Published in Gastroenterology on December 01, 2007
Identification of gastric cancer stem cells using the cell surface marker CD44. Stem Cells (2009) 4.08
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell (2013) 2.10
A CK19(CreERT) knockin mouse line allows for conditional DNA recombination in epithelial cells in multiple endodermal organs. Genesis (2008) 2.10
Nature meets nurture: molecular genetics of gastric cancer. Hum Genet (2009) 1.87
Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology (2011) 1.67
Gastric cancer stem cells. J Clin Oncol (2008) 1.59
The adult Drosophila gastric and stomach organs are maintained by a multipotent stem cell pool at the foregut/midgut junction in the cardia (proventriculus). Cell Cycle (2011) 1.57
Paneth cells in intestinal homeostasis and tissue injury. PLoS One (2012) 1.57
Stomach Organ and Cell Lineage Differentiation: from Embryogenesis to Adult Homeostasis. Cell Mol Gastroenterol Hepatol (2016) 1.46
Spermine oxidase mediates the gastric cancer risk associated with Helicobacter pylori CagA. Gastroenterology (2011) 1.41
Gastric epithelial stem cells. Gastroenterology (2010) 1.39
Stem cells and cancer of the stomach and intestine. Mol Oncol (2010) 1.37
Stem cells in gastroenterology and hepatology. Nat Rev Gastroenterol Hepatol (2009) 1.23
Sequential expression of putative stem cell markers in gastric carcinogenesis. Br J Cancer (2011) 1.22
ChePep controls Helicobacter pylori Infection of the gastric glands and chemotaxis in the Epsilonproteobacteria. MBio (2011) 1.22
Wnt signaling, stem cells, and cancer of the gastrointestinal tract. Cold Spring Harb Perspect Biol (2012) 1.19
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology (2014) 1.16
Pathobiology of Helicobacter pylori-Induced Gastric Cancer. Gastroenterology (2015) 1.13
Mouse models of gastric cancer. Cancers (Basel) (2013) 1.07
Inflammation and stem cells in gastrointestinal carcinogenesis. Physiology (Bethesda) (2008) 1.06
Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05
Gastric cancer stem cells: a novel therapeutic target. Cancer Lett (2013) 1.04
Notch signaling regulates gastric antral LGR5 stem cell function. EMBO J (2015) 0.99
Gastric carcinogenesis. World J Gastroenterol (2012) 0.97
Stem cells in gastric cancer. World J Gastroenterol (2015) 0.96
Altered expression of a putative progenitor cell marker DCAMKL1 in the rat gastric mucosa in regeneration, metaplasia and dysplasia. BMC Gastroenterol (2010) 0.95
CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5. Proc Natl Acad Sci U S A (2012) 0.93
Cancer stem cells: the 'heartbeat' of gastric cancer. J Gastroenterol (2012) 0.88
Identification of quiescent, stem-like cells in the distal female reproductive tract. PLoS One (2012) 0.87
Gastric cancer stem cells: evidence, potential markers, and clinical implications. J Gastroenterol (2015) 0.87
Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges. Gut Pathog (2012) 0.86
Helicobacter and salmonella persistent infection strategies. Cold Spring Harb Perspect Med (2013) 0.85
Mouse models of gastric carcinogenesis. J Gastric Cancer (2014) 0.84
Cooperativity of E-cadherin and Smad4 loss to promote diffuse-type gastric adenocarcinoma and metastasis. Mol Cancer Res (2014) 0.83
Gastrointestinal stem cells in health and disease: from flies to humans. Dis Model Mech (2016) 0.82
Expression of α-taxilin in the murine gastrointestinal tract: potential implication in cell proliferation. Histochem Cell Biol (2013) 0.82
The specific linker phosphorylation of Smad2/3 indicates epithelial stem cells in stomach; particularly increasing in mucosae of Helicobacter-associated gastritis. J Gastroenterol (2011) 0.81
Complementary expression and repulsive signaling suggest that EphB receptors and ephrin-B ligands control cell positioning in the gastric epithelium. Histochem Cell Biol (2011) 0.80
Conditional deletion of menin results in antral G cell hyperplasia and hypergastrinemia. Am J Physiol Gastrointest Liver Physiol (2012) 0.80
KLF4 deletion alters gastric cell lineage and induces MUC2 expression. Cell Death Dis (2016) 0.80
Cell-cycle quiescence maintains Caenorhabditis elegans germline stem cells independent of GLP-1/Notch. Elife (2015) 0.79
Notch regulation of gastrointestinal stem cells. J Physiol (2016) 0.78
Current Status on Stem Cells and Cancers of the Gastric Epithelium. Int J Mol Sci (2015) 0.78
Stomach development, stem cells and disease. Development (2016) 0.77
Cellular plasticity in the adult liver and stomach. J Physiol (2016) 0.76
Transgenic and gene knockout mice in gastric cancer research. Oncotarget (2016) 0.75
Notch as a Driver of Gastric Epithelial Cell Proliferation. Cell Mol Gastroenterol Hepatol (2017) 0.75
Cytokeratin 19 promoter directs the expression of Cre recombinase in various epithelia of transgenic mice. Oncotarget (2017) 0.75
A unified model of the hierarchical and stochastic theories of gastric cancer. Br J Cancer (2017) 0.75
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage. Development (2016) 0.75
Initiation and Maintenance of Gastric Cancer: A Focus on CD44 Variant Isoforms and Cancer Stem Cells. Cell Mol Gastroenterol Hepatol (2017) 0.75
Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet (1999) 55.63
Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development (1990) 8.37
Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature (2003) 8.14
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. V. Unitarian Theory of the origin of the four epithelial cell types. Am J Anat (1974) 8.05
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
Gastric cancer originating from bone marrow-derived cells. Science (2004) 6.04
PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet (2007) 4.09
Cdx2 ectopic expression induces gastric intestinal metaplasia in transgenic mice. Gastroenterology (2002) 3.39
Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development (2004) 2.62
Unraveling the mystery of the gastroesophageal junction: a pathologist's perspective. Am J Gastroenterol (2005) 2.25
Identification of a metaplastic cell lineage associated with human gastric adenocarcinoma. Lab Invest (1999) 2.10
Epithelial cell proliferation and islet neogenesis in IFN-g transgenic mice. Development (1993) 1.95
Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues. Dev Biol (2005) 1.94
Helicobacter pylori and gastric cancer: a new paradigm for inflammation-associated epithelial cancers. Gastroenterology (2005) 1.91
Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130. Gastroenterology (2004) 1.79
Somatic mutation, monoclonality and stochastic models of stem cell organization in the intestinal crypt. J Theor Biol (1993) 1.71
Crypt fission in the small intestine and colon. A mechanism for the emergence of G6PD locus-mutated crypts after treatment with mutagens. Am J Pathol (1995) 1.64
Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene (2005) 1.59
Targeted disruption of the mouse villin gene does not impair the morphogenesis of microvilli. Dev Dyn (1998) 1.51
Multipotential stem cells in adult mouse gastric epithelium. Am J Physiol Gastrointest Liver Physiol (2002) 1.41
Helicobacter felis eradication restores normal architecture and inhibits gastric cancer progression in C57BL/6 mice. Gastroenterology (2005) 1.39
Crypt production in normal and diseased human colonic epithelium. Anat Rec (1986) 1.38
Inducible production of interferon-gamma in the developing brain causes cerebellar dysplasia with activation of the Sonic hedgehog pathway. Mol Cell Neurosci (2004) 1.36
Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest (2005) 1.36
Use of transgenic mice to study regulation of gene expression in the parietal cell lineage of gastric units. J Biol Chem (1993) 1.35
Interferon-gamma induced medulloblastoma in the developing cerebellum. J Neurosci (2004) 1.35
Helicobacter pylori and gastric cancer: state of the art. Cancer Epidemiol Biomarkers Prev (1996) 1.25
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features. Am J Anat (1982) 1.23
Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization. J Theor Biol (1997) 1.17
Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain. J Clin Invest (2003) 1.16
Villin: A marker for development of the epithelial pyloric border. Dev Dyn (2002) 1.15
Dynamic histology of the antral epithelium in the mouse stomach: II. Ultrastructure and renewal of isthmal cells. Am J Anat (1985) 1.12
Clonal expansion in the human gut: mitochondrial DNA mutations show us the way. Cell Cycle (2006) 1.02
Lineage and clonal development of gastric glands. Dev Biol (1998) 1.01
Gastric endocrine cells share a clonal origin with other gut cell lineages. Development (1990) 0.93
Dynamic histology of the antral epithelium in the mouse stomach: IV. Ultrastructure and renewal of gland cells. Am J Anat (1985) 0.93
Clonal analysis of isolated single fundic and pyloric gland of stomach using X-linked polymorphism. Biochem Biophys Res Commun (1996) 0.93
Individually dosed oral drug administration to socially-living transponder-tagged mice by a water dispenser under RFID control. J Neurosci Methods (2006) 0.91
Fractographic study on the growth and multiplication of the gastric gland of the hamster. The gland division cycle. Cell Tissue Res (1974) 0.82
Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism. Gut (1998) 0.82
Clonal analysis of glandular stomach carcinogenesis in C3H/HeN<==>BALB/c chimeric mice treated with N-methyl-N-nitrosourea. Cancer Lett (1994) 0.82
Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem (2002) 7.74
Helicobacter pylori cag-type IV secretion system facilitates corpus colonization to induce precancerous conditions in Mongolian gerbils. Gastroenterology (2005) 2.68
Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development (2004) 2.62
Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development (2011) 2.45
Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res (2006) 2.14
Global gene expression analysis reveals evidence for decreased lipid biosynthesis and increased innate immunity in uninvolved psoriatic skin. J Invest Dermatol (2009) 2.06
Morphogenesis of the trachea and esophagus: current players and new roles for noggin and Bmps. Differentiation (2006) 2.04
Integrin acts upstream of netrin signaling to regulate formation of the anchor cell's invasive membrane in C. elegans. Dev Cell (2009) 2.03
Paracrine Hedgehog signaling in stomach and intestine: new roles for hedgehog in gastrointestinal patterning. Gastroenterology (2009) 1.76
ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis. Biochem Biophys Res Commun (2003) 1.70
Genetic variation in C57BL/6 ES cell lines and genetic instability in the Bruce4 C57BL/6 ES cell line. Mamm Genome (2007) 1.68
The same pocket in menin binds both MLL and JUND but has opposite effects on transcription. Nature (2012) 1.62
Altered control of gastric acid secretion in gastrin-cholecystokinin double mutant mice. Gastroenterology (2004) 1.60
Chronic gastritis in the hypochlorhydric gastrin-deficient mouse progresses to adenocarcinoma. Oncogene (2005) 1.59
Interleukin-1beta promotes gastric atrophy through suppression of Sonic Hedgehog. Gastroenterology (2009) 1.58
Conditional deletion of beta1 integrins in the intestinal epithelium causes a loss of Hedgehog expression, intestinal hyperplasia, and early postnatal lethality. J Cell Biol (2006) 1.44
Genetic or chemical hypochlorhydria is associated with inflammation that modulates parietal and G-cell populations in mice. Gastroenterology (2002) 1.43
Mouse atonal homolog 1 directs intestinal progenitors to secretory cell rather than absorptive cell fate. Dev Biol (2010) 1.41
p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice. J Clin Invest (2010) 1.41
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cells. J Biol Chem (2005) 1.39
Bone morphogenetic protein signaling regulates gastric epithelial cell development and proliferation in mice. Gastroenterology (2010) 1.38
Interferon gamma induction of gastric mucous neck cell hypertrophy. Lab Invest (2005) 1.36
Intestinal Neurogenin 3 directs differentiation of a bipotential secretory progenitor to endocrine cell rather than goblet cell fate. Dev Biol (2007) 1.32
Acinetobacter lwoffii infection and gastritis. Microbes Infect (2003) 1.31
Deconvoluting the intestine: molecular evidence for a major role of the mesenchyme in the modulation of signaling cross talk. Physiol Genomics (2007) 1.27
The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment. Blood (2008) 1.27
Blockade of individual Notch ligands and receptors controls graft-versus-host disease. J Clin Invest (2013) 1.27
Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation. J Biol Chem (2007) 1.26
Gastric Sonic Hedgehog acts as a macrophage chemoattractant during the immune response to Helicobacter pylori. Gastroenterology (2012) 1.26
Parietal cell hyperstimulation and autoimmune gastritis in cholera toxin transgenic mice. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Intracellular calcium release and protein kinase C activation stimulate sonic hedgehog gene expression during gastric acid secretion. Gastroenterology (2010) 1.24
Helicobacter pylori-secreted factors inhibit dendritic cell IL-12 secretion: a mechanism of ineffective host defense. Am J Physiol Gastrointest Liver Physiol (2006) 1.24
Gastric tuft cells express DCLK1 and are expanded in hyperplasia. Histochem Cell Biol (2011) 1.23
Hip1r is expressed in gastric parietal cells and is required for tubulovesicle formation and cell survival in mice. J Clin Invest (2008) 1.22
A deficiency in the autophagy gene Atg16L1 enhances resistance to enteric bacterial infection. Cell Host Microbe (2013) 1.21
Hedgehog-responsive mesenchymal clusters direct patterning and emergence of intestinal villi. Proc Natl Acad Sci U S A (2012) 1.20
Lipopolysaccharide-induced expression of multiple alternatively spliced MEFV transcripts in human synovial fibroblasts: a prominent splice isoform lacks the C-terminal domain that is highly mutated in familial Mediterranean fever. Arthritis Rheum (2004) 1.20
Treatment of Helicobacter gastritis with IL-4 requires somatostatin. Proc Natl Acad Sci U S A (2003) 1.19
Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis. Development (2011) 1.18
Hedgehog is an anti-inflammatory epithelial signal for the intestinal lamina propria. Gastroenterology (2010) 1.17
Gene expression profiling of gastrin target genes in parietal cells. Physiol Genomics (2005) 1.17
Villin: A marker for development of the epithelial pyloric border. Dev Dyn (2002) 1.15
Evidence that loss of sonic hedgehog is an indicator of Helicobater pylori-induced atrophic gastritis progressing to gastric cancer. Am J Gastroenterol (2005) 1.15
The netrin receptor DCC focuses invadopodia-driven basement membrane transmigration in vivo. J Cell Biol (2013) 1.11
Mutation of p53 in recurrent hepatocellular carcinoma and its association with the expression of ZBP-89. Am J Pathol (2003) 1.10
Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. Am J Physiol Gastrointest Liver Physiol (2003) 1.09
Pyrin and ASC co-localize to cellular sites that are rich in polymerizing actin. Exp Biol Med (Maywood) (2009) 1.09
Characterization of mice lacking the gene for cholecystokinin. Am J Physiol Regul Integr Comp Physiol (2007) 1.09
Hedgehog signaling and gastrointestinal cancer. Biochim Biophys Acta (2010) 1.07
Cytodifferentiation of the postnatal mouse stomach in normal and Huntingtin-interacting protein 1-related-deficient mice. Am J Physiol Gastrointest Liver Physiol (2010) 1.07
Gli1 deletion prevents Helicobacter-induced gastric metaplasia and expansion of myeloid cell subsets. PLoS One (2013) 1.06
Current molecular markers for gastric progenitor cells and gastric cancer stem cells. J Gastroenterol (2011) 1.05
Multiple Shh signaling centers participate in fungiform papilla and taste bud formation and maintenance. Dev Biol (2013) 1.04
A role for CITED2, a CBP/p300 interacting protein, in colon cancer cell invasion. FEBS Lett (2007) 1.03
Kinetic properties of ASC protein aggregation in epithelial cells. J Cell Physiol (2010) 1.03
Recruitment of ataxia-telangiectasia mutated to the p21(waf1) promoter by ZBP-89 plays a role in mucosal protection. Gastroenterology (2006) 1.03
Analysis of germline GLI1 variation implicates hedgehog signalling in the regulation of intestinal inflammatory pathways. PLoS Med (2008) 1.02
An isoform of ZBP-89 predisposes the colon to colitis. Nucleic Acids Res (2006) 1.02
Differentiation of the gastric mucosa. II. Role of gastrin in gastric epithelial cell proliferation and maturation. Am J Physiol Gastrointest Liver Physiol (2006) 1.01
Hedgehog signaling controls homeostasis of adult intestinal smooth muscle. Dev Biol (2011) 1.01
Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol (2013) 1.01
ZBP-89 regulates expression of tryptophan hydroxylase I and mucosal defense against Salmonella typhimurium in mice. Gastroenterology (2013) 1.00
Kinetic profiles of p300 occupancy in vivo predict common features of promoter structure and coactivator recruitment. Proc Natl Acad Sci U S A (2004) 1.00
Dynamic patterning at the pylorus: formation of an epithelial intestine-stomach boundary in late fetal life. Dev Dyn (2009) 1.00
Re-expression of sonic hedgehog and reduction of CDX2 after Helicobacter pylori eradication prior to incomplete intestinal metaplasia. Int J Cancer (2007) 0.99
Dual oxidases control release of hydrogen peroxide by the gastric epithelium to prevent Helicobacter felis infection and inflammation in mice. Gastroenterology (2013) 0.98
Sumoylation-dependent control of homotypic and heterotypic synergy by the Kruppel-type zinc finger protein ZBP-89. J Biol Chem (2007) 0.98
Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis in mice. Gastroenterology (2013) 0.98
The histone deacetylase inhibitor LBH589 inhibits expression of mitotic genes causing G2/M arrest and cell death in head and neck squamous cell carcinoma cell lines. J Pathol (2009) 0.96
Hypergastrinemia in response to gastric inflammation suppresses somatostatin. Am J Physiol Gastrointest Liver Physiol (2002) 0.96
Effect of gallbladder hypomotility on cholesterol crystallization and growth in CCK-deficient mice. Biochim Biophys Acta (2009) 0.93
A high-fat diet regulates gastrin and acid secretion through primary cilia. FASEB J (2012) 0.93
Familial Mediterranean fever in the post-genomic era: how an ancient disease is providing new insights into inflammatory pathways. Curr Drug Targets Inflamm Allergy (2005) 0.93
Mutagenesis in rodents using the L1 retrotransposon. Genome Biol (2007) 0.92
Intestinal overexpression of ZNF148 suppresses ApcMin/+ neoplasia. Mamm Genome (2006) 0.92