Acids Res (2012) 3.41
Optimization of scarless human stem cell genome editing. Nucleic Acids Res (2013) 2.78
Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription. Cell (2014) 2.64
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration. Nature (2016) 2.37
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res (2012) 2.09
CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc (2013) 2.05
Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry. Science (2013) 1.91
Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci (2012) 1.89
Directed evolution of APEX2 for electron microscopy and proximity labeling. Nat Methods (2014) 1.84
An iCRISPR platform for rapid, multiplexable, and inducible genome editing in human pluripotent stem cells. Cell Stem Cell (2014) 1.83
Using membrane transporters to improve crops for sustainable food production. Nature (2013) 1.73
Repeating pattern of non-RVD variations in DNA-binding modules enhances TALEN activity. Sci Rep (2013) 1.73
An essential receptor for adeno-associated virus infection. Nature (2016) 1.69
Noncoding RNA NORAD Regulates Genomic Stability by Sequestering PUMILIO Proteins. Cell (2015) 1.68
Selective elimination of mitochondrial mutations in the germline by genome editing. Cell (2015) 1.65
The iCRISPR platform for rapid genome editing in human pluripotent stem cells. Methods Enzymol (2014) 1.64
Inducible in vivo genome editing with CRISPR-Cas9. Nat Biotechnol (2015) 1.64
Seamless gene correction of β-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res (2014) 1.63
Tunable and multifunctional eukaryotic transcription factors based on CRISPR/Cas. ACS Synth Biol (2013) 1.58
Targeted chromosomal deletions and inversions in zebrafish. Genome Res (2013) 1.57
Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State. Dev Cell (2015) 1.50
PLA2G16 represents a switch between entry and clearance of Picornaviridae. Nature (2017) 1.48
Neurobeachin is required postsynaptically for electrical and chemical synapse formation. Curr Biol (2014) 1.45
Characterization of vitamin K-dependent carboxylase mutations that cause bleeding and nonbleeding disorders. Blood (2016) 1.45
Genome-editing Technologies for Gene and Cell Therapy. Mol Ther (2016) 1.41
MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter. EMBO Rep (2014) 1.40
Chimeric TALE recombinases with programmable DNA sequence specificity. Nucleic Acids Res (2012) 1.38
Genome editing of human pluripotent stem cells to generate human cellular disease models. Dis Model Mech (2013) 1.37
TALEN-based gene disruption in the dengue vector Aedes aegypti. PLoS One (2013) 1.31
Locus-specific epigenetic remodeling controls addiction- and depression-related behaviors. Nat Neurosci (2014) 1.30
Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors. Proc Natl Acad Sci U S A (2013) 1.26
Efficient targeted mutagenesis in medaka using custom-designed transcription activator-like effector nucleases. Genetics (2013) 1.26
Reprogramming to pluripotency using designer TALE transcription factors targeting enhancers. Stem Cell Reports (2013) 1.22
Efficient methods for targeted mutagenesis in zebrafish using zinc-finger nucleases: data from targeting of nine genes using CompoZr or CoDA ZFNs. PLoS One (2013) 1.19
Fundamentals of vitamin D hormone-regulated gene expression. J Steroid Biochem Mol Biol (2013) 1.15
Comparison of T7E1 and surveyor mismatch cleavage assays to detect mutations triggered by engineered nucleases. G3 (Bethesda) (2015) 1.13
Advances in genome editing technology and its promising application in evolutionary and ecological studies. Gigascience (2014) 1.11
Targeted gene knockout in chickens mediated by TALENs. Proc Natl Acad Sci U S A (2014) 1.11
ULtiMATE system for rapid assembly of customized TAL effectors. PLoS One (2013) 1.10
Laying a solid foundation for Manhattan--'setting the functional basis for the post-GWAS era'. Trends Genet (2014) 1.10
Targeted genome engineering techniques in Drosophila. Methods (2014) 1.09
Macrophages eat cancer cells using their own calreticulin as a guide: roles of TLR and Btk. Proc Natl Acad Sci U S A (2015) 1.08
ALS mutant FUS proteins are recruited into stress granules in induced pluripotent stem cell-derived motoneurons. Dis Model Mech (2015) 1.07
Newer gene editing technologies toward HIV gene therapy. Viruses (2013) 1.07
Natural zinc ribbon HNH endonucleases and engineered zinc finger nicking endonuclease. Nucleic Acids Res (2012) 1.06
Expanded activity of dimer nucleases by combining ZFN and TALEN for genome editing. Sci Rep (2013) 1.06
Development of synthetic selfish elements based on modular nucleases in Drosophila melanogaster. Nucleic Acids Res (2014) 1.05
Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. Mol Ther (2014) 1.03
TALE-mediated epigenetic suppression of CDKN2A increases replication in human fibroblasts. J Clin Invest (2015) 1.02
The long non-coding RNA Dali is an epigenetic regulator of neural differentiation. Elife (2014) 1.01
Dynamin recruitment and membrane scission at the neck of a clathrin-coated pit. Mol Biol Cell (2014) 0.99
Generation of targeted mouse mutants by embryo microinjection of TALEN mRNA. Nat Protoc (2013) 0.99
Hoxb5 marks long-term haematopoietic stem cells and reveals a homogenous perivascular niche. Nature (2016) 0.99
Seamless genome editing in human pluripotent stem cells using custom endonuclease-based gene targeting and the piggyBac transposon. Nat Protoc (2013) 0.97
New and TALENted genome engineering toolbox. Circ Res (2013) 0.96
Control of plasma membrane lipid homeostasis by the extended synaptotagmins. Nat Cell Biol (2016) 0.95
Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P. Cell (2016) 0.94
From genetics of inflammatory bowel disease towards mechanistic insights. Trends Immunol (2013) 0.94
Massively parallel measurements of molecular interaction kinetics on a microfluidic platform. Proc Natl Acad Sci U S A (2012) 0.93
Gene knockout using transcription activator-like effector nucleases (TALENs) reveals that human NDUFA9 protein is essential for stabilizing the junction between membrane and matrix arms of complex I. J Biol Chem (2012) 0.93
True-breeding targeted gene knock-out in barley using designer TALE-nuclease in haploid cells. PLoS One (2014) 0.93
Engineering synthetic TALE and CRISPR/Cas9 transcription factors for regulating gene expression. Methods (2014) 0.93
Inheritable and precise large genomic deletions of non-coding RNA genes in zebrafish using TALENs. PLoS One (2013) 0.93
Stable enhanced green fluorescent protein expression after differentiation and transplantation of reporter human induced pluripotent stem cells generated by AAVS1 transcription activator-like effector nucleases. Stem Cells Transl Med (2014) 0.92
Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest (2016) 0.91
mRNA transfection of a novel TAL effector nuclease (TALEN) facilitates efficient knockout of HIV co-receptor CCR5. Nucleic Acids Res (2015) 0.91
miR-34 and p53: New Insights into a Complex Functional Relationship. PLoS One (2015) 0.91
EENdb: a database and knowledge base of ZFNs and TALENs for endonuclease engineering. Nucleic Acids Res (2012) 0.90
TALEN and CRISPR/Cas Genome Editing Systems: Tools of Discovery. Acta Naturae (2014) 0.89
A Potential New Therapeutic Approach for Friedreich Ataxia: Induction of Frataxin Expression With TALE Proteins. Mol Ther Nucleic Acids (2013) 0.89
DNA methylation and its implications and accessibility for neuropsychiatric therapeutics. Annu Rev Pharmacol Toxicol (2014) 0.89
Physical constraints on biological integral control design for homeostasis and sensory adaptation. Biophys J (2013) 0.89
ZO-1 knockout by TALEN-mediated gene targeting in MDCK cells: involvement of ZO-1 in the regulation of cytoskeleton and cell shape. PLoS One (2014) 0.88
Precise gene modification mediated by TALEN and single-stranded oligodeoxynucleotides in human cells. PLoS One (2014) 0.88
Differential requirement for irf8 in formation of embryonic and adult macrophages in zebrafish. PLoS One (2015) 0.88
FusX: A Rapid One-Step Transcription Activator-Like Effector Assembly System for Genome Science. Hum Gene Ther (2016) 0.88
Systems and synthetic biology approaches to alter plant cell walls and reduce biomass recalcitrance. Plant Biotechnol J (2014) 0.87
The genomic and genetic toolbox of the teleost medaka (Oryzias latipes). Genetics (2015) 0.87
Stochastic promoter activation affects Nanog expression variability in mouse embryonic stem cells. Sci Rep (2014) 0.87
Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells. Nucleic Acids Res (2013) 0.87
Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Cell Stem Cell (2016) 0.87
Modeling Disease In Vivo With CRISPR/Cas9. Trends Mol Med (2015) 0.87
A TALEN-based strategy for efficient bi-allelic miRNA ablation in human cells. RNA (2014) 0.86
A modified TALEN-based system for robust generation of knock-out human pluripotent stem cell lines and disease models. BMC Genomics (2013) 0.86
Beyond the antigen receptor: editing the genome of T-cells for cancer adoptive cellular therapies. Front Immunol (2013) 0.86
Screening methods to identify TALEN-mediated knockout mice. Exp Anim (2014) 0.86
Screening for protein-DNA interactions by automatable DNA-protein interaction ELISA. PLoS One (2013) 0.86
A do-it-yourself protocol for simple transcription activator-like effector assembly. Biol Proced Online (2013) 0.85
A perspective on micro-evo-devo: progress and potential. Genetics (2013) 0.85
Directed evolution of improved zinc finger methyltransferases. PLoS One (2014) 0.85
A simple and efficient method for assembling TALE protein based on plasmid library. PLoS One (2013) 0.85
Evaluation of warfarin resistance using transcription activator-like effector nucleases-mediated vitamin K epoxide reductase knockout HEK293 cells. J Thromb Haemost (2013) 0.85
A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res (2001) 124.61
Transformation of yeast. Proc Natl Acad Sci U S A (1978) 46.46
The double-strand-break repair model for recombination. Cell (1983) 31.21
A TALE nuclease architecture for efficient genome editing. Nat Biotechnol (2010) 26.47
Breaking the code of DNA binding specificity of TAL-type III effectors. Science (2009) 22.33
A simple cipher governs DNA recognition by TAL effectors. Science (2009) 19.99
Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature (2005) 19.15
Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science (2002) 17.71
Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic Acids Res (2011) 16.53
Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A. Science (1991) 15.97
Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases. Nat Biotechnol (2008) 14.75
Targeting DNA double-strand breaks with TAL effector nucleases. Genetics (2010) 14.49
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol (2011) 11.76
Quantification of mRNA using real-time RT-PCR. Nat Protoc (2006) 11.43
Targeted genome editing across species using ZFNs and TALENs. Science (2011) 9.84
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods (2010) 8.86
Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell (1997) 8.68
Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol (2011) 8.45
Heritable gene targeting in zebrafish using customized TALENs. Nat Biotechnol (2011) 8.34
Xanthomonas AvrBs3 family-type III effectors: discovery and function. Annu Rev Phytopathol (2010) 7.70
TAL effectors: finding plant genes for disease and defense. Curr Opin Plant Biol (2010) 7.13
Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat Biotechnol (2011) 7.05
High frequency targeting of genes to specific sites in the mammalian genome. Cell (1986) 6.91
A rapid and general assay for monitoring endogenous gene modification. Methods Mol Biol (2010) 6.77
TAL nucleases (TALNs): hybrid proteins composed of TAL effectors and FokI DNA-cleavage domain. Nucleic Acids Res (2010) 6.65
De novo-engineered transcription activator-like effector (TALE) hybrid nuclease with novel DNA binding specificity creates double-strand breaks. Proc Natl Acad Sci U S A (2011) 6.12
A one pot, one step, precision cloning method with high throughput capability. PLoS One (2008) 5.94
Regulation of selected genome loci using de novo-engineered transcription activator-like effector (TALE)-type transcription factors. Proc Natl Acad Sci U S A (2010) 5.65
Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes. PLoS One (2009) 5.24
High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases. Proc Natl Acad Sci U S A (2010) 4.78
Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes. Nucleic Acids Res (2011) 4.75
Plant pathogen recognition mediated by promoter activation of the pepper Bs3 resistance gene. Science (2007) 4.39
A bacterial effector acts as a plant transcription factor and induces a cell size regulator. Science (2007) 4.27
Genome editing with modularly assembled zinc-finger nucleases. Nat Methods (2010) 3.79
Cre-mediated somatic site-specific recombination in mice. Nucleic Acids Res (1997) 3.70
Identification of a functional transposase of the Tol2 element, an Ac-like element from the Japanese medaka fish, and its transposition in the zebrafish germ lineage. Proc Natl Acad Sci U S A (2000) 3.30
Assembly of custom TALE-type DNA binding domains by modular cloning. Nucleic Acids Res (2011) 3.22
Transcriptional activators of human genes with programmable DNA-specificity. PLoS One (2011) 3.16
Assembly of designer TAL effectors by Golden Gate cloning. PLoS One (2011) 3.05
Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays. Nat Protoc (2009) 3.01
DNA resection in eukaryotes: deciding how to fix the break. Nat Struct Mol Biol (2010) 2.81
Mutation detection using a novel plant endonuclease. Nucleic Acids Res (1998) 2.78
TAL effectors are remote controls for gene activation. Curr Opin Microbiol (2011) 2.50
A novel engineered meganuclease induces homologous recombination in yeast and mammalian cells. Nucleic Acids Res (2003) 2.49
Detailed analysis of the DNA recognition motifs of the Xanthomonas type III effectors AvrBs3 and AvrBs3Deltarep16. Plant J (2009) 2.44
A modular cloning system for standardized assembly of multigene constructs. PLoS One (2011) 2.39
Mismatch cleavage by single-strand specific nucleases. Nucleic Acids Res (2004) 2.14
Recognition of AvrBs3-like proteins is mediated by specific binding to promoters of matching pepper Bs3 alleles. Plant Physiol (2009) 2.13
AAV-mediated gene targeting methods for human cells. Nat Protoc (2011) 1.70
Purification, cloning, and characterization of the CEL I nuclease. Biochemistry (2000) 1.68
The discovery of zinc fingers and their development for practical applications in gene regulation and genome manipulation. Q Rev Biophys (2010) 1.63
The repeat domain of the type III effector protein PthA shows a TPR-like structure and undergoes conformational changes upon DNA interaction. Proteins (2010) 1.51
Structural basis for catalytic activation of a serine recombinase. Structure (2011) 1.39
Functional zinc finger/sleeping beauty transposase chimeras exhibit attenuated overproduction inhibition. FEBS Lett (2005) 1.35
Structure-guided reprogramming of serine recombinase DNA sequence specificity. Proc Natl Acad Sci U S A (2010) 1.31
CEL I enzymatic mutation detection assay. Biotechniques (2000) 1.15
Targeted plasmid integration into the human genome by an engineered zinc-finger recombinase. Nucleic Acids Res (2011) 1.13
The use of resolvases T4 endonuclease VII and T7 endonuclease I in mutation detection. Mol Biotechnol (2003) 0.98
Multiplex genome engineering using CRISPR/Cas systems. Science (2013) 55.53
Millisecond-timescale, genetically targeted optical control of neural activity. Nat Neurosci (2005) 28.08
One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell (2013) 24.00
DNA targeting specificity of RNA-guided Cas9 nucleases. Nat Biotechnol (2013) 19.99
RNA-guided editing of bacterial genomes using CRISPR-Cas systems. Nat Biotechnol (2013) 15.51
Targeting DNA double-strand breaks with TAL effector nucleases. Genetics (2010) 14.49
Whole-genome sequencing in a patient with Charcot-Marie-Tooth neuropathy. N Engl J Med (2010) 13.57
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell (2013) 13.37
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature (2011) 13.25
Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription. Nat Biotechnol (2011) 12.86
Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet (2009) 12.44
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex. Nature (2002) 11.85
Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Nature (2009) 11.74
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Nature (2009) 10.79
Common genetic determinants of vitamin D insufficiency: a genome-wide association study. Lancet (2010) 8.89
Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nat Methods (2010) 8.86
Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Science (2009) 8.76
Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Nature (2007) 8.22
An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. J Neural Eng (2007) 7.74
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron (2007) 7.59
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia. Am J Hum Genet (2008) 7.33
National survey of drug-resistant tuberculosis in China. N Engl J Med (2012) 6.28
Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci (2007) 6.28
Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature (2011) 5.62
Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. Nature (2007) 4.59
Excitatory transmission from the amygdala to nucleus accumbens facilitates reward seeking. Nature (2011) 4.58
Mechanisms for human genomic rearrangements. Pathogenetics (2008) 4.54
A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell (2012) 4.49
Closing gaps in the human genome with fosmid resources generated from multiple individuals. Nat Genet (2007) 4.30
Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population. PLoS Genet (2012) 4.05
Cell type–specific channelrhodopsin-2 transgenic mice for optogenetic dissection of neural circuitry function. Nat Methods (2011) 4.02
Next-generation optical technologies for illuminating genetically targeted brain circuits. J Neurosci (2006) 3.95
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol (2011) 3.88
Rates of adult schizophrenia following prenatal exposure to the Chinese famine of 1959-1961. JAMA (2005) 3.83
Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2. Nat Protoc (2010) 3.71
Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature (2010) 3.61
Comprehensive interrogation of natural TALE DNA-binding modules and transcriptional repressor domains. Nat Commun (2012) 3.60
Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system. Nucleic Acids Res (2013) 3.51
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure. Nat Genet (2011) 3.40
Activation of specific interneurons improves V1 feature selectivity and visual perception. Nature (2012) 3.27
Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol (2011) 3.24
Sustained axon regeneration induced by co-deletion of PTEN and SOCS3. Nature (2011) 3.18
The DNA sequence of human chromosome 7. Nature (2003) 3.18
Chromosome catastrophes involve replication mechanisms generating complex genomic rearrangements. Cell (2011) 3.03
Biological applications of gold nanoparticles. Chem Soc Rev (2008) 3.01
Genetic evidence supports demic diffusion of Han culture. Nature (2004) 2.92
Crystal structure of the channelrhodopsin light-gated cation channel. Nature (2012) 2.83
Assembly of endocytic machinery around individual influenza viruses during viral entry. Nat Struct Mol Biol (2004) 2.77
Comparison of Francisella tularensis genomes reveals evolutionary events associated with the emergence of human pathogenic strains. Genome Biol (2007) 2.68
Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science (2014) 2.63
Dynamic remodeling of dendritic arbors in GABAergic interneurons of adult visual cortex. PLoS Biol (2005) 2.61
Efficient genome editing in plants using a CRISPR/Cas system. Cell Res (2013) 2.57
Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. Nature (2003) 2.51
Complex rearrangements in patients with duplications of MECP2 can occur by fork stalling and template switching. Hum Mol Genet (2009) 2.50
Increased LIS1 expression affects human and mouse brain development. Nat Genet (2009) 2.45
Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior. J Neurosci (2011) 2.37
Transcription activator-like effector nucleases enable efficient plant genome engineering. Plant Physiol (2012) 2.36
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genet (2010) 2.24
Unexpected consequences of a sudden and massive transposon amplification on rice gene expression. Nature (2009) 2.24
Optogenetic stimulation of lateral orbitofronto-striatal pathway suppresses compulsive behaviors. Science (2013) 2.21
Role of SMAD and non-SMAD signals in the development of Th17 and regulatory T cells. J Immunol (2010) 2.20
Habenula "cholinergic" neurons co-release glutamate and acetylcholine and activate postsynaptic neurons via distinct transmission modes. Neuron (2011) 2.14
Genetic variation at the O-antigen biosynthetic locus in Pseudomonas aeruginosa. J Bacteriol (2002) 2.13
Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Brain Cell Biol (2008) 2.12
Iterative capped assembly: rapid and scalable synthesis of repeat-module DNA such as TAL effectors from individual monomers. Nucleic Acids Res (2012) 2.09
NIPA2 located in 15q11.2 is mutated in patients with childhood absence epilepsy. Hum Genet (2012) 2.08
Analysis of the genome of the Escherichia coli O157:H7 2006 spinach-associated outbreak isolate indicates candidate genes that may enhance virulence. Infect Immun (2009) 2.07
Autism and other neuropsychiatric symptoms are prevalent in individuals with MeCP2 duplication syndrome. Ann Neurol (2009) 2.07
Pharmaceutical applications of hot-melt extrusion: part I. Drug Dev Ind Pharm (2007) 2.07
Adherence to anti-tuberculosis treatment among pulmonary tuberculosis patients: a qualitative and quantitative study. BMC Health Serv Res (2009) 2.07
Transarticular screw and C1 hook fixation for os odontoideum with atlantoaxial dislocation. World Neurosurg (2011) 2.07
Minimally invasive pedicle screw fixation combined with percutaneous vertebroplasty in the surgical treatment of thoracolumbar osteoporosis fracture. J Neurosurg Spine (2013) 2.05
Schizophrenia-related neural and behavioral phenotypes in transgenic mice expressing truncated Disc1. J Neurosci (2008) 2.04
Postsynaptic requirement for Abl kinases in assembly of the neuromuscular junction. Nat Neurosci (2003) 2.03
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum (2010) 2.02
Genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4. Nat Genet (2002) 2.00
Metabolic syndrome is associated with better nutritional status, but not with cardiovascular disease or all-cause mortality in patients on haemodialysis. Arch Cardiovasc Dis (2012) 1.99
The primordial, blue-cone color system of the mouse retina. J Neurosci (2005) 1.94
Methylobacterium genome sequences: a reference blueprint to investigate microbial metabolism of C1 compounds from natural and industrial sources. PLoS One (2009) 1.94
The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics (2010) 1.91
Dissecting neural function using targeted genome engineering technologies. ACS Chem Neurosci (2012) 1.89
Visual function in mice with photoreceptor degeneration and transgenic expression of channelrhodopsin 2 in ganglion cells. J Neurosci (2010) 1.87
Activity-dependent development of callosal projections in the somatosensory cortex. J Neurosci (2007) 1.87
A quantitative fluorescence study of protein monolayer formation on colloidal nanoparticles. Nat Nanotechnol (2009) 1.85
Expression of lymphocytes and lymphocyte subsets in patients with severe acute respiratory syndrome. Clin Infect Dis (2003) 1.84
Synaptic dynamism measured over minutes to months: age-dependent decline in an autonomic ganglion. Nat Neurosci (2003) 1.77
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22. Ann Rheum Dis (2010) 1.75
Selective optical drive of thalamic reticular nucleus generates thalamic bursts and cortical spindles. Nat Neurosci (2011) 1.74
Environment. Building a "green" railway in China. Science (2007) 1.73
A role of matrix metalloproteinase-8 in atherosclerosis. Circ Res (2009) 1.72
Prevalence of diabetic retinopathy in rural China: the Handan Eye Study. Ophthalmology (2009) 1.70
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming. J Biol Chem (2007) 1.70
Genome-scale promoter engineering by coselection MAGE. Nat Methods (2012) 1.69
Interventions for accelerating orthodontic tooth movement: a systematic review. Angle Orthod (2012) 1.65
Two-photon imaging reveals somatodendritic chloride gradient in retinal ON-type bipolar cells expressing the biosensor Clomeleon. Neuron (2006) 1.63
Transposition of the rice miniature inverted repeat transposable element mPing in Arabidopsis thaliana. Proc Natl Acad Sci U S A (2007) 1.63
Fabrication and Magnetic Properties of Fe65Co35-ZnO Nano-Granular Films. Nanoscale Res Lett (2010) 1.63
Homologous recombination is very rare or absent in human influenza A virus. J Virol (2008) 1.63