Tackling the cancer stem cells - what challenges do they pose?

Lipid Desaturation Is a Metabolic Marker and Therapeutic Target of Ovarian Cancer Stem Cells. Cell Stem Cell (2016) 2.69

Targeting Notch, Hedgehog, and Wnt pathways in cancer stem cells: clinical update. Nat Rev Clin Oncol (2015) 2.02

Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells. J Invest Dermatol (2015) 1.43

Exploiting replicative stress to treat cancer. Nat Rev Drug Discov (2015) 1.27

The Warburg effect: evolving interpretations of an established concept. Free Radic Biol Med (2014) 1.07

The network of epithelial-mesenchymal transition: potential new targets for tumor resistance. J Cancer Res Clin Oncol (2014) 1.04

Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. J R Soc Interface (2014) 1.04

Cancer stem cell metabolism. Breast Cancer Res (2016) 0.99

Preclinical Mouse Cancer Models: A Maze of Opportunities and Challenges. Cell (2015) 0.99

Balancing the innate immune system in tumor development. Trends Cell Biol (2014) 0.98

Cancer stem cell plasticity and tumor hierarchy. World J Stem Cells (2015) 0.96

Novel clinical therapeutics targeting the epithelial to mesenchymal transition. Clin Transl Med (2014) 0.93

New Findings on Breast Cancer Stem Cells: A Review. J Breast Cancer (2015) 0.92

Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science (2016) 0.92

Tumorsphere as an effective in vitro platform for screening anti-cancer stem cell drugs. Oncotarget (2016) 0.91

Phase I Trial of a Yeast-Based Therapeutic Cancer Vaccine (GI-6301) Targeting the Transcription Factor Brachyury. Cancer Immunol Res (2015) 0.90

Proliferation and enrichment of CD133(+) glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds. Biomaterials (2014) 0.89

Chemical Disruption of Wnt-dependent Cell Fate Decision-making Mechanisms in Cancer and Regenerative Medicine. Curr Med Chem (2015) 0.89

Deciphering the cellular source of tumor relapse identifies CD44 as a major therapeutic target in pancreatic adenocarcinoma. Oncotarget (2015) 0.89

The influence of subclonal resistance mutations on targeted cancer therapy. Nat Rev Clin Oncol (2015) 0.89

Patient-derived glioblastoma stem cells are killed by CD133-specific CAR T cells but induce the T cell aging marker CD57. Oncotarget (2015) 0.88

Hes1: a key role in stemness, metastasis and multidrug resistance. Cancer Biol Ther (2015) 0.88

The migration ability of stem cells can explain the existence of cancer of unknown primary site. Rethinking metastasis. Oncoscience (2015) 0.86

Phenotypic diversity of patient-derived melanoma populations in stem cell medium. Lab Invest (2015) 0.84

Common stemness regulators of embryonic and cancer stem cells. World J Stem Cells (2015) 0.84

Optimum 3D Matrix Stiffness for Maintenance of Cancer Stem Cells Is Dependent on Tissue Origin of Cancer Cells. PLoS One (2015) 0.83

Chemotherapy targeting cancer stem cells. Am J Cancer Res (2015) 0.83

Drug Transporter-Mediated Protection of Cancer Stem Cells From Ionophore Antibiotics. Stem Cells Transl Med (2015) 0.82

Bioinformatic approaches to augment study of epithelial-to-mesenchymal transition in lung cancer. Physiol Genomics (2014) 0.82

Differentiation and transdifferentiation potentials of cancer stem cells. Oncotarget (2015) 0.82

The metastasis suppressor, NDRG1, inhibits "stemness" of colorectal cancer via down-regulation of nuclear β-catenin and CD44. Oncotarget (2015) 0.82

Clusterin, a gene enriched in intestinal stem cells, is required for L1-mediated colon cancer metastasis. Oncotarget (2015) 0.81

Blocking the epithelial-to-mesenchymal transition pathway abrogates resistance to anti-folate chemotherapy in lung cancer. Cell Death Dis (2015) 0.81

Temozolomide nanoparticles for targeted glioblastoma therapy. ACS Appl Mater Interfaces (2015) 0.81

Establishment and characterization of a human intrahepatic cholangiocarcinoma cell line derived from an Italian patient. Tumour Biol (2015) 0.81

Leptin as a mediator of tumor-stromal interactions promotes breast cancer stem cell activity. Oncotarget (2016) 0.81

Prolonged pemetrexed pretreatment augments persistence of cisplatin-induced DNA damage and eliminates resistant lung cancer stem-like cells associated with EMT. BMC Cancer (2016) 0.81

Anti-Cancer Stem-like Cell Compounds in Clinical Development - An Overview and Critical Appraisal. Front Oncol (2016) 0.80

MiR-744 increases tumorigenicity of pancreatic cancer by activating Wnt/β-catenin pathway. Oncotarget (2015) 0.80

Anti-protozoal and anti-bacterial antibiotics that inhibit protein synthesis kill cancer subtypes enriched for stem cell-like properties. Cell Cycle (2015) 0.80

Cancer stem cell-driven efficacy of trastuzumab (Herceptin): towards a reclassification of clinically HER2-positive breast carcinomas. Oncotarget (2015) 0.80

Risk stratification in myeloma by detection of circulating plasma cells prior to autologous stem cell transplantation in the novel agent era. Blood Cancer J (2016) 0.80

Induction of the intestinal stem cell signature gene SMOC-2 is required for L1-mediated colon cancer progression. Oncogene (2015) 0.80

3D matrix-based cell cultures: Automated analysis of tumor cell survival and proliferation. Int J Oncol (2015) 0.79

MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway. Oncotarget (2015) 0.79

EpCAM Aptamer-mediated Survivin Silencing Sensitized Cancer Stem Cells to Doxorubicin in a Breast Cancer Model. Theranostics (2015) 0.79

Integrin-β4 identifies cancer stem cell-enriched populations of partially mesenchymal carcinoma cells. Proc Natl Acad Sci U S A (2017) 0.78

Drug Delivery Using Nanoparticles for Cancer Stem-Like Cell Targeting. Front Pharmacol (2016) 0.78

Cancer Stem Cell Quiescence and Plasticity as Major Challenges in Cancer Therapy. Stem Cells Int (2016) 0.78

RB1 deficiency in triple-negative breast cancer induces mitochondrial protein translation. J Clin Invest (2016) 0.78

Association Between Expression of Cancer Stem Cell Markers and Poor Differentiation of Hepatocellular Carcinoma: A Meta-Analysis (PRISMA). Medicine (Baltimore) (2015) 0.78

ABCG2 regulates self-renewal and stem cell marker expression but not tumorigenicity or radiation resistance of glioma cells. Sci Rep (2016) 0.78

Heparan sulfate hexasaccharide selectively inhibits cancer stem cells self-renewal by activating p38 MAP kinase. Oncotarget (2016) 0.78

Natural killer cell immunotherapy to target stem-like tumor cells. J Immunother Cancer (2016) 0.78

Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget (2016) 0.78

Attacking the supply wagons to starve cancer cells to death. FEBS Lett (2016) 0.77

The Arf-like GTPase Arl8b is essential for three-dimensional invasive growth of prostate cancer in vitro and xenograft formation and growth in vivo. Oncotarget (2016) 0.77

High prevalence of side population in human cancer cell lines. Oncoscience (2016) 0.77

Novel function of MDA-9/Syntenin (SDCBP) as a regulator of survival and stemness in glioma stem cells. Oncotarget (2016) 0.77

Prognostic significance of S100A4 expression in stage II and III colorectal cancer: results from a population-based series and a randomized phase III study on adjuvant chemotherapy. Cancer Med (2016) 0.77

EMT in immuno-resistance. Oncoscience (2015) 0.76

Targeting cancer stem cells with p53 modulators. Oncotarget (2016) 0.76

Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. J R Soc Interface (2016) 0.76

Downregulated miR-495 [Corrected] Inhibits the G1-S Phase Transition by Targeting Bmi-1 in Breast Cancer. Medicine (Baltimore) (2015) 0.76

NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer? J Nanobiotechnology (2016) 0.76

SOX9 is a novel cancer stem cell marker surrogated by osteopontin in human hepatocellular carcinoma. Sci Rep (2016) 0.76

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol Cancer (2017) 0.76

Targeting SOX2 as a Therapeutic Strategy in Glioblastoma. Front Oncol (2016) 0.76

DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep (2016) 0.76

Reversing drug resistance of soft tumor-repopulating cells by tumor cell-derived chemotherapeutic microparticles. Cell Res (2016) 0.76

SOX9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin. Sci Rep (2016) 0.76

TGFβ-Responsive HMOX1 Expression Is Associated with Stemness and Invasion in Glioblastoma Multiforme. Stem Cells (2016) 0.76

The Epigenomics of Embryonic Pathway Signaling in Colorectal Cancer. Front Pharmacol (2017) 0.76

Aptamer-siRNA Chimeras: Discovery, Progress, and Future Prospects. Biomedicines (2017) 0.76

SIRT6 Suppresses Cancer Stem-like Capacity in Tumors with PI3K Activation Independently of Its Deacetylase Activity. Cell Rep (2017) 0.76

Cancer Stem Cells (CSCs) in Melanoma: There's Smoke, But Is There Fire? J Cell Physiol (2017) 0.75

Human lung cancer-derived microparticles enhanced angiogenesis and growth of hepatoma cells in rodent lung parenchyma. Am J Transl Res (2016) 0.75

GP73-regulated oncolytic adenoviruses possess potent killing effect on human liver cancer stem-like cells. Oncotarget (2016) 0.75

Wnt Drug Discovery: Weaving Through the Screens, Patents and Clinical Trials. Cancers (Basel) (2016) 0.75

Engineered Breast Cancer Cell Spheroids Reproduce Biologic Properties of Solid Tumors. Adv Healthc Mater (2016) 0.75

Targeting tissue factor as a novel therapeutic oncotarget for eradication of cancer stem cells isolated from tumor cell lines, tumor xenografts and patients of breast, lung and ovarian cancer. Oncotarget (2016) 0.75

In Vitro Growth Inhibitory Activities of Natural Products from Irciniid Sponges against Cancer Cells: A Comparative Study. Biomed Res Int (2016) 0.75

Dual Targeting of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase and Histone Deacetylase as a Therapy for Colorectal Cancer. EBioMedicine (2016) 0.75

Anti-Müllerian Hormone Signaling Regulates Epithelial Plasticity and Chemoresistance in Lung Cancer. Cell Rep (2016) 0.75

YAP1 regulates ABCG2 and cancer cell side population in human lung cancer cells. Oncotarget (2016) 0.75

Lysine-specific demethylase KDM3A regulates ovarian cancer stemness and chemoresistance. Oncogene (2016) 0.75

Malignant Pleural Effusion and Ascites Induce Epithelial-Mesenchymal Transition and Cancer Stem-Like Cell Properties via VEGF/PI3K/Akt/mTOR Pathway. J Biol Chem (2016) 0.75

Combining a GSI and BCL-2 inhibitor to overcome melanoma's resistance to current treatments. Oncotarget (2016) 0.75

Caenorhabditis elegans as a model for cancer research. Mol Cell Oncol (2014) 0.75

Optimized Stem Cell Detection Using the DyeCycle-Triggered Side Population Phenotype. Stem Cells Int (2015) 0.75

Stem Cell Extracellular Vesicles: Extended Messages of Regeneration. Annu Rev Pharmacol Toxicol (2016) 0.75

Ribonucleic acid (RNA) biosynthesis in human cancer. Cancer Cell Int (2015) 0.75

Design and Characterization of Bioengineered Cancer-Like Stem Cells. PLoS One (2015) 0.75

Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells. Front Pharmacol (2016) 0.75

Pharmacological and immunological targeting of tumor mesenchymalization. Pharmacol Ther (2016) 0.75

Cancer Stem Cells: Plasticity Works against Therapy. Acta Naturae (2016) 0.75

FXR1a-associated microRNP: a driver of specialized non-canonical translation in quiescent conditions. RNA Biol (2016) 0.75

Tumor proliferation and diffusion on percolation clusters. J Biol Phys (2016) 0.75

Large molecular systems landscape uncovers T cell trapping in human skin cancer. Sci Rep (2016) 0.75

Mammary gland stem cells and their application in breast cancer. Oncotarget (2016) 0.75

Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 67.34

Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A (2003) 59.17

An integrated genomic analysis of human glioblastoma multiforme. Science (2008) 51.36

The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell (2008) 46.08

Epithelial-mesenchymal transitions in development and disease. Cell (2009) 39.17

Identification of human brain tumour initiating cells. Nature (2004) 38.87

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy (2006) 37.55

Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer (2002) 34.99

Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09

Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63

IDH1 and IDH2 mutations in gliomas. N Engl J Med (2009) 32.41

Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature (2007) 29.32

The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 24.94

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature (2006) 24.52

Identification and expansion of human colon-cancer-initiating cells. Nature (2006) 24.44

Identification of a cancer stem cell in human brain tumors. Cancer Res (2003) 24.02

ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell (2007) 22.89

A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature (1994) 21.59

In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev (2003) 20.77

Tumour evolution inferred by single-cell sequencing. Nature (2011) 19.13

Identification of pancreatic cancer stem cells. Cancer Res (2007) 18.36

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature (2008) 18.20

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Efficient tumour formation by single human melanoma cells. Nature (2008) 16.35

Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell (2007) 14.87

Tumour-educated macrophages promote tumour progression and metastasis. Nat Rev Cancer (2004) 14.55

Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res (2005) 13.89

Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A (2007) 13.58

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer Cell (2010) 13.13

Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96

Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A (2007) 11.94

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med (2001) 11.94

Transformation from committed progenitor to leukaemia stem cell initiated by MLL-AF9. Nature (2006) 11.90

The landscape of cancer genes and mutational processes in breast cancer. Nature (2012) 11.24

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Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Science (2013) 10.87

Tumor growth need not be driven by rare cancer stem cells. Science (2007) 10.34

TGF-beta and epithelial-to-mesenchymal transitions. Oncogene (2005) 10.02

Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J Exp Med (2001) 9.99

Friends or foes - bipolar effects of the tumour stroma in cancer. Nat Rev Cancer (2004) 9.68

Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol (2009) 9.43

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature (2009) 9.15

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